Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models
- Autores
- Yokobori, Noemi; López, Beatriz; Geffner, Laura; Sabio y García, Carmen; Schierloh, Pablo; Barrera, Lucía; de la Barrera, Silvia; Sakai, Shunsuke; Kawamura, Ikuo; Mitsuyama, Masao; Ritacco, Viviana; Sasiain, María Del Carmen
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Yokobori, Noemi. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina.
Fil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Geffner, Laura. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina.
Fil: Sabio y García, Carmen. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina.
Fil: Schierloh, Pablo. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina.
Fil: Barrera, Lucía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: de la Barrera, Silvia. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina.
Fil: Sakai, Shunsuke. Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Kyoto; Japón.
Fil: Kawamura, Ikuo. Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Kyoto; Japón.
Fil: Mitsuyama, Masao. Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Kyoto; Japón.
Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Sasiain, María Del Carmen. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina.
Mycobacterium tuberculosis has a considerable degree of genetic variability resulting in different epidemiology and disease outcomes. We evaluated the pathogen-host cell interaction of two genetically closely-related multidrug-resistant M. tuberculosis strains of the Haarlem family, namely the strain M, responsible for an extensive multidrug-resistant tuberculosis outbreak, and its kin strain 410 which caused a single case in two decades. Intracellular growth and cytokine responses were evaluated in human monocyte-derived macrophages and dU937 macrophage-like cells. In monocyte-derived macrophages, strain M grew more slowly and induced lower levels of TNF-α and IL-10 than 410, contrasting with previous studies with other strains, where a direct correlation was observed between increased intracellular growth and epidemiological success. On the other hand, in dU937 cells, no difference in growth was observed between both strains, and strain M induced significantly higher TNF-α levels than strain 410. We found that both cell models differed critically in the expression of receptors for M. tuberculosis entry, which might explain the different infection outcomes. Our results in monocyte-derived macrophages suggest that strain M relies on a modest replication rate and cytokine induction, keeping a state of quiescence and remaining rather unnoticed by the host. Collectively, our results underscore the impact of M. tuberculosis intra-species variations on the outcome of host cell infection and show that results can differ depending on the in vitro infection model. - Fuente
- Infection, Genetics and Evolution 2013; 16:151-6.
- Materia
-
Resistencia a Múltiples Medicamentos
Mycobacterium tuberculosis
Macrófagos - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- none
- Repositorio
- Institución
- Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
- OAI Identificador
- oai:sgc.anlis.gob.ar:123456789/2048
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Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage modelsYokobori, NoemiLópez, BeatrizGeffner, LauraSabio y García, CarmenSchierloh, PabloBarrera, Lucíade la Barrera, SilviaSakai, ShunsukeKawamura, IkuoMitsuyama, MasaoRitacco, VivianaSasiain, María Del CarmenResistencia a Múltiples MedicamentosMycobacterium tuberculosisMacrófagosFil: Yokobori, Noemi. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina.Fil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Geffner, Laura. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina.Fil: Sabio y García, Carmen. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina.Fil: Schierloh, Pablo. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina.Fil: Barrera, Lucía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: de la Barrera, Silvia. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina.Fil: Sakai, Shunsuke. Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Kyoto; Japón.Fil: Kawamura, Ikuo. Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Kyoto; Japón.Fil: Mitsuyama, Masao. Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Kyoto; Japón.Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Sasiain, María Del Carmen. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina.Mycobacterium tuberculosis has a considerable degree of genetic variability resulting in different epidemiology and disease outcomes. We evaluated the pathogen-host cell interaction of two genetically closely-related multidrug-resistant M. tuberculosis strains of the Haarlem family, namely the strain M, responsible for an extensive multidrug-resistant tuberculosis outbreak, and its kin strain 410 which caused a single case in two decades. Intracellular growth and cytokine responses were evaluated in human monocyte-derived macrophages and dU937 macrophage-like cells. In monocyte-derived macrophages, strain M grew more slowly and induced lower levels of TNF-α and IL-10 than 410, contrasting with previous studies with other strains, where a direct correlation was observed between increased intracellular growth and epidemiological success. On the other hand, in dU937 cells, no difference in growth was observed between both strains, and strain M induced significantly higher TNF-α levels than strain 410. We found that both cell models differed critically in the expression of receptors for M. tuberculosis entry, which might explain the different infection outcomes. Our results in monocyte-derived macrophages suggest that strain M relies on a modest replication rate and cytokine induction, keeping a state of quiescence and remaining rather unnoticed by the host. Collectively, our results underscore the impact of M. tuberculosis intra-species variations on the outcome of host cell infection and show that results can differ depending on the in vitro infection model.Elsevier2013-06info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1567-1348https://www.sciencedirect.com/science/article/abs/pii/S1567134813000245?via%3Dihubhttp://sgc.anlis.gob.ar/handle/123456789/204810.1016/j.meegid.2013.01.007Infection, Genetics and Evolution 2013; 16:151-6.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseasesnoneinfo:eu-repo/semantics/openAccesseng2025-09-29T14:30:35Zoai:sgc.anlis.gob.ar:123456789/2048Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:35.877Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false |
dc.title.none.fl_str_mv |
Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models |
title |
Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models |
spellingShingle |
Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models Yokobori, Noemi Resistencia a Múltiples Medicamentos Mycobacterium tuberculosis Macrófagos |
title_short |
Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models |
title_full |
Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models |
title_fullStr |
Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models |
title_full_unstemmed |
Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models |
title_sort |
Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models |
dc.creator.none.fl_str_mv |
Yokobori, Noemi López, Beatriz Geffner, Laura Sabio y García, Carmen Schierloh, Pablo Barrera, Lucía de la Barrera, Silvia Sakai, Shunsuke Kawamura, Ikuo Mitsuyama, Masao Ritacco, Viviana Sasiain, María Del Carmen |
author |
Yokobori, Noemi |
author_facet |
Yokobori, Noemi López, Beatriz Geffner, Laura Sabio y García, Carmen Schierloh, Pablo Barrera, Lucía de la Barrera, Silvia Sakai, Shunsuke Kawamura, Ikuo Mitsuyama, Masao Ritacco, Viviana Sasiain, María Del Carmen |
author_role |
author |
author2 |
López, Beatriz Geffner, Laura Sabio y García, Carmen Schierloh, Pablo Barrera, Lucía de la Barrera, Silvia Sakai, Shunsuke Kawamura, Ikuo Mitsuyama, Masao Ritacco, Viviana Sasiain, María Del Carmen |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Resistencia a Múltiples Medicamentos Mycobacterium tuberculosis Macrófagos |
topic |
Resistencia a Múltiples Medicamentos Mycobacterium tuberculosis Macrófagos |
dc.description.none.fl_txt_mv |
Fil: Yokobori, Noemi. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina. Fil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. Fil: Geffner, Laura. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina. Fil: Sabio y García, Carmen. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina. Fil: Schierloh, Pablo. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina. Fil: Barrera, Lucía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. Fil: de la Barrera, Silvia. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina. Fil: Sakai, Shunsuke. Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Kyoto; Japón. Fil: Kawamura, Ikuo. Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Kyoto; Japón. Fil: Mitsuyama, Masao. Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Kyoto; Japón. Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. Fil: Sasiain, María Del Carmen. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina. Mycobacterium tuberculosis has a considerable degree of genetic variability resulting in different epidemiology and disease outcomes. We evaluated the pathogen-host cell interaction of two genetically closely-related multidrug-resistant M. tuberculosis strains of the Haarlem family, namely the strain M, responsible for an extensive multidrug-resistant tuberculosis outbreak, and its kin strain 410 which caused a single case in two decades. Intracellular growth and cytokine responses were evaluated in human monocyte-derived macrophages and dU937 macrophage-like cells. In monocyte-derived macrophages, strain M grew more slowly and induced lower levels of TNF-α and IL-10 than 410, contrasting with previous studies with other strains, where a direct correlation was observed between increased intracellular growth and epidemiological success. On the other hand, in dU937 cells, no difference in growth was observed between both strains, and strain M induced significantly higher TNF-α levels than strain 410. We found that both cell models differed critically in the expression of receptors for M. tuberculosis entry, which might explain the different infection outcomes. Our results in monocyte-derived macrophages suggest that strain M relies on a modest replication rate and cytokine induction, keeping a state of quiescence and remaining rather unnoticed by the host. Collectively, our results underscore the impact of M. tuberculosis intra-species variations on the outcome of host cell infection and show that results can differ depending on the in vitro infection model. |
description |
Fil: Yokobori, Noemi. Instituto de Medicina Experimental (IMEX) – CONICET, Academia Nacional de Medicina, Buenos Aires; Argentina. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06 |
dc.type.none.fl_str_mv |
info:ar-repo/semantics/articulo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
1567-1348 https://www.sciencedirect.com/science/article/abs/pii/S1567134813000245?via%3Dihub http://sgc.anlis.gob.ar/handle/123456789/2048 10.1016/j.meegid.2013.01.007 |
identifier_str_mv |
1567-1348 10.1016/j.meegid.2013.01.007 |
url |
https://www.sciencedirect.com/science/article/abs/pii/S1567134813000245?via%3Dihub http://sgc.anlis.gob.ar/handle/123456789/2048 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases |
dc.rights.none.fl_str_mv |
none info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
none |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
Infection, Genetics and Evolution 2013; 16:151-6. reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" instacron:ANLIS |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
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Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
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biblioteca@anlis.gov.ar |
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