Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism

Autores
Carreira, V.P.; Mensch, J.; Fanara, J.J.
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Even though substantial progress has been made to elucidate the physiological and environmental factors underpinning differences in body size, little is known about its genetic architecture. Furthermore, all animal species bear a specific relationship between the size of each organ and overall body size, so different body size traits should be investigated as well as their sexual dimorphism that may have an important impact on the evolution of body size. We have surveyed 191 co-isogenic lines of Drosophila melanogaster, each one of them homozygous for a single P-element insertion, and assessed the effects of mutations on different body size traits compared to the P-element-free co-isogenic control. Nearly 60% of the lines showed significant differences with respect to the control for these traits in one or both sexes and almost 35% showed trait- and sex-specific effects. Candidate gene mutations frequently increased body size in males and decreased it in females. Among the 92 genes identified, most are involved in development and/or metabolic processes and their molecular functions principally include protein-binding and nucleic acid-binding activities. Although several genes showed pleiotropic effects in relation to body size, few of them were involved in the expression of all traits in one or both sexes. These genes seem to be important for different aspects related to the general functioning of the organism. In general, our results indicate that the genetic architecture of body size traits involves a large fraction of the genome and is largely sex and trait specific. © 2009 Macmillan Publishers Limited All rights reserved.
Fil:Carreira, V.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Mensch, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Fanara, J.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
Heredity 2009;102(3):246-256
Materia
Allometry
Body size
Drosophila melanogaster
Genetic architecture
P-element mutagenesis
Sexual dimorphism
Drosophila protein
allometry
body size
environmental factor
evolutionary biology
fly
genetics
mutagenicity
sexual dimorphism
animal
article
body size
Drosophila melanogaster
female
gene expression regulation
genetics
male
physiology
quantitative trait
sexual development
Animals
Body Size
Drosophila melanogaster
Drosophila Proteins
Female
Male
Mutagenesis, Insertional
Quantitative Trait, Heritable
Sex Characteristics
Animalia
Drosophila melanogaster
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_0018067X_v102_n3_p246_Carreira

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oai_identifier_str paperaa:paper_0018067X_v102_n3_p246_Carreira
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repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Body size in Drosophila: Genetic architecture, allometries and sexual dimorphismCarreira, V.P.Mensch, J.Fanara, J.J.AllometryBody sizeDrosophila melanogasterGenetic architectureP-element mutagenesisSexual dimorphismDrosophila proteinallometrybody sizeenvironmental factorevolutionary biologyflygeneticsmutagenicitysexual dimorphismanimalarticlebody sizeDrosophila melanogasterfemalegene expression regulationgeneticsmalephysiologyquantitative traitsexual developmentAnimalsBody SizeDrosophila melanogasterDrosophila ProteinsFemaleMaleMutagenesis, InsertionalQuantitative Trait, HeritableSex CharacteristicsAnimaliaDrosophila melanogasterEven though substantial progress has been made to elucidate the physiological and environmental factors underpinning differences in body size, little is known about its genetic architecture. Furthermore, all animal species bear a specific relationship between the size of each organ and overall body size, so different body size traits should be investigated as well as their sexual dimorphism that may have an important impact on the evolution of body size. We have surveyed 191 co-isogenic lines of Drosophila melanogaster, each one of them homozygous for a single P-element insertion, and assessed the effects of mutations on different body size traits compared to the P-element-free co-isogenic control. Nearly 60% of the lines showed significant differences with respect to the control for these traits in one or both sexes and almost 35% showed trait- and sex-specific effects. Candidate gene mutations frequently increased body size in males and decreased it in females. Among the 92 genes identified, most are involved in development and/or metabolic processes and their molecular functions principally include protein-binding and nucleic acid-binding activities. Although several genes showed pleiotropic effects in relation to body size, few of them were involved in the expression of all traits in one or both sexes. These genes seem to be important for different aspects related to the general functioning of the organism. In general, our results indicate that the genetic architecture of body size traits involves a large fraction of the genome and is largely sex and trait specific. © 2009 Macmillan Publishers Limited All rights reserved.Fil:Carreira, V.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Mensch, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Fanara, J.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2009info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_0018067X_v102_n3_p246_CarreiraHeredity 2009;102(3):246-256reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:43:10Zpaperaa:paper_0018067X_v102_n3_p246_CarreiraInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:43:10.972Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
title Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
spellingShingle Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
Carreira, V.P.
Allometry
Body size
Drosophila melanogaster
Genetic architecture
P-element mutagenesis
Sexual dimorphism
Drosophila protein
allometry
body size
environmental factor
evolutionary biology
fly
genetics
mutagenicity
sexual dimorphism
animal
article
body size
Drosophila melanogaster
female
gene expression regulation
genetics
male
physiology
quantitative trait
sexual development
Animals
Body Size
Drosophila melanogaster
Drosophila Proteins
Female
Male
Mutagenesis, Insertional
Quantitative Trait, Heritable
Sex Characteristics
Animalia
Drosophila melanogaster
title_short Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
title_full Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
title_fullStr Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
title_full_unstemmed Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
title_sort Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
dc.creator.none.fl_str_mv Carreira, V.P.
Mensch, J.
Fanara, J.J.
author Carreira, V.P.
author_facet Carreira, V.P.
Mensch, J.
Fanara, J.J.
author_role author
author2 Mensch, J.
Fanara, J.J.
author2_role author
author
dc.subject.none.fl_str_mv Allometry
Body size
Drosophila melanogaster
Genetic architecture
P-element mutagenesis
Sexual dimorphism
Drosophila protein
allometry
body size
environmental factor
evolutionary biology
fly
genetics
mutagenicity
sexual dimorphism
animal
article
body size
Drosophila melanogaster
female
gene expression regulation
genetics
male
physiology
quantitative trait
sexual development
Animals
Body Size
Drosophila melanogaster
Drosophila Proteins
Female
Male
Mutagenesis, Insertional
Quantitative Trait, Heritable
Sex Characteristics
Animalia
Drosophila melanogaster
topic Allometry
Body size
Drosophila melanogaster
Genetic architecture
P-element mutagenesis
Sexual dimorphism
Drosophila protein
allometry
body size
environmental factor
evolutionary biology
fly
genetics
mutagenicity
sexual dimorphism
animal
article
body size
Drosophila melanogaster
female
gene expression regulation
genetics
male
physiology
quantitative trait
sexual development
Animals
Body Size
Drosophila melanogaster
Drosophila Proteins
Female
Male
Mutagenesis, Insertional
Quantitative Trait, Heritable
Sex Characteristics
Animalia
Drosophila melanogaster
dc.description.none.fl_txt_mv Even though substantial progress has been made to elucidate the physiological and environmental factors underpinning differences in body size, little is known about its genetic architecture. Furthermore, all animal species bear a specific relationship between the size of each organ and overall body size, so different body size traits should be investigated as well as their sexual dimorphism that may have an important impact on the evolution of body size. We have surveyed 191 co-isogenic lines of Drosophila melanogaster, each one of them homozygous for a single P-element insertion, and assessed the effects of mutations on different body size traits compared to the P-element-free co-isogenic control. Nearly 60% of the lines showed significant differences with respect to the control for these traits in one or both sexes and almost 35% showed trait- and sex-specific effects. Candidate gene mutations frequently increased body size in males and decreased it in females. Among the 92 genes identified, most are involved in development and/or metabolic processes and their molecular functions principally include protein-binding and nucleic acid-binding activities. Although several genes showed pleiotropic effects in relation to body size, few of them were involved in the expression of all traits in one or both sexes. These genes seem to be important for different aspects related to the general functioning of the organism. In general, our results indicate that the genetic architecture of body size traits involves a large fraction of the genome and is largely sex and trait specific. © 2009 Macmillan Publishers Limited All rights reserved.
Fil:Carreira, V.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Mensch, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Fanara, J.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description Even though substantial progress has been made to elucidate the physiological and environmental factors underpinning differences in body size, little is known about its genetic architecture. Furthermore, all animal species bear a specific relationship between the size of each organ and overall body size, so different body size traits should be investigated as well as their sexual dimorphism that may have an important impact on the evolution of body size. We have surveyed 191 co-isogenic lines of Drosophila melanogaster, each one of them homozygous for a single P-element insertion, and assessed the effects of mutations on different body size traits compared to the P-element-free co-isogenic control. Nearly 60% of the lines showed significant differences with respect to the control for these traits in one or both sexes and almost 35% showed trait- and sex-specific effects. Candidate gene mutations frequently increased body size in males and decreased it in females. Among the 92 genes identified, most are involved in development and/or metabolic processes and their molecular functions principally include protein-binding and nucleic acid-binding activities. Although several genes showed pleiotropic effects in relation to body size, few of them were involved in the expression of all traits in one or both sexes. These genes seem to be important for different aspects related to the general functioning of the organism. In general, our results indicate that the genetic architecture of body size traits involves a large fraction of the genome and is largely sex and trait specific. © 2009 Macmillan Publishers Limited All rights reserved.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_0018067X_v102_n3_p246_Carreira
url http://hdl.handle.net/20.500.12110/paper_0018067X_v102_n3_p246_Carreira
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Heredity 2009;102(3):246-256
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
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