In vitro susceptibility studies of Cryptococcus neoformans isolated from patients with no clinical response to amphotericin B therapy

Autores
Rodero, Laura; Córdoba, Susana; Cahn, Pedro; Hochenfellner, F.; Davel, Graciela Odelsia; Canteros, C. E.; Kaufman, Sara; Guelfand, Liliana
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Rodero, Laura. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Córdoba, Susana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Cahn, Pedro. Hospital General de Agudos Dr. Juan A. Fernández; Argentina.
Fil: Hochenfellner, F. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Davel, Graciela Odelsia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Canteros, C. E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Kaufman, Sara. Hospital General de Agudos Dr. Juan A. Fernández; Argentina.
Fil: Guelfand, Liliana. Hospital General de Agudos Dr. Juan A. Fernández; Argentina.
The in vitro activities of three antifungal drugs alone and in combination were evaluated against five isolates of Cryptococcus neoformans using time–kill curves (TKC). The isolates were from AIDS patients who had either died or had failed to show a clinical response during amphotericin B (AMB) treatment. AMB, fluconazole (FCZ) and flucytosine (5FC), and combinations of the drugs (AMB plus 5FC, AMB plus rifampicin (RIF) and FCZ plus 5FC), were evaluated. With all five isolates AMB did not show fungicidal activity; instead, a persistent or tolerant effect was observed. Combinations of AMB plus 5FC and AMB plus RIF showed a clear synergic effect, except for one isolate tested with AMB plus RIF. In contrast, the FCZ plus 5FC combination did not inhibit growth of any isolate.
Fuente
Journal of Antimicrobial Chemotherapy, 2000, 45(2), 239–242.
Journal of Antimicrobial Chemotherapy 2000; 45(2):239-242
Materia
Anfotericina B
Cryptococcus neoformans
Humanos
Farmacorresistencia Microbiana
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/368
Acceder
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oai_identifier_str oai:sgc.anlis.gob.ar:Publications/123456789/368
network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling In vitro susceptibility studies of Cryptococcus neoformans isolated from patients with no clinical response to amphotericin B therapyRodero, LauraCórdoba, SusanaCahn, PedroHochenfellner, F.Davel, Graciela OdelsiaCanteros, C. E.Kaufman, SaraGuelfand, LilianaAnfotericina BCryptococcus neoformansHumanosFarmacorresistencia MicrobianaFil: Rodero, Laura. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Córdoba, Susana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Cahn, Pedro. Hospital General de Agudos Dr. Juan A. Fernández; Argentina.Fil: Hochenfellner, F. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Davel, Graciela Odelsia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Canteros, C. E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Kaufman, Sara. Hospital General de Agudos Dr. Juan A. Fernández; Argentina.Fil: Guelfand, Liliana. Hospital General de Agudos Dr. Juan A. Fernández; Argentina.The in vitro activities of three antifungal drugs alone and in combination were evaluated against five isolates of Cryptococcus neoformans using time–kill curves (TKC). The isolates were from AIDS patients who had either died or had failed to show a clinical response during amphotericin B (AMB) treatment. AMB, fluconazole (FCZ) and flucytosine (5FC), and combinations of the drugs (AMB plus 5FC, AMB plus rifampicin (RIF) and FCZ plus 5FC), were evaluated. With all five isolates AMB did not show fungicidal activity; instead, a persistent or tolerant effect was observed. Combinations of AMB plus 5FC and AMB plus RIF showed a clear synergic effect, except for one isolate tested with AMB plus RIF. In contrast, the FCZ plus 5FC combination did not inhibit growth of any isolate.2000-02-01info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1460-2091http://sgc.anlis.gob.ar/handle/123456789/368http://jac.oxfordjournals.org/content/45/2/239.full.pdf+htmlJournal of Antimicrobial Chemotherapy, 2000, 45(2), 239–242.Journal of Antimicrobial Chemotherapy 2000; 45(2):239-242reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISThe Journal of antimicrobial chemotherapyenginfo:eu-repo/semantics/openAccess2025-09-29T14:29:59Zoai:sgc.anlis.gob.ar:Publications/123456789/368Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:00.339Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv In vitro susceptibility studies of Cryptococcus neoformans isolated from patients with no clinical response to amphotericin B therapy
title In vitro susceptibility studies of Cryptococcus neoformans isolated from patients with no clinical response to amphotericin B therapy
spellingShingle In vitro susceptibility studies of Cryptococcus neoformans isolated from patients with no clinical response to amphotericin B therapy
Rodero, Laura
Anfotericina B
Cryptococcus neoformans
Humanos
Farmacorresistencia Microbiana
title_short In vitro susceptibility studies of Cryptococcus neoformans isolated from patients with no clinical response to amphotericin B therapy
title_full In vitro susceptibility studies of Cryptococcus neoformans isolated from patients with no clinical response to amphotericin B therapy
title_fullStr In vitro susceptibility studies of Cryptococcus neoformans isolated from patients with no clinical response to amphotericin B therapy
title_full_unstemmed In vitro susceptibility studies of Cryptococcus neoformans isolated from patients with no clinical response to amphotericin B therapy
title_sort In vitro susceptibility studies of Cryptococcus neoformans isolated from patients with no clinical response to amphotericin B therapy
dc.creator.none.fl_str_mv Rodero, Laura
Córdoba, Susana
Cahn, Pedro
Hochenfellner, F.
Davel, Graciela Odelsia
Canteros, C. E.
Kaufman, Sara
Guelfand, Liliana
author Rodero, Laura
author_facet Rodero, Laura
Córdoba, Susana
Cahn, Pedro
Hochenfellner, F.
Davel, Graciela Odelsia
Canteros, C. E.
Kaufman, Sara
Guelfand, Liliana
author_role author
author2 Córdoba, Susana
Cahn, Pedro
Hochenfellner, F.
Davel, Graciela Odelsia
Canteros, C. E.
Kaufman, Sara
Guelfand, Liliana
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anfotericina B
Cryptococcus neoformans
Humanos
Farmacorresistencia Microbiana
topic Anfotericina B
Cryptococcus neoformans
Humanos
Farmacorresistencia Microbiana
dc.description.none.fl_txt_mv Fil: Rodero, Laura. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Córdoba, Susana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Cahn, Pedro. Hospital General de Agudos Dr. Juan A. Fernández; Argentina.
Fil: Hochenfellner, F. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Davel, Graciela Odelsia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Canteros, C. E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Kaufman, Sara. Hospital General de Agudos Dr. Juan A. Fernández; Argentina.
Fil: Guelfand, Liliana. Hospital General de Agudos Dr. Juan A. Fernández; Argentina.
The in vitro activities of three antifungal drugs alone and in combination were evaluated against five isolates of Cryptococcus neoformans using time–kill curves (TKC). The isolates were from AIDS patients who had either died or had failed to show a clinical response during amphotericin B (AMB) treatment. AMB, fluconazole (FCZ) and flucytosine (5FC), and combinations of the drugs (AMB plus 5FC, AMB plus rifampicin (RIF) and FCZ plus 5FC), were evaluated. With all five isolates AMB did not show fungicidal activity; instead, a persistent or tolerant effect was observed. Combinations of AMB plus 5FC and AMB plus RIF showed a clear synergic effect, except for one isolate tested with AMB plus RIF. In contrast, the FCZ plus 5FC combination did not inhibit growth of any isolate.
description Fil: Rodero, Laura. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
publishDate 2000
dc.date.none.fl_str_mv 2000-02-01
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1460-2091
http://sgc.anlis.gob.ar/handle/123456789/368
http://jac.oxfordjournals.org/content/45/2/239.full.pdf+html
identifier_str_mv 1460-2091
url http://sgc.anlis.gob.ar/handle/123456789/368
http://jac.oxfordjournals.org/content/45/2/239.full.pdf+html
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv The Journal of antimicrobial chemotherapy
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Journal of Antimicrobial Chemotherapy, 2000, 45(2), 239–242.
Journal of Antimicrobial Chemotherapy 2000; 45(2):239-242
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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score 12.558318

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