Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins

Autores
Del C. Batlle, A.M.; De Salamanca, R.E.; Chinarro, S.; Afonso, S.G.; Stella, A.M.
Año de publicación
1986
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986.
Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Afonso, S.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
Int. J. Biochem. 1986;18(2):143-147
Materia
porphyrin
uroporphyrinogen decarboxylase
blood and hemopoietic system
enzyme inactivation
erythrocyte
human
human cell
photoactivation
Carboxy-Lyases
Erythrocytes
Humans
Kinetics
Photolysis
Porphyrins
Thermodynamics
Ultraviolet Rays
Uroporphyrinogen Decarboxylase
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_0020711X_v18_n2_p143_DelCBatlle
Acceder
id BDUBAFCEN_adc083ec6b916fb240bbd4da0c1df237
oai_identifier_str paperaa:paper_0020711X_v18_n2_p143_DelCBatlle
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrinsDel C. Batlle, A.M.De Salamanca, R.E.Chinarro, S.Afonso, S.G.Stella, A.M.porphyrinuroporphyrinogen decarboxylaseblood and hemopoietic systemenzyme inactivationerythrocytehumanhuman cellphotoactivationCarboxy-LyasesErythrocytesHumansKineticsPhotolysisPorphyrinsThermodynamicsUltraviolet RaysUroporphyrinogen Decarboxylase1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986.Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Afonso, S.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.1986info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlleInt. J. Biochem. 1986;18(2):143-147reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-10-23T11:18:12Zpaperaa:paper_0020711X_v18_n2_p143_DelCBatlleInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-10-23 11:18:13.226Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
spellingShingle Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
Del C. Batlle, A.M.
porphyrin
uroporphyrinogen decarboxylase
blood and hemopoietic system
enzyme inactivation
erythrocyte
human
human cell
photoactivation
Carboxy-Lyases
Erythrocytes
Humans
Kinetics
Photolysis
Porphyrins
Thermodynamics
Ultraviolet Rays
Uroporphyrinogen Decarboxylase
title_short Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_full Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_fullStr Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_full_unstemmed Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
title_sort Photodynamic inactivation of red cell uroporphyrinogen decarboxylase by porphyrins
dc.creator.none.fl_str_mv Del C. Batlle, A.M.
De Salamanca, R.E.
Chinarro, S.
Afonso, S.G.
Stella, A.M.
author Del C. Batlle, A.M.
author_facet Del C. Batlle, A.M.
De Salamanca, R.E.
Chinarro, S.
Afonso, S.G.
Stella, A.M.
author_role author
author2 De Salamanca, R.E.
Chinarro, S.
Afonso, S.G.
Stella, A.M.
author2_role author
author
author
author
dc.subject.none.fl_str_mv porphyrin
uroporphyrinogen decarboxylase
blood and hemopoietic system
enzyme inactivation
erythrocyte
human
human cell
photoactivation
Carboxy-Lyases
Erythrocytes
Humans
Kinetics
Photolysis
Porphyrins
Thermodynamics
Ultraviolet Rays
Uroporphyrinogen Decarboxylase
topic porphyrin
uroporphyrinogen decarboxylase
blood and hemopoietic system
enzyme inactivation
erythrocyte
human
human cell
photoactivation
Carboxy-Lyases
Erythrocytes
Humans
Kinetics
Photolysis
Porphyrins
Thermodynamics
Ultraviolet Rays
Uroporphyrinogen Decarboxylase
dc.description.none.fl_txt_mv 1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986.
Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Afonso, S.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description 1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m2 of UV light intensity, 40-45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. © 1986.
publishDate 1986
dc.date.none.fl_str_mv 1986
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle
url http://hdl.handle.net/20.500.12110/paper_0020711X_v18_n2_p143_DelCBatlle
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Int. J. Biochem. 1986;18(2):143-147
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
_version_ 1846784874883579904
score 12.982451

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