Deletion of the Correia element in the mtr gene complex of Neisseria meningitidis

Autores
Enríquez, Rocío; Abad, Raquel; Chanto, Grettel; Corso, Alejandra; Cruces, Raquel; Gabastou, Jean-Marc; Gorla, María Cecilia; Maldonado, Aurora; Moreno, Jaime; Muros-Le Rouzic, Erwan; Sorhouet Pereira, Cecilia; Vázquez, Julio A.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The mtr gene complex in Neisseria meningitidis encodes an efflux pump that is responsible for export of antibacterial hydrophobic agents. The promoter region of the mtrCDE operon harbours an insertion sequence known as a Correia element, and a binding site for the integration host factor (IHF) is present at the centre of the Correia element. It has been suggested that the expression of the mtrCDE operon in meningococci is subject to transcriptional regulation by the IHF and post-transcriptional regulation by cleavage in the inverted repeat of the Correia element. The promoter region of the mtrCDE operon as well as the association of changes at that point with decreased susceptibility to antimicrobial drugs in 606 Neisseria meningitidis strains were analysed in this study. Two different deletions were present in the analysed region. The first one, found in seven strains, corresponded to absence of the Correia element. The second one, affecting the -10 region and first 100 bp of the mtrR gene and present in 57 isolates, was only found in ST-1624 isolates. None of the deletions were associated with decreased susceptibility to antimicrobial drugs. Although most of the meningococcal strains carry the Correia element at that position, its deletion is not an exception.
Fil: Enríquez, Rocío. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.
Fil: Abad, Raquel. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.
Fil: Chanto, Grettel. Centro Nacional de Referencia en Bacteriología (INCIENSA); Costa Rica.
Fil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Bacteriología; Argentina.
Fil: Cruces, Raquel. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.
Fil: Marc Gabastou, Jean. Pan American Health Organization (PAHO). Unidad de Medicamentos Esenciales; Ecuador.
Fil: Gorla, María Cecilia. Adolfo Lutz Institute. Bacteriology Branch. Brasil.
Fil: Maldonado, Aurora. Instituto de Salud Pública (ISP). Bacteriología; Chile.
Fil: Moreno, Jaime. Instituto Nacional de Salud (INS). Microbiología. Colombia.
Fil: Muros-Le Rouzic, Erwan. Sanofi-Pasteur. Global Scientific & Medical Affairs; Francia.
Fil: Sorhouet, Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Bacteriología; Argentina.
Fil: Vazquez, Julio A. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.
Fuente
Journal of Medical Microbiology, 2010, 59(9), 1055–1060.
Materia
Neisseria meningitidis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/363
Acceder
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oai_identifier_str oai:sgc.anlis.gob.ar:Publications/123456789/363
network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Deletion of the Correia element in the mtr gene complex of Neisseria meningitidisEnríquez, RocíoAbad, RaquelChanto, GrettelCorso, AlejandraCruces, RaquelGabastou, Jean-MarcGorla, María CeciliaMaldonado, AuroraMoreno, JaimeMuros-Le Rouzic, ErwanSorhouet Pereira, CeciliaVázquez, Julio A.Neisseria meningitidisThe mtr gene complex in Neisseria meningitidis encodes an efflux pump that is responsible for export of antibacterial hydrophobic agents. The promoter region of the mtrCDE operon harbours an insertion sequence known as a Correia element, and a binding site for the integration host factor (IHF) is present at the centre of the Correia element. It has been suggested that the expression of the mtrCDE operon in meningococci is subject to transcriptional regulation by the IHF and post-transcriptional regulation by cleavage in the inverted repeat of the Correia element. The promoter region of the mtrCDE operon as well as the association of changes at that point with decreased susceptibility to antimicrobial drugs in 606 Neisseria meningitidis strains were analysed in this study. Two different deletions were present in the analysed region. The first one, found in seven strains, corresponded to absence of the Correia element. The second one, affecting the -10 region and first 100 bp of the mtrR gene and present in 57 isolates, was only found in ST-1624 isolates. None of the deletions were associated with decreased susceptibility to antimicrobial drugs. Although most of the meningococcal strains carry the Correia element at that position, its deletion is not an exception.Fil: Enríquez, Rocío. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.Fil: Abad, Raquel. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.Fil: Chanto, Grettel. Centro Nacional de Referencia en Bacteriología (INCIENSA); Costa Rica.Fil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Bacteriología; Argentina.Fil: Cruces, Raquel. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.Fil: Marc Gabastou, Jean. Pan American Health Organization (PAHO). Unidad de Medicamentos Esenciales; Ecuador.Fil: Gorla, María Cecilia. Adolfo Lutz Institute. Bacteriology Branch. Brasil.Fil: Maldonado, Aurora. Instituto de Salud Pública (ISP). Bacteriología; Chile.Fil: Moreno, Jaime. Instituto Nacional de Salud (INS). Microbiología. Colombia.Fil: Muros-Le Rouzic, Erwan. Sanofi-Pasteur. Global Scientific & Medical Affairs; Francia.Fil: Sorhouet, Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Bacteriología; Argentina.Fil: Vazquez, Julio A. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.2010info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf0022-2615http://jmm.sgmjournals.org/content/59/9/1055.full.pdfhttp://sgc.anlis.gob.ar/handle/123456789/363Journal of Medical Microbiology, 2010, 59(9), 1055–1060.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISenginfo:eu-repo/semantics/openAccess2025-09-04T11:15:47Zoai:sgc.anlis.gob.ar:Publications/123456789/363Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:15:47.438Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Deletion of the Correia element in the mtr gene complex of Neisseria meningitidis
title Deletion of the Correia element in the mtr gene complex of Neisseria meningitidis
spellingShingle Deletion of the Correia element in the mtr gene complex of Neisseria meningitidis
Enríquez, Rocío
Neisseria meningitidis
title_short Deletion of the Correia element in the mtr gene complex of Neisseria meningitidis
title_full Deletion of the Correia element in the mtr gene complex of Neisseria meningitidis
title_fullStr Deletion of the Correia element in the mtr gene complex of Neisseria meningitidis
title_full_unstemmed Deletion of the Correia element in the mtr gene complex of Neisseria meningitidis
title_sort Deletion of the Correia element in the mtr gene complex of Neisseria meningitidis
dc.creator.none.fl_str_mv Enríquez, Rocío
Abad, Raquel
Chanto, Grettel
Corso, Alejandra
Cruces, Raquel
Gabastou, Jean-Marc
Gorla, María Cecilia
Maldonado, Aurora
Moreno, Jaime
Muros-Le Rouzic, Erwan
Sorhouet Pereira, Cecilia
Vázquez, Julio A.
author Enríquez, Rocío
author_facet Enríquez, Rocío
Abad, Raquel
Chanto, Grettel
Corso, Alejandra
Cruces, Raquel
Gabastou, Jean-Marc
Gorla, María Cecilia
Maldonado, Aurora
Moreno, Jaime
Muros-Le Rouzic, Erwan
Sorhouet Pereira, Cecilia
Vázquez, Julio A.
author_role author
author2 Abad, Raquel
Chanto, Grettel
Corso, Alejandra
Cruces, Raquel
Gabastou, Jean-Marc
Gorla, María Cecilia
Maldonado, Aurora
Moreno, Jaime
Muros-Le Rouzic, Erwan
Sorhouet Pereira, Cecilia
Vázquez, Julio A.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neisseria meningitidis
topic Neisseria meningitidis
dc.description.none.fl_txt_mv The mtr gene complex in Neisseria meningitidis encodes an efflux pump that is responsible for export of antibacterial hydrophobic agents. The promoter region of the mtrCDE operon harbours an insertion sequence known as a Correia element, and a binding site for the integration host factor (IHF) is present at the centre of the Correia element. It has been suggested that the expression of the mtrCDE operon in meningococci is subject to transcriptional regulation by the IHF and post-transcriptional regulation by cleavage in the inverted repeat of the Correia element. The promoter region of the mtrCDE operon as well as the association of changes at that point with decreased susceptibility to antimicrobial drugs in 606 Neisseria meningitidis strains were analysed in this study. Two different deletions were present in the analysed region. The first one, found in seven strains, corresponded to absence of the Correia element. The second one, affecting the -10 region and first 100 bp of the mtrR gene and present in 57 isolates, was only found in ST-1624 isolates. None of the deletions were associated with decreased susceptibility to antimicrobial drugs. Although most of the meningococcal strains carry the Correia element at that position, its deletion is not an exception.
Fil: Enríquez, Rocío. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.
Fil: Abad, Raquel. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.
Fil: Chanto, Grettel. Centro Nacional de Referencia en Bacteriología (INCIENSA); Costa Rica.
Fil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Bacteriología; Argentina.
Fil: Cruces, Raquel. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.
Fil: Marc Gabastou, Jean. Pan American Health Organization (PAHO). Unidad de Medicamentos Esenciales; Ecuador.
Fil: Gorla, María Cecilia. Adolfo Lutz Institute. Bacteriology Branch. Brasil.
Fil: Maldonado, Aurora. Instituto de Salud Pública (ISP). Bacteriología; Chile.
Fil: Moreno, Jaime. Instituto Nacional de Salud (INS). Microbiología. Colombia.
Fil: Muros-Le Rouzic, Erwan. Sanofi-Pasteur. Global Scientific & Medical Affairs; Francia.
Fil: Sorhouet, Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Bacteriología; Argentina.
Fil: Vazquez, Julio A. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.
description The mtr gene complex in Neisseria meningitidis encodes an efflux pump that is responsible for export of antibacterial hydrophobic agents. The promoter region of the mtrCDE operon harbours an insertion sequence known as a Correia element, and a binding site for the integration host factor (IHF) is present at the centre of the Correia element. It has been suggested that the expression of the mtrCDE operon in meningococci is subject to transcriptional regulation by the IHF and post-transcriptional regulation by cleavage in the inverted repeat of the Correia element. The promoter region of the mtrCDE operon as well as the association of changes at that point with decreased susceptibility to antimicrobial drugs in 606 Neisseria meningitidis strains were analysed in this study. Two different deletions were present in the analysed region. The first one, found in seven strains, corresponded to absence of the Correia element. The second one, affecting the -10 region and first 100 bp of the mtrR gene and present in 57 isolates, was only found in ST-1624 isolates. None of the deletions were associated with decreased susceptibility to antimicrobial drugs. Although most of the meningococcal strains carry the Correia element at that position, its deletion is not an exception.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 0022-2615
http://jmm.sgmjournals.org/content/59/9/1055.full.pdf
http://sgc.anlis.gob.ar/handle/123456789/363
identifier_str_mv 0022-2615
url http://jmm.sgmjournals.org/content/59/9/1055.full.pdf
http://sgc.anlis.gob.ar/handle/123456789/363
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Journal of Medical Microbiology, 2010, 59(9), 1055–1060.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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score 12.623145

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