Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group

Autores
Maiztegui, Julio I.; McKee Jr, Kelly T.; Barrera Oro, Julio G.; Harrison, Lee H; Gibbs, P H; Feuillade, María Rosa; Enria, Delia; Briggiler, Ana M.; Levis, Silvana; Ambrosio, Ana María; Halsey, Neal A.; Peters, Clarence J.
Año de publicación
1998
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Maiztegui, Julio I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: McKee Jr, K. T. Womack Army Medical Center, Fort Bragg, North Carolina; Estados Unidos.
Fil: Barrera Oro, J G. ANLIS Dr.C.G.Malbrán; Argentina.
Fil: Harrison, L H. University of Pittsburgh Graduate School of Public Health,Pittsburgh, Pennsylvania; Estados Unidos.
Fil: Gibbs, P H. Division of Disease Assessment, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701; Estados Unidos.
Fil: Feuillade, María Rosa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Enria, Delia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Briggiler, Ana M. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Levis, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Ambrosio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Halsey, N A. Department of International Health, Johns Hopkins Medical Institutions, Baltimore, Maryland; Estados Unidos.
Fil: Peters, C J. Special Pathogens Branch, Centers for Disease Control, Atlanta, Georgia; Estados Unidos.
Argentine hemorrhagic fever (AHF), caused by the arenavirus Junin, is a major public health problem among agricultural workers in Argentina. A prospective, randomized, double-blind, placebo-controlled, efficacy trial of Candid 1, a live attenuated Junin virus vaccine, was conducted over two consecutive epidemic seasons among 6500 male agricultural workers in the AHF-endemic region. Twenty-three men developed laboratory-confirmed AHF during the study; 22 received placebo and 1 received vaccine (vaccine efficacy 95%; 95% confidence interval [CI], 82%-99%). Three additional subjects in each group developed laboratory-confirmed Junin virus infection associated with mild illnesses that did not fulfill the clinical case definition for AHF, yielding a protective efficacy for prevention of any illness associated with Junin virus infection of 84% (95% CI, 60%-94%). No serious adverse events were attributed to vaccination. Candid 1, the first vaccine for the prevention of illness caused by an arenavirus, is safe and highly efficacious.
Fuente
Journal of infectious diseases 1998; 177(2):277-83.
Materia
Fiebre Hemorrágica Americana
Arenavirus
Virus Junin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/2221
Acceder
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network_acronym_str SGCANLIS
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network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study GroupMaiztegui, Julio I.McKee Jr, Kelly T.Barrera Oro, Julio G.Harrison, Lee HGibbs, P HFeuillade, María RosaEnria, DeliaBriggiler, Ana M.Levis, SilvanaAmbrosio, Ana MaríaHalsey, Neal A.Peters, Clarence J.Fiebre Hemorrágica AmericanaArenavirusVirus JuninFil: Maiztegui, Julio I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: McKee Jr, K. T. Womack Army Medical Center, Fort Bragg, North Carolina; Estados Unidos.Fil: Barrera Oro, J G. ANLIS Dr.C.G.Malbrán; Argentina.Fil: Harrison, L H. University of Pittsburgh Graduate School of Public Health,Pittsburgh, Pennsylvania; Estados Unidos.Fil: Gibbs, P H. Division of Disease Assessment, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701; Estados Unidos.Fil: Feuillade, María Rosa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Enria, Delia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Briggiler, Ana M. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Levis, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Ambrosio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Halsey, N A. Department of International Health, Johns Hopkins Medical Institutions, Baltimore, Maryland; Estados Unidos.Fil: Peters, C J. Special Pathogens Branch, Centers for Disease Control, Atlanta, Georgia; Estados Unidos.Argentine hemorrhagic fever (AHF), caused by the arenavirus Junin, is a major public health problem among agricultural workers in Argentina. A prospective, randomized, double-blind, placebo-controlled, efficacy trial of Candid 1, a live attenuated Junin virus vaccine, was conducted over two consecutive epidemic seasons among 6500 male agricultural workers in the AHF-endemic region. Twenty-three men developed laboratory-confirmed AHF during the study; 22 received placebo and 1 received vaccine (vaccine efficacy 95%; 95% confidence interval [CI], 82%-99%). Three additional subjects in each group developed laboratory-confirmed Junin virus infection associated with mild illnesses that did not fulfill the clinical case definition for AHF, yielding a protective efficacy for prevention of any illness associated with Junin virus infection of 84% (95% CI, 60%-94%). No serious adverse events were attributed to vaccination. Candid 1, the first vaccine for the prevention of illness caused by an arenavirus, is safe and highly efficacious.Oxford University Press1998-02info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf0022-1899http://sgc.anlis.gob.ar/handle/123456789/222110.1086/514211Journal of infectious diseases 1998; 177(2):277-83.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISThe Journal of infectious diseasesenginfo:eu-repo/semantics/openAccess2025-10-23T11:23:45Zoai:sgc.anlis.gob.ar:Publications/123456789/2221Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-10-23 11:23:45.493Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group
title Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group
spellingShingle Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group
Maiztegui, Julio I.
Fiebre Hemorrágica Americana
Arenavirus
Virus Junin
title_short Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group
title_full Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group
title_fullStr Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group
title_full_unstemmed Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group
title_sort Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group
dc.creator.none.fl_str_mv Maiztegui, Julio I.
McKee Jr, Kelly T.
Barrera Oro, Julio G.
Harrison, Lee H
Gibbs, P H
Feuillade, María Rosa
Enria, Delia
Briggiler, Ana M.
Levis, Silvana
Ambrosio, Ana María
Halsey, Neal A.
Peters, Clarence J.
author Maiztegui, Julio I.
author_facet Maiztegui, Julio I.
McKee Jr, Kelly T.
Barrera Oro, Julio G.
Harrison, Lee H
Gibbs, P H
Feuillade, María Rosa
Enria, Delia
Briggiler, Ana M.
Levis, Silvana
Ambrosio, Ana María
Halsey, Neal A.
Peters, Clarence J.
author_role author
author2 McKee Jr, Kelly T.
Barrera Oro, Julio G.
Harrison, Lee H
Gibbs, P H
Feuillade, María Rosa
Enria, Delia
Briggiler, Ana M.
Levis, Silvana
Ambrosio, Ana María
Halsey, Neal A.
Peters, Clarence J.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Fiebre Hemorrágica Americana
Arenavirus
Virus Junin
topic Fiebre Hemorrágica Americana
Arenavirus
Virus Junin
dc.description.none.fl_txt_mv Fil: Maiztegui, Julio I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: McKee Jr, K. T. Womack Army Medical Center, Fort Bragg, North Carolina; Estados Unidos.
Fil: Barrera Oro, J G. ANLIS Dr.C.G.Malbrán; Argentina.
Fil: Harrison, L H. University of Pittsburgh Graduate School of Public Health,Pittsburgh, Pennsylvania; Estados Unidos.
Fil: Gibbs, P H. Division of Disease Assessment, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701; Estados Unidos.
Fil: Feuillade, María Rosa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Enria, Delia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Briggiler, Ana M. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Levis, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Ambrosio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Halsey, N A. Department of International Health, Johns Hopkins Medical Institutions, Baltimore, Maryland; Estados Unidos.
Fil: Peters, C J. Special Pathogens Branch, Centers for Disease Control, Atlanta, Georgia; Estados Unidos.
Argentine hemorrhagic fever (AHF), caused by the arenavirus Junin, is a major public health problem among agricultural workers in Argentina. A prospective, randomized, double-blind, placebo-controlled, efficacy trial of Candid 1, a live attenuated Junin virus vaccine, was conducted over two consecutive epidemic seasons among 6500 male agricultural workers in the AHF-endemic region. Twenty-three men developed laboratory-confirmed AHF during the study; 22 received placebo and 1 received vaccine (vaccine efficacy 95%; 95% confidence interval [CI], 82%-99%). Three additional subjects in each group developed laboratory-confirmed Junin virus infection associated with mild illnesses that did not fulfill the clinical case definition for AHF, yielding a protective efficacy for prevention of any illness associated with Junin virus infection of 84% (95% CI, 60%-94%). No serious adverse events were attributed to vaccination. Candid 1, the first vaccine for the prevention of illness caused by an arenavirus, is safe and highly efficacious.
description Fil: Maiztegui, Julio I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
publishDate 1998
dc.date.none.fl_str_mv 1998-02
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 0022-1899
http://sgc.anlis.gob.ar/handle/123456789/2221
10.1086/514211
identifier_str_mv 0022-1899
10.1086/514211
url http://sgc.anlis.gob.ar/handle/123456789/2221
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv The Journal of infectious diseases
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Journal of infectious diseases 1998; 177(2):277-83.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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score 12.471625

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