Genetically modified mouse models in studies of luteinising hormone action
- Autores
- Huhtaniemi, Ilpo; Ahtiainen, Petteri; Pakarainen, Tomi; Rulli, Susana Beatriz; Zhang, Fu Ping; Poutanen, Mattu
- Año de publicación
- 2006
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-alpha(Calpha), luteinising hormone (LH) beta and follicle-stimulating hormone (FSH) beta subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+).
Fil: Huhtaniemi, Ilpo. Imperial College London; Reino Unido. University of Turku; Finlandia
Fil: Ahtiainen, Petteri. University of Turku; Finlandia
Fil: Pakarainen, Tomi. University of Turku; Finlandia
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Zhang, Fu Ping. University of Helsinki; Finlandia
Fil: Poutanen, Mattu. University of Turku; Finlandia - Materia
-
Luteinising Hormone
Choriogonadotrophin
Lh Receptor
Knock-Out Mice
Transgenic Mice - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/18519
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Genetically modified mouse models in studies of luteinising hormone actionHuhtaniemi, IlpoAhtiainen, PetteriPakarainen, TomiRulli, Susana BeatrizZhang, Fu PingPoutanen, MattuLuteinising HormoneChoriogonadotrophinLh ReceptorKnock-Out MiceTransgenic Micehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-alpha(Calpha), luteinising hormone (LH) beta and follicle-stimulating hormone (FSH) beta subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+).Fil: Huhtaniemi, Ilpo. Imperial College London; Reino Unido. University of Turku; FinlandiaFil: Ahtiainen, Petteri. University of Turku; FinlandiaFil: Pakarainen, Tomi. University of Turku; FinlandiaFil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Zhang, Fu Ping. University of Helsinki; FinlandiaFil: Poutanen, Mattu. University of Turku; FinlandiaElsevier Ireland2006-06-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/18519Huhtaniemi, Ilpo; Ahtiainen, Petteri; Pakarainen, Tomi; Rulli, Susana Beatriz; Zhang, Fu Ping; et al.; Genetically modified mouse models in studies of luteinising hormone action; Elsevier Ireland; Molecular And Cellular Endocrinology; 252; 1-2; 27-6-2006; 126-1350303-72071872-8057CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720706001213info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2006.03.026info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:06Zoai:ri.conicet.gov.ar:11336/18519instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:06.444CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Genetically modified mouse models in studies of luteinising hormone action |
title |
Genetically modified mouse models in studies of luteinising hormone action |
spellingShingle |
Genetically modified mouse models in studies of luteinising hormone action Huhtaniemi, Ilpo Luteinising Hormone Choriogonadotrophin Lh Receptor Knock-Out Mice Transgenic Mice |
title_short |
Genetically modified mouse models in studies of luteinising hormone action |
title_full |
Genetically modified mouse models in studies of luteinising hormone action |
title_fullStr |
Genetically modified mouse models in studies of luteinising hormone action |
title_full_unstemmed |
Genetically modified mouse models in studies of luteinising hormone action |
title_sort |
Genetically modified mouse models in studies of luteinising hormone action |
dc.creator.none.fl_str_mv |
Huhtaniemi, Ilpo Ahtiainen, Petteri Pakarainen, Tomi Rulli, Susana Beatriz Zhang, Fu Ping Poutanen, Mattu |
author |
Huhtaniemi, Ilpo |
author_facet |
Huhtaniemi, Ilpo Ahtiainen, Petteri Pakarainen, Tomi Rulli, Susana Beatriz Zhang, Fu Ping Poutanen, Mattu |
author_role |
author |
author2 |
Ahtiainen, Petteri Pakarainen, Tomi Rulli, Susana Beatriz Zhang, Fu Ping Poutanen, Mattu |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Luteinising Hormone Choriogonadotrophin Lh Receptor Knock-Out Mice Transgenic Mice |
topic |
Luteinising Hormone Choriogonadotrophin Lh Receptor Knock-Out Mice Transgenic Mice |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-alpha(Calpha), luteinising hormone (LH) beta and follicle-stimulating hormone (FSH) beta subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+). Fil: Huhtaniemi, Ilpo. Imperial College London; Reino Unido. University of Turku; Finlandia Fil: Ahtiainen, Petteri. University of Turku; Finlandia Fil: Pakarainen, Tomi. University of Turku; Finlandia Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Zhang, Fu Ping. University of Helsinki; Finlandia Fil: Poutanen, Mattu. University of Turku; Finlandia |
description |
Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-alpha(Calpha), luteinising hormone (LH) beta and follicle-stimulating hormone (FSH) beta subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+). |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-06-27 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/18519 Huhtaniemi, Ilpo; Ahtiainen, Petteri; Pakarainen, Tomi; Rulli, Susana Beatriz; Zhang, Fu Ping; et al.; Genetically modified mouse models in studies of luteinising hormone action; Elsevier Ireland; Molecular And Cellular Endocrinology; 252; 1-2; 27-6-2006; 126-135 0303-7207 1872-8057 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/18519 |
identifier_str_mv |
Huhtaniemi, Ilpo; Ahtiainen, Petteri; Pakarainen, Tomi; Rulli, Susana Beatriz; Zhang, Fu Ping; et al.; Genetically modified mouse models in studies of luteinising hormone action; Elsevier Ireland; Molecular And Cellular Endocrinology; 252; 1-2; 27-6-2006; 126-135 0303-7207 1872-8057 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720706001213 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2006.03.026 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Ireland |
publisher.none.fl_str_mv |
Elsevier Ireland |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613129963569152 |
score |
13.070432 |