Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region

Autores
Abad, Raquel; Agudelo, Clara Inés; Brandileone, María Cristina; Chanto, Grettel; Gabastou, Jean-Marc; Hormazabal, Juan Carlos; O Gorla, M Cecilia; Maldonado, Aurora; Moreno, Jaime; Muros-Le Rouzic, Erwan; Lersch, Robert; Regueira, Mabel; Salcedo, Celia; Sorhouet Pereira, Cecilia; Vázquez, Julio A.
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Abad, Raquel. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.
Fil: Agudelo, Clara Inés. Instituto Nacional de Salud (INS). Microbiología; Colombia.
Fil: Brandileone, María Cristina. Adolfo Lutz Institute. Bacteriology Branch; Brasil.
Fil: Chanto, Grettel. Centro Nacional de Referencia en Bacteriología (INCIENSA); Costa Rica.
Fil: Gabastou, Jean-Marc. Pan American Health Organization (PAHO)/World Health Organization (WHO). Vacunas y Tecnologías de Salud. Unidad de Medicamentos Esenciales; Ecuador.
Fil: Hormazabal, Juan Carlos. Instituto de Salud Pública (ISP). Bacteriología; Chile.
Fil: O Gorla, M Cecilia. Adolfo Lutz Institute. Bacteriology Branch; Brasil.
Fil: Maldonado, Aurora. Instituto de Salud Pública (ISP). Bacteriología; Chile.
Fil: Moreno, Jaime. Instituto Nacional de Salud (INS). Microbiología; Colombia.
Fil: Muros-Le Rouzic, Erwan. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia.
Fil: Lersch, Robert. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia.
Fil: Regueira, Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Salcedo, Celia. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.
Fil: Sorhouet, Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Vázquez, Julio A. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.
Objectives: To improve the understanding of serogroup Y invasive meningococcal disease (IMD) in Latin America, particularly IMD molecular epidemiology; 166 Y serogroup isolates received at the National Reference Laboratories of Argentina, Brazil, Chile, Colombia, and Costa Rica during 2000-2006 were characterized by their molecular markers. Methods: This analysis included serological assays to determine serogroup/serotype/serosubtype, DNA sequencing and genotyping of the porB and/or porA genes, multilocus sequence typing (MLST) and fetA allele determination. Results: Sixteen different antigenic combinations were observed. Sixty-two (37.3%) isolates were NT:P1.5 and 36 (21.7%) isolates were 14:NST. Thirty-two different STs appeared, but 3 STs (ST-1624, ST-23, and ST-5770) accounted for 69.9% (116) of the strains. Most of the IMD isolates belonged to the ST-23, ST-167 clonal complexes or the group composed by ST-5770 and related STs. Conclusions: Isolates obtained in Colombia and Costa Rica were similar to that of the United States, in that most sequence types belonged to the ST-23 clonal complex. IMD isolates found in Argentina appear to be the result of an independent event and did not spread from nearby countries, being the sequence type ST-1624 (ST-167 clonal complex) the most frequently found. We were unable to correlate an antigenic shift of outer membrane proteins with an increase of serogroup Y meningococcal cases in our collection of isolates.
Fuente
Journal of Infection 2009;59(2):104-114
Materia
Neisseria meningitidis Serogrupo Y
Neisseria meningitidis
Infecciones Meningocócicas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
none
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/1949

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network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America regionAbad, RaquelAgudelo, Clara InésBrandileone, María CristinaChanto, GrettelGabastou, Jean-MarcHormazabal, Juan CarlosO Gorla, M CeciliaMaldonado, AuroraMoreno, JaimeMuros-Le Rouzic, ErwanLersch, RobertRegueira, MabelSalcedo, CeliaSorhouet Pereira, CeciliaVázquez, Julio A.Neisseria meningitidis Serogrupo YNeisseria meningitidisInfecciones MeningocócicasFil: Abad, Raquel. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.Fil: Agudelo, Clara Inés. Instituto Nacional de Salud (INS). Microbiología; Colombia.Fil: Brandileone, María Cristina. Adolfo Lutz Institute. Bacteriology Branch; Brasil.Fil: Chanto, Grettel. Centro Nacional de Referencia en Bacteriología (INCIENSA); Costa Rica.Fil: Gabastou, Jean-Marc. Pan American Health Organization (PAHO)/World Health Organization (WHO). Vacunas y Tecnologías de Salud. Unidad de Medicamentos Esenciales; Ecuador.Fil: Hormazabal, Juan Carlos. Instituto de Salud Pública (ISP). Bacteriología; Chile.Fil: O Gorla, M Cecilia. Adolfo Lutz Institute. Bacteriology Branch; Brasil.Fil: Maldonado, Aurora. Instituto de Salud Pública (ISP). Bacteriología; Chile.Fil: Moreno, Jaime. Instituto Nacional de Salud (INS). Microbiología; Colombia.Fil: Muros-Le Rouzic, Erwan. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia.Fil: Lersch, Robert. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia.Fil: Regueira, Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.Fil: Salcedo, Celia. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.Fil: Sorhouet, Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.Fil: Vázquez, Julio A. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.Objectives: To improve the understanding of serogroup Y invasive meningococcal disease (IMD) in Latin America, particularly IMD molecular epidemiology; 166 Y serogroup isolates received at the National Reference Laboratories of Argentina, Brazil, Chile, Colombia, and Costa Rica during 2000-2006 were characterized by their molecular markers. Methods: This analysis included serological assays to determine serogroup/serotype/serosubtype, DNA sequencing and genotyping of the porB and/or porA genes, multilocus sequence typing (MLST) and fetA allele determination. Results: Sixteen different antigenic combinations were observed. Sixty-two (37.3%) isolates were NT:P1.5 and 36 (21.7%) isolates were 14:NST. Thirty-two different STs appeared, but 3 STs (ST-1624, ST-23, and ST-5770) accounted for 69.9% (116) of the strains. Most of the IMD isolates belonged to the ST-23, ST-167 clonal complexes or the group composed by ST-5770 and related STs. Conclusions: Isolates obtained in Colombia and Costa Rica were similar to that of the United States, in that most sequence types belonged to the ST-23 clonal complex. IMD isolates found in Argentina appear to be the result of an independent event and did not spread from nearby countries, being the sequence type ST-1624 (ST-167 clonal complex) the most frequently found. We were unable to correlate an antigenic shift of outer membrane proteins with an increase of serogroup Y meningococcal cases in our collection of isolates.2009-08info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf0163-4453http://sgc.anlis.gob.ar/handle/123456789/194910.1016/j.jinf.2009.06.001Journal of Infection 2009;59(2):104-114reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISJournal of infectionnoneinfo:eu-repo/semantics/openAccesseng2025-09-04T11:18:01Zoai:sgc.anlis.gob.ar:Publications/123456789/1949Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:18:01.532Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region
title Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region
spellingShingle Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region
Abad, Raquel
Neisseria meningitidis Serogrupo Y
Neisseria meningitidis
Infecciones Meningocócicas
title_short Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region
title_full Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region
title_fullStr Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region
title_full_unstemmed Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region
title_sort Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region
dc.creator.none.fl_str_mv Abad, Raquel
Agudelo, Clara Inés
Brandileone, María Cristina
Chanto, Grettel
Gabastou, Jean-Marc
Hormazabal, Juan Carlos
O Gorla, M Cecilia
Maldonado, Aurora
Moreno, Jaime
Muros-Le Rouzic, Erwan
Lersch, Robert
Regueira, Mabel
Salcedo, Celia
Sorhouet Pereira, Cecilia
Vázquez, Julio A.
author Abad, Raquel
author_facet Abad, Raquel
Agudelo, Clara Inés
Brandileone, María Cristina
Chanto, Grettel
Gabastou, Jean-Marc
Hormazabal, Juan Carlos
O Gorla, M Cecilia
Maldonado, Aurora
Moreno, Jaime
Muros-Le Rouzic, Erwan
Lersch, Robert
Regueira, Mabel
Salcedo, Celia
Sorhouet Pereira, Cecilia
Vázquez, Julio A.
author_role author
author2 Agudelo, Clara Inés
Brandileone, María Cristina
Chanto, Grettel
Gabastou, Jean-Marc
Hormazabal, Juan Carlos
O Gorla, M Cecilia
Maldonado, Aurora
Moreno, Jaime
Muros-Le Rouzic, Erwan
Lersch, Robert
Regueira, Mabel
Salcedo, Celia
Sorhouet Pereira, Cecilia
Vázquez, Julio A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neisseria meningitidis Serogrupo Y
Neisseria meningitidis
Infecciones Meningocócicas
topic Neisseria meningitidis Serogrupo Y
Neisseria meningitidis
Infecciones Meningocócicas
dc.description.none.fl_txt_mv Fil: Abad, Raquel. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.
Fil: Agudelo, Clara Inés. Instituto Nacional de Salud (INS). Microbiología; Colombia.
Fil: Brandileone, María Cristina. Adolfo Lutz Institute. Bacteriology Branch; Brasil.
Fil: Chanto, Grettel. Centro Nacional de Referencia en Bacteriología (INCIENSA); Costa Rica.
Fil: Gabastou, Jean-Marc. Pan American Health Organization (PAHO)/World Health Organization (WHO). Vacunas y Tecnologías de Salud. Unidad de Medicamentos Esenciales; Ecuador.
Fil: Hormazabal, Juan Carlos. Instituto de Salud Pública (ISP). Bacteriología; Chile.
Fil: O Gorla, M Cecilia. Adolfo Lutz Institute. Bacteriology Branch; Brasil.
Fil: Maldonado, Aurora. Instituto de Salud Pública (ISP). Bacteriología; Chile.
Fil: Moreno, Jaime. Instituto Nacional de Salud (INS). Microbiología; Colombia.
Fil: Muros-Le Rouzic, Erwan. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia.
Fil: Lersch, Robert. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia.
Fil: Regueira, Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Salcedo, Celia. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.
Fil: Sorhouet, Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
Fil: Vázquez, Julio A. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.
Objectives: To improve the understanding of serogroup Y invasive meningococcal disease (IMD) in Latin America, particularly IMD molecular epidemiology; 166 Y serogroup isolates received at the National Reference Laboratories of Argentina, Brazil, Chile, Colombia, and Costa Rica during 2000-2006 were characterized by their molecular markers. Methods: This analysis included serological assays to determine serogroup/serotype/serosubtype, DNA sequencing and genotyping of the porB and/or porA genes, multilocus sequence typing (MLST) and fetA allele determination. Results: Sixteen different antigenic combinations were observed. Sixty-two (37.3%) isolates were NT:P1.5 and 36 (21.7%) isolates were 14:NST. Thirty-two different STs appeared, but 3 STs (ST-1624, ST-23, and ST-5770) accounted for 69.9% (116) of the strains. Most of the IMD isolates belonged to the ST-23, ST-167 clonal complexes or the group composed by ST-5770 and related STs. Conclusions: Isolates obtained in Colombia and Costa Rica were similar to that of the United States, in that most sequence types belonged to the ST-23 clonal complex. IMD isolates found in Argentina appear to be the result of an independent event and did not spread from nearby countries, being the sequence type ST-1624 (ST-167 clonal complex) the most frequently found. We were unable to correlate an antigenic shift of outer membrane proteins with an increase of serogroup Y meningococcal cases in our collection of isolates.
description Fil: Abad, Raquel. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.
publishDate 2009
dc.date.none.fl_str_mv 2009-08
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 0163-4453
http://sgc.anlis.gob.ar/handle/123456789/1949
10.1016/j.jinf.2009.06.001
identifier_str_mv 0163-4453
10.1016/j.jinf.2009.06.001
url http://sgc.anlis.gob.ar/handle/123456789/1949
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of infection
dc.rights.none.fl_str_mv none
info:eu-repo/semantics/openAccess
rights_invalid_str_mv none
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Journal of Infection 2009;59(2):104-114
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
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repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
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