Optimal chemotherapy schedules from tumor entropy
- Autores
- Barrea, Andres Alberto; Hernandez, Matias Ezequiel; Spies, Ruben Daniel
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We propose a model for the dynamics of an heterogeneous tumor, which consists of sensitive and resistant cells. The model is analyzed and validated using a cellular automaton whose local rules are classic and widely accepted in Biology. We then extend the model to a tumor under therapy. We consider Shannon’s entropy for the tumor and analyze the problem of minimizing this entropy. From this minimization problem, we find viable therapies that maintain at low level the entropy of the tumor. These therapies could provide a valuable tool for designing protocols for disease control, maintaining a very low growth level, while the tumor remains composed mainly of sensitive cells.
Fil: Barrea, Andres Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; Argentina
Fil: Hernandez, Matias Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; Argentina
Fil: Spies, Ruben Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; Argentina - Materia
-
Cancer
Chemotheraphy
Entropy
Optimization - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/53100
Ver los metadatos del registro completo
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Optimal chemotherapy schedules from tumor entropyBarrea, Andres AlbertoHernandez, Matias EzequielSpies, Ruben DanielCancerChemotheraphyEntropyOptimizationhttps://purl.org/becyt/ford/1.1https://purl.org/becyt/ford/1We propose a model for the dynamics of an heterogeneous tumor, which consists of sensitive and resistant cells. The model is analyzed and validated using a cellular automaton whose local rules are classic and widely accepted in Biology. We then extend the model to a tumor under therapy. We consider Shannon’s entropy for the tumor and analyze the problem of minimizing this entropy. From this minimization problem, we find viable therapies that maintain at low level the entropy of the tumor. These therapies could provide a valuable tool for designing protocols for disease control, maintaining a very low growth level, while the tumor remains composed mainly of sensitive cells.Fil: Barrea, Andres Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; ArgentinaFil: Hernandez, Matias Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; ArgentinaFil: Spies, Ruben Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; ArgentinaSociedade Brasileira de Matemática Aplicada e Computacional2017-06-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53100Barrea, Andres Alberto; Hernandez, Matias Ezequiel; Spies, Ruben Daniel; Optimal chemotherapy schedules from tumor entropy; Sociedade Brasileira de Matemática Aplicada e Computacional; Matematica Aplicada E Computacional; 36; 2; 15-6-2017; 991-10080101-8205CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s40314-015-0275-7info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs40314-015-0275-7info:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/early/2018/02/10/263327info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:37:39Zoai:ri.conicet.gov.ar:11336/53100instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:37:39.54CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Optimal chemotherapy schedules from tumor entropy |
title |
Optimal chemotherapy schedules from tumor entropy |
spellingShingle |
Optimal chemotherapy schedules from tumor entropy Barrea, Andres Alberto Cancer Chemotheraphy Entropy Optimization |
title_short |
Optimal chemotherapy schedules from tumor entropy |
title_full |
Optimal chemotherapy schedules from tumor entropy |
title_fullStr |
Optimal chemotherapy schedules from tumor entropy |
title_full_unstemmed |
Optimal chemotherapy schedules from tumor entropy |
title_sort |
Optimal chemotherapy schedules from tumor entropy |
dc.creator.none.fl_str_mv |
Barrea, Andres Alberto Hernandez, Matias Ezequiel Spies, Ruben Daniel |
author |
Barrea, Andres Alberto |
author_facet |
Barrea, Andres Alberto Hernandez, Matias Ezequiel Spies, Ruben Daniel |
author_role |
author |
author2 |
Hernandez, Matias Ezequiel Spies, Ruben Daniel |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Cancer Chemotheraphy Entropy Optimization |
topic |
Cancer Chemotheraphy Entropy Optimization |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.1 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
We propose a model for the dynamics of an heterogeneous tumor, which consists of sensitive and resistant cells. The model is analyzed and validated using a cellular automaton whose local rules are classic and widely accepted in Biology. We then extend the model to a tumor under therapy. We consider Shannon’s entropy for the tumor and analyze the problem of minimizing this entropy. From this minimization problem, we find viable therapies that maintain at low level the entropy of the tumor. These therapies could provide a valuable tool for designing protocols for disease control, maintaining a very low growth level, while the tumor remains composed mainly of sensitive cells. Fil: Barrea, Andres Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; Argentina Fil: Hernandez, Matias Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; Argentina Fil: Spies, Ruben Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; Argentina |
description |
We propose a model for the dynamics of an heterogeneous tumor, which consists of sensitive and resistant cells. The model is analyzed and validated using a cellular automaton whose local rules are classic and widely accepted in Biology. We then extend the model to a tumor under therapy. We consider Shannon’s entropy for the tumor and analyze the problem of minimizing this entropy. From this minimization problem, we find viable therapies that maintain at low level the entropy of the tumor. These therapies could provide a valuable tool for designing protocols for disease control, maintaining a very low growth level, while the tumor remains composed mainly of sensitive cells. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-15 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/53100 Barrea, Andres Alberto; Hernandez, Matias Ezequiel; Spies, Ruben Daniel; Optimal chemotherapy schedules from tumor entropy; Sociedade Brasileira de Matemática Aplicada e Computacional; Matematica Aplicada E Computacional; 36; 2; 15-6-2017; 991-1008 0101-8205 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/53100 |
identifier_str_mv |
Barrea, Andres Alberto; Hernandez, Matias Ezequiel; Spies, Ruben Daniel; Optimal chemotherapy schedules from tumor entropy; Sociedade Brasileira de Matemática Aplicada e Computacional; Matematica Aplicada E Computacional; 36; 2; 15-6-2017; 991-1008 0101-8205 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s40314-015-0275-7 info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs40314-015-0275-7 info:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/early/2018/02/10/263327 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Matemática Aplicada e Computacional |
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Sociedade Brasileira de Matemática Aplicada e Computacional |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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