Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas disease

Autores
Albareda, María Cecilia; Laucella, Susana Adriana
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Laucella, Susana Adriana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
The aim of this review is to describe the contributions of the knowledge of T-cell responses to the understanding of the physiopathology and the responsiveness to etiological treatment during the chronic phase of Chagas disease. T-helper (Th)1 and interleukin (IL)-10 Trypanosoma cruzi-specific T-cells have been linked to the asymptomatic phase or to severe clinical forms of the disease, respectively or vice versa, depending on the T. cruzi antigen source, the patient's location and the performed immunological assays. Parasite-specific T-cell responses are modulated after benznidazole (BZ) treatment in chronically T. cruzi-infected subjects in association with a significant decrease in T. cruzi-specific antibodies. Accumulating evidence has indicated that treatment efficacy during experimental infection with T. cruzi results from the combined action of BZ and the activation of appropriate immune responses in the host. However, strong support of this interaction in T. cruzi-infected humans remains lacking. Overall, the quality of T-cell responses might be a key factor in not only disease evolution, but also chemotherapy responsiveness. Immunological parameters are potential indicators of treatment response regardless of achievement of cure. Providing tools to monitor and provide early predictions of treatment success will allow the development of new therapeutic options.
Fuente
Memorias do instituto Oswaldo Cruz 2015;110(3):414-421
Materia
Linfocitos T
Enfermedad de Chagas
Trypanosoma cruzi
Quimioterapia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/1462

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network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas diseaseAlbareda, María CeciliaLaucella, Susana AdrianaLinfocitos TEnfermedad de ChagasTrypanosoma cruziQuimioterapiaFil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Laucella, Susana Adriana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.The aim of this review is to describe the contributions of the knowledge of T-cell responses to the understanding of the physiopathology and the responsiveness to etiological treatment during the chronic phase of Chagas disease. T-helper (Th)1 and interleukin (IL)-10 Trypanosoma cruzi-specific T-cells have been linked to the asymptomatic phase or to severe clinical forms of the disease, respectively or vice versa, depending on the T. cruzi antigen source, the patient's location and the performed immunological assays. Parasite-specific T-cell responses are modulated after benznidazole (BZ) treatment in chronically T. cruzi-infected subjects in association with a significant decrease in T. cruzi-specific antibodies. Accumulating evidence has indicated that treatment efficacy during experimental infection with T. cruzi results from the combined action of BZ and the activation of appropriate immune responses in the host. However, strong support of this interaction in T. cruzi-infected humans remains lacking. Overall, the quality of T-cell responses might be a key factor in not only disease evolution, but also chemotherapy responsiveness. Immunological parameters are potential indicators of treatment response regardless of achievement of cure. Providing tools to monitor and provide early predictions of treatment success will allow the development of new therapeutic options.2015-05info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1678-8060http://sgc.anlis.gob.ar/handle/123456789/146210.1590/0074-02760140386Memorias do instituto Oswaldo Cruz 2015;110(3):414-421reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISMemorias do Instituto Oswaldo Cruzenginfo:eu-repo/semantics/openAccess2025-09-04T11:17:12Zoai:sgc.anlis.gob.ar:Publications/123456789/1462Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:17:12.363Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas disease
title Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas disease
spellingShingle Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas disease
Albareda, María Cecilia
Linfocitos T
Enfermedad de Chagas
Trypanosoma cruzi
Quimioterapia
title_short Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas disease
title_full Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas disease
title_fullStr Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas disease
title_full_unstemmed Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas disease
title_sort Modulation of Trypanosoma cruzi-specific T-cell responses after chemotherapy for chronic Chagas disease
dc.creator.none.fl_str_mv Albareda, María Cecilia
Laucella, Susana Adriana
author Albareda, María Cecilia
author_facet Albareda, María Cecilia
Laucella, Susana Adriana
author_role author
author2 Laucella, Susana Adriana
author2_role author
dc.subject.none.fl_str_mv Linfocitos T
Enfermedad de Chagas
Trypanosoma cruzi
Quimioterapia
topic Linfocitos T
Enfermedad de Chagas
Trypanosoma cruzi
Quimioterapia
dc.description.none.fl_txt_mv Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Laucella, Susana Adriana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
The aim of this review is to describe the contributions of the knowledge of T-cell responses to the understanding of the physiopathology and the responsiveness to etiological treatment during the chronic phase of Chagas disease. T-helper (Th)1 and interleukin (IL)-10 Trypanosoma cruzi-specific T-cells have been linked to the asymptomatic phase or to severe clinical forms of the disease, respectively or vice versa, depending on the T. cruzi antigen source, the patient's location and the performed immunological assays. Parasite-specific T-cell responses are modulated after benznidazole (BZ) treatment in chronically T. cruzi-infected subjects in association with a significant decrease in T. cruzi-specific antibodies. Accumulating evidence has indicated that treatment efficacy during experimental infection with T. cruzi results from the combined action of BZ and the activation of appropriate immune responses in the host. However, strong support of this interaction in T. cruzi-infected humans remains lacking. Overall, the quality of T-cell responses might be a key factor in not only disease evolution, but also chemotherapy responsiveness. Immunological parameters are potential indicators of treatment response regardless of achievement of cure. Providing tools to monitor and provide early predictions of treatment success will allow the development of new therapeutic options.
description Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1678-8060
http://sgc.anlis.gob.ar/handle/123456789/1462
10.1590/0074-02760140386
identifier_str_mv 1678-8060
10.1590/0074-02760140386
url http://sgc.anlis.gob.ar/handle/123456789/1462
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Memorias do Instituto Oswaldo Cruz
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Memorias do instituto Oswaldo Cruz 2015;110(3):414-421
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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