Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment

Autores
Porrás, Analía I; Yadón, Zaida E.; Altcheh, Jaime; Britto, Constança; Chaves, Gabriela C; Flevaud, Laurence; Martins-Filho, Olindo Assis; Ribeiro, Isabela; Schijman, Alejandro G.; Shikanai-Yasuda, Maria Aparecida; Sosa-Estani, Sergio; Stobbaerts, Eric; Zicker, Fabio
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Porrás, Analía I. Pan American Health Organization, Regional Office of the World Health Organization, Washington, D.C.; Estados Unidos.
Fil: Yadón, Zaida E. Pan American Health Organization, Regional Office of the World Health Organization, Washington, D.C.; Estados Unidos.
Fil: Altcheh, Jaime. Servicio de Parasitología y Chagas, Hospital de Niños Ricardo Gutiérrez, Ciudad de Buenos Aires; Argentina.
Fil: Britto, Constança. Laboratório de Biologia Molecular e Doenças Endêmicas, Oswaldo Cruz Institute, Laboratory of Molecular Biology and Endemic Diseases, FIOCRUZ, Rio de Janeiro; Brasil.
Fil: Chaves, Gabriela C. Sergio Arouca National School of Public Health, FIOCRUZ, Rio de Janeiro; Brasil.
Fil: Flevaud, Laurence. Médecins Sans Frontières-Médecins Sans Frontières Operational Center Barcelona-Athens (OCBA), Barcelona; España.
Fil: Martins-Filho, Olindo Assis. René Rachou Research Center, Laboratory of Biomarkers of Diagnostic and Monitoring, Oswaldo Cruz Institute, Minas Gerais; Brasil.
Fil: Ribeiro, Isabela. Latin America Regional Office, Drugs for Neglected Diseases initiative, Rio de Janeiro; Brasil.
Fil: Schijman, Alejandro G. Laboratorio de Biología Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr Hector Torres" (INGEBI-CONICET), Buenos Aires; Argentina.
Fil: Shikanai-Yasuda, Maria Aparecida. Department of Infectious and Parasitic Diseases, Faculdade de Medicina, University of São Paulo, Sao Paulo; Brasil.
Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Stobbaerts, Eric. Latin America Regional Office, Drugs for Neglected Diseases initiative, Rio de Janeiro; Brasil.
Fil: Zicker, Fabio. Center for Technological Development in Health, Oswaldo Cruz Foundation, (FIOCRUZ), Rio de Janeiro; Brasil.
Chagas disease, or American trypanosomiasis, affects 8 million people, largely in Latin America, where it is endemic in all countries. With an overall estimate of 65 million people at risk of contracting the disease, 28,000 new cases every year, and 12,000 deaths annually, Chagas disease is the most important parasitic disease in the Americas [1]. In addition, nonendemic countries such as the United States [2,3], Canada [4], Germany [5], Italy [6], Spain [7,8], Switzerland [9,10], and France [11] have experienced the occurrence of Trypanosoma cruzi–infected and Chagas disease cases; the majority of these cases are among immigrants coming from endemic Latin American countries [12]. Like other neglected tropical diseases (NTDs), Chagas disease affects mostly poor populations with limited access to health services. Vector transmission is associated with poor housing in periurban and rural areas. After infection, the disease is characterized by an acute phase, usually asymptomatic, which evolves in 20%–30% of the patients to a chronic disabling cardiac and/or digestive clinical form. The remaining infected individuals evolve to a chronic asymptomatic but infective clinical phase [13]. Reactivation of chronic Chagas disease may occur associated with comorbidities such as HIV/AIDS, organ transplants, or immunosuppressive therapy [14].
Fuente
PLoS neglected tropical diseases 2015; 9(6):e0003697.
Materia
Trypanosoma cruzi
Enfermedad de Chagas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/1475

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oai_identifier_str oai:sgc.anlis.gob.ar:123456789/1475
network_acronym_str SGCANLIS
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network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to TreatmentPorrás, Analía IYadón, Zaida E.Altcheh, JaimeBritto, ConstançaChaves, Gabriela CFlevaud, LaurenceMartins-Filho, Olindo AssisRibeiro, IsabelaSchijman, Alejandro G.Shikanai-Yasuda, Maria AparecidaSosa-Estani, SergioStobbaerts, EricZicker, FabioTrypanosoma cruziEnfermedad de ChagasFil: Porrás, Analía I. Pan American Health Organization, Regional Office of the World Health Organization, Washington, D.C.; Estados Unidos.Fil: Yadón, Zaida E. Pan American Health Organization, Regional Office of the World Health Organization, Washington, D.C.; Estados Unidos.Fil: Altcheh, Jaime. Servicio de Parasitología y Chagas, Hospital de Niños Ricardo Gutiérrez, Ciudad de Buenos Aires; Argentina.Fil: Britto, Constança. Laboratório de Biologia Molecular e Doenças Endêmicas, Oswaldo Cruz Institute, Laboratory of Molecular Biology and Endemic Diseases, FIOCRUZ, Rio de Janeiro; Brasil.Fil: Chaves, Gabriela C. Sergio Arouca National School of Public Health, FIOCRUZ, Rio de Janeiro; Brasil.Fil: Flevaud, Laurence. Médecins Sans Frontières-Médecins Sans Frontières Operational Center Barcelona-Athens (OCBA), Barcelona; España.Fil: Martins-Filho, Olindo Assis. René Rachou Research Center, Laboratory of Biomarkers of Diagnostic and Monitoring, Oswaldo Cruz Institute, Minas Gerais; Brasil.Fil: Ribeiro, Isabela. Latin America Regional Office, Drugs for Neglected Diseases initiative, Rio de Janeiro; Brasil.Fil: Schijman, Alejandro G. Laboratorio de Biología Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr Hector Torres" (INGEBI-CONICET), Buenos Aires; Argentina.Fil: Shikanai-Yasuda, Maria Aparecida. Department of Infectious and Parasitic Diseases, Faculdade de Medicina, University of São Paulo, Sao Paulo; Brasil.Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Stobbaerts, Eric. Latin America Regional Office, Drugs for Neglected Diseases initiative, Rio de Janeiro; Brasil.Fil: Zicker, Fabio. Center for Technological Development in Health, Oswaldo Cruz Foundation, (FIOCRUZ), Rio de Janeiro; Brasil.Chagas disease, or American trypanosomiasis, affects 8 million people, largely in Latin America, where it is endemic in all countries. With an overall estimate of 65 million people at risk of contracting the disease, 28,000 new cases every year, and 12,000 deaths annually, Chagas disease is the most important parasitic disease in the Americas [1]. In addition, nonendemic countries such as the United States [2,3], Canada [4], Germany [5], Italy [6], Spain [7,8], Switzerland [9,10], and France [11] have experienced the occurrence of Trypanosoma cruzi–infected and Chagas disease cases; the majority of these cases are among immigrants coming from endemic Latin American countries [12]. Like other neglected tropical diseases (NTDs), Chagas disease affects mostly poor populations with limited access to health services. Vector transmission is associated with poor housing in periurban and rural areas. After infection, the disease is characterized by an acute phase, usually asymptomatic, which evolves in 20%–30% of the patients to a chronic disabling cardiac and/or digestive clinical form. The remaining infected individuals evolve to a chronic asymptomatic but infective clinical phase [13]. Reactivation of chronic Chagas disease may occur associated with comorbidities such as HIV/AIDS, organ transplants, or immunosuppressive therapy [14].Yes2015-06-04info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1935-2735http://sgc.anlis.gob.ar/handle/123456789/147510.1371/journal.pntd.0003697PLoS neglected tropical diseases 2015; 9(6):e0003697.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISPLoS neglected tropical diseasesenginfo:eu-repo/semantics/openAccess2025-09-04T11:17:12Zoai:sgc.anlis.gob.ar:123456789/1475Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:17:12.401Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment
title Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment
spellingShingle Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment
Porrás, Analía I
Trypanosoma cruzi
Enfermedad de Chagas
title_short Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment
title_full Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment
title_fullStr Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment
title_full_unstemmed Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment
title_sort Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment
dc.creator.none.fl_str_mv Porrás, Analía I
Yadón, Zaida E.
Altcheh, Jaime
Britto, Constança
Chaves, Gabriela C
Flevaud, Laurence
Martins-Filho, Olindo Assis
Ribeiro, Isabela
Schijman, Alejandro G.
Shikanai-Yasuda, Maria Aparecida
Sosa-Estani, Sergio
Stobbaerts, Eric
Zicker, Fabio
author Porrás, Analía I
author_facet Porrás, Analía I
Yadón, Zaida E.
Altcheh, Jaime
Britto, Constança
Chaves, Gabriela C
Flevaud, Laurence
Martins-Filho, Olindo Assis
Ribeiro, Isabela
Schijman, Alejandro G.
Shikanai-Yasuda, Maria Aparecida
Sosa-Estani, Sergio
Stobbaerts, Eric
Zicker, Fabio
author_role author
author2 Yadón, Zaida E.
Altcheh, Jaime
Britto, Constança
Chaves, Gabriela C
Flevaud, Laurence
Martins-Filho, Olindo Assis
Ribeiro, Isabela
Schijman, Alejandro G.
Shikanai-Yasuda, Maria Aparecida
Sosa-Estani, Sergio
Stobbaerts, Eric
Zicker, Fabio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trypanosoma cruzi
Enfermedad de Chagas
topic Trypanosoma cruzi
Enfermedad de Chagas
dc.description.none.fl_txt_mv Fil: Porrás, Analía I. Pan American Health Organization, Regional Office of the World Health Organization, Washington, D.C.; Estados Unidos.
Fil: Yadón, Zaida E. Pan American Health Organization, Regional Office of the World Health Organization, Washington, D.C.; Estados Unidos.
Fil: Altcheh, Jaime. Servicio de Parasitología y Chagas, Hospital de Niños Ricardo Gutiérrez, Ciudad de Buenos Aires; Argentina.
Fil: Britto, Constança. Laboratório de Biologia Molecular e Doenças Endêmicas, Oswaldo Cruz Institute, Laboratory of Molecular Biology and Endemic Diseases, FIOCRUZ, Rio de Janeiro; Brasil.
Fil: Chaves, Gabriela C. Sergio Arouca National School of Public Health, FIOCRUZ, Rio de Janeiro; Brasil.
Fil: Flevaud, Laurence. Médecins Sans Frontières-Médecins Sans Frontières Operational Center Barcelona-Athens (OCBA), Barcelona; España.
Fil: Martins-Filho, Olindo Assis. René Rachou Research Center, Laboratory of Biomarkers of Diagnostic and Monitoring, Oswaldo Cruz Institute, Minas Gerais; Brasil.
Fil: Ribeiro, Isabela. Latin America Regional Office, Drugs for Neglected Diseases initiative, Rio de Janeiro; Brasil.
Fil: Schijman, Alejandro G. Laboratorio de Biología Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr Hector Torres" (INGEBI-CONICET), Buenos Aires; Argentina.
Fil: Shikanai-Yasuda, Maria Aparecida. Department of Infectious and Parasitic Diseases, Faculdade de Medicina, University of São Paulo, Sao Paulo; Brasil.
Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Stobbaerts, Eric. Latin America Regional Office, Drugs for Neglected Diseases initiative, Rio de Janeiro; Brasil.
Fil: Zicker, Fabio. Center for Technological Development in Health, Oswaldo Cruz Foundation, (FIOCRUZ), Rio de Janeiro; Brasil.
Chagas disease, or American trypanosomiasis, affects 8 million people, largely in Latin America, where it is endemic in all countries. With an overall estimate of 65 million people at risk of contracting the disease, 28,000 new cases every year, and 12,000 deaths annually, Chagas disease is the most important parasitic disease in the Americas [1]. In addition, nonendemic countries such as the United States [2,3], Canada [4], Germany [5], Italy [6], Spain [7,8], Switzerland [9,10], and France [11] have experienced the occurrence of Trypanosoma cruzi–infected and Chagas disease cases; the majority of these cases are among immigrants coming from endemic Latin American countries [12]. Like other neglected tropical diseases (NTDs), Chagas disease affects mostly poor populations with limited access to health services. Vector transmission is associated with poor housing in periurban and rural areas. After infection, the disease is characterized by an acute phase, usually asymptomatic, which evolves in 20%–30% of the patients to a chronic disabling cardiac and/or digestive clinical form. The remaining infected individuals evolve to a chronic asymptomatic but infective clinical phase [13]. Reactivation of chronic Chagas disease may occur associated with comorbidities such as HIV/AIDS, organ transplants, or immunosuppressive therapy [14].
description Fil: Porrás, Analía I. Pan American Health Organization, Regional Office of the World Health Organization, Washington, D.C.; Estados Unidos.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-04
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1935-2735
http://sgc.anlis.gob.ar/handle/123456789/1475
10.1371/journal.pntd.0003697
identifier_str_mv 1935-2735
10.1371/journal.pntd.0003697
url http://sgc.anlis.gob.ar/handle/123456789/1475
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS neglected tropical diseases
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Yes
publisher.none.fl_str_mv Yes
dc.source.none.fl_str_mv PLoS neglected tropical diseases 2015; 9(6):e0003697.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
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instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
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repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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