Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS

Autores
Rodero, Laura; Córdoba, Susana; Cahn, Pedro; Soria, Marcelo; Lucarini, M; Davel, Graciela Odelsia; Kaufman, Sara; Canteros, Cristina Elena; Guelfand, Liliana
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Rodero, L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Córdoba, Susana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Cahn, Pedro. Infectology Unit., Hospital Juan A. Fernandez, Buenos Aires; Argentina.
Fil: Soria, Marcelo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Lucarini, M. Infectology Unit., Hospital Juan A. Fernandez, Buenos Aires; Argentina.
Fil: Davel, Graciela Odelsia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Kaufman, Sara. Microbiology Laboratory, Hospital Juan A. Fernandez, Buenos Aires; Argentina.
Fil: Canteros, Cristina Elena. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Guelfand, Liliana. Microbiology Laboratory, Hospital Juan A. Fernández, Buenos Aires, Argentina.
Infection with Cryptococcus neoformans is an increasing problem in immunocompromised patients, particularly those with acquired immune deficiency syndrome (AIDS). Amphotericin B and fluconazole are currently acceptable therapies for cryptococcal meningitis; however, their effects remain suboptimal and recurrence or treatment failure is still a problem. Antifungal susceptibility testing may be an important tool for guiding therapy, but for C. neoformans, a reliable method is still not available. This retrospective study evaluated minimal inhibitory concentration (MIC) for amphotericin B and fluconazole, and minimal fungicidal concentration (MFC) and timed-kill curves for amphotericin B against 16 clinical isolates of C. neoformans obtained from AIDS patients with cryptococcal meningitis. No correlation between clinical outcome and MIC was observed for amphotericin B. In selected cases, the MFC seemed to be a better predictor of outcome than MIC. In this study, amphotericin B timed-kill curves appeared to show a correlation with clinical outcome of the 16 patients with AIDS-associated cryptococcal meningitis. These in vitro tests must be further evaluated in prospective studies to confirm their potential usefulness for guiding cryptococcal meningitis therapy.
Fuente
Medical Mycology 2000; 38(3):201-7.
Materia
Criptococosis
Cryptococcus neoformans
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/2111
Acceder
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spelling Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDSRodero, LauraCórdoba, SusanaCahn, PedroSoria, MarceloLucarini, MDavel, Graciela OdelsiaKaufman, SaraCanteros, Cristina ElenaGuelfand, LilianaCriptococosisCryptococcus neoformansFil: Rodero, L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Córdoba, Susana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Cahn, Pedro. Infectology Unit., Hospital Juan A. Fernandez, Buenos Aires; Argentina.Fil: Soria, Marcelo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Lucarini, M. Infectology Unit., Hospital Juan A. Fernandez, Buenos Aires; Argentina.Fil: Davel, Graciela Odelsia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Kaufman, Sara. Microbiology Laboratory, Hospital Juan A. Fernandez, Buenos Aires; Argentina.Fil: Canteros, Cristina Elena. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Guelfand, Liliana. Microbiology Laboratory, Hospital Juan A. Fernández, Buenos Aires, Argentina.Infection with Cryptococcus neoformans is an increasing problem in immunocompromised patients, particularly those with acquired immune deficiency syndrome (AIDS). Amphotericin B and fluconazole are currently acceptable therapies for cryptococcal meningitis; however, their effects remain suboptimal and recurrence or treatment failure is still a problem. Antifungal susceptibility testing may be an important tool for guiding therapy, but for C. neoformans, a reliable method is still not available. This retrospective study evaluated minimal inhibitory concentration (MIC) for amphotericin B and fluconazole, and minimal fungicidal concentration (MFC) and timed-kill curves for amphotericin B against 16 clinical isolates of C. neoformans obtained from AIDS patients with cryptococcal meningitis. No correlation between clinical outcome and MIC was observed for amphotericin B. In selected cases, the MFC seemed to be a better predictor of outcome than MIC. In this study, amphotericin B timed-kill curves appeared to show a correlation with clinical outcome of the 16 patients with AIDS-associated cryptococcal meningitis. These in vitro tests must be further evaluated in prospective studies to confirm their potential usefulness for guiding cryptococcal meningitis therapy.Oxford University Press2000-06info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1369-3786http://sgc.anlis.gob.ar/handle/123456789/211110.1080/mmy.38.3.201.207Medical Mycology 2000; 38(3):201-7.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISMedical mycologyenginfo:eu-repo/semantics/openAccess2025-09-29T14:30:39Zoai:sgc.anlis.gob.ar:123456789/2111Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:39.896Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS
title Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS
spellingShingle Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS
Rodero, Laura
Criptococosis
Cryptococcus neoformans
title_short Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS
title_full Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS
title_fullStr Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS
title_full_unstemmed Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS
title_sort Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS
dc.creator.none.fl_str_mv Rodero, Laura
Córdoba, Susana
Cahn, Pedro
Soria, Marcelo
Lucarini, M
Davel, Graciela Odelsia
Kaufman, Sara
Canteros, Cristina Elena
Guelfand, Liliana
author Rodero, Laura
author_facet Rodero, Laura
Córdoba, Susana
Cahn, Pedro
Soria, Marcelo
Lucarini, M
Davel, Graciela Odelsia
Kaufman, Sara
Canteros, Cristina Elena
Guelfand, Liliana
author_role author
author2 Córdoba, Susana
Cahn, Pedro
Soria, Marcelo
Lucarini, M
Davel, Graciela Odelsia
Kaufman, Sara
Canteros, Cristina Elena
Guelfand, Liliana
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Criptococosis
Cryptococcus neoformans
topic Criptococosis
Cryptococcus neoformans
dc.description.none.fl_txt_mv Fil: Rodero, L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Córdoba, Susana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Cahn, Pedro. Infectology Unit., Hospital Juan A. Fernandez, Buenos Aires; Argentina.
Fil: Soria, Marcelo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Lucarini, M. Infectology Unit., Hospital Juan A. Fernandez, Buenos Aires; Argentina.
Fil: Davel, Graciela Odelsia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Kaufman, Sara. Microbiology Laboratory, Hospital Juan A. Fernandez, Buenos Aires; Argentina.
Fil: Canteros, Cristina Elena. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Guelfand, Liliana. Microbiology Laboratory, Hospital Juan A. Fernández, Buenos Aires, Argentina.
Infection with Cryptococcus neoformans is an increasing problem in immunocompromised patients, particularly those with acquired immune deficiency syndrome (AIDS). Amphotericin B and fluconazole are currently acceptable therapies for cryptococcal meningitis; however, their effects remain suboptimal and recurrence or treatment failure is still a problem. Antifungal susceptibility testing may be an important tool for guiding therapy, but for C. neoformans, a reliable method is still not available. This retrospective study evaluated minimal inhibitory concentration (MIC) for amphotericin B and fluconazole, and minimal fungicidal concentration (MFC) and timed-kill curves for amphotericin B against 16 clinical isolates of C. neoformans obtained from AIDS patients with cryptococcal meningitis. No correlation between clinical outcome and MIC was observed for amphotericin B. In selected cases, the MFC seemed to be a better predictor of outcome than MIC. In this study, amphotericin B timed-kill curves appeared to show a correlation with clinical outcome of the 16 patients with AIDS-associated cryptococcal meningitis. These in vitro tests must be further evaluated in prospective studies to confirm their potential usefulness for guiding cryptococcal meningitis therapy.
description Fil: Rodero, L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
publishDate 2000
dc.date.none.fl_str_mv 2000-06
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1369-3786
http://sgc.anlis.gob.ar/handle/123456789/2111
10.1080/mmy.38.3.201.207
identifier_str_mv 1369-3786
10.1080/mmy.38.3.201.207
url http://sgc.anlis.gob.ar/handle/123456789/2111
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Medical mycology
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Medical Mycology 2000; 38(3):201-7.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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score 12.558318

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