Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

• Autores: Feasey, Nicholas A; Hadfield, James; Keddy, Karen H; Dallman, Timothy J; Jacobs, Jan; Deng, Xiangyu; Wigley, Paul; Barquist, Lars; Langridge, Gemma C; Feltwell, Theresa; Harris, Simon R; Mather, Alison E; Fookes, Maria; Aslett, Martin; Msefula, Chisomo; Kariuki, Samuel; Maclennan, Calman A; Onsare, Robert S; Weill, François-Xavier; Le Hello, Simon; Smith, Anthony M; McClelland, Michael; Desai, Prerak; Parry, Christopher M; Cheesbrough, John; French, Neil; Campos, Josefina; Chabalgoity, Jose A; Betancor, Laura; Hopkins, Katie L; Nair, Satheesh; Humphrey, Tom J; Lunguya, Octavie; Cogan, Tristan A; Tapia, Milagritos D; Sow, Samba O; Tennant, Sharon M.; Bornstein, Kristin; Levine, Myron M; Lacharme-Lora, Lizeth; Everett, Dean B; Kingsley, Robert A; Parkhill, Julian; Heyderman, Robert S; Dougan, Gordon; Gordon, Melita A; Thomson, Nicholas R
• Año de publicación: 2016
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Nature Genetics 2016; 48(10):1211–1217
• Materia: Adaptación Biológica; África del Sur del Sahara; Animales; Pollos; Enterocolitis; Epidemias; Genoma Bacteriano; Humanos; Renta; Plásmidos; Enfermedades de las Aves de Corral; Infecciones por Salmonella; Análisis de Secuencia de ADN; Salmonella enteritidis
• Institución: Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"

Fil: Feasey, Nicholas A. Liverpool School of Tropical Medicine; Reino Unido.
Fil: Hadfield, James. Wellcome Trust Sanger Institute; Reino Unido.
Fil: Keddy, Karen H. National Institute for Communicable Diseases. Centre for Enteric Diseases; Sudáfrica.
Fil: Dallman, Timothy J. Public Health England. Gastrointestinal Bacteria Reference Unit; Reino Unido.
Fil: Jacobs, Jan. Institute of Tropical Medicine; Bélgica.
Fil: Deng, Xiangyu. University of Georgia. Center for Food Safety, Department of Food Science and Technology; Estados Unidos.
Fil: Wigley, Paul. University of Liverpool. Institute of Infection and Global Health; Reino Unido.
Fil: Barquist, Lars. University of Würzburg. Institute for Molecular Infection Biology; Alemania.
Fil: Langridge, Gemma C. Wellcome Trust Sanger Institute; Reino Unido.
Fil: Feltwell, Theresa. Wellcome Trust Sanger Institute; Reino Unido.
Fil: Harris, Simon R. Wellcome Trust Sanger Institute; Reino Unido.
Fil: Mather, Alison E. Wellcome Trust Sanger Institute; Reino Unido.
Fil: Fookes, Maria. Wellcome Trust Sanger Institute; Reino Unido.
Fil: Aslett, Martin. Wellcome Trust Sanger Institute; Reino Unido.
Fil: Msefula, Chisomo. University of Malawi. College of Medicine. Malawi Liverpool Wellcome Trust Clinical Research Programme; Malaui.
Fil: Kariuki, Samuel. Kenya Medical Research Institute. Centre for Microbiology Research; Kenia.
Fil: Maclennan, Calman A. Wellcome Trust Sanger Institute; Reino Unido.
Fil: Onsare, Robert S. Kenya Medical Research Institute. Centre for Microbiology Research; Kenia.
Fil: Weill, François-Xavier. Institut Pasteur; Francia.
Fil: Le Hello, Simon. Institut Pasteur; Francia.
Fil: Smith. Anthony M. National Institute for Communicable Diseases. Centre for Enteric Diseases; Sudáfrica.
Fil: McClelland, Michael. University of California. Department of Microbiology and Molecular Genetics; Estados Unidos.
Fil: Desai, Prerak. University of California. Department of Microbiology and Molecular Genetics; Estados Unidos.
Fil: Parry, Christopher M. University of California. Department of Microbiology and Molecular Genetics; Estados Unidos.
Fil: Cheesbrough, John. University of Liverpool. Department of Epidemiology and Population Health; Reino Unido.
Fil: French, Neil. University of Liverpool. Institute of Infection and Global Health; Reino Unido.
Fil: Campos, Josefina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas.
Fil: Chabalgoity, Jose A. Universidad de la República. Facultad de Medicina. Instituto de Higiene; Uruguay.
Fil: Betancor, Laura. Universidad de la República. Facultad de Medicina. Instituto de Higiene; Uruguay.
Fil: Hopkins, Katie L. Public Health England. Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit; Reino Unido.
Fil: Nair, Satheesh. Public Health England. Gastrointestinal Bacteria Reference Unit; Reino Unido.
Fil: Humphrey, Tom J. Swansea University. Swansea Medical School; Reino Unido.
Fil: Lunguya, Octavie. National Institute of Biomedical Research, República Democrática del Congo.
Fil: Cogan, Tristan A. University of Bristol. School of Veterinary Sciences; Reino Unido.
Fil: Tapia, Milagritos D. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos.
Fil: Sow, Samba O. Centre pour le Développement des Vaccins, Malí.
Fil: Tennant, Sharon M. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos.
Fil: Bornstein, Kristin. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos.
Fil: Levine, Myron M. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos.
Fil: Lacharme-Lora, Lizeth. University of Liverpool. Institute of Infection and Global Health; Reino Unido.
Fil: Everett, Dean B. University of Liverpool. Institute of Infection and Global Health; Reino Unido.
Fil: Kingsley, Robert A. Wellcome Trust Sanger Institute; Reino Unido.
Fil: Parkhill, Julian. Wellcome Trust Sanger Institute; Reino Unido.
Fil: Heyderman, Robert S. University of Malawi. College of Medicine. Malawi Liverpool Wellcome Trust Clinical Research Programme; Malaui.
Fil: Dougan, Gordon. Wellcome Trust Sanger Institute; Reino Unido.
Fil: Gordon, Melita A. University of Malawi. College of Medicine. Malawi Liverpool Wellcome Trust Clinical Research Programme; Malaui.
Fil: Thomson, Nicholas R. Wellcome Trust Sanger Institute; Reino Unido.
An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.