Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis
- Autores
- Ciapponi, Agustin; Bardach, Ariel; Glujovsky, Demian; Gibbons, Luz; Picconi, María Alejandra
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Ciapponi, Agustin. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina.
Fil: Bardach, Ariel. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina.
Fil: Glujovsky, Demian. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina.
Fil: Gibbons, Luz. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina.
Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología. Servicio Virus Oncogénicos; Argentina.
Background: Cervical cancer is a major public health problem in Latin America and the Caribbean (LA&C), showing some of the highest incidence and mortality rates worldwide. Information on HPV type distribution in high-grade cervical lesions (HSIL) and invasive cervical cancer (ICC) is crucial to predict the future impact of HPV16/18 vaccines and screening programmes, and to establish an appropriate post-vaccinal virologic surveillance. The aim was to assess the prevalence of HPV types in HSIL and ICC in studies in LA&C. Methods and Findings: We performed a systematic review, following the MOOSE guidelines for systematic reviews of observational studies, and the PRISMA statement for reporting systematic reviews and meta-analyses. Inclusion criteria were at least ten cases of HSIL/ICC, and HPV-type elicitation. The search, without language restrictions, was performed in MEDLINE, Cochrane Library, EMBASE, LILACS from inception date to December 2009, proceedings, reference lists and consulting experts. A meta-analysis was performed using arc-sine transformations to stabilize the variance of simple proportions. Seventy-nine studies from 18 countries were identified, including 2446 cases of HSIL and 5540 of ICC. Overall, 46.5% of HSIL cases harbored HPV 16 and 8.9% HPV18; in ICC, 53.2% of cases harbored HPV 16 and 13.2% HPV 18. The next five most common types, in decreasing frequency, were HPV 31, 58, 33, 45, and 52. Study's limitations comprise the cross-sectional design of most included studies and their inherent risk of bias, the lack of representativeness, and variations in the HPV type-specific sensitivity of different PCR protocols. Conclusions: This study is the broadest summary of HPV type distribution in HSIL and ICC in LA&C to date. These data are essential for local decision makers regarding HPV screening and vaccination policies. Continued HPV surveillance would be useful, to assess the potential for changing type-specific HPV prevalence in the post-vaccination era in Latin America. - Fuente
- PloS One 2011; 6(10): e25493.
- Materia
-
Neoplasias
Neoplasias del Cuello Uterino
Infecciones por Papillomavirus
América Latina
Región del Caribe - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
- Institución
- Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
- OAI Identificador
- oai:sgc.anlis.gob.ar:Publications/123456789/398
Ver los metadatos del registro completo
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Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-AnalysisCiapponi, AgustinBardach, ArielGlujovsky, DemianGibbons, LuzPicconi, María AlejandraNeoplasiasNeoplasias del Cuello UterinoInfecciones por PapillomavirusAmérica LatinaRegión del CaribeFil: Ciapponi, Agustin. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina.Fil: Bardach, Ariel. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina.Fil: Glujovsky, Demian. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina.Fil: Gibbons, Luz. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina.Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología. Servicio Virus Oncogénicos; Argentina.Background: Cervical cancer is a major public health problem in Latin America and the Caribbean (LA&C), showing some of the highest incidence and mortality rates worldwide. Information on HPV type distribution in high-grade cervical lesions (HSIL) and invasive cervical cancer (ICC) is crucial to predict the future impact of HPV16/18 vaccines and screening programmes, and to establish an appropriate post-vaccinal virologic surveillance. The aim was to assess the prevalence of HPV types in HSIL and ICC in studies in LA&C. Methods and Findings: We performed a systematic review, following the MOOSE guidelines for systematic reviews of observational studies, and the PRISMA statement for reporting systematic reviews and meta-analyses. Inclusion criteria were at least ten cases of HSIL/ICC, and HPV-type elicitation. The search, without language restrictions, was performed in MEDLINE, Cochrane Library, EMBASE, LILACS from inception date to December 2009, proceedings, reference lists and consulting experts. A meta-analysis was performed using arc-sine transformations to stabilize the variance of simple proportions. Seventy-nine studies from 18 countries were identified, including 2446 cases of HSIL and 5540 of ICC. Overall, 46.5% of HSIL cases harbored HPV 16 and 8.9% HPV18; in ICC, 53.2% of cases harbored HPV 16 and 13.2% HPV 18. The next five most common types, in decreasing frequency, were HPV 31, 58, 33, 45, and 52. Study's limitations comprise the cross-sectional design of most included studies and their inherent risk of bias, the lack of representativeness, and variations in the HPV type-specific sensitivity of different PCR protocols. Conclusions: This study is the broadest summary of HPV type distribution in HSIL and ICC in LA&C to date. These data are essential for local decision makers regarding HPV screening and vaccination policies. Continued HPV surveillance would be useful, to assess the potential for changing type-specific HPV prevalence in the post-vaccination era in Latin America.Yes2011info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1932-6203http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025493http://sgc.anlis.gob.ar/handle/123456789/39810.1371/journal.pone.0025493.PloS One 2011; 6(10): e25493.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISPlos oneAmérica LatinaRegión del CaribeRegión del Caribeenginfo:eu-repo/semantics/openAccess2025-09-29T14:30:01Zoai:sgc.anlis.gob.ar:Publications/123456789/398Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:02.15Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false |
dc.title.none.fl_str_mv |
Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis |
title |
Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis |
spellingShingle |
Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis Ciapponi, Agustin Neoplasias Neoplasias del Cuello Uterino Infecciones por Papillomavirus América Latina Región del Caribe |
title_short |
Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis |
title_full |
Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis |
title_fullStr |
Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis |
title_full_unstemmed |
Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis |
title_sort |
Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis |
dc.creator.none.fl_str_mv |
Ciapponi, Agustin Bardach, Ariel Glujovsky, Demian Gibbons, Luz Picconi, María Alejandra |
author |
Ciapponi, Agustin |
author_facet |
Ciapponi, Agustin Bardach, Ariel Glujovsky, Demian Gibbons, Luz Picconi, María Alejandra |
author_role |
author |
author2 |
Bardach, Ariel Glujovsky, Demian Gibbons, Luz Picconi, María Alejandra |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Neoplasias Neoplasias del Cuello Uterino Infecciones por Papillomavirus América Latina Región del Caribe |
topic |
Neoplasias Neoplasias del Cuello Uterino Infecciones por Papillomavirus América Latina Región del Caribe |
dc.description.none.fl_txt_mv |
Fil: Ciapponi, Agustin. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina. Fil: Bardach, Ariel. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina. Fil: Glujovsky, Demian. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina. Fil: Gibbons, Luz. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina. Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología. Servicio Virus Oncogénicos; Argentina. Background: Cervical cancer is a major public health problem in Latin America and the Caribbean (LA&C), showing some of the highest incidence and mortality rates worldwide. Information on HPV type distribution in high-grade cervical lesions (HSIL) and invasive cervical cancer (ICC) is crucial to predict the future impact of HPV16/18 vaccines and screening programmes, and to establish an appropriate post-vaccinal virologic surveillance. The aim was to assess the prevalence of HPV types in HSIL and ICC in studies in LA&C. Methods and Findings: We performed a systematic review, following the MOOSE guidelines for systematic reviews of observational studies, and the PRISMA statement for reporting systematic reviews and meta-analyses. Inclusion criteria were at least ten cases of HSIL/ICC, and HPV-type elicitation. The search, without language restrictions, was performed in MEDLINE, Cochrane Library, EMBASE, LILACS from inception date to December 2009, proceedings, reference lists and consulting experts. A meta-analysis was performed using arc-sine transformations to stabilize the variance of simple proportions. Seventy-nine studies from 18 countries were identified, including 2446 cases of HSIL and 5540 of ICC. Overall, 46.5% of HSIL cases harbored HPV 16 and 8.9% HPV18; in ICC, 53.2% of cases harbored HPV 16 and 13.2% HPV 18. The next five most common types, in decreasing frequency, were HPV 31, 58, 33, 45, and 52. Study's limitations comprise the cross-sectional design of most included studies and their inherent risk of bias, the lack of representativeness, and variations in the HPV type-specific sensitivity of different PCR protocols. Conclusions: This study is the broadest summary of HPV type distribution in HSIL and ICC in LA&C to date. These data are essential for local decision makers regarding HPV screening and vaccination policies. Continued HPV surveillance would be useful, to assess the potential for changing type-specific HPV prevalence in the post-vaccination era in Latin America. |
description |
Fil: Ciapponi, Agustin. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 |
dc.type.none.fl_str_mv |
info:ar-repo/semantics/articulo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
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1932-6203 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025493 http://sgc.anlis.gob.ar/handle/123456789/398 10.1371/journal.pone.0025493. |
identifier_str_mv |
1932-6203 10.1371/journal.pone.0025493. |
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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025493 http://sgc.anlis.gob.ar/handle/123456789/398 |
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eng |
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application/pdf |
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América Latina Región del Caribe Región del Caribe |
dc.publisher.none.fl_str_mv |
Yes |
publisher.none.fl_str_mv |
Yes |
dc.source.none.fl_str_mv |
PloS One 2011; 6(10): e25493. reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" instacron:ANLIS |
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