A fast field-cycling MRI relaxometer for physical contrasts design and pre-clinical studies in small animals

Autores
Romero, Javier Agustin; Rodriguez, Gonzalo Gabriel; Anoardo, Esteban
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We present a fast field-cycling NMR relaxometer with added magnetic resonance imaging capabilities. The instrument operates at a maximum proton Larmor frequency of 5 MHz for a sample volume of 35 mL. The magnetic field homogeneity across the sample is 1400 ppm. The main field is generated with a notch-coil electromagnet of own design, fed with a current whose stability is 220 ppm. We show that images of reasonable quality can still be produced under such conditions. The machine is being designed for concept testing of the involved instrumentation and specific contrast agents aimed for field-cycling magnetic resonance imaging applications. The general performance of the prototype was tested through localized relaxometry experiments, T1-dispersion weighted images, temperature maps and T1-weighted images at different magnetic field intensities. We introduce the concept of positive and negative contrast depending on the use of pre-polarized or non-polarized sequences. The system is being improved for pre-clinical studies in small animals.
Fil: Romero, Javier Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad Nacional de Córdoba; Grupo de Resonancia Magnética Nuclear; Laboratorio de Relaxometría y Técnicas Especiales (LaRTE); Argentina
Fil: Rodriguez, Gonzalo Gabriel. Universidad Nacional de Córdoba; Grupo de Resonancia Magnética Nuclear; Laboratorio de Relaxometría y Técnicas Especiales (LaRTE); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Anoardo, Esteban. Universidad Nacional de Córdoba; Grupo de Resonancia Magnética Nuclear; Laboratorio de Relaxometría y Técnicas Especiales (LaRTE); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Materia
CONTRAST
FIELD-CYCLING
MRI
NMR
RELAXOMETRY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/124283
Acceder
id CONICETDig_0268966a4cffb4b5b9ae4cc14bebd03b
oai_identifier_str oai:ri.conicet.gov.ar:11336/124283
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A fast field-cycling MRI relaxometer for physical contrasts design and pre-clinical studies in small animalsRomero, Javier AgustinRodriguez, Gonzalo GabrielAnoardo, EstebanCONTRASTFIELD-CYCLINGMRINMRRELAXOMETRYhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1We present a fast field-cycling NMR relaxometer with added magnetic resonance imaging capabilities. The instrument operates at a maximum proton Larmor frequency of 5 MHz for a sample volume of 35 mL. The magnetic field homogeneity across the sample is 1400 ppm. The main field is generated with a notch-coil electromagnet of own design, fed with a current whose stability is 220 ppm. We show that images of reasonable quality can still be produced under such conditions. The machine is being designed for concept testing of the involved instrumentation and specific contrast agents aimed for field-cycling magnetic resonance imaging applications. The general performance of the prototype was tested through localized relaxometry experiments, T1-dispersion weighted images, temperature maps and T1-weighted images at different magnetic field intensities. We introduce the concept of positive and negative contrast depending on the use of pre-polarized or non-polarized sequences. The system is being improved for pre-clinical studies in small animals.Fil: Romero, Javier Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad Nacional de Córdoba; Grupo de Resonancia Magnética Nuclear; Laboratorio de Relaxometría y Técnicas Especiales (LaRTE); ArgentinaFil: Rodriguez, Gonzalo Gabriel. Universidad Nacional de Córdoba; Grupo de Resonancia Magnética Nuclear; Laboratorio de Relaxometría y Técnicas Especiales (LaRTE); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Anoardo, Esteban. Universidad Nacional de Córdoba; Grupo de Resonancia Magnética Nuclear; Laboratorio de Relaxometría y Técnicas Especiales (LaRTE); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaAcademic Press Inc Elsevier Science2020-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/124283Romero, Javier Agustin; Rodriguez, Gonzalo Gabriel; Anoardo, Esteban; A fast field-cycling MRI relaxometer for physical contrasts design and pre-clinical studies in small animals; Academic Press Inc Elsevier Science; Journal Of Magnetic Resonance; 311; 1-3-2020; 1-11; 1066821090-7807CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1090780719303210info:eu-repo/semantics/altIdentifier/url/https://arxiv.org/abs/1903.09500info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jmr.2019.106682info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:21:36Zoai:ri.conicet.gov.ar:11336/124283instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:21:37.157CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A fast field-cycling MRI relaxometer for physical contrasts design and pre-clinical studies in small animals
title A fast field-cycling MRI relaxometer for physical contrasts design and pre-clinical studies in small animals
spellingShingle A fast field-cycling MRI relaxometer for physical contrasts design and pre-clinical studies in small animals
Romero, Javier Agustin
CONTRAST
FIELD-CYCLING
MRI
NMR
RELAXOMETRY
title_short A fast field-cycling MRI relaxometer for physical contrasts design and pre-clinical studies in small animals
title_full A fast field-cycling MRI relaxometer for physical contrasts design and pre-clinical studies in small animals
title_fullStr A fast field-cycling MRI relaxometer for physical contrasts design and pre-clinical studies in small animals
title_full_unstemmed A fast field-cycling MRI relaxometer for physical contrasts design and pre-clinical studies in small animals
title_sort A fast field-cycling MRI relaxometer for physical contrasts design and pre-clinical studies in small animals
dc.creator.none.fl_str_mv Romero, Javier Agustin
Rodriguez, Gonzalo Gabriel
Anoardo, Esteban
author Romero, Javier Agustin
author_facet Romero, Javier Agustin
Rodriguez, Gonzalo Gabriel
Anoardo, Esteban
author_role author
author2 Rodriguez, Gonzalo Gabriel
Anoardo, Esteban
author2_role author
author
dc.subject.none.fl_str_mv CONTRAST
FIELD-CYCLING
MRI
NMR
RELAXOMETRY
topic CONTRAST
FIELD-CYCLING
MRI
NMR
RELAXOMETRY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We present a fast field-cycling NMR relaxometer with added magnetic resonance imaging capabilities. The instrument operates at a maximum proton Larmor frequency of 5 MHz for a sample volume of 35 mL. The magnetic field homogeneity across the sample is 1400 ppm. The main field is generated with a notch-coil electromagnet of own design, fed with a current whose stability is 220 ppm. We show that images of reasonable quality can still be produced under such conditions. The machine is being designed for concept testing of the involved instrumentation and specific contrast agents aimed for field-cycling magnetic resonance imaging applications. The general performance of the prototype was tested through localized relaxometry experiments, T1-dispersion weighted images, temperature maps and T1-weighted images at different magnetic field intensities. We introduce the concept of positive and negative contrast depending on the use of pre-polarized or non-polarized sequences. The system is being improved for pre-clinical studies in small animals.
Fil: Romero, Javier Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad Nacional de Córdoba; Grupo de Resonancia Magnética Nuclear; Laboratorio de Relaxometría y Técnicas Especiales (LaRTE); Argentina
Fil: Rodriguez, Gonzalo Gabriel. Universidad Nacional de Córdoba; Grupo de Resonancia Magnética Nuclear; Laboratorio de Relaxometría y Técnicas Especiales (LaRTE); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Anoardo, Esteban. Universidad Nacional de Córdoba; Grupo de Resonancia Magnética Nuclear; Laboratorio de Relaxometría y Técnicas Especiales (LaRTE); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
description We present a fast field-cycling NMR relaxometer with added magnetic resonance imaging capabilities. The instrument operates at a maximum proton Larmor frequency of 5 MHz for a sample volume of 35 mL. The magnetic field homogeneity across the sample is 1400 ppm. The main field is generated with a notch-coil electromagnet of own design, fed with a current whose stability is 220 ppm. We show that images of reasonable quality can still be produced under such conditions. The machine is being designed for concept testing of the involved instrumentation and specific contrast agents aimed for field-cycling magnetic resonance imaging applications. The general performance of the prototype was tested through localized relaxometry experiments, T1-dispersion weighted images, temperature maps and T1-weighted images at different magnetic field intensities. We introduce the concept of positive and negative contrast depending on the use of pre-polarized or non-polarized sequences. The system is being improved for pre-clinical studies in small animals.
publishDate 2020
dc.date.none.fl_str_mv 2020-03-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/124283
Romero, Javier Agustin; Rodriguez, Gonzalo Gabriel; Anoardo, Esteban; A fast field-cycling MRI relaxometer for physical contrasts design and pre-clinical studies in small animals; Academic Press Inc Elsevier Science; Journal Of Magnetic Resonance; 311; 1-3-2020; 1-11; 106682
1090-7807
CONICET Digital
CONICET
url http://hdl.handle.net/11336/124283
identifier_str_mv Romero, Javier Agustin; Rodriguez, Gonzalo Gabriel; Anoardo, Esteban; A fast field-cycling MRI relaxometer for physical contrasts design and pre-clinical studies in small animals; Academic Press Inc Elsevier Science; Journal Of Magnetic Resonance; 311; 1-3-2020; 1-11; 106682
1090-7807
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1090780719303210
info:eu-repo/semantics/altIdentifier/url/https://arxiv.org/abs/1903.09500
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jmr.2019.106682
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082606504869888
score 13.22299

Publicaciones similares