Characterization of a vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970
- Autores
- Lewis, Adrian P.; Bok, Karin; Perez, O.; DeFillippo, J.; Paolazzi, C.; Gomez, Jorge A.
- Año de publicación
- 2005
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Lewis, Adrian P. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.
Fil: Bok, Karin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.
Fil: Perez, O. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
Fil: DeFillippo, J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
Fil: Paolazzi, C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
Fil: Gomez, Jorge A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.
Due to recent political developments, smallpox has re-emerged as a serious threat. We recovered and characterized an old batch of smallpox vaccine, Malbrán strain, produced between 1945 and 1949. The virus was re-isolated and characterized by sequence analysis and biological activity in animals. Phylogenetic analysis using the hemagglutinin and A45R genes showed that the Malbrán strain was closely related to the Lister strain of vaccinia virus. In animals, the Malbrán strain exhibited low pathogenicity, confirming historical records. Mice immunized with the Malbrán strain survived a lethal challenge with cowpox virus. Thus, this strain of vaccinia virus remains a viable candidate as a smallpox vaccine. - Fuente
- Archives of Virology, 2005, 150(7), 1485-1491.
- Materia
-
Argentina
Vacuna contra Viruela
Virus Vaccinia
Vacunas Atenuadas
Proteínas del Envoltorio Viral - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
- Institución
- Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
- OAI Identificador
- oai:sgc.anlis.gob.ar:123456789/384
Ver los metadatos del registro completo
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Characterization of a vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970Lewis, Adrian P.Bok, KarinPerez, O.DeFillippo, J.Paolazzi, C.Gomez, Jorge A.ArgentinaVacuna contra ViruelaVirus VacciniaVacunas AtenuadasProteínas del Envoltorio ViralFil: Lewis, Adrian P. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.Fil: Bok, Karin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.Fil: Perez, O. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Fil: DeFillippo, J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Fil: Paolazzi, C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.Fil: Gomez, Jorge A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.Due to recent political developments, smallpox has re-emerged as a serious threat. We recovered and characterized an old batch of smallpox vaccine, Malbrán strain, produced between 1945 and 1949. The virus was re-isolated and characterized by sequence analysis and biological activity in animals. Phylogenetic analysis using the hemagglutinin and A45R genes showed that the Malbrán strain was closely related to the Lister strain of vaccinia virus. In animals, the Malbrán strain exhibited low pathogenicity, confirming historical records. Mice immunized with the Malbrán strain survived a lethal challenge with cowpox virus. Thus, this strain of vaccinia virus remains a viable candidate as a smallpox vaccine.2005info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1432-8798http://sgc.anlis.gob.ar/handle/123456789/384http://link.springer.com/article/10.1007%2Fs00705-005-0498-9Archives of Virology, 2005, 150(7), 1485-1491.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISArchives of virologyARG1937-1970enginfo:eu-repo/semantics/openAccess2025-09-04T11:15:47Zoai:sgc.anlis.gob.ar:123456789/384Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:15:47.546Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false |
dc.title.none.fl_str_mv |
Characterization of a vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970 |
title |
Characterization of a vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970 |
spellingShingle |
Characterization of a vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970 Lewis, Adrian P. Argentina Vacuna contra Viruela Virus Vaccinia Vacunas Atenuadas Proteínas del Envoltorio Viral |
title_short |
Characterization of a vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970 |
title_full |
Characterization of a vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970 |
title_fullStr |
Characterization of a vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970 |
title_full_unstemmed |
Characterization of a vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970 |
title_sort |
Characterization of a vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970 |
dc.creator.none.fl_str_mv |
Lewis, Adrian P. Bok, Karin Perez, O. DeFillippo, J. Paolazzi, C. Gomez, Jorge A. |
author |
Lewis, Adrian P. |
author_facet |
Lewis, Adrian P. Bok, Karin Perez, O. DeFillippo, J. Paolazzi, C. Gomez, Jorge A. |
author_role |
author |
author2 |
Bok, Karin Perez, O. DeFillippo, J. Paolazzi, C. Gomez, Jorge A. |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Argentina Vacuna contra Viruela Virus Vaccinia Vacunas Atenuadas Proteínas del Envoltorio Viral |
topic |
Argentina Vacuna contra Viruela Virus Vaccinia Vacunas Atenuadas Proteínas del Envoltorio Viral |
dc.description.none.fl_txt_mv |
Fil: Lewis, Adrian P. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina. Fil: Bok, Karin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina. Fil: Perez, O. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina. Fil: DeFillippo, J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina. Fil: Paolazzi, C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina. Fil: Gomez, Jorge A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina. Due to recent political developments, smallpox has re-emerged as a serious threat. We recovered and characterized an old batch of smallpox vaccine, Malbrán strain, produced between 1945 and 1949. The virus was re-isolated and characterized by sequence analysis and biological activity in animals. Phylogenetic analysis using the hemagglutinin and A45R genes showed that the Malbrán strain was closely related to the Lister strain of vaccinia virus. In animals, the Malbrán strain exhibited low pathogenicity, confirming historical records. Mice immunized with the Malbrán strain survived a lethal challenge with cowpox virus. Thus, this strain of vaccinia virus remains a viable candidate as a smallpox vaccine. |
description |
Fil: Lewis, Adrian P. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005 |
dc.type.none.fl_str_mv |
info:ar-repo/semantics/articulo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
1432-8798 http://sgc.anlis.gob.ar/handle/123456789/384 http://link.springer.com/article/10.1007%2Fs00705-005-0498-9 |
identifier_str_mv |
1432-8798 |
url |
http://sgc.anlis.gob.ar/handle/123456789/384 http://link.springer.com/article/10.1007%2Fs00705-005-0498-9 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives of virology |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
ARG 1937-1970 |
dc.source.none.fl_str_mv |
Archives of Virology, 2005, 150(7), 1485-1491. reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" instacron:ANLIS |
reponame_str |
Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
collection |
Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
instname_str |
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
instacron_str |
ANLIS |
institution |
ANLIS |
repository.name.fl_str_mv |
Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
repository.mail.fl_str_mv |
biblioteca@anlis.gov.ar |
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12.623145 |