Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events

• Autores: Baker, Stephen; Pickard, Derek J; Parkhill, Julian; Page, Andrew J; Feasey, Nicholas A; Kingsley, Robert A; Thomson, Nicholas R; Keane, Jacqueline A; Weill, François-Xavier; Edwards, David J; Hawkey, Jane; Harris, Simon R; Mather, Alison E; Cain, Amy K; Hadfield, James; Hart, Peter J; Thieu, Nga Tran Vu; Klemm, Elizabeth J; Glinos, Dafni A; Breiman, Robert F; Watson, Conall H; Kariuki, Samuel; Gordon, Melita A; Heyderman, Robert S; Okoro, Chinyere; Jacobs, Jan; Lunguya, Octavie; Edmunds, W John; Msefula, Chisomo; Chabalgoity, Jose A; Kama, Mike; Jenkins, Kylie; Dutta, Shanta; Marks, Florian; Campos, Josefina; Thompson, Corinne; Obaro, Stephen; Maclennan, Calman A; Dolecek, Christiane; Keddy, Karen H; Smith, Anthony M; Parry, Christopher M; Karkey, Abhilasha; Mulholland, E Kim; Campbell, James I; Dongol, Sabina; Basnyat, Buddha; Dufour, Muriel; Bandaranayake, Don; Naseri, Take Toleafoa; Singh, Shalini Pravin; Hatta, Mochammad; Newton, Paul; Onsare, Robert S; Isaia, Lupeoletalalei; Dance, David; Davong, Viengmon; Thwaites, Guy; Wijedoru, Lalith; Crump, John A; De Pinna, Elizabeth; Nair, Satheesh; Nilles, Eric J; Thanh, Duy Pham; Turner, Paul; Soeng, Sona; Valcanis, Mary; Powling, Joan; Dimovski, Karolina; Hogg, Geoff; Farrar, Jeremy; Holt, Kathryn E; Dougan, Gordon
• Año de publicación: 2015
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Nature Genetics 2015;47(6):632-639
• Materia: Infecciones por Salmonella; Salmonella; Transmisión de enfermedad infecciosa
• Institución: Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"

Fil: Wong, Vanessa K. Wellcome Trust Sanger Institute, Hinxton; Reino Unido. Cambridge University Hospitals National Health Service (NHS) Foundation Trust. Addenbrooke's Hospital. Department of Microbiology; Cambridge; Reino Unido.
Fil: Baker, Stephen. Oxford University Clinical Research Unit. Hospital for Tropical Diseases. Wellcome Trust Major Overseas Programme; Vietnam.Oxford University. Nuffield Department of Clinical Medicine. Centre for Tropical Medicine and Global Health, Oxford; Reino Unido. London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases, Londres; Reino Unido.
Fil: Pickard, Derek J. Wellcome Trust Sanger Institute, Hinxton; Reino Unido.
Fil: Parkhill, Julian. Wellcome Trust Sanger Institute, Hinxton; Reino Unido.
Fil: Page, Andrew J. Wellcome Trust Sanger Institute, Hinxton; Reino Unido.
Fil: Feasey, Nicholas A. Liverpool School of Tropical Medicine, Liverpool, UK.
Fil: Kingsley, Robert A. Wellcome Trust Sanger Institute, Hinxton; Reino Unido. UK. Institute of Food Research; Norwich; Reino Unido.
Fil: Thomson, Nicholas R. Wellcome Trust Sanger Institute, Hinxton; Reino Unido. London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases, Londres; Reino Unido.
Fil: Keane, Jacqueline A. Wellcome Trust Sanger Institute, Hinxton; Reino Unido.
Fil: Weill, François-Xavier. Institut Pasteur, Unité des Bactéries Pathogènes Entériques, París; Francia.
Fil: Edwards, David J. University of Melbourne. Bio21 Molecular Science and Biotechnology Institute. Department of Biochemistry and Molecular Biology; Australia.
Fil: Hawkey, Jane. University of Melbourne. Faculty of Veterinary and Agricultural Sciences. Bio21 Molecular Science and Biotechnology Institute. Department of Biochemistry and Molecular Biology; Australia.
Fil: Harris, Simon R. Wellcome Trust Sanger Institute, Hinxton; Reino Unido.
Fil: Mather, Alison E. Wellcome Trust Sanger Institute, Hinxton; Reino Unido.
Fil: Cain, Amy K. Wellcome Trust Sanger Institute, Hinxton; Reino Unido.
Fil: Hadfield, James. Wellcome Trust Sanger Institute, Hinxton; Reino Unido.
Fil: Hart, Peter J. University of Birmingham. School of Immunity and Infection, College of Medicine and Dental Sciences. Institute of Biomedical Research; Reino Unido.
Fil: Thieu, Nga Tran Vu. Oxford University Clinical Research Unit. Wellcome Trust Major Overseas Programme. Hospital for Tropical Diseases; Vietnam.
Fil: Klemm, Elizabeth J. Wellcome Trust Sanger Institute, Hinxton; Reino Unido.
Fil: Glinos, Dafni A. Wellcome Trust Sanger Institute, Hinxton; Reino Unido.
Fil: Breiman, Robert F. Kenya Medical Research Institute (KEMRI), Nairobi; Kenia. Centers for Disease Control and Prevention, Atlanta, Georgia; Estados Unidos. Emory Global Health Institute, Atlanta, Georgia; Estados Unidos.
Fil: Watson, Conall H. London School of Hygiene and Tropical Medicine. Department of Infectious Disease Epidemiology. Centre for the Mathematical Modelling of Infectious Diseases, Londres; Reino Unido.
Fil: Kariuki, Samuel. Wellcome Trust Sanger Institute, Hinxton; Reino Unido. Kenya Medical Research Institute (KEMRI); Kenia.
Fil: Gordon, Melita A. University of Liverpool. Institute of Infection and Global Health; Reino Unido.
Fil: Heyderman, Robert S. University of Malawi. College of Medicine. Malawi-Liverpool Wellcome Trust Clinical Research Programme; Malaui.
Fil: Okoro, Chinyere. Wellcome Trust Sanger Institute, Hinxton; Reino Unido.
Fil: Jacobs, Jan. Institute of Tropical Medicine, Antwerp. Department of Clinical Sciences; Bélgica. University of Leuven. Katholieke Universiteit (KU) Leuven. Department of Microbiology and Immunology; Bélgica.
Fil: Lunguya, Octavie. National Institute for Biomedical Research, Kinshasa; República Democrática del Congo. University Hospital of Kinshasa, Kinshasa; República Democrática del Congo.
Fil: Edmunds, W. John. London School of Hygiene and Tropical Medicine. Department of Infectious Disease Epidemiology. Centre for the Mathematical Modelling of Infectious Diseases, Londres; Reino Unido.
Fil: Msefula, Chisomo. University of Malawi. College of Medicine. Malawi-Liverpool Wellcome Trust Clinical Research Programme; Malaui. University of Malawi. College of Medicine. Microbiology Department; Malaui.
Fil: Chabalgoity, Jose A. Facultad de Medicina. Instituto de Higiene. Departamento de Desarrollo Biotecnológico, Montevideo; Uruguay.
Fil: Kama, Mike. Ministry of Health, Suva; Fiyi.
Fil: Jenkins, Kylie. Fiji Health Sector Support Program; Fiyi.
Fil: Dutta, Shanta. National Institute of Cholera and Enteric Diseases, Kolkata; India.
Fil: Marks, Florian. International Vaccine Institute. Department of Epidemiology, Seúl; Corea del Sur.
Fil: Campos, Josefina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Thompson, Corinne. Oxford University Clinical Research Unit. Wellcome Trust Major Overseas Programme. Hospital for Tropical Diseases, Ho Chi Minh City; Vietnam. Oxford University. Nuffield Department of Clinical Medicine. Centre for Tropical Medicine and Global Health, Oxford; Reino Unido.
Fil: Obaro, Stephen. University of Nebraska Medical Center. Division of Pediatric Infectious Diseases, Omaha, Nebraska; Estados Unidos. University of Abuja Teaching Hospital, Abuja; Nigeria. Bingham University, Karu; Nigeria.
Fil: Maclennan, Calman A. Wellcome Trust Sanger Institute, Hinxton; Reino Unido. University of Birmingham. College of Medicine and Dental Sciences. Institute of Biomedical Research, School of Immunity and Infection; Reino Unido. Novartis Vaccines Institute for Global Health, Siena; Italia.
Fil: Dolecek, Christiane. Oxford University. Nuffield Department of Clinical Medicine. Centre for Tropical Medicine and Global Health; Reino Unido.
Fil: Keddy, Karen H. University of the Witwatersrand. Division in the National Health Laboratory Service. National Institute for Communicable Diseases. Centre for Enteric Diseases; Sudáfrica.
Fil: Smith, Anthony M. University of the Witwatersrand. Division in the National Health Laboratory Service. National Institute for Communicable Diseases. Centre for Enteric Diseases; Sudáfrica.
Fil: Parry, Christopher M. London School of Hygiene and Tropical Medicine. Department of Clinical Research, Londres; Reino Unido. Nagasaki University. Graduate School of Tropical Medicine and Global Health; Japón.
Fil: Karkey, Abhilasha. Oxford University Clinical Research Unit. Wellcome Trust Major Overseas Programme. Patan Academy of Health Sciences; Nepal.
Fil: Mulholland, E Kim. London School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases, Londres; Reino Unido. [2] Murdoch Childrens Research Institute; Australia.
Fil: Campbell, James I. Oxford University Clinical Research Unit. Wellcome Trust Major Overseas Programme. Hospital for Tropical Diseases, Ho Chi Minh City; Vietnam. Oxford University. Nuffield Department of Clinical Medicine. Centre for Tropical Medicine and Global Health, Oxford; Reino Unido.
Fil: Dongol, Sabina. Oxford University Clinical Research Unit. Wellcome Trust Major Overseas Programme. Patan Academy of Health Sciences; Nepal.
Fil: Basnyat, Buddha. Oxford University Clinical Research Unit. Wellcome Trust Major Overseas Programme. Patan Academy of Health Sciences; Nepal.
Fil: Dufour, Muriel. Institute of Environmental Science and Research, Ltd. (ESR). Enteric and Leptospira Reference Laboratory; Nueva Zelanda.
Fil: Bandaranayake, Don. Institute of Environmental Science and Research. National Centre for Biosecurity and Infectious Disease; Nueva Zelanda.
Fil: Naseri, Take Toleafoa. Samoa Ministry of Health, Apia; Samoa.
Fil: Singh, Shalini Pravin. Center for Communicable Disease Control. National Influenza Center, World Health Organization, Suva; Fiyi.
Fil: Hatta, Mochammad. Hasanuddin University. Department of Microbiology; Indonesia.
Fil: Newton, Paul. Oxford University. Nuffield Department of Clinical Medicine. Centre for Tropical Medicine and Global Health, Oxford; Reino Unido. Mahosot Hospital. Microbiology Laboratory. Lao Oxford Mahosot Wellcome Trust Research Unit; Laos.
Fil: Onsare, Robert S. Kenya Medical Research Institute (KEMRI), Nairobi; Kenia.
Fil: Isaia, Lupeoletalalei. Tupua Tamasese Meaole Hospital. National Health Services; Samoa.
Fil: Dance, David. Oxford University. Nuffield Department of Clinical Medicine. Centre for Tropical Medicine and Global Health, Oxford; Reino Unido. Mahosot Hospital. Microbiology Laboratory. Lao Oxford Mahosot Wellcome Trust Research Unit; Laos.
Fil: Davong, Viengmon. Mahosot Hospital. Microbiology Laboratory. Lao Oxford Mahosot Wellcome Trust Research Unit; Laos.
Fil: Thwaites, Guy. Oxford University Clinical Research Unit. Wellcome Trust Major Overseas Programme. Hospital for Tropical Diseases, Ho Chi Minh City; Vietnam. Oxford University. Nuffield Department of Clinical Medicine. Centre for Tropical Medicine and Global Health, Oxford; Reino Unido.
Fil: Wijedoru, Lalith. Center for Communicable Disease Control. National Influenza Center, World Health Organization, Suva; Fiyi.
Fil: Crump, John A. University of Otago. Dunedin School of Medicine. Centre for International Health and Otago International Health Research Network; Nueva Zelanda.
Fil: De Pinna, Elizabeth. Public Health England. Salmonella Reference Service, Londres; Reino Unido.
Fil: Nair, Satheesh. Public Health England. Salmonella Reference Service, Londres; Reino Unido.
Fil: Nilles, Eric J. World Health Organization. Division of Pacific Technical Support. Emerging Disease Surveillance and Response, Suva; Fiyi.
Fil: Thanh, Duy Pham. Oxford University Clinical Research Unit. Wellcome Trust Major Overseas Programme. Hospital for Tropical Diseases; Vietnam.
Fil: Turner, Paul. Oxford University. Nuffield Department of Clinical Medicine. Centre for Tropical Medicine and Global Health, Oxford, Reino Unido. Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit; Tailandia. Angkor Hospital for Children. Cambodia-Oxford Medical Research Unit; Cambodia.
Fil: Soeng, Sona. Angkor Hospital for Children. Cambodia-Oxford Medical Research Unit; Cambodia.
Fil: Valcanis, Mary. University of Melbourne. Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity. Microbiological Diagnostic Unit-Public Health Laboratory; Australia.
Fil: Powling, Joan. University of Melbourne. Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity. Microbiological Diagnostic Unit-Public Health Laboratory; Australia.
Fil: Dimovski, Karolina. University of Melbourne. Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity. Microbiological Diagnostic Unit-Public Health Laboratory; Australia.
Fil: Hogg, Geoff. University of Melbourne. Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity. Microbiological Diagnostic Unit-Public Health Laboratory; Australia.
Fil: Farrar, Jeremy. Oxford University Clinical Research Unit. Wellcome Trust Major Overseas Programme. Hospital for Tropical Diseases, Ho Chi Minh City; Vietnam. Oxford University. Nuffield Department of Clinical Medicine. Centre for Tropical Medicine and Global Health, Oxford; Reino Unido.
Fil: Holt, Kathryn E. University of Melbourne. Bio21 Molecular Science and Biotechnology Institute. Department of Biochemistry and Molecular Biology; Australia.
Fil: Dougan, Gordon. Wellcome Trust Sanger Institute, Hinxton; Reino Unido.
The emergence of multidrug-resistant (MDR) typhoid is a major global health threat affecting many countries where the disease is endemic. Here whole-genome sequence analysis of 1,832 Salmonella enterica serovar Typhi (S. Typhi) identifies a single dominant MDR lineage, H58, that has emerged and spread throughout Asia and Africa over the last 30 years. Our analysis identifies numerous transmissions of H58, including multiple transfers from Asia to Africa and an ongoing, unrecognized MDR epidemic within Africa itself. Notably, our analysis indicates that H58 lineages are displacing antibiotic-sensitive isolates, transforming the global population structure of this pathogen. H58 isolates can harbor a complex MDR element residing either on transmissible IncHI1 plasmids or within multiple chromosomal integration sites. We also identify new mutations that define the H58 lineage. This phylogeographical analysis provides a framework to facilitate global management of MDR typhoid and is applicable to similar MDR lineages emerging in other bacterial species.