Seroprevalence of human herpesvirus-8 in blood donors from different geographical regions of Argentina, Brazil, and Chile

• Autores: Pérez, Celeste Luján; Tous, Mónica; Gallego, S. V.; Zala, Norma; Rabinovich, Oscar; Garbiero, Susana; Martínez, María José; Cunha, Andrèa Mendonça Gusmão; Camino, Sofia; Cámara, Alicia; Costa, Sandra Cecília Botelho; Larrondo, Milton; Francalancia, Verónica; Landreau, Fernando; Bartomioli, Miguel Angel
• Año de publicación: 2004
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Journal of Medical Virology 2004; 72(4):661-7.
• Materia: Herpesviridae; Sarcoma de Kaposi; Trastornos Linfoproliferativos
• Institución: Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"

Fil: Pérez, Celeste. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.
Fil: Tous, Mónica. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.
Fil: Gallego, S. V. Laboratorio de Virus Linfotrópicos Humanos, Instituto de Virología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba; Argentina.
Fil: Zala, Norma. Servicio de Hemoterapia e Inmunohematología, Hospital de Enfermedades Infecciosas Francisco J. Muñiz, Buenos Aires; Argentina.
Fil: Rabinovich, Oscar. Servicio de Hemoterapia, Hospital Británico, Buenos Aires; Argentina.
Fil: Garbiero, Susana. Servicio de Hemoterapia, Hospital Privado del Sur, Bahía Blanca; Argentina.
Fil: Martínez, María José. Programa Virología, I.C.B.M., Universidad de Chile, Escuela de Medicina, Santiago; Chile.
Fil: Cunha, Andrèa Mendonça Gusmão. Universidade da Campinas (UNICAMP), São Paulo; Brasil.
Fil: Camino, Sofía. Servicio de Hemoterapia e Inmunohematología, Hospital de Enfermedades Infecciosas Francisco J. Muñiz, Buenos Aires; Argentina.
Fil: Cámara, Alicia. Laboratorio de Virus Linfotrópicos Humanos, Instituto de Virología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba; Argentina.
Fil: Costa, Sandra Cecília Botelho. Universidade da Campinas (UNICAMP), São Paulo; Brasil.
Fil: Larrondo, Milton. Banco de Sangre, Universidad de Chile, Hospital Clínico J.J. Aguirre; Chile.
Fil: Francalancia, Verónica. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.
Fil: Landreau, Fernando. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.
Fil: Bartomioli, Miguel Angel. Servicio de Hemoterapia, Hospital Privado del Sur, Bahía Blanca; Argentina.
Human herpesvirus-8 (HHV-8) causes Kaposi's sarcoma (KS) and lymphoproliferative disorders in both HIV-infected and uninfected patients. HHV-8 has a worldwide occurrence but infection rates vary according to a combination of geographic and behavioral risks. The main transmission route seems to be sexual, nevertheless, nasal secretions, saliva, blood, and organ graft have been proposed. HHV-8 was postulated as a new infectious agent for screening in blood donors. The aim of this study was to evaluate the prevalence of antibodies against HHV-8 antigens in blood donors of South America. Serum samples from 2,470 blood donors from Argentina, Brazil, and Chile corresponding to five geographic regions were studied by indirect immunofluorescence assay (IFA). Seroprevalence rate was 3.7% (92/2,470; 95% CI 2.9-4.5) in the entire blood donor population distributed as follows: Argentina, 4.0% (Buenos Aires city, 4.3%; Bahia Blanca, 2.4%; and Córdoba, 4.0%), Campinas (Brazil), 2.8%; and Santiago de Chile, 3.0%. There was no difference (P>0.05) between men and women or age related, except in Brazil where positive cases were 30-49-year-old males. The present study, which includes different geographical areas of multiple countries from South America, has not been done before. The results show similar prevalence rates among the studied zones corresponding to low-prevalence regions. South America is a large sub-continent with a wide spectrum of population and geographical characteristics, thus, more HHV-8 prevalence studies should be necessary to establish possible regional differences.