Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I

Autores
Rios de Molina del, M.C.; Wainstok de Calmanovici, R.; San Martin de Viale, L.C.
Año de publicación
1987
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987.
Fil:Rios de Molina del, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Wainstok de Calmanovici, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:San Martin de Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
Int. J. Biochem. 1987;19(4):365-372
Materia
hexachlorobenzene
uroporphyrinogen decarboxylase
animal model
liver
nonhuman
porphyria
rat
Animal
Carboxy-Lyases
Chlorobenzenes
Female
Hexachlorobenzene
Liver
Porphyria
Porphyrinogens
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uroporphyrinogen Decarboxylase
Uroporphyrinogens
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_0020711X_v19_n4_p365_RiosdeMolinadel
Acceder
id BDUBAFCEN_87b60a25bc3a0efa51f286bc0d37c726
oai_identifier_str paperaa:paper_0020711X_v19_n4_p365_RiosdeMolinadel
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen IRios de Molina del, M.C.Wainstok de Calmanovici, R.San Martin de Viale, L.C.hexachlorobenzeneuroporphyrinogen decarboxylaseanimal modellivernonhumanporphyriaratAnimalCarboxy-LyasesChlorobenzenesFemaleHexachlorobenzeneLiverPorphyriaPorphyrinogensRatsRats, Inbred StrainsSupport, Non-U.S. Gov'tUroporphyrinogen DecarboxylaseUroporphyrinogens1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987.Fil:Rios de Molina del, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Wainstok de Calmanovici, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:San Martin de Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.1987info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_0020711X_v19_n4_p365_RiosdeMolinadelInt. J. Biochem. 1987;19(4):365-372reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-10-23T11:18:14Zpaperaa:paper_0020711X_v19_n4_p365_RiosdeMolinadelInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-10-23 11:18:16.148Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
spellingShingle Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
Rios de Molina del, M.C.
hexachlorobenzene
uroporphyrinogen decarboxylase
animal model
liver
nonhuman
porphyria
rat
Animal
Carboxy-Lyases
Chlorobenzenes
Female
Hexachlorobenzene
Liver
Porphyria
Porphyrinogens
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uroporphyrinogen Decarboxylase
Uroporphyrinogens
title_short Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_full Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_fullStr Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_full_unstemmed Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_sort Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
dc.creator.none.fl_str_mv Rios de Molina del, M.C.
Wainstok de Calmanovici, R.
San Martin de Viale, L.C.
author Rios de Molina del, M.C.
author_facet Rios de Molina del, M.C.
Wainstok de Calmanovici, R.
San Martin de Viale, L.C.
author_role author
author2 Wainstok de Calmanovici, R.
San Martin de Viale, L.C.
author2_role author
author
dc.subject.none.fl_str_mv hexachlorobenzene
uroporphyrinogen decarboxylase
animal model
liver
nonhuman
porphyria
rat
Animal
Carboxy-Lyases
Chlorobenzenes
Female
Hexachlorobenzene
Liver
Porphyria
Porphyrinogens
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uroporphyrinogen Decarboxylase
Uroporphyrinogens
topic hexachlorobenzene
uroporphyrinogen decarboxylase
animal model
liver
nonhuman
porphyria
rat
Animal
Carboxy-Lyases
Chlorobenzenes
Female
Hexachlorobenzene
Liver
Porphyria
Porphyrinogens
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Uroporphyrinogen Decarboxylase
Uroporphyrinogens
dc.description.none.fl_txt_mv 1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987.
Fil:Rios de Molina del, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Wainstok de Calmanovici, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:San Martin de Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description 1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987.
publishDate 1987
dc.date.none.fl_str_mv 1987
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_0020711X_v19_n4_p365_RiosdeMolinadel
url http://hdl.handle.net/20.500.12110/paper_0020711X_v19_n4_p365_RiosdeMolinadel
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Int. J. Biochem. 1987;19(4):365-372
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
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score 12.982451

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