Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact

Autores
Larrieu, Edmundo; Mujica, Guillermo; Gauci, Charles G; Vizcaychipi, Katherina A.; Seleiman, Marcos; Herrero, Eduardo; Labanchi, Jose Luis; Araya, Daniel; Sepulveda, Luis; Grizmado, Claudia; Calabro, Arnoldo; Talmon, Gabriel; Poggio, Thelma Verónica; Crowley, Pablo; Céspedes, Graciela; Santillan, Graciela; García Cachau, Mariela; Lamberti, Roberto; Gino, Lilia; Donadeu, Meritxell; Lightowlers, Marshall W
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Larrieu, Edmundo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Mujica, Guillermo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Gauci, Charles G. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Fil: Vizcaychipi, Katherina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Seleiman, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Herrero, Eduardo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Labanchi, José Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Araya, Daniel. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Sepúlveda, Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Grizmado, Claudia. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Calabro, Arnoldo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Talmon, Gabriel. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Poggio, Thelma Verónica. Cesar Milstein-CONICET/Instituto de Ciencia y Tecnología.. Centro de Virología Animal (CEVAN); Argentina.
Fil: Crowley, Pablo. Universidad Nacional de Río Negro. Escuela de Veterinaria; Argentina.
Fil: Cespedes, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Santillán, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: García Cachau, Mariela. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Lamberti, Roberto. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Gino, Lilia. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Donadeu, Meritxell. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Fil: Lightowlers, Marshall W. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Background Cystic echinococcosis (CE) is an important zoonotic disease caused by the cestode parasite Echinococcus granulosus. It occurs in many parts of the world where pastoral activities predominate, including the Rio Negro province of Argentina. Although CE control activities have been undertaken in the western regions of Rio Negro for more than two decades, the disease continues to remain prevalent in both the human and livestock animal populations. Vaccination of animal intermediate hosts of CE with the EG95 vaccine may provide a new opportunity to improve the effectiveness of CE control measures, although data are lacking about field application of the vaccine. Aims Evaluate the impact of EG95 vaccination in sheep on the transmission of Echinococcus granulosus in a field environment. Methodology Two trial sites were established in western Rio Negro province within indigenous communities. Vaccination of lambs born into one trial site was introduced and continued for 6 years. Prior to initiation of the trial, and at the end of the trial, the prevalence of CE in sheep was determined by necropsy. Weaned lambs received two injections of EG95 vaccine, approximately one month apart, and a single booster injection one year later. Vaccination was not implemented at the second trial site. A total of 2725 animals were vaccinated in the first year. Animals from this cohort as well as age-matched sheep from the control area were evaluated by necropsy. Key results Introduction of the vaccine led to a statistically significant in the number and size of hydatid cysts in comparison to the situation prior to the introduction of the vaccine, or compared to CE prevalence in the control area where the vaccine was not applied. The prevalence of infection in the vaccinated area was also significantly reduced by 62% compared to the reintervention level, being lower than the prevalence seen in the control area, although the difference from the control area after the intervention was not significant possibly due to limitations in the numbers of animals available for necropsy. Conclusions Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.
Fuente
PLOS Neglected Tropical Diseases 2015;9(10):e0004134
Materia
Equinococosis
Vacunación
Diagnóstico
Control
Análisis Espacial
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/2126

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network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of ImpactLarrieu, EdmundoMujica, GuillermoGauci, Charles GVizcaychipi, Katherina A.Seleiman, MarcosHerrero, EduardoLabanchi, Jose LuisAraya, DanielSepulveda, LuisGrizmado, ClaudiaCalabro, ArnoldoTalmon, GabrielPoggio, Thelma VerónicaCrowley, PabloCéspedes, GracielaSantillan, GracielaGarcía Cachau, MarielaLamberti, RobertoGino, LiliaDonadeu, MeritxellLightowlers, Marshall WEquinococosisVacunaciónDiagnósticoControlAnálisis EspacialFil: Larrieu, Edmundo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.Fil: Mujica, Guillermo. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Gauci, Charles G. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.Fil: Vizcaychipi, Katherina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.Fil: Seleiman, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Herrero, Eduardo. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Labanchi, José Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Araya, Daniel. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Sepúlveda, Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Grizmado, Claudia. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Calabro, Arnoldo. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Talmon, Gabriel. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Poggio, Thelma Verónica. Cesar Milstein-CONICET/Instituto de Ciencia y Tecnología.. Centro de Virología Animal (CEVAN); Argentina.Fil: Crowley, Pablo. Universidad Nacional de Río Negro. Escuela de Veterinaria; Argentina.Fil: Cespedes, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.Fil: Santillán, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.Fil: García Cachau, Mariela. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.Fil: Lamberti, Roberto. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.Fil: Gino, Lilia. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.Fil: Donadeu, Meritxell. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.Fil: Lightowlers, Marshall W. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.Background Cystic echinococcosis (CE) is an important zoonotic disease caused by the cestode parasite Echinococcus granulosus. It occurs in many parts of the world where pastoral activities predominate, including the Rio Negro province of Argentina. Although CE control activities have been undertaken in the western regions of Rio Negro for more than two decades, the disease continues to remain prevalent in both the human and livestock animal populations. Vaccination of animal intermediate hosts of CE with the EG95 vaccine may provide a new opportunity to improve the effectiveness of CE control measures, although data are lacking about field application of the vaccine. Aims Evaluate the impact of EG95 vaccination in sheep on the transmission of Echinococcus granulosus in a field environment. Methodology Two trial sites were established in western Rio Negro province within indigenous communities. Vaccination of lambs born into one trial site was introduced and continued for 6 years. Prior to initiation of the trial, and at the end of the trial, the prevalence of CE in sheep was determined by necropsy. Weaned lambs received two injections of EG95 vaccine, approximately one month apart, and a single booster injection one year later. Vaccination was not implemented at the second trial site. A total of 2725 animals were vaccinated in the first year. Animals from this cohort as well as age-matched sheep from the control area were evaluated by necropsy. Key results Introduction of the vaccine led to a statistically significant in the number and size of hydatid cysts in comparison to the situation prior to the introduction of the vaccine, or compared to CE prevalence in the control area where the vaccine was not applied. The prevalence of infection in the vaccinated area was also significantly reduced by 62% compared to the reintervention level, being lower than the prevalence seen in the control area, although the difference from the control area after the intervention was not significant possibly due to limitations in the numbers of animals available for necropsy. Conclusions Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.2015-10-30info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1935-2735http://sgc.anlis.gob.ar/handle/123456789/212610.1371/journal.pntd.0004134PLOS Neglected Tropical Diseases 2015;9(10):e0004134reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISPLoS Neglected Tropical Diseasesenginfo:eu-repo/semantics/openAccess2025-09-29T14:30:39Zoai:sgc.anlis.gob.ar:Publications/123456789/2126Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:40.007Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
title Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
spellingShingle Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
Larrieu, Edmundo
Equinococosis
Vacunación
Diagnóstico
Control
Análisis Espacial
title_short Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
title_full Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
title_fullStr Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
title_full_unstemmed Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
title_sort Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
dc.creator.none.fl_str_mv Larrieu, Edmundo
Mujica, Guillermo
Gauci, Charles G
Vizcaychipi, Katherina A.
Seleiman, Marcos
Herrero, Eduardo
Labanchi, Jose Luis
Araya, Daniel
Sepulveda, Luis
Grizmado, Claudia
Calabro, Arnoldo
Talmon, Gabriel
Poggio, Thelma Verónica
Crowley, Pablo
Céspedes, Graciela
Santillan, Graciela
García Cachau, Mariela
Lamberti, Roberto
Gino, Lilia
Donadeu, Meritxell
Lightowlers, Marshall W
author Larrieu, Edmundo
author_facet Larrieu, Edmundo
Mujica, Guillermo
Gauci, Charles G
Vizcaychipi, Katherina A.
Seleiman, Marcos
Herrero, Eduardo
Labanchi, Jose Luis
Araya, Daniel
Sepulveda, Luis
Grizmado, Claudia
Calabro, Arnoldo
Talmon, Gabriel
Poggio, Thelma Verónica
Crowley, Pablo
Céspedes, Graciela
Santillan, Graciela
García Cachau, Mariela
Lamberti, Roberto
Gino, Lilia
Donadeu, Meritxell
Lightowlers, Marshall W
author_role author
author2 Mujica, Guillermo
Gauci, Charles G
Vizcaychipi, Katherina A.
Seleiman, Marcos
Herrero, Eduardo
Labanchi, Jose Luis
Araya, Daniel
Sepulveda, Luis
Grizmado, Claudia
Calabro, Arnoldo
Talmon, Gabriel
Poggio, Thelma Verónica
Crowley, Pablo
Céspedes, Graciela
Santillan, Graciela
García Cachau, Mariela
Lamberti, Roberto
Gino, Lilia
Donadeu, Meritxell
Lightowlers, Marshall W
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Equinococosis
Vacunación
Diagnóstico
Control
Análisis Espacial
topic Equinococosis
Vacunación
Diagnóstico
Control
Análisis Espacial
dc.description.none.fl_txt_mv Fil: Larrieu, Edmundo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Mujica, Guillermo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Gauci, Charles G. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Fil: Vizcaychipi, Katherina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Seleiman, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Herrero, Eduardo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Labanchi, José Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Araya, Daniel. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Sepúlveda, Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Grizmado, Claudia. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Calabro, Arnoldo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Talmon, Gabriel. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Poggio, Thelma Verónica. Cesar Milstein-CONICET/Instituto de Ciencia y Tecnología.. Centro de Virología Animal (CEVAN); Argentina.
Fil: Crowley, Pablo. Universidad Nacional de Río Negro. Escuela de Veterinaria; Argentina.
Fil: Cespedes, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Santillán, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: García Cachau, Mariela. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Lamberti, Roberto. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Gino, Lilia. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Donadeu, Meritxell. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Fil: Lightowlers, Marshall W. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Background Cystic echinococcosis (CE) is an important zoonotic disease caused by the cestode parasite Echinococcus granulosus. It occurs in many parts of the world where pastoral activities predominate, including the Rio Negro province of Argentina. Although CE control activities have been undertaken in the western regions of Rio Negro for more than two decades, the disease continues to remain prevalent in both the human and livestock animal populations. Vaccination of animal intermediate hosts of CE with the EG95 vaccine may provide a new opportunity to improve the effectiveness of CE control measures, although data are lacking about field application of the vaccine. Aims Evaluate the impact of EG95 vaccination in sheep on the transmission of Echinococcus granulosus in a field environment. Methodology Two trial sites were established in western Rio Negro province within indigenous communities. Vaccination of lambs born into one trial site was introduced and continued for 6 years. Prior to initiation of the trial, and at the end of the trial, the prevalence of CE in sheep was determined by necropsy. Weaned lambs received two injections of EG95 vaccine, approximately one month apart, and a single booster injection one year later. Vaccination was not implemented at the second trial site. A total of 2725 animals were vaccinated in the first year. Animals from this cohort as well as age-matched sheep from the control area were evaluated by necropsy. Key results Introduction of the vaccine led to a statistically significant in the number and size of hydatid cysts in comparison to the situation prior to the introduction of the vaccine, or compared to CE prevalence in the control area where the vaccine was not applied. The prevalence of infection in the vaccinated area was also significantly reduced by 62% compared to the reintervention level, being lower than the prevalence seen in the control area, although the difference from the control area after the intervention was not significant possibly due to limitations in the numbers of animals available for necropsy. Conclusions Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.
description Fil: Larrieu, Edmundo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
publishDate 2015
dc.date.none.fl_str_mv 2015-10-30
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1935-2735
http://sgc.anlis.gob.ar/handle/123456789/2126
10.1371/journal.pntd.0004134
identifier_str_mv 1935-2735
10.1371/journal.pntd.0004134
url http://sgc.anlis.gob.ar/handle/123456789/2126
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS Neglected Tropical Diseases
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv PLOS Neglected Tropical Diseases 2015;9(10):e0004134
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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