Human papillomavirus cervical infection in Guarani Indians from the rainforest of Misiones, Argentina

Autores
Tonon, Sergio Andrés; Picconi, María Alejandra; Zinovich, Jorge Bruno; Nardari, Wanda; Mampaey, Mariana; Badano, Inés; di Lello, Federico; Galuppo, Juan Antonio; Alonio, Lidia V.; Teyssie, Angelica R.
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
To evaluate the prevalence of human papillomavirus (HPV) cervical infection in women from the South American Guarani Indian tribe located in the rain forest of Misiones, north-eastern Argentina; a region with a high incidence of cervical carcinoma. Methods: A cross-sectional cytological and HPV screening of sexually active Guarani women from nine Indian settlements was conducted. Demographic data, information about sexual behavior, and gynaecological history were recorded. Fresh cervical specimens from 239 patients were collected, of which 207 were included in this study. Cytology and microbiological detection were carried out by the Papanicolaou and Gram stain methods, respectively. HPV detection and typing were analyzed by PCR and RFLP. Results: Pap smears in 96% of all patients showed an inflammatory pattern. A possible etiologic agent was found in 58% of cases: 52% Trichomonas vaginalis, 35% Gardnerella vaginalis and 13% Candida sp. Seven cases had cytological changes compatible with Low Grade Intraepithelial Lesion (LGSIL), one with High Grade Intraepithelial Lesion (HGSIL) and one in situ cervical cancer. The prevalence for generic HPV infection was 64% (133/207). Genotyping gave a 26% prevalence for HPV types 16/18, 13% for types 6/11 and 30% for other types, with nine mixed infections. Conclusion: This work reports for the first time the prevalence of cervical HPV infection in Guarani women. Nearly all Guarani women had some grade of cervical disease. Generic HPV infection prevalence was elevated (64%), with predominance of high risk types 16/18. A large variety of viral types was detected, including high to intermediate risk types not found previously in the region.
Fil: Tonon, Sergio Andrés. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.
Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Zinovich, Jorge Bruno. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.
Fil: Nardari, Wanda. Ministerio de Salud Pública de la Provincia de Misiones; Argentina.
Fil: Mampaey, Mariana. Ministerio de Salud Pública de la Provincia de Misiones; Argentina.
Fil: Badano, Inés. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.
Fil: di Lello, Federico. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.
Fil: Galuppo, Juan Antonio. Universidad Nacional de Misiones. Cátedra de Citología e Histología; Argentina.
Fil: Alonio, Lidia Virginia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Teyssie, Angélica Rita. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fuente
International Journal of Infectious Diseases, 2004, 8(1), 13-19.
Materia
Infecciones por Papillomavirus
Neoplasias del Cuello Uterino
Enfermedades de Transmisión Sexual
Argentina
Misiones
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/423
Acceder
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oai_identifier_str oai:sgc.anlis.gob.ar:Publications/123456789/423
network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Human papillomavirus cervical infection in Guarani Indians from the rainforest of Misiones, ArgentinaTonon, Sergio AndrésPicconi, María AlejandraZinovich, Jorge BrunoNardari, WandaMampaey, MarianaBadano, Inésdi Lello, FedericoGaluppo, Juan AntonioAlonio, Lidia V.Teyssie, Angelica R.Infecciones por PapillomavirusNeoplasias del Cuello UterinoEnfermedades de Transmisión SexualArgentinaMisionesTo evaluate the prevalence of human papillomavirus (HPV) cervical infection in women from the South American Guarani Indian tribe located in the rain forest of Misiones, north-eastern Argentina; a region with a high incidence of cervical carcinoma. Methods: A cross-sectional cytological and HPV screening of sexually active Guarani women from nine Indian settlements was conducted. Demographic data, information about sexual behavior, and gynaecological history were recorded. Fresh cervical specimens from 239 patients were collected, of which 207 were included in this study. Cytology and microbiological detection were carried out by the Papanicolaou and Gram stain methods, respectively. HPV detection and typing were analyzed by PCR and RFLP. Results: Pap smears in 96% of all patients showed an inflammatory pattern. A possible etiologic agent was found in 58% of cases: 52% Trichomonas vaginalis, 35% Gardnerella vaginalis and 13% Candida sp. Seven cases had cytological changes compatible with Low Grade Intraepithelial Lesion (LGSIL), one with High Grade Intraepithelial Lesion (HGSIL) and one in situ cervical cancer. The prevalence for generic HPV infection was 64% (133/207). Genotyping gave a 26% prevalence for HPV types 16/18, 13% for types 6/11 and 30% for other types, with nine mixed infections. Conclusion: This work reports for the first time the prevalence of cervical HPV infection in Guarani women. Nearly all Guarani women had some grade of cervical disease. Generic HPV infection prevalence was elevated (64%), with predominance of high risk types 16/18. A large variety of viral types was detected, including high to intermediate risk types not found previously in the region.Fil: Tonon, Sergio Andrés. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.Fil: Zinovich, Jorge Bruno. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.Fil: Nardari, Wanda. Ministerio de Salud Pública de la Provincia de Misiones; Argentina.Fil: Mampaey, Mariana. Ministerio de Salud Pública de la Provincia de Misiones; Argentina.Fil: Badano, Inés. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.Fil: di Lello, Federico. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.Fil: Galuppo, Juan Antonio. Universidad Nacional de Misiones. Cátedra de Citología e Histología; Argentina.Fil: Alonio, Lidia Virginia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.Fil: Teyssie, Angélica Rita. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.2004info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1201-9712http://download.journals.elsevierhealth.com/pdfs/journals/1201-9712/PIIS1201971203000031.pdfhttp://sgc.anlis.gob.ar/handle/123456789/423International Journal of Infectious Diseases, 2004, 8(1), 13-19.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISARGMisionesenginfo:eu-repo/semantics/openAccess2025-09-29T14:30:01Zoai:sgc.anlis.gob.ar:Publications/123456789/423Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:02.3Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Human papillomavirus cervical infection in Guarani Indians from the rainforest of Misiones, Argentina
title Human papillomavirus cervical infection in Guarani Indians from the rainforest of Misiones, Argentina
spellingShingle Human papillomavirus cervical infection in Guarani Indians from the rainforest of Misiones, Argentina
Tonon, Sergio Andrés
Infecciones por Papillomavirus
Neoplasias del Cuello Uterino
Enfermedades de Transmisión Sexual
Argentina
Misiones
title_short Human papillomavirus cervical infection in Guarani Indians from the rainforest of Misiones, Argentina
title_full Human papillomavirus cervical infection in Guarani Indians from the rainforest of Misiones, Argentina
title_fullStr Human papillomavirus cervical infection in Guarani Indians from the rainforest of Misiones, Argentina
title_full_unstemmed Human papillomavirus cervical infection in Guarani Indians from the rainforest of Misiones, Argentina
title_sort Human papillomavirus cervical infection in Guarani Indians from the rainforest of Misiones, Argentina
dc.creator.none.fl_str_mv Tonon, Sergio Andrés
Picconi, María Alejandra
Zinovich, Jorge Bruno
Nardari, Wanda
Mampaey, Mariana
Badano, Inés
di Lello, Federico
Galuppo, Juan Antonio
Alonio, Lidia V.
Teyssie, Angelica R.
author Tonon, Sergio Andrés
author_facet Tonon, Sergio Andrés
Picconi, María Alejandra
Zinovich, Jorge Bruno
Nardari, Wanda
Mampaey, Mariana
Badano, Inés
di Lello, Federico
Galuppo, Juan Antonio
Alonio, Lidia V.
Teyssie, Angelica R.
author_role author
author2 Picconi, María Alejandra
Zinovich, Jorge Bruno
Nardari, Wanda
Mampaey, Mariana
Badano, Inés
di Lello, Federico
Galuppo, Juan Antonio
Alonio, Lidia V.
Teyssie, Angelica R.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Infecciones por Papillomavirus
Neoplasias del Cuello Uterino
Enfermedades de Transmisión Sexual
Argentina
Misiones
topic Infecciones por Papillomavirus
Neoplasias del Cuello Uterino
Enfermedades de Transmisión Sexual
Argentina
Misiones
dc.description.none.fl_txt_mv To evaluate the prevalence of human papillomavirus (HPV) cervical infection in women from the South American Guarani Indian tribe located in the rain forest of Misiones, north-eastern Argentina; a region with a high incidence of cervical carcinoma. Methods: A cross-sectional cytological and HPV screening of sexually active Guarani women from nine Indian settlements was conducted. Demographic data, information about sexual behavior, and gynaecological history were recorded. Fresh cervical specimens from 239 patients were collected, of which 207 were included in this study. Cytology and microbiological detection were carried out by the Papanicolaou and Gram stain methods, respectively. HPV detection and typing were analyzed by PCR and RFLP. Results: Pap smears in 96% of all patients showed an inflammatory pattern. A possible etiologic agent was found in 58% of cases: 52% Trichomonas vaginalis, 35% Gardnerella vaginalis and 13% Candida sp. Seven cases had cytological changes compatible with Low Grade Intraepithelial Lesion (LGSIL), one with High Grade Intraepithelial Lesion (HGSIL) and one in situ cervical cancer. The prevalence for generic HPV infection was 64% (133/207). Genotyping gave a 26% prevalence for HPV types 16/18, 13% for types 6/11 and 30% for other types, with nine mixed infections. Conclusion: This work reports for the first time the prevalence of cervical HPV infection in Guarani women. Nearly all Guarani women had some grade of cervical disease. Generic HPV infection prevalence was elevated (64%), with predominance of high risk types 16/18. A large variety of viral types was detected, including high to intermediate risk types not found previously in the region.
Fil: Tonon, Sergio Andrés. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.
Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Zinovich, Jorge Bruno. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.
Fil: Nardari, Wanda. Ministerio de Salud Pública de la Provincia de Misiones; Argentina.
Fil: Mampaey, Mariana. Ministerio de Salud Pública de la Provincia de Misiones; Argentina.
Fil: Badano, Inés. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.
Fil: di Lello, Federico. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.
Fil: Galuppo, Juan Antonio. Universidad Nacional de Misiones. Cátedra de Citología e Histología; Argentina.
Fil: Alonio, Lidia Virginia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Teyssie, Angélica Rita. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
description To evaluate the prevalence of human papillomavirus (HPV) cervical infection in women from the South American Guarani Indian tribe located in the rain forest of Misiones, north-eastern Argentina; a region with a high incidence of cervical carcinoma. Methods: A cross-sectional cytological and HPV screening of sexually active Guarani women from nine Indian settlements was conducted. Demographic data, information about sexual behavior, and gynaecological history were recorded. Fresh cervical specimens from 239 patients were collected, of which 207 were included in this study. Cytology and microbiological detection were carried out by the Papanicolaou and Gram stain methods, respectively. HPV detection and typing were analyzed by PCR and RFLP. Results: Pap smears in 96% of all patients showed an inflammatory pattern. A possible etiologic agent was found in 58% of cases: 52% Trichomonas vaginalis, 35% Gardnerella vaginalis and 13% Candida sp. Seven cases had cytological changes compatible with Low Grade Intraepithelial Lesion (LGSIL), one with High Grade Intraepithelial Lesion (HGSIL) and one in situ cervical cancer. The prevalence for generic HPV infection was 64% (133/207). Genotyping gave a 26% prevalence for HPV types 16/18, 13% for types 6/11 and 30% for other types, with nine mixed infections. Conclusion: This work reports for the first time the prevalence of cervical HPV infection in Guarani women. Nearly all Guarani women had some grade of cervical disease. Generic HPV infection prevalence was elevated (64%), with predominance of high risk types 16/18. A large variety of viral types was detected, including high to intermediate risk types not found previously in the region.
publishDate 2004
dc.date.none.fl_str_mv 2004
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1201-9712
http://download.journals.elsevierhealth.com/pdfs/journals/1201-9712/PIIS1201971203000031.pdf
http://sgc.anlis.gob.ar/handle/123456789/423
identifier_str_mv 1201-9712
url http://download.journals.elsevierhealth.com/pdfs/journals/1201-9712/PIIS1201971203000031.pdf
http://sgc.anlis.gob.ar/handle/123456789/423
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv ARG
Misiones
dc.source.none.fl_str_mv International Journal of Infectious Diseases, 2004, 8(1), 13-19.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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score 12.559606

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