Anti-inflammatory agents reduce microglial response, demyelinating process and neuronal toxin uptake in a model of encephalopathy produced by Shiga Toxin 2

Autores
Pinto, Alipio; Berdasco, Clara; Arenas-Mosquera, David; Cangelosi, Adriana; Geoghegan, Patricia A.; Nuñez, Myriam C; Goldstein, Jorge
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Pinto, Alipio. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.
Fil: Berdasco, Clara. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.
Fil: Arenas-Mosquera, David. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.
Fil: Cangelosi, Adriana. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos (CNCCB); Argentina.
Fil: Geoghegan, Patricia A. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos (CNCCB); Argentina.
Fil: Nuñez, Myriam C. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Matemáticas; Argentina.
Fil: Goldstein, Jorge. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.
Infections by Enterohemorrhagic Escherichia coli may cause in addition to hemolytic uremic syndrome neurological disorders which may lead to fatal outcomes in patients. The brain striatum is usually affected during this outcome. The aim of this study was to determine in this area the role of the microglia in pro-inflammatory events that may occur during Shiga toxin 2 intoxication and consequently to this, whether oligodendrocytes were being affected. In the present paper we demonstrated that anti-inflammatory treatments reduced deleterious effects in brain striatal cells exposed to Shiga toxin 2 and LPS. While dexamethasone treatment decreased microglial activation and recovered myelin integrity in the mice striatum, etanercept treatment decreased neuronal uptake of Stx2 in rat striatal neurons, improving the affected area from toxin-derived injury. In conclusion, microglial activation is related to pro-inflammatory events that may deteriorate the brain function during intoxication with Stx2 and LPS. Consequently, the role of anti-inflammatory agents in the treatment of EHEC-derived encephalopathy should be studied in clinical trials.
Materia
Dexametasona
Encefalopatía
Síndrome Hemolítico-Urémico
Inflamación
Neuroprotección
Nivel de accesibilidad
acceso abierto
Condiciones de uso
none
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/1642
Acceder
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oai_identifier_str oai:sgc.anlis.gob.ar:123456789/1642
network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Anti-inflammatory agents reduce microglial response, demyelinating process and neuronal toxin uptake in a model of encephalopathy produced by Shiga Toxin 2Pinto, AlipioBerdasco, ClaraArenas-Mosquera, DavidCangelosi, AdrianaGeoghegan, Patricia A.Nuñez, Myriam CGoldstein, JorgeDexametasonaEncefalopatíaSíndrome Hemolítico-UrémicoInflamaciónNeuroprotecciónFil: Pinto, Alipio. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.Fil: Berdasco, Clara. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.Fil: Arenas-Mosquera, David. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.Fil: Cangelosi, Adriana. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos (CNCCB); Argentina.Fil: Geoghegan, Patricia A. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos (CNCCB); Argentina.Fil: Nuñez, Myriam C. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Matemáticas; Argentina.Fil: Goldstein, Jorge. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.Infections by Enterohemorrhagic Escherichia coli may cause in addition to hemolytic uremic syndrome neurological disorders which may lead to fatal outcomes in patients. The brain striatum is usually affected during this outcome. The aim of this study was to determine in this area the role of the microglia in pro-inflammatory events that may occur during Shiga toxin 2 intoxication and consequently to this, whether oligodendrocytes were being affected. In the present paper we demonstrated that anti-inflammatory treatments reduced deleterious effects in brain striatal cells exposed to Shiga toxin 2 and LPS. While dexamethasone treatment decreased microglial activation and recovered myelin integrity in the mice striatum, etanercept treatment decreased neuronal uptake of Stx2 in rat striatal neurons, improving the affected area from toxin-derived injury. In conclusion, microglial activation is related to pro-inflammatory events that may deteriorate the brain function during intoxication with Stx2 and LPS. Consequently, the role of anti-inflammatory agents in the treatment of EHEC-derived encephalopathy should be studied in clinical trials.2018-12info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://sgc.anlis.gob.ar/handle/123456789/164210.1016/j.ijmm.2018.09.007International journal of medical microbiology : IJMMnoneinfo:eu-repo/semantics/openAccessengreponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLIS2025-09-29T14:30:20Zoai:sgc.anlis.gob.ar:123456789/1642Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:21.01Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Anti-inflammatory agents reduce microglial response, demyelinating process and neuronal toxin uptake in a model of encephalopathy produced by Shiga Toxin 2
title Anti-inflammatory agents reduce microglial response, demyelinating process and neuronal toxin uptake in a model of encephalopathy produced by Shiga Toxin 2
spellingShingle Anti-inflammatory agents reduce microglial response, demyelinating process and neuronal toxin uptake in a model of encephalopathy produced by Shiga Toxin 2
Pinto, Alipio
Dexametasona
Encefalopatía
Síndrome Hemolítico-Urémico
Inflamación
Neuroprotección
title_short Anti-inflammatory agents reduce microglial response, demyelinating process and neuronal toxin uptake in a model of encephalopathy produced by Shiga Toxin 2
title_full Anti-inflammatory agents reduce microglial response, demyelinating process and neuronal toxin uptake in a model of encephalopathy produced by Shiga Toxin 2
title_fullStr Anti-inflammatory agents reduce microglial response, demyelinating process and neuronal toxin uptake in a model of encephalopathy produced by Shiga Toxin 2
title_full_unstemmed Anti-inflammatory agents reduce microglial response, demyelinating process and neuronal toxin uptake in a model of encephalopathy produced by Shiga Toxin 2
title_sort Anti-inflammatory agents reduce microglial response, demyelinating process and neuronal toxin uptake in a model of encephalopathy produced by Shiga Toxin 2
dc.creator.none.fl_str_mv Pinto, Alipio
Berdasco, Clara
Arenas-Mosquera, David
Cangelosi, Adriana
Geoghegan, Patricia A.
Nuñez, Myriam C
Goldstein, Jorge
author Pinto, Alipio
author_facet Pinto, Alipio
Berdasco, Clara
Arenas-Mosquera, David
Cangelosi, Adriana
Geoghegan, Patricia A.
Nuñez, Myriam C
Goldstein, Jorge
author_role author
author2 Berdasco, Clara
Arenas-Mosquera, David
Cangelosi, Adriana
Geoghegan, Patricia A.
Nuñez, Myriam C
Goldstein, Jorge
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Dexametasona
Encefalopatía
Síndrome Hemolítico-Urémico
Inflamación
Neuroprotección
topic Dexametasona
Encefalopatía
Síndrome Hemolítico-Urémico
Inflamación
Neuroprotección
dc.description.none.fl_txt_mv Fil: Pinto, Alipio. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.
Fil: Berdasco, Clara. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.
Fil: Arenas-Mosquera, David. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.
Fil: Cangelosi, Adriana. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos (CNCCB); Argentina.
Fil: Geoghegan, Patricia A. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos (CNCCB); Argentina.
Fil: Nuñez, Myriam C. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Matemáticas; Argentina.
Fil: Goldstein, Jorge. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.
Infections by Enterohemorrhagic Escherichia coli may cause in addition to hemolytic uremic syndrome neurological disorders which may lead to fatal outcomes in patients. The brain striatum is usually affected during this outcome. The aim of this study was to determine in this area the role of the microglia in pro-inflammatory events that may occur during Shiga toxin 2 intoxication and consequently to this, whether oligodendrocytes were being affected. In the present paper we demonstrated that anti-inflammatory treatments reduced deleterious effects in brain striatal cells exposed to Shiga toxin 2 and LPS. While dexamethasone treatment decreased microglial activation and recovered myelin integrity in the mice striatum, etanercept treatment decreased neuronal uptake of Stx2 in rat striatal neurons, improving the affected area from toxin-derived injury. In conclusion, microglial activation is related to pro-inflammatory events that may deteriorate the brain function during intoxication with Stx2 and LPS. Consequently, the role of anti-inflammatory agents in the treatment of EHEC-derived encephalopathy should be studied in clinical trials.
description Fil: Pinto, Alipio. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica "Houssay". Laboratorio de Neurofisiopatología; Argentina.
publishDate 2018
dc.date.none.fl_str_mv 2018-12
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sgc.anlis.gob.ar/handle/123456789/1642
10.1016/j.ijmm.2018.09.007
url http://sgc.anlis.gob.ar/handle/123456789/1642
identifier_str_mv 10.1016/j.ijmm.2018.09.007
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International journal of medical microbiology : IJMM
dc.rights.none.fl_str_mv none
info:eu-repo/semantics/openAccess
rights_invalid_str_mv none
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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score 12.559606

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