Survival of an epidemic MDR strain of Mycobacterium tuberculosis and its non-prosperous variant within activated macrophages

Autores
Yokobori, Noemi; Monteserin, Johana; Rearte, Bárbara; Paul, Roxana; Simboli, Norberto; López, Beatriz; Ritacco, Viviana; Sasiain, María Del Carmen
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Yokobori, Noemi. Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina, Pacheco de Melo 3081, C1425AUM Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires; Argentina.
Fil: Monteserin, Johana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Rearte, Bárbara. Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina, Pacheco de Melo 3081, C1425AUM Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires; Argentina.
Fil: Paul, Roxana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Simboli, Norberto. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Sasiain, María Del Carmen. Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina, Pacheco de Melo 3081, C1425AUM Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires; Argentina.
The fitness of a pathogen results from the interaction of multiple factors favoring either epidemiological success or failure. Herein, we studied the performance of the M strain, a highly successful multidrug resistant Mycobacterium tuberculosis genotype, and its non-prosperous variant, the 410 strain, in activated human monocyte-derived macrophages. Both strains showed comparable ability to induce necrotic cell death and to survive in apoptotic macrophages. Of the various macrophage activation conditions tested, none led to an enhanced control of the outbreak strain. The combination of 1,25(OH)2 vitaminD3 and IFN-γ favored significantly the control of the non-prosperous 410 strain. These observations indicate that the ability of the M strain to survive within the hostile intracellular milieu is conserved, and the overall fitness cost paid by this genotype would be low. Our results provide additional evidence on bacterial traits that may have contributed to the epidemiological success of the M strain.
Fuente
Infection, Genetics and Evolution 2019; 73:248-254.
Materia
Apoptosis
Mycobacterium tuberculosis
Vitamina D
Nivel de accesibilidad
acceso abierto
Condiciones de uso
none
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/1308

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spelling Survival of an epidemic MDR strain of Mycobacterium tuberculosis and its non-prosperous variant within activated macrophagesYokobori, NoemiMonteserin, JohanaRearte, BárbaraPaul, RoxanaSimboli, NorbertoLópez, BeatrizRitacco, VivianaSasiain, María Del CarmenApoptosisMycobacterium tuberculosisVitamina DFil: Yokobori, Noemi. Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina, Pacheco de Melo 3081, C1425AUM Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires; Argentina.Fil: Monteserin, Johana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Rearte, Bárbara. Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina, Pacheco de Melo 3081, C1425AUM Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires; Argentina.Fil: Paul, Roxana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Simboli, Norberto. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Sasiain, María Del Carmen. Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina, Pacheco de Melo 3081, C1425AUM Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires; Argentina.The fitness of a pathogen results from the interaction of multiple factors favoring either epidemiological success or failure. Herein, we studied the performance of the M strain, a highly successful multidrug resistant Mycobacterium tuberculosis genotype, and its non-prosperous variant, the 410 strain, in activated human monocyte-derived macrophages. Both strains showed comparable ability to induce necrotic cell death and to survive in apoptotic macrophages. Of the various macrophage activation conditions tested, none led to an enhanced control of the outbreak strain. The combination of 1,25(OH)2 vitaminD3 and IFN-γ favored significantly the control of the non-prosperous 410 strain. These observations indicate that the ability of the M strain to survive within the hostile intracellular milieu is conserved, and the overall fitness cost paid by this genotype would be low. Our results provide additional evidence on bacterial traits that may have contributed to the epidemiological success of the M strain.Elsevier2019-09info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1567-1348http://sgc.anlis.gob.ar/handle/123456789/130810.1016/j.meegid.2019.05.005Infection, Genetics and Evolution 2019; 73:248-254.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseasesnoneinfo:eu-repo/semantics/openAccesseng2025-09-29T14:30:16Zoai:sgc.anlis.gob.ar:Publications/123456789/1308Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:16.697Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Survival of an epidemic MDR strain of Mycobacterium tuberculosis and its non-prosperous variant within activated macrophages
title Survival of an epidemic MDR strain of Mycobacterium tuberculosis and its non-prosperous variant within activated macrophages
spellingShingle Survival of an epidemic MDR strain of Mycobacterium tuberculosis and its non-prosperous variant within activated macrophages
Yokobori, Noemi
Apoptosis
Mycobacterium tuberculosis
Vitamina D
title_short Survival of an epidemic MDR strain of Mycobacterium tuberculosis and its non-prosperous variant within activated macrophages
title_full Survival of an epidemic MDR strain of Mycobacterium tuberculosis and its non-prosperous variant within activated macrophages
title_fullStr Survival of an epidemic MDR strain of Mycobacterium tuberculosis and its non-prosperous variant within activated macrophages
title_full_unstemmed Survival of an epidemic MDR strain of Mycobacterium tuberculosis and its non-prosperous variant within activated macrophages
title_sort Survival of an epidemic MDR strain of Mycobacterium tuberculosis and its non-prosperous variant within activated macrophages
dc.creator.none.fl_str_mv Yokobori, Noemi
Monteserin, Johana
Rearte, Bárbara
Paul, Roxana
Simboli, Norberto
López, Beatriz
Ritacco, Viviana
Sasiain, María Del Carmen
author Yokobori, Noemi
author_facet Yokobori, Noemi
Monteserin, Johana
Rearte, Bárbara
Paul, Roxana
Simboli, Norberto
López, Beatriz
Ritacco, Viviana
Sasiain, María Del Carmen
author_role author
author2 Monteserin, Johana
Rearte, Bárbara
Paul, Roxana
Simboli, Norberto
López, Beatriz
Ritacco, Viviana
Sasiain, María Del Carmen
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Apoptosis
Mycobacterium tuberculosis
Vitamina D
topic Apoptosis
Mycobacterium tuberculosis
Vitamina D
dc.description.none.fl_txt_mv Fil: Yokobori, Noemi. Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina, Pacheco de Melo 3081, C1425AUM Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires; Argentina.
Fil: Monteserin, Johana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Rearte, Bárbara. Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina, Pacheco de Melo 3081, C1425AUM Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires; Argentina.
Fil: Paul, Roxana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Simboli, Norberto. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Sasiain, María Del Carmen. Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina, Pacheco de Melo 3081, C1425AUM Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires; Argentina.
The fitness of a pathogen results from the interaction of multiple factors favoring either epidemiological success or failure. Herein, we studied the performance of the M strain, a highly successful multidrug resistant Mycobacterium tuberculosis genotype, and its non-prosperous variant, the 410 strain, in activated human monocyte-derived macrophages. Both strains showed comparable ability to induce necrotic cell death and to survive in apoptotic macrophages. Of the various macrophage activation conditions tested, none led to an enhanced control of the outbreak strain. The combination of 1,25(OH)2 vitaminD3 and IFN-γ favored significantly the control of the non-prosperous 410 strain. These observations indicate that the ability of the M strain to survive within the hostile intracellular milieu is conserved, and the overall fitness cost paid by this genotype would be low. Our results provide additional evidence on bacterial traits that may have contributed to the epidemiological success of the M strain.
description Fil: Yokobori, Noemi. Instituto de Medicina Experimental (IMEX)-CONICET-Academia Nacional de Medicina, Pacheco de Melo 3081, C1425AUM Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires; Argentina.
publishDate 2019
dc.date.none.fl_str_mv 2019-09
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1567-1348
http://sgc.anlis.gob.ar/handle/123456789/1308
10.1016/j.meegid.2019.05.005
identifier_str_mv 1567-1348
10.1016/j.meegid.2019.05.005
url http://sgc.anlis.gob.ar/handle/123456789/1308
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
dc.rights.none.fl_str_mv none
info:eu-repo/semantics/openAccess
rights_invalid_str_mv none
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Infection, Genetics and Evolution 2019; 73:248-254.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
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instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
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