Genetically modified mouse models in studies of luteinising hormone action

Autores
Huhtaniemi, Ilpo; Ahtiainen, Petteri; Pakarainen, Tomi; Rulli, Susana Beatriz; Zhang, Fu Ping; Poutanen, Mattu
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-alpha(Calpha), luteinising hormone (LH) beta and follicle-stimulating hormone (FSH) beta subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+).
Fil: Huhtaniemi, Ilpo. Imperial College London; Reino Unido. University of Turku; Finlandia
Fil: Ahtiainen, Petteri. University of Turku; Finlandia
Fil: Pakarainen, Tomi. University of Turku; Finlandia
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Zhang, Fu Ping. University of Helsinki; Finlandia
Fil: Poutanen, Mattu. University of Turku; Finlandia
Materia
Luteinising Hormone
Choriogonadotrophin
Lh Receptor
Knock-Out Mice
Transgenic Mice
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/18519
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/18519
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Genetically modified mouse models in studies of luteinising hormone actionHuhtaniemi, IlpoAhtiainen, PetteriPakarainen, TomiRulli, Susana BeatrizZhang, Fu PingPoutanen, MattuLuteinising HormoneChoriogonadotrophinLh ReceptorKnock-Out MiceTransgenic Micehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-alpha(Calpha), luteinising hormone (LH) beta and follicle-stimulating hormone (FSH) beta subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+).Fil: Huhtaniemi, Ilpo. Imperial College London; Reino Unido. University of Turku; FinlandiaFil: Ahtiainen, Petteri. University of Turku; FinlandiaFil: Pakarainen, Tomi. University of Turku; FinlandiaFil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Zhang, Fu Ping. University of Helsinki; FinlandiaFil: Poutanen, Mattu. University of Turku; FinlandiaElsevier Ireland2006-06-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/18519Huhtaniemi, Ilpo; Ahtiainen, Petteri; Pakarainen, Tomi; Rulli, Susana Beatriz; Zhang, Fu Ping; et al.; Genetically modified mouse models in studies of luteinising hormone action; Elsevier Ireland; Molecular And Cellular Endocrinology; 252; 1-2; 27-6-2006; 126-1350303-72071872-8057CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720706001213info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2006.03.026info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:04:10Zoai:ri.conicet.gov.ar:11336/18519instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:04:10.413CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Genetically modified mouse models in studies of luteinising hormone action
title Genetically modified mouse models in studies of luteinising hormone action
spellingShingle Genetically modified mouse models in studies of luteinising hormone action
Huhtaniemi, Ilpo
Luteinising Hormone
Choriogonadotrophin
Lh Receptor
Knock-Out Mice
Transgenic Mice
title_short Genetically modified mouse models in studies of luteinising hormone action
title_full Genetically modified mouse models in studies of luteinising hormone action
title_fullStr Genetically modified mouse models in studies of luteinising hormone action
title_full_unstemmed Genetically modified mouse models in studies of luteinising hormone action
title_sort Genetically modified mouse models in studies of luteinising hormone action
dc.creator.none.fl_str_mv Huhtaniemi, Ilpo
Ahtiainen, Petteri
Pakarainen, Tomi
Rulli, Susana Beatriz
Zhang, Fu Ping
Poutanen, Mattu
author Huhtaniemi, Ilpo
author_facet Huhtaniemi, Ilpo
Ahtiainen, Petteri
Pakarainen, Tomi
Rulli, Susana Beatriz
Zhang, Fu Ping
Poutanen, Mattu
author_role author
author2 Ahtiainen, Petteri
Pakarainen, Tomi
Rulli, Susana Beatriz
Zhang, Fu Ping
Poutanen, Mattu
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Luteinising Hormone
Choriogonadotrophin
Lh Receptor
Knock-Out Mice
Transgenic Mice
topic Luteinising Hormone
Choriogonadotrophin
Lh Receptor
Knock-Out Mice
Transgenic Mice
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-alpha(Calpha), luteinising hormone (LH) beta and follicle-stimulating hormone (FSH) beta subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+).
Fil: Huhtaniemi, Ilpo. Imperial College London; Reino Unido. University of Turku; Finlandia
Fil: Ahtiainen, Petteri. University of Turku; Finlandia
Fil: Pakarainen, Tomi. University of Turku; Finlandia
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Zhang, Fu Ping. University of Helsinki; Finlandia
Fil: Poutanen, Mattu. University of Turku; Finlandia
description Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-alpha(Calpha), luteinising hormone (LH) beta and follicle-stimulating hormone (FSH) beta subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+).
publishDate 2006
dc.date.none.fl_str_mv 2006-06-27
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/18519
Huhtaniemi, Ilpo; Ahtiainen, Petteri; Pakarainen, Tomi; Rulli, Susana Beatriz; Zhang, Fu Ping; et al.; Genetically modified mouse models in studies of luteinising hormone action; Elsevier Ireland; Molecular And Cellular Endocrinology; 252; 1-2; 27-6-2006; 126-135
0303-7207
1872-8057
CONICET Digital
CONICET
url http://hdl.handle.net/11336/18519
identifier_str_mv Huhtaniemi, Ilpo; Ahtiainen, Petteri; Pakarainen, Tomi; Rulli, Susana Beatriz; Zhang, Fu Ping; et al.; Genetically modified mouse models in studies of luteinising hormone action; Elsevier Ireland; Molecular And Cellular Endocrinology; 252; 1-2; 27-6-2006; 126-135
0303-7207
1872-8057
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720706001213
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2006.03.026
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781292096520192
score 12.982451

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