Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina

Autores
Mallimaci, María Cristina; Sosa-Estani, Sergio; Russomando, Graciela; Sanchez Leon, Zunilda; Sijvarger, Carina; Alvarez, Isabel Marcela; Barrionuevo, Lola; Lopez, Carlos; Segura, Elsa L.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chagas’ disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanasoma cruzi . It is estimated that 15,000 new cases of congenital T. cruzi transmission occur in the Americas each year. The aim of this study was to estimate the rate of congenital T. cruzi infection in infants born to infected women living in Ushuaia, Argentina, as well to assess a serologic test using Shed Acute Phase Antigen (SAPA) for a timely diagnosis of congenital infection. The rate of congenital infection among children in the study was 4.4% (3/68). Our results show that for infants younger than 30 days of age, matched blood samples from mother and infant were capable of identifying congenital transmission of infection using an enzyme-linked immunosorbent assay with SAPA. For infants older than 3 months, congenital infection could be ruled out using the same procedure.
Fil: Mallimaci, María Cristina. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina.
Fil: Russomando, Graciela. Universidad Nacional de Asunción. Departamento de Biología Molecular y Genética; Paraguay.
Fil: Sanchez, Zunilda. Universidad Nacional de Asunción. Departamento de Biología Molecular y Genética; Paraguay.
Fil: Sijvarger, Carina. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Alvarez, Isabel Marcela. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Barrionuevo, Lola. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Lopez, Carlos. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Segura, Elsa, Leonor. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.
Fuente
The American Journal of Tropical Medicine and Hygiene, 2010, 82(1), 55–59.
Materia
Trypanosoma cruzi
Enfermedad de Chagas
Recién Nacido
Complicaciones Parasitarias del Embarazo
Argentina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/238
Acceder
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network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, ArgentinaMallimaci, María CristinaSosa-Estani, SergioRussomando, GracielaSanchez Leon, ZunildaSijvarger, CarinaAlvarez, Isabel MarcelaBarrionuevo, LolaLopez, CarlosSegura, Elsa L.Trypanosoma cruziEnfermedad de ChagasRecién NacidoComplicaciones Parasitarias del EmbarazoArgentinaChagas’ disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanasoma cruzi . It is estimated that 15,000 new cases of congenital T. cruzi transmission occur in the Americas each year. The aim of this study was to estimate the rate of congenital T. cruzi infection in infants born to infected women living in Ushuaia, Argentina, as well to assess a serologic test using Shed Acute Phase Antigen (SAPA) for a timely diagnosis of congenital infection. The rate of congenital infection among children in the study was 4.4% (3/68). Our results show that for infants younger than 30 days of age, matched blood samples from mother and infant were capable of identifying congenital transmission of infection using an enzyme-linked immunosorbent assay with SAPA. For infants older than 3 months, congenital infection could be ruled out using the same procedure.Fil: Mallimaci, María Cristina. Hospital Regional Ushuaia. Laboratorio Central; Argentina.Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina.Fil: Russomando, Graciela. Universidad Nacional de Asunción. Departamento de Biología Molecular y Genética; Paraguay.Fil: Sanchez, Zunilda. Universidad Nacional de Asunción. Departamento de Biología Molecular y Genética; Paraguay.Fil: Sijvarger, Carina. Hospital Regional Ushuaia. Laboratorio Central; Argentina.Fil: Alvarez, Isabel Marcela. Hospital Regional Ushuaia. Laboratorio Central; Argentina.Fil: Barrionuevo, Lola. Hospital Regional Ushuaia. Laboratorio Central; Argentina.Fil: Lopez, Carlos. Hospital Regional Ushuaia. Laboratorio Central; Argentina.Fil: Segura, Elsa, Leonor. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.2010info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1476-1645http://www.ajtmh.org/content/82/1/55.full.pdf+htmlhttp://sgc.anlis.gob.ar/handle/123456789/238The American Journal of Tropical Medicine and Hygiene, 2010, 82(1), 55–59.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISARGenginfo:eu-repo/semantics/openAccess2025-10-16T10:11:07Zoai:sgc.anlis.gob.ar:123456789/238Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-10-16 10:11:07.359Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
title Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
spellingShingle Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
Mallimaci, María Cristina
Trypanosoma cruzi
Enfermedad de Chagas
Recién Nacido
Complicaciones Parasitarias del Embarazo
Argentina
title_short Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
title_full Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
title_fullStr Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
title_full_unstemmed Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
title_sort Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
dc.creator.none.fl_str_mv Mallimaci, María Cristina
Sosa-Estani, Sergio
Russomando, Graciela
Sanchez Leon, Zunilda
Sijvarger, Carina
Alvarez, Isabel Marcela
Barrionuevo, Lola
Lopez, Carlos
Segura, Elsa L.
author Mallimaci, María Cristina
author_facet Mallimaci, María Cristina
Sosa-Estani, Sergio
Russomando, Graciela
Sanchez Leon, Zunilda
Sijvarger, Carina
Alvarez, Isabel Marcela
Barrionuevo, Lola
Lopez, Carlos
Segura, Elsa L.
author_role author
author2 Sosa-Estani, Sergio
Russomando, Graciela
Sanchez Leon, Zunilda
Sijvarger, Carina
Alvarez, Isabel Marcela
Barrionuevo, Lola
Lopez, Carlos
Segura, Elsa L.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trypanosoma cruzi
Enfermedad de Chagas
Recién Nacido
Complicaciones Parasitarias del Embarazo
Argentina
topic Trypanosoma cruzi
Enfermedad de Chagas
Recién Nacido
Complicaciones Parasitarias del Embarazo
Argentina
dc.description.none.fl_txt_mv Chagas’ disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanasoma cruzi . It is estimated that 15,000 new cases of congenital T. cruzi transmission occur in the Americas each year. The aim of this study was to estimate the rate of congenital T. cruzi infection in infants born to infected women living in Ushuaia, Argentina, as well to assess a serologic test using Shed Acute Phase Antigen (SAPA) for a timely diagnosis of congenital infection. The rate of congenital infection among children in the study was 4.4% (3/68). Our results show that for infants younger than 30 days of age, matched blood samples from mother and infant were capable of identifying congenital transmission of infection using an enzyme-linked immunosorbent assay with SAPA. For infants older than 3 months, congenital infection could be ruled out using the same procedure.
Fil: Mallimaci, María Cristina. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina.
Fil: Russomando, Graciela. Universidad Nacional de Asunción. Departamento de Biología Molecular y Genética; Paraguay.
Fil: Sanchez, Zunilda. Universidad Nacional de Asunción. Departamento de Biología Molecular y Genética; Paraguay.
Fil: Sijvarger, Carina. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Alvarez, Isabel Marcela. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Barrionuevo, Lola. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Lopez, Carlos. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Segura, Elsa, Leonor. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.
description Chagas’ disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanasoma cruzi . It is estimated that 15,000 new cases of congenital T. cruzi transmission occur in the Americas each year. The aim of this study was to estimate the rate of congenital T. cruzi infection in infants born to infected women living in Ushuaia, Argentina, as well to assess a serologic test using Shed Acute Phase Antigen (SAPA) for a timely diagnosis of congenital infection. The rate of congenital infection among children in the study was 4.4% (3/68). Our results show that for infants younger than 30 days of age, matched blood samples from mother and infant were capable of identifying congenital transmission of infection using an enzyme-linked immunosorbent assay with SAPA. For infants older than 3 months, congenital infection could be ruled out using the same procedure.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1476-1645
http://www.ajtmh.org/content/82/1/55.full.pdf+html
http://sgc.anlis.gob.ar/handle/123456789/238
identifier_str_mv 1476-1645
url http://www.ajtmh.org/content/82/1/55.full.pdf+html
http://sgc.anlis.gob.ar/handle/123456789/238
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv ARG
dc.source.none.fl_str_mv The American Journal of Tropical Medicine and Hygiene, 2010, 82(1), 55–59.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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score 12.712165

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