Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina

Autores
Olivera, Gabriela Carina; Albareda, María Cecilia; Alvarez, María Gabriela; De Rissio, Ana María; Fichera, Laura E.; Cooley, Gretchen; Yachelini, Pedro; Hrellac, Hugo A.; Riboldi, Hilda; Laucella, Susana A.; Tarleton, Rick; Postan, Miriam
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Olivera, Gabriela Carina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Alvarez, María Gabriela. Hospital “Eva Perón”, San Martín; Argentina
Fil: De Rissio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Fichera, Laura E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Cooley, Gretchen. Center for Tropical & Emerging Global Diseases, Coverdell Center for Biomedical Research (Rm 310B), University of Georgia, Athens; Estados Unidos.
Fil: Yachelini, Pedro. Instituto de Biomedicina, Universidad Católica de Santiago del Estero; Argentina.
Fil: Hrellac, Hugo A. Programa de Chagas. Secretaría de Salud de La Rioja; Argentina.
Fil: Riboldi, Hilda. Programa de Chagas. Secretaría de Salud de La Rioja; Argentina
Fil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Tarleton, Rick. Center for Tropical & Emerging Global Diseases, Coverdell Center for Biomedical Research (Rm 310B), University of Georgia, Athens; Estados Unidos.
Fil: Postan, Miriam. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Trypanosoma cruzi-specific immune responses were evaluated in a total of 88 subjects living in areas endemic of Chagas disease of Argentina by IFN-gamma ELISPOT assays and immunoblotting. Positive T. cruzi antigen-induced IFN-gamma responses were detected in 42% of subjects evaluated (15/26 positive by conventional serology and 22/62 seronegative subjects). Using immunoblotting, T. cruzi-specific IgG reactivity was detected in all seropositive subjects and in 11% (7/61) of subjects negative by conventional serology. Measurements of T cell responses and antibodies by immunoblotting, in conjunction with conventional serology, might enhance the capability of detection of exposure to T. cruzi in endemic areas.
Fuente
Microbes and infection / Institut Pasteur 2010; 12(5): 359-363.
Materia
Trypanosoma cruzi
Enfermedad de Chagas
Argentina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/532
Acceder
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network_acronym_str SGCANLIS
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network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of ArgentinaOlivera, Gabriela CarinaAlbareda, María CeciliaAlvarez, María GabrielaDe Rissio, Ana MaríaFichera, Laura E.Cooley, GretchenYachelini, PedroHrellac, Hugo A.Riboldi, HildaLaucella, Susana A.Tarleton, RickPostan, MiriamTrypanosoma cruziEnfermedad de ChagasArgentinaFil: Olivera, Gabriela Carina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Alvarez, María Gabriela. Hospital “Eva Perón”, San Martín; ArgentinaFil: De Rissio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Fichera, Laura E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Cooley, Gretchen. Center for Tropical & Emerging Global Diseases, Coverdell Center for Biomedical Research (Rm 310B), University of Georgia, Athens; Estados Unidos.Fil: Yachelini, Pedro. Instituto de Biomedicina, Universidad Católica de Santiago del Estero; Argentina.Fil: Hrellac, Hugo A. Programa de Chagas. Secretaría de Salud de La Rioja; Argentina.Fil: Riboldi, Hilda. Programa de Chagas. Secretaría de Salud de La Rioja; ArgentinaFil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Tarleton, Rick. Center for Tropical & Emerging Global Diseases, Coverdell Center for Biomedical Research (Rm 310B), University of Georgia, Athens; Estados Unidos.Fil: Postan, Miriam. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Trypanosoma cruzi-specific immune responses were evaluated in a total of 88 subjects living in areas endemic of Chagas disease of Argentina by IFN-gamma ELISPOT assays and immunoblotting. Positive T. cruzi antigen-induced IFN-gamma responses were detected in 42% of subjects evaluated (15/26 positive by conventional serology and 22/62 seronegative subjects). Using immunoblotting, T. cruzi-specific IgG reactivity was detected in all seropositive subjects and in 11% (7/61) of subjects negative by conventional serology. Measurements of T cell responses and antibodies by immunoblotting, in conjunction with conventional serology, might enhance the capability of detection of exposure to T. cruzi in endemic areas.Elsevier2010-02-01info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1286-4579http://sgc.anlis.gob.ar/handle/123456789/532https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856734/10.1016/j.micinf.2010.01.011.Microbes and infection / Institut Pasteur 2010; 12(5): 359-363.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISMicrobes and infectionenginfo:eu-repo/semantics/openAccess2025-10-16T10:11:16Zoai:sgc.anlis.gob.ar:123456789/532Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-10-16 10:11:17.245Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina
title Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina
spellingShingle Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina
Olivera, Gabriela Carina
Trypanosoma cruzi
Enfermedad de Chagas
Argentina
title_short Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina
title_full Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina
title_fullStr Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina
title_full_unstemmed Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina
title_sort Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina
dc.creator.none.fl_str_mv Olivera, Gabriela Carina
Albareda, María Cecilia
Alvarez, María Gabriela
De Rissio, Ana María
Fichera, Laura E.
Cooley, Gretchen
Yachelini, Pedro
Hrellac, Hugo A.
Riboldi, Hilda
Laucella, Susana A.
Tarleton, Rick
Postan, Miriam
author Olivera, Gabriela Carina
author_facet Olivera, Gabriela Carina
Albareda, María Cecilia
Alvarez, María Gabriela
De Rissio, Ana María
Fichera, Laura E.
Cooley, Gretchen
Yachelini, Pedro
Hrellac, Hugo A.
Riboldi, Hilda
Laucella, Susana A.
Tarleton, Rick
Postan, Miriam
author_role author
author2 Albareda, María Cecilia
Alvarez, María Gabriela
De Rissio, Ana María
Fichera, Laura E.
Cooley, Gretchen
Yachelini, Pedro
Hrellac, Hugo A.
Riboldi, Hilda
Laucella, Susana A.
Tarleton, Rick
Postan, Miriam
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trypanosoma cruzi
Enfermedad de Chagas
Argentina
topic Trypanosoma cruzi
Enfermedad de Chagas
Argentina
dc.description.none.fl_txt_mv Fil: Olivera, Gabriela Carina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Alvarez, María Gabriela. Hospital “Eva Perón”, San Martín; Argentina
Fil: De Rissio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Fichera, Laura E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Cooley, Gretchen. Center for Tropical & Emerging Global Diseases, Coverdell Center for Biomedical Research (Rm 310B), University of Georgia, Athens; Estados Unidos.
Fil: Yachelini, Pedro. Instituto de Biomedicina, Universidad Católica de Santiago del Estero; Argentina.
Fil: Hrellac, Hugo A. Programa de Chagas. Secretaría de Salud de La Rioja; Argentina.
Fil: Riboldi, Hilda. Programa de Chagas. Secretaría de Salud de La Rioja; Argentina
Fil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Tarleton, Rick. Center for Tropical & Emerging Global Diseases, Coverdell Center for Biomedical Research (Rm 310B), University of Georgia, Athens; Estados Unidos.
Fil: Postan, Miriam. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Trypanosoma cruzi-specific immune responses were evaluated in a total of 88 subjects living in areas endemic of Chagas disease of Argentina by IFN-gamma ELISPOT assays and immunoblotting. Positive T. cruzi antigen-induced IFN-gamma responses were detected in 42% of subjects evaluated (15/26 positive by conventional serology and 22/62 seronegative subjects). Using immunoblotting, T. cruzi-specific IgG reactivity was detected in all seropositive subjects and in 11% (7/61) of subjects negative by conventional serology. Measurements of T cell responses and antibodies by immunoblotting, in conjunction with conventional serology, might enhance the capability of detection of exposure to T. cruzi in endemic areas.
description Fil: Olivera, Gabriela Carina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
publishDate 2010
dc.date.none.fl_str_mv 2010-02-01
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1286-4579
http://sgc.anlis.gob.ar/handle/123456789/532
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856734/
10.1016/j.micinf.2010.01.011.
identifier_str_mv 1286-4579
10.1016/j.micinf.2010.01.011.
url http://sgc.anlis.gob.ar/handle/123456789/532
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856734/
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Microbes and infection
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Microbes and infection / Institut Pasteur 2010; 12(5): 359-363.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
_version_ 1846146147209445376
score 12.712165

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