Molecular biology and medicine at the end of the XXth century
- Autores
- Kornblihtt, A.R.
- Año de publicación
- 2000
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This paper reviews basic concepts of modern molecular biology with the premise that its influence in today's medicine is so important that its knowledge cannot remain limited to a few experts. I first analyze the overall structure and organization of human genes, their split nature and the flow of genetic information from DNA to protein. The role of transcriptional control in the regulation of gene expression and cell differentiation is described by introducing experimental examples that define the importance of "master" genes. Basic concepts of genetic engineering, the generation of transgenic and knock out animals and the uses of molecular biology in clinical diagnosis, paternity tests and forensic medicine are presented. Finally, I discuss the possibilities of gene therapy and the fantasies and realities of transgenesis and cloning by nuclear transplant in humans.
Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. - Fuente
- Medicina (Argentina) 2000;60(1):9-16
- Materia
-
Clonation
Knock out mice
Medicine
Molecular biology
Transgenic mice
animal
article
cloning
gene
gene expression regulation
gene therapy
genetic engineering
human
medicine
molecular biology
mouse
physiology
transgenic animal
transgenic mouse
Animals
Animals, Genetically Modified
Cloning, Organism
Gene Expression Regulation
Gene Therapy
Genes
Genetic Engineering
Humans
Medicine
Mice
Mice, Transgenic
Molecular Biology - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/2.5/ar
- Repositorio
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- Institución
- Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
- OAI Identificador
- paperaa:paper_00257680_v60_n1_p9_Kornblihtt
Ver los metadatos del registro completo
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Molecular biology and medicine at the end of the XXth century Kornblihtt, A.R.ClonationKnock out miceMedicineMolecular biologyTransgenic miceanimalarticlecloninggenegene expression regulationgene therapygenetic engineeringhumanmedicinemolecular biologymousephysiologytransgenic animaltransgenic mouseAnimalsAnimals, Genetically ModifiedCloning, OrganismGene Expression RegulationGene TherapyGenesGenetic EngineeringHumansMedicineMiceMice, TransgenicMolecular BiologyThis paper reviews basic concepts of modern molecular biology with the premise that its influence in today's medicine is so important that its knowledge cannot remain limited to a few experts. I first analyze the overall structure and organization of human genes, their split nature and the flow of genetic information from DNA to protein. The role of transcriptional control in the regulation of gene expression and cell differentiation is described by introducing experimental examples that define the importance of "master" genes. Basic concepts of genetic engineering, the generation of transgenic and knock out animals and the uses of molecular biology in clinical diagnosis, paternity tests and forensic medicine are presented. Finally, I discuss the possibilities of gene therapy and the fantasies and realities of transgenesis and cloning by nuclear transplant in humans.Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2000info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_00257680_v60_n1_p9_KornblihttMedicina (Argentina) 2000;60(1):9-16reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:43:09Zpaperaa:paper_00257680_v60_n1_p9_KornblihttInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:43:10.651Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse |
| dc.title.none.fl_str_mv |
Molecular biology and medicine at the end of the XXth century |
| title |
Molecular biology and medicine at the end of the XXth century |
| spellingShingle |
Molecular biology and medicine at the end of the XXth century Kornblihtt, A.R. Clonation Knock out mice Medicine Molecular biology Transgenic mice animal article cloning gene gene expression regulation gene therapy genetic engineering human medicine molecular biology mouse physiology transgenic animal transgenic mouse Animals Animals, Genetically Modified Cloning, Organism Gene Expression Regulation Gene Therapy Genes Genetic Engineering Humans Medicine Mice Mice, Transgenic Molecular Biology |
| title_short |
Molecular biology and medicine at the end of the XXth century |
| title_full |
Molecular biology and medicine at the end of the XXth century |
| title_fullStr |
Molecular biology and medicine at the end of the XXth century |
| title_full_unstemmed |
Molecular biology and medicine at the end of the XXth century |
| title_sort |
Molecular biology and medicine at the end of the XXth century |
| dc.creator.none.fl_str_mv |
Kornblihtt, A.R. |
| author |
Kornblihtt, A.R. |
| author_facet |
Kornblihtt, A.R. |
| author_role |
author |
| dc.subject.none.fl_str_mv |
Clonation Knock out mice Medicine Molecular biology Transgenic mice animal article cloning gene gene expression regulation gene therapy genetic engineering human medicine molecular biology mouse physiology transgenic animal transgenic mouse Animals Animals, Genetically Modified Cloning, Organism Gene Expression Regulation Gene Therapy Genes Genetic Engineering Humans Medicine Mice Mice, Transgenic Molecular Biology |
| topic |
Clonation Knock out mice Medicine Molecular biology Transgenic mice animal article cloning gene gene expression regulation gene therapy genetic engineering human medicine molecular biology mouse physiology transgenic animal transgenic mouse Animals Animals, Genetically Modified Cloning, Organism Gene Expression Regulation Gene Therapy Genes Genetic Engineering Humans Medicine Mice Mice, Transgenic Molecular Biology |
| dc.description.none.fl_txt_mv |
This paper reviews basic concepts of modern molecular biology with the premise that its influence in today's medicine is so important that its knowledge cannot remain limited to a few experts. I first analyze the overall structure and organization of human genes, their split nature and the flow of genetic information from DNA to protein. The role of transcriptional control in the regulation of gene expression and cell differentiation is described by introducing experimental examples that define the importance of "master" genes. Basic concepts of genetic engineering, the generation of transgenic and knock out animals and the uses of molecular biology in clinical diagnosis, paternity tests and forensic medicine are presented. Finally, I discuss the possibilities of gene therapy and the fantasies and realities of transgenesis and cloning by nuclear transplant in humans. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. |
| description |
This paper reviews basic concepts of modern molecular biology with the premise that its influence in today's medicine is so important that its knowledge cannot remain limited to a few experts. I first analyze the overall structure and organization of human genes, their split nature and the flow of genetic information from DNA to protein. The role of transcriptional control in the regulation of gene expression and cell differentiation is described by introducing experimental examples that define the importance of "master" genes. Basic concepts of genetic engineering, the generation of transgenic and knock out animals and the uses of molecular biology in clinical diagnosis, paternity tests and forensic medicine are presented. Finally, I discuss the possibilities of gene therapy and the fantasies and realities of transgenesis and cloning by nuclear transplant in humans. |
| publishDate |
2000 |
| dc.date.none.fl_str_mv |
2000 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12110/paper_00257680_v60_n1_p9_Kornblihtt |
| url |
http://hdl.handle.net/20.500.12110/paper_00257680_v60_n1_p9_Kornblihtt |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by/2.5/ar |
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application/pdf |
| dc.source.none.fl_str_mv |
Medicina (Argentina) 2000;60(1):9-16 reponame:Biblioteca Digital (UBA-FCEN) instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales instacron:UBA-FCEN |
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Biblioteca Digital (UBA-FCEN) |
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Biblioteca Digital (UBA-FCEN) |
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Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
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UBA-FCEN |
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UBA-FCEN |
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Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
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ana@bl.fcen.uba.ar |
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| score |
13.070432 |