Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region
- Autores
- Abad, Raquel; Agudelo, Clara Inés; Brandileone, María Cristina; Chanto, Grettel; Gabastou, Jean-Marc; Hormazabal, Juan Carlos; O Gorla, M Cecilia; Maldonado, Aurora; Moreno, Jaime; Muros-Le Rouzic, Erwan; Lersch, Robert; Regueira, Mabel; Salcedo, Celia; Sorhouet Pereira, Cecilia; Vázquez, Julio A.
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Abad, Raquel. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.
Fil: Agudelo, Clara Inés. Instituto Nacional de Salud (INS). Microbiología; Colombia.
Fil: Brandileone, María Cristina. Adolfo Lutz Institute. Bacteriology Branch; Brasil.
Fil: Chanto, Grettel. Centro Nacional de Referencia en Bacteriología (INCIENSA); Costa Rica.
Fil: Gabastou, Jean-Marc. Pan American Health Organization (PAHO)/World Health Organization (WHO). Vacunas y Tecnologías de Salud. Unidad de Medicamentos Esenciales; Ecuador.
Fil: Hormazabal, Juan Carlos. Instituto de Salud Pública (ISP). Bacteriología; Chile.
Fil: O Gorla, M Cecilia. Adolfo Lutz Institute. Bacteriology Branch; Brasil.
Fil: Maldonado, Aurora. Instituto de Salud Pública (ISP). Bacteriología; Chile.
Fil: Moreno, Jaime. Instituto Nacional de Salud (INS). Microbiología; Colombia.
Fil: Muros-Le Rouzic, Erwan. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia.
Fil: Lersch, Robert. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia.
Fil: Regueira, Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Salcedo, Celia. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.
Fil: Sorhouet, Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Vázquez, Julio A. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.
Objectives: To improve the understanding of serogroup Y invasive meningococcal disease (IMD) in Latin America, particularly IMD molecular epidemiology; 166 Y serogroup isolates received at the National Reference Laboratories of Argentina, Brazil, Chile, Colombia, and Costa Rica during 2000-2006 were characterized by their molecular markers. Methods: This analysis included serological assays to determine serogroup/serotype/serosubtype, DNA sequencing and genotyping of the porB and/or porA genes, multilocus sequence typing (MLST) and fetA allele determination. Results: Sixteen different antigenic combinations were observed. Sixty-two (37.3%) isolates were NT:P1.5 and 36 (21.7%) isolates were 14:NST. Thirty-two different STs appeared, but 3 STs (ST-1624, ST-23, and ST-5770) accounted for 69.9% (116) of the strains. Most of the IMD isolates belonged to the ST-23, ST-167 clonal complexes or the group composed by ST-5770 and related STs. Conclusions: Isolates obtained in Colombia and Costa Rica were similar to that of the United States, in that most sequence types belonged to the ST-23 clonal complex. IMD isolates found in Argentina appear to be the result of an independent event and did not spread from nearby countries, being the sequence type ST-1624 (ST-167 clonal complex) the most frequently found. We were unable to correlate an antigenic shift of outer membrane proteins with an increase of serogroup Y meningococcal cases in our collection of isolates. - Fuente
- Journal of Infection 2009;59(2):104-114
- Materia
-
Neisseria meningitidis Serogrupo Y
Neisseria meningitidis
Infecciones Meningocócicas - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- none
- Repositorio
- Institución
- Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
- OAI Identificador
- oai:sgc.anlis.gob.ar:Publications/123456789/1949
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Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America regionAbad, RaquelAgudelo, Clara InésBrandileone, María CristinaChanto, GrettelGabastou, Jean-MarcHormazabal, Juan CarlosO Gorla, M CeciliaMaldonado, AuroraMoreno, JaimeMuros-Le Rouzic, ErwanLersch, RobertRegueira, MabelSalcedo, CeliaSorhouet Pereira, CeciliaVázquez, Julio A.Neisseria meningitidis Serogrupo YNeisseria meningitidisInfecciones MeningocócicasFil: Abad, Raquel. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.Fil: Agudelo, Clara Inés. Instituto Nacional de Salud (INS). Microbiología; Colombia.Fil: Brandileone, María Cristina. Adolfo Lutz Institute. Bacteriology Branch; Brasil.Fil: Chanto, Grettel. Centro Nacional de Referencia en Bacteriología (INCIENSA); Costa Rica.Fil: Gabastou, Jean-Marc. Pan American Health Organization (PAHO)/World Health Organization (WHO). Vacunas y Tecnologías de Salud. Unidad de Medicamentos Esenciales; Ecuador.Fil: Hormazabal, Juan Carlos. Instituto de Salud Pública (ISP). Bacteriología; Chile.Fil: O Gorla, M Cecilia. Adolfo Lutz Institute. Bacteriology Branch; Brasil.Fil: Maldonado, Aurora. Instituto de Salud Pública (ISP). Bacteriología; Chile.Fil: Moreno, Jaime. Instituto Nacional de Salud (INS). Microbiología; Colombia.Fil: Muros-Le Rouzic, Erwan. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia.Fil: Lersch, Robert. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia.Fil: Regueira, Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.Fil: Salcedo, Celia. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.Fil: Sorhouet, Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.Fil: Vázquez, Julio A. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.Objectives: To improve the understanding of serogroup Y invasive meningococcal disease (IMD) in Latin America, particularly IMD molecular epidemiology; 166 Y serogroup isolates received at the National Reference Laboratories of Argentina, Brazil, Chile, Colombia, and Costa Rica during 2000-2006 were characterized by their molecular markers. Methods: This analysis included serological assays to determine serogroup/serotype/serosubtype, DNA sequencing and genotyping of the porB and/or porA genes, multilocus sequence typing (MLST) and fetA allele determination. Results: Sixteen different antigenic combinations were observed. Sixty-two (37.3%) isolates were NT:P1.5 and 36 (21.7%) isolates were 14:NST. Thirty-two different STs appeared, but 3 STs (ST-1624, ST-23, and ST-5770) accounted for 69.9% (116) of the strains. Most of the IMD isolates belonged to the ST-23, ST-167 clonal complexes or the group composed by ST-5770 and related STs. Conclusions: Isolates obtained in Colombia and Costa Rica were similar to that of the United States, in that most sequence types belonged to the ST-23 clonal complex. IMD isolates found in Argentina appear to be the result of an independent event and did not spread from nearby countries, being the sequence type ST-1624 (ST-167 clonal complex) the most frequently found. We were unable to correlate an antigenic shift of outer membrane proteins with an increase of serogroup Y meningococcal cases in our collection of isolates.2009-08info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf0163-4453http://sgc.anlis.gob.ar/handle/123456789/194910.1016/j.jinf.2009.06.001Journal of Infection 2009;59(2):104-114reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISJournal of infectionnoneinfo:eu-repo/semantics/openAccesseng2025-09-04T11:18:01Zoai:sgc.anlis.gob.ar:Publications/123456789/1949Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:18:01.532Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false |
dc.title.none.fl_str_mv |
Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region |
title |
Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region |
spellingShingle |
Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region Abad, Raquel Neisseria meningitidis Serogrupo Y Neisseria meningitidis Infecciones Meningocócicas |
title_short |
Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region |
title_full |
Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region |
title_fullStr |
Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region |
title_full_unstemmed |
Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region |
title_sort |
Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region |
dc.creator.none.fl_str_mv |
Abad, Raquel Agudelo, Clara Inés Brandileone, María Cristina Chanto, Grettel Gabastou, Jean-Marc Hormazabal, Juan Carlos O Gorla, M Cecilia Maldonado, Aurora Moreno, Jaime Muros-Le Rouzic, Erwan Lersch, Robert Regueira, Mabel Salcedo, Celia Sorhouet Pereira, Cecilia Vázquez, Julio A. |
author |
Abad, Raquel |
author_facet |
Abad, Raquel Agudelo, Clara Inés Brandileone, María Cristina Chanto, Grettel Gabastou, Jean-Marc Hormazabal, Juan Carlos O Gorla, M Cecilia Maldonado, Aurora Moreno, Jaime Muros-Le Rouzic, Erwan Lersch, Robert Regueira, Mabel Salcedo, Celia Sorhouet Pereira, Cecilia Vázquez, Julio A. |
author_role |
author |
author2 |
Agudelo, Clara Inés Brandileone, María Cristina Chanto, Grettel Gabastou, Jean-Marc Hormazabal, Juan Carlos O Gorla, M Cecilia Maldonado, Aurora Moreno, Jaime Muros-Le Rouzic, Erwan Lersch, Robert Regueira, Mabel Salcedo, Celia Sorhouet Pereira, Cecilia Vázquez, Julio A. |
author2_role |
author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Neisseria meningitidis Serogrupo Y Neisseria meningitidis Infecciones Meningocócicas |
topic |
Neisseria meningitidis Serogrupo Y Neisseria meningitidis Infecciones Meningocócicas |
dc.description.none.fl_txt_mv |
Fil: Abad, Raquel. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España. Fil: Agudelo, Clara Inés. Instituto Nacional de Salud (INS). Microbiología; Colombia. Fil: Brandileone, María Cristina. Adolfo Lutz Institute. Bacteriology Branch; Brasil. Fil: Chanto, Grettel. Centro Nacional de Referencia en Bacteriología (INCIENSA); Costa Rica. Fil: Gabastou, Jean-Marc. Pan American Health Organization (PAHO)/World Health Organization (WHO). Vacunas y Tecnologías de Salud. Unidad de Medicamentos Esenciales; Ecuador. Fil: Hormazabal, Juan Carlos. Instituto de Salud Pública (ISP). Bacteriología; Chile. Fil: O Gorla, M Cecilia. Adolfo Lutz Institute. Bacteriology Branch; Brasil. Fil: Maldonado, Aurora. Instituto de Salud Pública (ISP). Bacteriología; Chile. Fil: Moreno, Jaime. Instituto Nacional de Salud (INS). Microbiología; Colombia. Fil: Muros-Le Rouzic, Erwan. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia. Fil: Lersch, Robert. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia. Fil: Regueira, Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina. Fil: Salcedo, Celia. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España. Fil: Sorhouet, Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina. Fil: Vázquez, Julio A. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España. Objectives: To improve the understanding of serogroup Y invasive meningococcal disease (IMD) in Latin America, particularly IMD molecular epidemiology; 166 Y serogroup isolates received at the National Reference Laboratories of Argentina, Brazil, Chile, Colombia, and Costa Rica during 2000-2006 were characterized by their molecular markers. Methods: This analysis included serological assays to determine serogroup/serotype/serosubtype, DNA sequencing and genotyping of the porB and/or porA genes, multilocus sequence typing (MLST) and fetA allele determination. Results: Sixteen different antigenic combinations were observed. Sixty-two (37.3%) isolates were NT:P1.5 and 36 (21.7%) isolates were 14:NST. Thirty-two different STs appeared, but 3 STs (ST-1624, ST-23, and ST-5770) accounted for 69.9% (116) of the strains. Most of the IMD isolates belonged to the ST-23, ST-167 clonal complexes or the group composed by ST-5770 and related STs. Conclusions: Isolates obtained in Colombia and Costa Rica were similar to that of the United States, in that most sequence types belonged to the ST-23 clonal complex. IMD isolates found in Argentina appear to be the result of an independent event and did not spread from nearby countries, being the sequence type ST-1624 (ST-167 clonal complex) the most frequently found. We were unable to correlate an antigenic shift of outer membrane proteins with an increase of serogroup Y meningococcal cases in our collection of isolates. |
description |
Fil: Abad, Raquel. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-08 |
dc.type.none.fl_str_mv |
info:ar-repo/semantics/articulo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
0163-4453 http://sgc.anlis.gob.ar/handle/123456789/1949 10.1016/j.jinf.2009.06.001 |
identifier_str_mv |
0163-4453 10.1016/j.jinf.2009.06.001 |
url |
http://sgc.anlis.gob.ar/handle/123456789/1949 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of infection |
dc.rights.none.fl_str_mv |
none info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
none |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Journal of Infection 2009;59(2):104-114 reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" instacron:ANLIS |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
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Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
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