APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged women
- Autores
- Bañares, Virginia; Bardach, Ariel; Peterson, G.; Tavella, M.; Schreier, Laura
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Bañares, Virginia. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina.
Fil: Bardach, A. Universidad Nacional de La Plata. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Programa de Prevención del Infarto en Argentina; Argentina.
Fil: Peterson, G. Universidad Nacional de La Plata. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Programa de Prevención del Infarto en Argentina; Argentina.
Fil: Tavella, M. Instituto de Investigaciones Bioquímicas de La Plata; Argentina.
Fil: Schreier, Laura. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica. Laboratorio de Lípidos y Lipoproteínas; Argentina.
Genetic variability of the APOE gene confers susceptibility to coronary artery disease (CAD). Beyond variability on the coding region, polymorphisms in the regulatory region of the APOE gene have been associated with variation on plasma cholesterol levels. It has also been demonstrated a complex and multifactorial association between, APOE gene polymorphisms, gender, plasma lipids levels and risk of CAD. In the present case-control study, we examined polymorphisms -427 T/C and -491 A/T in the promoter region of APOE in relation to lipid profile and the coronary atherosclerosis, in a sample of Argentinean adults with (cases) and without (controls) atherosclerotic injuries regarding gender and age. In females below 60 years APOE -491 T allele was less prevalent in cases than in controls (OR 0.12, 95% CI 0.04-0.76). Among females cases the T allele was more frequent with increasing age (OR 0.49, 95% CI 0.27-0.90). Female up to 45 years who were carriers of the T allele showed lower levels of total (P = 0.01) and LDL cholesterol (P = 0.02) compared with non-carriers. Levels of total and LDL cholesterol increased with the age only in female carriers (P < 0.01 and P < 0.01). No differences were observed for HDL and TG levels. Allele C of polymorphism APOE -427 was associated with higher levels of triglycerides (P < 0.01). We conclude that, in middle-aged women, APOE -491 T allele contributes keeping lower levels of LDL cholesterol in the population studied, and would have a putative protective effect for the development of CAD. - Materia
-
Predisposición Genética a la Enfermedad
Enfermedad de la Arteria Coronaria
Aterosclerosis
Polimorfismo de Nucleótido Simple
Placa Aterosclerótica - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- none
- Repositorio
- Institución
- Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
- OAI Identificador
- oai:sgc.anlis.gob.ar:123456789/1940
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APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged womenBañares, VirginiaBardach, ArielPeterson, G.Tavella, M.Schreier, LauraPredisposición Genética a la EnfermedadEnfermedad de la Arteria CoronariaAterosclerosisPolimorfismo de Nucleótido SimplePlaca AteroscleróticaFil: Bañares, Virginia. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina.Fil: Bardach, A. Universidad Nacional de La Plata. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Programa de Prevención del Infarto en Argentina; Argentina.Fil: Peterson, G. Universidad Nacional de La Plata. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Programa de Prevención del Infarto en Argentina; Argentina.Fil: Tavella, M. Instituto de Investigaciones Bioquímicas de La Plata; Argentina.Fil: Schreier, Laura. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica. Laboratorio de Lípidos y Lipoproteínas; Argentina.Genetic variability of the APOE gene confers susceptibility to coronary artery disease (CAD). Beyond variability on the coding region, polymorphisms in the regulatory region of the APOE gene have been associated with variation on plasma cholesterol levels. It has also been demonstrated a complex and multifactorial association between, APOE gene polymorphisms, gender, plasma lipids levels and risk of CAD. In the present case-control study, we examined polymorphisms -427 T/C and -491 A/T in the promoter region of APOE in relation to lipid profile and the coronary atherosclerosis, in a sample of Argentinean adults with (cases) and without (controls) atherosclerotic injuries regarding gender and age. In females below 60 years APOE -491 T allele was less prevalent in cases than in controls (OR 0.12, 95% CI 0.04-0.76). Among females cases the T allele was more frequent with increasing age (OR 0.49, 95% CI 0.27-0.90). Female up to 45 years who were carriers of the T allele showed lower levels of total (P = 0.01) and LDL cholesterol (P = 0.02) compared with non-carriers. Levels of total and LDL cholesterol increased with the age only in female carriers (P < 0.01 and P < 0.01). No differences were observed for HDL and TG levels. Allele C of polymorphism APOE -427 was associated with higher levels of triglycerides (P < 0.01). We conclude that, in middle-aged women, APOE -491 T allele contributes keeping lower levels of LDL cholesterol in the population studied, and would have a putative protective effect for the development of CAD.2012-03info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1573-4919http://sgc.anlis.gob.ar/handle/123456789/194010.1007/s11010-011-1134-5Molecular and cellular biochemistrynoneinfo:eu-repo/semantics/openAccessengreponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLIS2025-09-29T14:30:33Zoai:sgc.anlis.gob.ar:123456789/1940Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:33.484Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false |
dc.title.none.fl_str_mv |
APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged women |
title |
APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged women |
spellingShingle |
APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged women Bañares, Virginia Predisposición Genética a la Enfermedad Enfermedad de la Arteria Coronaria Aterosclerosis Polimorfismo de Nucleótido Simple Placa Aterosclerótica |
title_short |
APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged women |
title_full |
APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged women |
title_fullStr |
APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged women |
title_full_unstemmed |
APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged women |
title_sort |
APOE -491 T allele may reduce the risk of atherosclerotic lesions among middle-aged women |
dc.creator.none.fl_str_mv |
Bañares, Virginia Bardach, Ariel Peterson, G. Tavella, M. Schreier, Laura |
author |
Bañares, Virginia |
author_facet |
Bañares, Virginia Bardach, Ariel Peterson, G. Tavella, M. Schreier, Laura |
author_role |
author |
author2 |
Bardach, Ariel Peterson, G. Tavella, M. Schreier, Laura |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Predisposición Genética a la Enfermedad Enfermedad de la Arteria Coronaria Aterosclerosis Polimorfismo de Nucleótido Simple Placa Aterosclerótica |
topic |
Predisposición Genética a la Enfermedad Enfermedad de la Arteria Coronaria Aterosclerosis Polimorfismo de Nucleótido Simple Placa Aterosclerótica |
dc.description.none.fl_txt_mv |
Fil: Bañares, Virginia. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina. Fil: Bardach, A. Universidad Nacional de La Plata. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Programa de Prevención del Infarto en Argentina; Argentina. Fil: Peterson, G. Universidad Nacional de La Plata. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Programa de Prevención del Infarto en Argentina; Argentina. Fil: Tavella, M. Instituto de Investigaciones Bioquímicas de La Plata; Argentina. Fil: Schreier, Laura. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica. Laboratorio de Lípidos y Lipoproteínas; Argentina. Genetic variability of the APOE gene confers susceptibility to coronary artery disease (CAD). Beyond variability on the coding region, polymorphisms in the regulatory region of the APOE gene have been associated with variation on plasma cholesterol levels. It has also been demonstrated a complex and multifactorial association between, APOE gene polymorphisms, gender, plasma lipids levels and risk of CAD. In the present case-control study, we examined polymorphisms -427 T/C and -491 A/T in the promoter region of APOE in relation to lipid profile and the coronary atherosclerosis, in a sample of Argentinean adults with (cases) and without (controls) atherosclerotic injuries regarding gender and age. In females below 60 years APOE -491 T allele was less prevalent in cases than in controls (OR 0.12, 95% CI 0.04-0.76). Among females cases the T allele was more frequent with increasing age (OR 0.49, 95% CI 0.27-0.90). Female up to 45 years who were carriers of the T allele showed lower levels of total (P = 0.01) and LDL cholesterol (P = 0.02) compared with non-carriers. Levels of total and LDL cholesterol increased with the age only in female carriers (P < 0.01 and P < 0.01). No differences were observed for HDL and TG levels. Allele C of polymorphism APOE -427 was associated with higher levels of triglycerides (P < 0.01). We conclude that, in middle-aged women, APOE -491 T allele contributes keeping lower levels of LDL cholesterol in the population studied, and would have a putative protective effect for the development of CAD. |
description |
Fil: Bañares, Virginia. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-03 |
dc.type.none.fl_str_mv |
info:ar-repo/semantics/articulo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
1573-4919 http://sgc.anlis.gob.ar/handle/123456789/1940 10.1007/s11010-011-1134-5 |
identifier_str_mv |
1573-4919 10.1007/s11010-011-1134-5 |
url |
http://sgc.anlis.gob.ar/handle/123456789/1940 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Molecular and cellular biochemistry |
dc.rights.none.fl_str_mv |
none info:eu-repo/semantics/openAccess |
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none |
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openAccess |
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application/pdf |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
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Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
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