Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
- Autores
- Rios de Molina del, M.C.; Wainstok de Calmanovici, R.; San Martin de Viale, L.C.
- Año de publicación
- 1987
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- 1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987.
Fil:Rios de Molina del, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Wainstok de Calmanovici, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:San Martin de Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. - Fuente
- Int. J. Biochem. 1987;19(4):365-372
- Materia
-
hexachlorobenzene
uroporphyrinogen decarboxylase
animal model
liver
nonhuman
porphyria
rat
Animal
Carboxy-Lyases
Chlorobenzenes
Female
Hexachlorobenzene
Liver
Porphyria
Porphyrinogens
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uroporphyrinogen Decarboxylase
Uroporphyrinogens - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/2.5/ar
- Repositorio
- Institución
- Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
- OAI Identificador
- paperaa:paper_0020711X_v19_n4_p365_RiosdeMolinadel
Ver los metadatos del registro completo
id |
BDUBAFCEN_87b60a25bc3a0efa51f286bc0d37c726 |
---|---|
oai_identifier_str |
paperaa:paper_0020711X_v19_n4_p365_RiosdeMolinadel |
network_acronym_str |
BDUBAFCEN |
repository_id_str |
1896 |
network_name_str |
Biblioteca Digital (UBA-FCEN) |
spelling |
Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen IRios de Molina del, M.C.Wainstok de Calmanovici, R.San Martin de Viale, L.C.hexachlorobenzeneuroporphyrinogen decarboxylaseanimal modellivernonhumanporphyriaratAnimalCarboxy-LyasesChlorobenzenesFemaleHexachlorobenzeneLiverPorphyriaPorphyrinogensRatsRats, Inbred StrainsSupport, Non-U.S. Gov'tUroporphyrinogen DecarboxylaseUroporphyrinogens1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987.Fil:Rios de Molina del, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Wainstok de Calmanovici, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:San Martin de Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.1987info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_0020711X_v19_n4_p365_RiosdeMolinadelInt. J. Biochem. 1987;19(4):365-372reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:42:51Zpaperaa:paper_0020711X_v19_n4_p365_RiosdeMolinadelInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:42:52.983Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse |
dc.title.none.fl_str_mv |
Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I |
title |
Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I |
spellingShingle |
Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I Rios de Molina del, M.C. hexachlorobenzene uroporphyrinogen decarboxylase animal model liver nonhuman porphyria rat Animal Carboxy-Lyases Chlorobenzenes Female Hexachlorobenzene Liver Porphyria Porphyrinogens Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uroporphyrinogen Decarboxylase Uroporphyrinogens |
title_short |
Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I |
title_full |
Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I |
title_fullStr |
Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I |
title_full_unstemmed |
Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I |
title_sort |
Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I |
dc.creator.none.fl_str_mv |
Rios de Molina del, M.C. Wainstok de Calmanovici, R. San Martin de Viale, L.C. |
author |
Rios de Molina del, M.C. |
author_facet |
Rios de Molina del, M.C. Wainstok de Calmanovici, R. San Martin de Viale, L.C. |
author_role |
author |
author2 |
Wainstok de Calmanovici, R. San Martin de Viale, L.C. |
author2_role |
author author |
dc.subject.none.fl_str_mv |
hexachlorobenzene uroporphyrinogen decarboxylase animal model liver nonhuman porphyria rat Animal Carboxy-Lyases Chlorobenzenes Female Hexachlorobenzene Liver Porphyria Porphyrinogens Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uroporphyrinogen Decarboxylase Uroporphyrinogens |
topic |
hexachlorobenzene uroporphyrinogen decarboxylase animal model liver nonhuman porphyria rat Animal Carboxy-Lyases Chlorobenzenes Female Hexachlorobenzene Liver Porphyria Porphyrinogens Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uroporphyrinogen Decarboxylase Uroporphyrinogens |
dc.description.none.fl_txt_mv |
1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987. Fil:Rios de Molina del, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Wainstok de Calmanovici, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martin de Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. |
description |
1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987. |
publishDate |
1987 |
dc.date.none.fl_str_mv |
1987 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12110/paper_0020711X_v19_n4_p365_RiosdeMolinadel |
url |
http://hdl.handle.net/20.500.12110/paper_0020711X_v19_n4_p365_RiosdeMolinadel |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/2.5/ar |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Int. J. Biochem. 1987;19(4):365-372 reponame:Biblioteca Digital (UBA-FCEN) instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales instacron:UBA-FCEN |
reponame_str |
Biblioteca Digital (UBA-FCEN) |
collection |
Biblioteca Digital (UBA-FCEN) |
instname_str |
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
instacron_str |
UBA-FCEN |
institution |
UBA-FCEN |
repository.name.fl_str_mv |
Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
repository.mail.fl_str_mv |
ana@bl.fcen.uba.ar |
_version_ |
1844618733595656192 |
score |
13.070432 |