Clinical implications of hepatitis A virus ribonucleic acid detection and genotyping in acute liver failure in children in Argentina

Autores
Sasbón, Jorge; Buamscha, Daniel; Gianivelli, Silvina; Imventarza, Oscar; Devictor, Denis; Moreiro, Rita; Cambaceres, Carlos; Salip, Gonzalo; Ciocca, Mirta; Cuarterolo, Miriam; Vladimirsky, Sara; Otegui, Lucio; Castro, Raúl; Brajterman, Leonardo; Soto, Sonia; González, Jorge E.; Munné, María Silvina
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Sasbón, Jorge S. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado y Cuidados Intensivos; Argentina.
Fil: Buamscha, Daniel. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado y Cuidados Intensivos; Argentina.
Fil: Gianivelli, Silvina. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado y Cuidados Intensivos; Argentina.
Fil: Imventarza, Oscar. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado; Argentina.
Fil: Devictor, Denis. Hopital de Bicetre. Central Laboratory. Department de Pediatrie. Soins Intensift; Francia.
Fil: Moreiro, Rita. Hospital de Pediatría Dr. Juan P. Garrahan. Departamento de Hepatología; Argentina.
Fil: Cambaceres, Carlos. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado y Cuidados Intensivos; Argentina.
Fil: Salip, Gonzalo. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado; Argentina.
Fil: Ciocca, Mirta. Hospital de Pediatría Dr. Juan P. Garrahan. Laboratorio Nacional de Referencia para Hepatitis Virales: Argentina.
Fil: Cuarterolo, Miriam. Hospital de Pediatría Dr. Juan P. Garrahan. Laboratorio Nacional de Referencia para Hepatitis Virales: Argentina.
Fil: Vladimirsky, Sara. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Otegui, Lucio. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Castro, Raúl. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Brajterman, Leonardo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Soto, Sonia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: González, Jorge E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Munné, María Silvina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Objectives: To investigate the detection of hepatitis A virus ribonucleic acid in patients with acute liver failure and to assess if the results have any clinical implications for the evolution of acute liver failure in children. Hepatitis A infection, a vaccine-preventable disease, is an important cause of acute liver failure in children in Argentina. Universal vaccination in 1-yr-old children was implemented in June 2005. Design: Observational study in which patients were divided into Group 1 consisting of positive hepatitis A virus ribonucleic acid and Group 2 consisting of negative hepatitis A virus ribonucleic acid. Setting: Pediatric intensive care unit in National Pediatric Hospital "Dr. J. P. Garrahan," Buenos Aires, Argentina. Patients: Thirty-three patients with the diagnosis of acute liver failure secondary to hepatitis A virus infection and admitted to the Garrahan Pediatric Hospital between September 2003 and September 2005 were enrolled in the study. Twenty of these children were admitted to the pediatric intensive care unit. Interventions: None. Measurements and main results: Samples for total ribonucleic acid detection and genotyping were obtained from serum and/or stools on admission. We found positive hepatitis A virus ribonucleic acid in 13 patients and negative hepatitis A virus ribonucleic acid in 20 patients. The following clinical variables were evaluated: time of evolution, hospital stay, admission to the pediatric intensive care unit, pediatric intensive care unit stay, time on mechanical ventilation, criteria for orthotopic liver transplantation, and mortality. Characterization of the isolates did not reveal differences related to genotype; all cases were IA. No statistical significance was found as to the variables. However, positive hepatitis A virus ribonucleic acid showed lower percentages of pediatric intensive care unit admissions, criteria for orthotopic liver transplantation, number of orthotopic liver transplantation, and mortality than the group of patients with negative hepatitis A virus ribonucleic acid. Conclusions: Hepatitis A virus genotyping studies did not show any particularities, all cases were IA and, thus, apparent associations between genotype and the clinical presentation of acute liver failure could not be found.
Materia
Hepatitis A
Unidades de Cuidados Intensivos
Fallo Hepático Agudo
Heces
Nivel de accesibilidad
acceso abierto
Condiciones de uso
none
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/2287

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network_acronym_str SGCANLIS
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network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Clinical implications of hepatitis A virus ribonucleic acid detection and genotyping in acute liver failure in children in ArgentinaSasbón, JorgeBuamscha, DanielGianivelli, SilvinaImventarza, OscarDevictor, DenisMoreiro, RitaCambaceres, CarlosSalip, GonzaloCiocca, MirtaCuarterolo, MiriamVladimirsky, SaraOtegui, LucioCastro, RaúlBrajterman, LeonardoSoto, SoniaGonzález, Jorge E.Munné, María SilvinaHepatitis AUnidades de Cuidados IntensivosFallo Hepático AgudoHecesFil: Sasbón, Jorge S. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado y Cuidados Intensivos; Argentina.Fil: Buamscha, Daniel. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado y Cuidados Intensivos; Argentina.Fil: Gianivelli, Silvina. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado y Cuidados Intensivos; Argentina.Fil: Imventarza, Oscar. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado; Argentina.Fil: Devictor, Denis. Hopital de Bicetre. Central Laboratory. Department de Pediatrie. Soins Intensift; Francia.Fil: Moreiro, Rita. Hospital de Pediatría Dr. Juan P. Garrahan. Departamento de Hepatología; Argentina.Fil: Cambaceres, Carlos. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado y Cuidados Intensivos; Argentina.Fil: Salip, Gonzalo. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado; Argentina.Fil: Ciocca, Mirta. Hospital de Pediatría Dr. Juan P. Garrahan. Laboratorio Nacional de Referencia para Hepatitis Virales: Argentina.Fil: Cuarterolo, Miriam. Hospital de Pediatría Dr. Juan P. Garrahan. Laboratorio Nacional de Referencia para Hepatitis Virales: Argentina.Fil: Vladimirsky, Sara. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Otegui, Lucio. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Castro, Raúl. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Brajterman, Leonardo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Soto, Sonia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: González, Jorge E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Munné, María Silvina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Objectives: To investigate the detection of hepatitis A virus ribonucleic acid in patients with acute liver failure and to assess if the results have any clinical implications for the evolution of acute liver failure in children. Hepatitis A infection, a vaccine-preventable disease, is an important cause of acute liver failure in children in Argentina. Universal vaccination in 1-yr-old children was implemented in June 2005. Design: Observational study in which patients were divided into Group 1 consisting of positive hepatitis A virus ribonucleic acid and Group 2 consisting of negative hepatitis A virus ribonucleic acid. Setting: Pediatric intensive care unit in National Pediatric Hospital "Dr. J. P. Garrahan," Buenos Aires, Argentina. Patients: Thirty-three patients with the diagnosis of acute liver failure secondary to hepatitis A virus infection and admitted to the Garrahan Pediatric Hospital between September 2003 and September 2005 were enrolled in the study. Twenty of these children were admitted to the pediatric intensive care unit. Interventions: None. Measurements and main results: Samples for total ribonucleic acid detection and genotyping were obtained from serum and/or stools on admission. We found positive hepatitis A virus ribonucleic acid in 13 patients and negative hepatitis A virus ribonucleic acid in 20 patients. The following clinical variables were evaluated: time of evolution, hospital stay, admission to the pediatric intensive care unit, pediatric intensive care unit stay, time on mechanical ventilation, criteria for orthotopic liver transplantation, and mortality. Characterization of the isolates did not reveal differences related to genotype; all cases were IA. No statistical significance was found as to the variables. However, positive hepatitis A virus ribonucleic acid showed lower percentages of pediatric intensive care unit admissions, criteria for orthotopic liver transplantation, number of orthotopic liver transplantation, and mortality than the group of patients with negative hepatitis A virus ribonucleic acid. Conclusions: Hepatitis A virus genotyping studies did not show any particularities, all cases were IA and, thus, apparent associations between genotype and the clinical presentation of acute liver failure could not be found.2010-05info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1529-7535http://sgc.anlis.gob.ar/handle/123456789/228710.1097/PCC.0b013e3181ceadcaPediatric critical care medicinenoneinfo:eu-repo/semantics/openAccessengreponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLIS2025-09-04T11:18:28Zoai:sgc.anlis.gob.ar:Publications/123456789/2287Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:18:28.989Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Clinical implications of hepatitis A virus ribonucleic acid detection and genotyping in acute liver failure in children in Argentina
title Clinical implications of hepatitis A virus ribonucleic acid detection and genotyping in acute liver failure in children in Argentina
spellingShingle Clinical implications of hepatitis A virus ribonucleic acid detection and genotyping in acute liver failure in children in Argentina
Sasbón, Jorge
Hepatitis A
Unidades de Cuidados Intensivos
Fallo Hepático Agudo
Heces
title_short Clinical implications of hepatitis A virus ribonucleic acid detection and genotyping in acute liver failure in children in Argentina
title_full Clinical implications of hepatitis A virus ribonucleic acid detection and genotyping in acute liver failure in children in Argentina
title_fullStr Clinical implications of hepatitis A virus ribonucleic acid detection and genotyping in acute liver failure in children in Argentina
title_full_unstemmed Clinical implications of hepatitis A virus ribonucleic acid detection and genotyping in acute liver failure in children in Argentina
title_sort Clinical implications of hepatitis A virus ribonucleic acid detection and genotyping in acute liver failure in children in Argentina
dc.creator.none.fl_str_mv Sasbón, Jorge
Buamscha, Daniel
Gianivelli, Silvina
Imventarza, Oscar
Devictor, Denis
Moreiro, Rita
Cambaceres, Carlos
Salip, Gonzalo
Ciocca, Mirta
Cuarterolo, Miriam
Vladimirsky, Sara
Otegui, Lucio
Castro, Raúl
Brajterman, Leonardo
Soto, Sonia
González, Jorge E.
Munné, María Silvina
author Sasbón, Jorge
author_facet Sasbón, Jorge
Buamscha, Daniel
Gianivelli, Silvina
Imventarza, Oscar
Devictor, Denis
Moreiro, Rita
Cambaceres, Carlos
Salip, Gonzalo
Ciocca, Mirta
Cuarterolo, Miriam
Vladimirsky, Sara
Otegui, Lucio
Castro, Raúl
Brajterman, Leonardo
Soto, Sonia
González, Jorge E.
Munné, María Silvina
author_role author
author2 Buamscha, Daniel
Gianivelli, Silvina
Imventarza, Oscar
Devictor, Denis
Moreiro, Rita
Cambaceres, Carlos
Salip, Gonzalo
Ciocca, Mirta
Cuarterolo, Miriam
Vladimirsky, Sara
Otegui, Lucio
Castro, Raúl
Brajterman, Leonardo
Soto, Sonia
González, Jorge E.
Munné, María Silvina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hepatitis A
Unidades de Cuidados Intensivos
Fallo Hepático Agudo
Heces
topic Hepatitis A
Unidades de Cuidados Intensivos
Fallo Hepático Agudo
Heces
dc.description.none.fl_txt_mv Fil: Sasbón, Jorge S. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado y Cuidados Intensivos; Argentina.
Fil: Buamscha, Daniel. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado y Cuidados Intensivos; Argentina.
Fil: Gianivelli, Silvina. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado y Cuidados Intensivos; Argentina.
Fil: Imventarza, Oscar. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado; Argentina.
Fil: Devictor, Denis. Hopital de Bicetre. Central Laboratory. Department de Pediatrie. Soins Intensift; Francia.
Fil: Moreiro, Rita. Hospital de Pediatría Dr. Juan P. Garrahan. Departamento de Hepatología; Argentina.
Fil: Cambaceres, Carlos. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado y Cuidados Intensivos; Argentina.
Fil: Salip, Gonzalo. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado; Argentina.
Fil: Ciocca, Mirta. Hospital de Pediatría Dr. Juan P. Garrahan. Laboratorio Nacional de Referencia para Hepatitis Virales: Argentina.
Fil: Cuarterolo, Miriam. Hospital de Pediatría Dr. Juan P. Garrahan. Laboratorio Nacional de Referencia para Hepatitis Virales: Argentina.
Fil: Vladimirsky, Sara. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Otegui, Lucio. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Castro, Raúl. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Brajterman, Leonardo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Soto, Sonia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: González, Jorge E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Munné, María Silvina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Objectives: To investigate the detection of hepatitis A virus ribonucleic acid in patients with acute liver failure and to assess if the results have any clinical implications for the evolution of acute liver failure in children. Hepatitis A infection, a vaccine-preventable disease, is an important cause of acute liver failure in children in Argentina. Universal vaccination in 1-yr-old children was implemented in June 2005. Design: Observational study in which patients were divided into Group 1 consisting of positive hepatitis A virus ribonucleic acid and Group 2 consisting of negative hepatitis A virus ribonucleic acid. Setting: Pediatric intensive care unit in National Pediatric Hospital "Dr. J. P. Garrahan," Buenos Aires, Argentina. Patients: Thirty-three patients with the diagnosis of acute liver failure secondary to hepatitis A virus infection and admitted to the Garrahan Pediatric Hospital between September 2003 and September 2005 were enrolled in the study. Twenty of these children were admitted to the pediatric intensive care unit. Interventions: None. Measurements and main results: Samples for total ribonucleic acid detection and genotyping were obtained from serum and/or stools on admission. We found positive hepatitis A virus ribonucleic acid in 13 patients and negative hepatitis A virus ribonucleic acid in 20 patients. The following clinical variables were evaluated: time of evolution, hospital stay, admission to the pediatric intensive care unit, pediatric intensive care unit stay, time on mechanical ventilation, criteria for orthotopic liver transplantation, and mortality. Characterization of the isolates did not reveal differences related to genotype; all cases were IA. No statistical significance was found as to the variables. However, positive hepatitis A virus ribonucleic acid showed lower percentages of pediatric intensive care unit admissions, criteria for orthotopic liver transplantation, number of orthotopic liver transplantation, and mortality than the group of patients with negative hepatitis A virus ribonucleic acid. Conclusions: Hepatitis A virus genotyping studies did not show any particularities, all cases were IA and, thus, apparent associations between genotype and the clinical presentation of acute liver failure could not be found.
description Fil: Sasbón, Jorge S. Hospital de Pediatría Dr. Juan P. Garrahan. Unidad de Trasplante de Hígado y Cuidados Intensivos; Argentina.
publishDate 2010
dc.date.none.fl_str_mv 2010-05
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1529-7535
http://sgc.anlis.gob.ar/handle/123456789/2287
10.1097/PCC.0b013e3181ceadca
identifier_str_mv 1529-7535
10.1097/PCC.0b013e3181ceadca
url http://sgc.anlis.gob.ar/handle/123456789/2287
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pediatric critical care medicine
dc.rights.none.fl_str_mv none
info:eu-repo/semantics/openAccess
rights_invalid_str_mv none
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
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