Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina

Autores
Mallimaci, María Cristina; Sosa-Estani, Sergio Alejandro; Russomando, Graciela Mabel; Sanchez, Zunilda; Sijvarger, Carina; Alvarez, Isabel Marcela; Barrionuevo, Lola; Lopez, Carlos; Segura, Elsa Leonor
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chagas' disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanasoma cruzi. It is estimated that 15,000 new cases of congenital T. cruzi transmission occur in the Americas each year. The aim of this study was to estimate the rate of congenital T. cruzi infection in infants born to infected women living in Ushuaia, Argentina, as well to assess a serologic test using Shed Acute Phase Antigen (SAPA) for a timely diagnosis of congenital infection. The rate of congenital infection among children in the study was 4.4% (3/68). Our results show that for infants younger than 30 days of age, matched blood samples from mother and infant were capable of identifying congenital transmission of infection using an enzyme-linked immunosorbent assay with SAPA. For infants older than 3 months, congenital infection could be ruled out using the same procedure
Fil: Mallimaci, María Cristina. Hospital Regional Ushuaia; Argentina
Fil: Sosa-Estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Russomando, Graciela Mabel. Universidad Nacional de Asunción; Paraguay
Fil: Sanchez, Zunilda. Universidad Nacional de Asunción; Paraguay
Fil: Sijvarger, Carina. Hospital Regional Ushuaia; Argentina
Fil: Alvarez, Isabel Marcela. Hospital Regional Ushuaia; Argentina
Fil: Barrionuevo, Lola. Hospital Regional Ushuaia; Argentina
Fil: Lopez, Carlos. Hospital Regional Ushuaia; Argentina
Fil: Segura, Elsa Leonor. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Congenital T. Cruzi Transmission
T.Cruzi Infection in Infants in Ushuaia, Argentina
Chagas' Disease, American Trypanosomiasis
Diagnosis Using Shed Acute Phase Antigen
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/53551
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, ArgentinaMallimaci, María CristinaSosa-Estani, Sergio AlejandroRussomando, Graciela MabelSanchez, ZunildaSijvarger, CarinaAlvarez, Isabel MarcelaBarrionuevo, LolaLopez, CarlosSegura, Elsa LeonorCongenital T. Cruzi TransmissionT.Cruzi Infection in Infants in Ushuaia, ArgentinaChagas' Disease, American TrypanosomiasisDiagnosis Using Shed Acute Phase Antigenhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Chagas' disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanasoma cruzi. It is estimated that 15,000 new cases of congenital T. cruzi transmission occur in the Americas each year. The aim of this study was to estimate the rate of congenital T. cruzi infection in infants born to infected women living in Ushuaia, Argentina, as well to assess a serologic test using Shed Acute Phase Antigen (SAPA) for a timely diagnosis of congenital infection. The rate of congenital infection among children in the study was 4.4% (3/68). Our results show that for infants younger than 30 days of age, matched blood samples from mother and infant were capable of identifying congenital transmission of infection using an enzyme-linked immunosorbent assay with SAPA. For infants older than 3 months, congenital infection could be ruled out using the same procedureFil: Mallimaci, María Cristina. Hospital Regional Ushuaia; ArgentinaFil: Sosa-Estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Russomando, Graciela Mabel. Universidad Nacional de Asunción; ParaguayFil: Sanchez, Zunilda. Universidad Nacional de Asunción; ParaguayFil: Sijvarger, Carina. Hospital Regional Ushuaia; ArgentinaFil: Alvarez, Isabel Marcela. Hospital Regional Ushuaia; ArgentinaFil: Barrionuevo, Lola. Hospital Regional Ushuaia; ArgentinaFil: Lopez, Carlos. Hospital Regional Ushuaia; ArgentinaFil: Segura, Elsa Leonor. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAmerican Society of Tropical Medicine and Hygiene2010-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53551Mallimaci, María Cristina; Sosa-Estani, Sergio Alejandro; Russomando, Graciela Mabel; Sanchez, Zunilda; Sijvarger, Carina; et al.; Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 82; 1; 1-2010; 55-590002-9637CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/docserver/fulltext/14761645/82/1/055.pdf?expires=1532984876&id=id&accname=guest&checksum=53065BBE95E20A5920D0FE394F963082info:eu-repo/semantics/altIdentifier/doi/10.4269%2Fajtmh.2010.09-0219info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:47Zoai:ri.conicet.gov.ar:11336/53551instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:47.734CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
title Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
spellingShingle Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
Mallimaci, María Cristina
Congenital T. Cruzi Transmission
T.Cruzi Infection in Infants in Ushuaia, Argentina
Chagas' Disease, American Trypanosomiasis
Diagnosis Using Shed Acute Phase Antigen
title_short Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
title_full Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
title_fullStr Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
title_full_unstemmed Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
title_sort Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina
dc.creator.none.fl_str_mv Mallimaci, María Cristina
Sosa-Estani, Sergio Alejandro
Russomando, Graciela Mabel
Sanchez, Zunilda
Sijvarger, Carina
Alvarez, Isabel Marcela
Barrionuevo, Lola
Lopez, Carlos
Segura, Elsa Leonor
author Mallimaci, María Cristina
author_facet Mallimaci, María Cristina
Sosa-Estani, Sergio Alejandro
Russomando, Graciela Mabel
Sanchez, Zunilda
Sijvarger, Carina
Alvarez, Isabel Marcela
Barrionuevo, Lola
Lopez, Carlos
Segura, Elsa Leonor
author_role author
author2 Sosa-Estani, Sergio Alejandro
Russomando, Graciela Mabel
Sanchez, Zunilda
Sijvarger, Carina
Alvarez, Isabel Marcela
Barrionuevo, Lola
Lopez, Carlos
Segura, Elsa Leonor
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Congenital T. Cruzi Transmission
T.Cruzi Infection in Infants in Ushuaia, Argentina
Chagas' Disease, American Trypanosomiasis
Diagnosis Using Shed Acute Phase Antigen
topic Congenital T. Cruzi Transmission
T.Cruzi Infection in Infants in Ushuaia, Argentina
Chagas' Disease, American Trypanosomiasis
Diagnosis Using Shed Acute Phase Antigen
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Chagas' disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanasoma cruzi. It is estimated that 15,000 new cases of congenital T. cruzi transmission occur in the Americas each year. The aim of this study was to estimate the rate of congenital T. cruzi infection in infants born to infected women living in Ushuaia, Argentina, as well to assess a serologic test using Shed Acute Phase Antigen (SAPA) for a timely diagnosis of congenital infection. The rate of congenital infection among children in the study was 4.4% (3/68). Our results show that for infants younger than 30 days of age, matched blood samples from mother and infant were capable of identifying congenital transmission of infection using an enzyme-linked immunosorbent assay with SAPA. For infants older than 3 months, congenital infection could be ruled out using the same procedure
Fil: Mallimaci, María Cristina. Hospital Regional Ushuaia; Argentina
Fil: Sosa-Estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Russomando, Graciela Mabel. Universidad Nacional de Asunción; Paraguay
Fil: Sanchez, Zunilda. Universidad Nacional de Asunción; Paraguay
Fil: Sijvarger, Carina. Hospital Regional Ushuaia; Argentina
Fil: Alvarez, Isabel Marcela. Hospital Regional Ushuaia; Argentina
Fil: Barrionuevo, Lola. Hospital Regional Ushuaia; Argentina
Fil: Lopez, Carlos. Hospital Regional Ushuaia; Argentina
Fil: Segura, Elsa Leonor. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Chagas' disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanasoma cruzi. It is estimated that 15,000 new cases of congenital T. cruzi transmission occur in the Americas each year. The aim of this study was to estimate the rate of congenital T. cruzi infection in infants born to infected women living in Ushuaia, Argentina, as well to assess a serologic test using Shed Acute Phase Antigen (SAPA) for a timely diagnosis of congenital infection. The rate of congenital infection among children in the study was 4.4% (3/68). Our results show that for infants younger than 30 days of age, matched blood samples from mother and infant were capable of identifying congenital transmission of infection using an enzyme-linked immunosorbent assay with SAPA. For infants older than 3 months, congenital infection could be ruled out using the same procedure
publishDate 2010
dc.date.none.fl_str_mv 2010-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/53551
Mallimaci, María Cristina; Sosa-Estani, Sergio Alejandro; Russomando, Graciela Mabel; Sanchez, Zunilda; Sijvarger, Carina; et al.; Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 82; 1; 1-2010; 55-59
0002-9637
CONICET Digital
CONICET
url http://hdl.handle.net/11336/53551
identifier_str_mv Mallimaci, María Cristina; Sosa-Estani, Sergio Alejandro; Russomando, Graciela Mabel; Sanchez, Zunilda; Sijvarger, Carina; et al.; Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 82; 1; 1-2010; 55-59
0002-9637
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/docserver/fulltext/14761645/82/1/055.pdf?expires=1532984876&id=id&accname=guest&checksum=53065BBE95E20A5920D0FE394F963082
info:eu-repo/semantics/altIdentifier/doi/10.4269%2Fajtmh.2010.09-0219
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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