Evolution of Streptococcus pneumoniae serotypes and penicillin susceptibility in Latin America, Sireva-Vigía Group, 1993 to 1999. PAHO Sireva-Vigía Study Group. Pan American Health...

• Autores: Di Fabio, J L; Castañeda, E; Agudelo, Clara Inés; De La Hoz, F; Hortal, M; Camou, T; Echániz-Avilés, G; Carnalla Barajas, M N; Heitmann, I; Hormazabal, J C; Brandileone, M C; Dias Vieira, V S; Regueira, Mabel; Ruvinsky, R O; Corso, Alejandra; Lovgren, M; Talbot, J A; De Quadros, C
• Año de publicación: 2001
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Pediatric Infectious Disease Journal 2001; 20(10):959-67
• Materia: Niño; Preescolar; Femenino; Humanos; Lactante; Modelos Logísticos; Masculino; México; Penicilinas; Infecciones Neumocócicas; Vigilancia de la Población; Garantía de la Calidad de Atención de Salud; Control de Calidad; Serotipificación; América del Sur; Streptococcus pneumoniae; Resistencia a las Penicilinas
• Institución: Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"

Fil: Di Fabio, José Luis. Pan American Health Organization. Division of Vaccines and Immunization; Estados Unidos.
Fil: Castañeda, Elizabeth. Instituto Nacional de Salud; Colombia.
Fil: Agudelo, Clara Inés. Instituto Nacional de Salud; Colombia.
Fil: De La Hoz, Fernando. Universidad Nacional de Colombia. Facultad de Medicina. Departamento de Salud Pública. Instituto de Salud Pública; Colombia.
Fil: Hortal, María. Departamento de Laboratorios de Salud Pública; Uruguay.
Fil: Camou, Teresa. Departamento de Laboratorios de Salud Pública; Uruguay.
Fil: Echániz-Avilés, Gabriela. Instituto Nacional de Salud Pública; México.
Fil: Barajas, María Noemi Carnalla. Instituto Nacional de Salud Pública; México.
Fil: Heitmann, Ingrid. Instituto de Salud Pública, Chile.
Fil: Hormazabal, Juan Carlos. Instituto de Salud Pública, Chile.
Fil: Brandileone, María Cristina C. Instituto Adolfo Lutz; Brasil.
Fil: Dias Vieira, Vera Simonsen. Instituto Adolfo Lutz; Brasil.
Fil: Regueira, Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Ruvinski, Raúl. Hospital Municipal M. Durand; Argentina.
Fil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Lovgren, Marguerite. National Centre for Streptococcus; Canadá.
Fil: Talbot, James A. National Centre for Streptococcus; Canadá.
Fil: De Quadros, Ciro. Pan American Health Organization. Division of Vaccines and Immunization; Estados Unidos.
Background: Since 1993 the Pan American Health Organization has coordinated a surveillance network with the National Reference Laboratories of Argentina, Brazil, Chile, Colombia, Mexico and Uruguay aimed at monitoring capsular types and antimicrobial susceptibility of Streptococcus pneumoniae causing invasive disease in children <6 years of age. Methods: The surveillance system included children 6 years of age and younger with invasive disease caused by S. pneumoniae. The identification, capsular typing and susceptibility to penicillin of the isolates were conducted using a common protocol, based on standard methodologies. Results: By June, 1999, 4,105 invasive pneumococcal isolates had been collected mainly from pneumonia (44.1%) and meningitis (41.1%) cases. Thirteen capsular types accounting for 86.1% of the isolates (14, 6A/6B, 5, 1, 23F, 19F, 18C, 19A, 9V, 7F, 3, 9N and 4) remained the most common types during the surveillance period. Diminished susceptibility to penicillin was detected in 28.6% of the isolates, 17.3% with intermediate and 11.3% with high level resistance. Resistance varied among countries and increased during this period in Argentina, Colombia and Uruguay. Serotypes 14 and 23F accounted for 66.6% of the resistance. Conclusion: These surveillance data clearly demonstrate the potential impact of the introduction of a conjugate vaccine on pneumococcal disease and the need for more judicious use of antibiotics to slow or reverse the development of antimicrobial resistance.