Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism
- Autores
- Carreira, V.P.; Mensch, J.; Fanara, J.J.
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Even though substantial progress has been made to elucidate the physiological and environmental factors underpinning differences in body size, little is known about its genetic architecture. Furthermore, all animal species bear a specific relationship between the size of each organ and overall body size, so different body size traits should be investigated as well as their sexual dimorphism that may have an important impact on the evolution of body size. We have surveyed 191 co-isogenic lines of Drosophila melanogaster, each one of them homozygous for a single P-element insertion, and assessed the effects of mutations on different body size traits compared to the P-element-free co-isogenic control. Nearly 60% of the lines showed significant differences with respect to the control for these traits in one or both sexes and almost 35% showed trait- and sex-specific effects. Candidate gene mutations frequently increased body size in males and decreased it in females. Among the 92 genes identified, most are involved in development and/or metabolic processes and their molecular functions principally include protein-binding and nucleic acid-binding activities. Although several genes showed pleiotropic effects in relation to body size, few of them were involved in the expression of all traits in one or both sexes. These genes seem to be important for different aspects related to the general functioning of the organism. In general, our results indicate that the genetic architecture of body size traits involves a large fraction of the genome and is largely sex and trait specific. © 2009 Macmillan Publishers Limited All rights reserved.
Fil:Carreira, V.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Mensch, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Fanara, J.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. - Fuente
- Heredity 2009;102(3):246-256
- Materia
-
Allometry
Body size
Drosophila melanogaster
Genetic architecture
P-element mutagenesis
Sexual dimorphism
Drosophila protein
allometry
body size
environmental factor
evolutionary biology
fly
genetics
mutagenicity
sexual dimorphism
animal
article
body size
Drosophila melanogaster
female
gene expression regulation
genetics
male
physiology
quantitative trait
sexual development
Animals
Body Size
Drosophila melanogaster
Drosophila Proteins
Female
Male
Mutagenesis, Insertional
Quantitative Trait, Heritable
Sex Characteristics
Animalia
Drosophila melanogaster - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/2.5/ar
- Repositorio
- Institución
- Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
- OAI Identificador
- paperaa:paper_0018067X_v102_n3_p246_Carreira
Ver los metadatos del registro completo
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Body size in Drosophila: Genetic architecture, allometries and sexual dimorphismCarreira, V.P.Mensch, J.Fanara, J.J.AllometryBody sizeDrosophila melanogasterGenetic architectureP-element mutagenesisSexual dimorphismDrosophila proteinallometrybody sizeenvironmental factorevolutionary biologyflygeneticsmutagenicitysexual dimorphismanimalarticlebody sizeDrosophila melanogasterfemalegene expression regulationgeneticsmalephysiologyquantitative traitsexual developmentAnimalsBody SizeDrosophila melanogasterDrosophila ProteinsFemaleMaleMutagenesis, InsertionalQuantitative Trait, HeritableSex CharacteristicsAnimaliaDrosophila melanogasterEven though substantial progress has been made to elucidate the physiological and environmental factors underpinning differences in body size, little is known about its genetic architecture. Furthermore, all animal species bear a specific relationship between the size of each organ and overall body size, so different body size traits should be investigated as well as their sexual dimorphism that may have an important impact on the evolution of body size. We have surveyed 191 co-isogenic lines of Drosophila melanogaster, each one of them homozygous for a single P-element insertion, and assessed the effects of mutations on different body size traits compared to the P-element-free co-isogenic control. Nearly 60% of the lines showed significant differences with respect to the control for these traits in one or both sexes and almost 35% showed trait- and sex-specific effects. Candidate gene mutations frequently increased body size in males and decreased it in females. Among the 92 genes identified, most are involved in development and/or metabolic processes and their molecular functions principally include protein-binding and nucleic acid-binding activities. Although several genes showed pleiotropic effects in relation to body size, few of them were involved in the expression of all traits in one or both sexes. These genes seem to be important for different aspects related to the general functioning of the organism. In general, our results indicate that the genetic architecture of body size traits involves a large fraction of the genome and is largely sex and trait specific. © 2009 Macmillan Publishers Limited All rights reserved.Fil:Carreira, V.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Mensch, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Fanara, J.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2009info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_0018067X_v102_n3_p246_CarreiraHeredity 2009;102(3):246-256reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:43:10Zpaperaa:paper_0018067X_v102_n3_p246_CarreiraInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:43:10.972Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse |
dc.title.none.fl_str_mv |
Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism |
title |
Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism |
spellingShingle |
Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism Carreira, V.P. Allometry Body size Drosophila melanogaster Genetic architecture P-element mutagenesis Sexual dimorphism Drosophila protein allometry body size environmental factor evolutionary biology fly genetics mutagenicity sexual dimorphism animal article body size Drosophila melanogaster female gene expression regulation genetics male physiology quantitative trait sexual development Animals Body Size Drosophila melanogaster Drosophila Proteins Female Male Mutagenesis, Insertional Quantitative Trait, Heritable Sex Characteristics Animalia Drosophila melanogaster |
title_short |
Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism |
title_full |
Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism |
title_fullStr |
Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism |
title_full_unstemmed |
Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism |
title_sort |
Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism |
dc.creator.none.fl_str_mv |
Carreira, V.P. Mensch, J. Fanara, J.J. |
author |
Carreira, V.P. |
author_facet |
Carreira, V.P. Mensch, J. Fanara, J.J. |
author_role |
author |
author2 |
Mensch, J. Fanara, J.J. |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Allometry Body size Drosophila melanogaster Genetic architecture P-element mutagenesis Sexual dimorphism Drosophila protein allometry body size environmental factor evolutionary biology fly genetics mutagenicity sexual dimorphism animal article body size Drosophila melanogaster female gene expression regulation genetics male physiology quantitative trait sexual development Animals Body Size Drosophila melanogaster Drosophila Proteins Female Male Mutagenesis, Insertional Quantitative Trait, Heritable Sex Characteristics Animalia Drosophila melanogaster |
topic |
Allometry Body size Drosophila melanogaster Genetic architecture P-element mutagenesis Sexual dimorphism Drosophila protein allometry body size environmental factor evolutionary biology fly genetics mutagenicity sexual dimorphism animal article body size Drosophila melanogaster female gene expression regulation genetics male physiology quantitative trait sexual development Animals Body Size Drosophila melanogaster Drosophila Proteins Female Male Mutagenesis, Insertional Quantitative Trait, Heritable Sex Characteristics Animalia Drosophila melanogaster |
dc.description.none.fl_txt_mv |
Even though substantial progress has been made to elucidate the physiological and environmental factors underpinning differences in body size, little is known about its genetic architecture. Furthermore, all animal species bear a specific relationship between the size of each organ and overall body size, so different body size traits should be investigated as well as their sexual dimorphism that may have an important impact on the evolution of body size. We have surveyed 191 co-isogenic lines of Drosophila melanogaster, each one of them homozygous for a single P-element insertion, and assessed the effects of mutations on different body size traits compared to the P-element-free co-isogenic control. Nearly 60% of the lines showed significant differences with respect to the control for these traits in one or both sexes and almost 35% showed trait- and sex-specific effects. Candidate gene mutations frequently increased body size in males and decreased it in females. Among the 92 genes identified, most are involved in development and/or metabolic processes and their molecular functions principally include protein-binding and nucleic acid-binding activities. Although several genes showed pleiotropic effects in relation to body size, few of them were involved in the expression of all traits in one or both sexes. These genes seem to be important for different aspects related to the general functioning of the organism. In general, our results indicate that the genetic architecture of body size traits involves a large fraction of the genome and is largely sex and trait specific. © 2009 Macmillan Publishers Limited All rights reserved. Fil:Carreira, V.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Mensch, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Fanara, J.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. |
description |
Even though substantial progress has been made to elucidate the physiological and environmental factors underpinning differences in body size, little is known about its genetic architecture. Furthermore, all animal species bear a specific relationship between the size of each organ and overall body size, so different body size traits should be investigated as well as their sexual dimorphism that may have an important impact on the evolution of body size. We have surveyed 191 co-isogenic lines of Drosophila melanogaster, each one of them homozygous for a single P-element insertion, and assessed the effects of mutations on different body size traits compared to the P-element-free co-isogenic control. Nearly 60% of the lines showed significant differences with respect to the control for these traits in one or both sexes and almost 35% showed trait- and sex-specific effects. Candidate gene mutations frequently increased body size in males and decreased it in females. Among the 92 genes identified, most are involved in development and/or metabolic processes and their molecular functions principally include protein-binding and nucleic acid-binding activities. Although several genes showed pleiotropic effects in relation to body size, few of them were involved in the expression of all traits in one or both sexes. These genes seem to be important for different aspects related to the general functioning of the organism. In general, our results indicate that the genetic architecture of body size traits involves a large fraction of the genome and is largely sex and trait specific. © 2009 Macmillan Publishers Limited All rights reserved. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12110/paper_0018067X_v102_n3_p246_Carreira |
url |
http://hdl.handle.net/20.500.12110/paper_0018067X_v102_n3_p246_Carreira |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/2.5/ar |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Heredity 2009;102(3):246-256 reponame:Biblioteca Digital (UBA-FCEN) instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales instacron:UBA-FCEN |
reponame_str |
Biblioteca Digital (UBA-FCEN) |
collection |
Biblioteca Digital (UBA-FCEN) |
instname_str |
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
instacron_str |
UBA-FCEN |
institution |
UBA-FCEN |
repository.name.fl_str_mv |
Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
repository.mail.fl_str_mv |
ana@bl.fcen.uba.ar |
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13.070432 |