Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS
- Autores
- Rodero, Laura; Córdoba, Susana; Cahn, Pedro; Soria, Marcelo; Lucarini, M; Davel, Graciela Odelsia; Kaufman, Sara; Canteros, Cristina Elena; Guelfand, Liliana
- Año de publicación
- 2000
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Rodero, L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Córdoba, Susana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Cahn, Pedro. Infectology Unit., Hospital Juan A. Fernandez, Buenos Aires; Argentina.
Fil: Soria, Marcelo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Lucarini, M. Infectology Unit., Hospital Juan A. Fernandez, Buenos Aires; Argentina.
Fil: Davel, Graciela Odelsia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Kaufman, Sara. Microbiology Laboratory, Hospital Juan A. Fernandez, Buenos Aires; Argentina.
Fil: Canteros, Cristina Elena. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Guelfand, Liliana. Microbiology Laboratory, Hospital Juan A. Fernández, Buenos Aires, Argentina.
Infection with Cryptococcus neoformans is an increasing problem in immunocompromised patients, particularly those with acquired immune deficiency syndrome (AIDS). Amphotericin B and fluconazole are currently acceptable therapies for cryptococcal meningitis; however, their effects remain suboptimal and recurrence or treatment failure is still a problem. Antifungal susceptibility testing may be an important tool for guiding therapy, but for C. neoformans, a reliable method is still not available. This retrospective study evaluated minimal inhibitory concentration (MIC) for amphotericin B and fluconazole, and minimal fungicidal concentration (MFC) and timed-kill curves for amphotericin B against 16 clinical isolates of C. neoformans obtained from AIDS patients with cryptococcal meningitis. No correlation between clinical outcome and MIC was observed for amphotericin B. In selected cases, the MFC seemed to be a better predictor of outcome than MIC. In this study, amphotericin B timed-kill curves appeared to show a correlation with clinical outcome of the 16 patients with AIDS-associated cryptococcal meningitis. These in vitro tests must be further evaluated in prospective studies to confirm their potential usefulness for guiding cryptococcal meningitis therapy. - Fuente
- Medical Mycology 2000; 38(3):201-7.
- Materia
-
Criptococosis
Cryptococcus neoformans - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
- Institución
- Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
- OAI Identificador
- oai:sgc.anlis.gob.ar:123456789/2111
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Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDSRodero, LauraCórdoba, SusanaCahn, PedroSoria, MarceloLucarini, MDavel, Graciela OdelsiaKaufman, SaraCanteros, Cristina ElenaGuelfand, LilianaCriptococosisCryptococcus neoformansFil: Rodero, L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Córdoba, Susana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Cahn, Pedro. Infectology Unit., Hospital Juan A. Fernandez, Buenos Aires; Argentina.Fil: Soria, Marcelo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Lucarini, M. Infectology Unit., Hospital Juan A. Fernandez, Buenos Aires; Argentina.Fil: Davel, Graciela Odelsia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Kaufman, Sara. Microbiology Laboratory, Hospital Juan A. Fernandez, Buenos Aires; Argentina.Fil: Canteros, Cristina Elena. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.Fil: Guelfand, Liliana. Microbiology Laboratory, Hospital Juan A. Fernández, Buenos Aires, Argentina.Infection with Cryptococcus neoformans is an increasing problem in immunocompromised patients, particularly those with acquired immune deficiency syndrome (AIDS). Amphotericin B and fluconazole are currently acceptable therapies for cryptococcal meningitis; however, their effects remain suboptimal and recurrence or treatment failure is still a problem. Antifungal susceptibility testing may be an important tool for guiding therapy, but for C. neoformans, a reliable method is still not available. This retrospective study evaluated minimal inhibitory concentration (MIC) for amphotericin B and fluconazole, and minimal fungicidal concentration (MFC) and timed-kill curves for amphotericin B against 16 clinical isolates of C. neoformans obtained from AIDS patients with cryptococcal meningitis. No correlation between clinical outcome and MIC was observed for amphotericin B. In selected cases, the MFC seemed to be a better predictor of outcome than MIC. In this study, amphotericin B timed-kill curves appeared to show a correlation with clinical outcome of the 16 patients with AIDS-associated cryptococcal meningitis. These in vitro tests must be further evaluated in prospective studies to confirm their potential usefulness for guiding cryptococcal meningitis therapy.Oxford University Press2000-06info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1369-3786http://sgc.anlis.gob.ar/handle/123456789/211110.1080/mmy.38.3.201.207Medical Mycology 2000; 38(3):201-7.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISMedical mycologyenginfo:eu-repo/semantics/openAccess2025-09-04T11:18:15Zoai:sgc.anlis.gob.ar:123456789/2111Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:18:15.266Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false |
dc.title.none.fl_str_mv |
Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS |
title |
Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS |
spellingShingle |
Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS Rodero, Laura Criptococosis Cryptococcus neoformans |
title_short |
Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS |
title_full |
Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS |
title_fullStr |
Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS |
title_full_unstemmed |
Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS |
title_sort |
Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS |
dc.creator.none.fl_str_mv |
Rodero, Laura Córdoba, Susana Cahn, Pedro Soria, Marcelo Lucarini, M Davel, Graciela Odelsia Kaufman, Sara Canteros, Cristina Elena Guelfand, Liliana |
author |
Rodero, Laura |
author_facet |
Rodero, Laura Córdoba, Susana Cahn, Pedro Soria, Marcelo Lucarini, M Davel, Graciela Odelsia Kaufman, Sara Canteros, Cristina Elena Guelfand, Liliana |
author_role |
author |
author2 |
Córdoba, Susana Cahn, Pedro Soria, Marcelo Lucarini, M Davel, Graciela Odelsia Kaufman, Sara Canteros, Cristina Elena Guelfand, Liliana |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Criptococosis Cryptococcus neoformans |
topic |
Criptococosis Cryptococcus neoformans |
dc.description.none.fl_txt_mv |
Fil: Rodero, L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina. Fil: Córdoba, Susana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina. Fil: Cahn, Pedro. Infectology Unit., Hospital Juan A. Fernandez, Buenos Aires; Argentina. Fil: Soria, Marcelo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina. Fil: Lucarini, M. Infectology Unit., Hospital Juan A. Fernandez, Buenos Aires; Argentina. Fil: Davel, Graciela Odelsia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina. Fil: Kaufman, Sara. Microbiology Laboratory, Hospital Juan A. Fernandez, Buenos Aires; Argentina. Fil: Canteros, Cristina Elena. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina. Fil: Guelfand, Liliana. Microbiology Laboratory, Hospital Juan A. Fernández, Buenos Aires, Argentina. Infection with Cryptococcus neoformans is an increasing problem in immunocompromised patients, particularly those with acquired immune deficiency syndrome (AIDS). Amphotericin B and fluconazole are currently acceptable therapies for cryptococcal meningitis; however, their effects remain suboptimal and recurrence or treatment failure is still a problem. Antifungal susceptibility testing may be an important tool for guiding therapy, but for C. neoformans, a reliable method is still not available. This retrospective study evaluated minimal inhibitory concentration (MIC) for amphotericin B and fluconazole, and minimal fungicidal concentration (MFC) and timed-kill curves for amphotericin B against 16 clinical isolates of C. neoformans obtained from AIDS patients with cryptococcal meningitis. No correlation between clinical outcome and MIC was observed for amphotericin B. In selected cases, the MFC seemed to be a better predictor of outcome than MIC. In this study, amphotericin B timed-kill curves appeared to show a correlation with clinical outcome of the 16 patients with AIDS-associated cryptococcal meningitis. These in vitro tests must be further evaluated in prospective studies to confirm their potential usefulness for guiding cryptococcal meningitis therapy. |
description |
Fil: Rodero, L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-06 |
dc.type.none.fl_str_mv |
info:ar-repo/semantics/articulo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
1369-3786 http://sgc.anlis.gob.ar/handle/123456789/2111 10.1080/mmy.38.3.201.207 |
identifier_str_mv |
1369-3786 10.1080/mmy.38.3.201.207 |
url |
http://sgc.anlis.gob.ar/handle/123456789/2111 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Medical mycology |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
Medical Mycology 2000; 38(3):201-7. reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" instacron:ANLIS |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
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Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
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biblioteca@anlis.gov.ar |
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