Phylogenetic analysis of porcine rotavirus in Argentina: increasing diversity of G4 strains and evidence of interspecies transmission

• Autores: Irala Parra, Juan Gabriel; Vidales, Graciela; Gomez, Jorge A.; Fernandez, Fernando M; Parreño, Viviana; Bok, Karin
• Año de publicación: 2008
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Veterinary Microbiology 2008;126(1-3):243-250
• Materia: Rotavirus; Porcinos; Variación Genética; Genotipo; Argentina
• Institución: Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"

Fil: Irala Parra, Juan Gabriel. National University of Asuncion. IICS. Molecular Biology Department; Paraguay.
Fil: Vidales, Graciela. Universidad Nacional de Luján; Argentina.
Fil: Gomez, Jorge A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Fernandez, Fernando M. Instituto Nacional de Tecnología Agropecuaria; Argentina.
Fil: Parreño, Viviana. Instituto Nacional de Tecnología Agropecuaria; Argentina.
Fil: Bok, Karin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Group A rotaviruses are one of the most frequently detected viral agents associated with neonatal diarrhea in piglets. In order to characterize rotavirus (RV) strains circulating in Argentinean swine, four porcine production farms located in Buenos Aires were studied. RV strains genotyped as P[6]G4, P[6]G8 and P[1]G6 were found in piglets under 30 days of age, without diarrhea. Phylogenetic and sequence analysis of the VP7 gene from G4 strains available in databases, reveals five porcine new lineages (III-VII) and three sublineages (VIIa-VIIc). The G4 porcine Argentinean strains were grouped with a porcine RV strain isolated in Brazil and another RV strain isolated from a child with diarrhea in Mexico, constituting an American lineage (VII). On the other hand, porcine G6 and G8 were closely related to RV's circulating in Argentinean cattle and South-American camelids, respectively. The fact that G4 porcine lineages were epidemiologically related to human strains, and G6 and G8 Argentinean porcine strains were found related to bovine and South-American camelids, respectively, suggests that pigs might play a crucial role as reservoir and generator of newly adapted emerging RV strains for human and other species.