Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics

Autores
Talevi, Alan; Bellera, Carolina Leticia
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Drug repurposing(or repositioning) implies finding new therapeutic indications for existingdrugs (including approved, failed, discontinued and experimental drugs), andrepresents a substantial percentage of recent drug approvals, generating anestimated revenue of USD 250 billion per annum (25% of the total revenue).Accordingly, the drug discovery community is now actively engaged in organized,systematic drug repositioning.Here, we present a brief overview of the mainchallenges faced by repurposing projects, including legal and commercialbarriers, the need of tools to assimilate heterogeneous large-scale data, andthe fact that the universe of repurposing candidates is finite and expandsslowly, possibly requiring to progressively move repurposing efforts tounexplored areas of therapeutics.Opportunities within the field are alsobriefly presented, including newcollaborative models and the impact ofprecision medicine, ar also discussed.
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bellera, Carolina Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina
Materia
DRUG REPURPOSING
DRUG REPOSITIONING
INTELLECTUAL PROPERTY
BIG DATA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/127305
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeuticsTalevi, AlanBellera, Carolina LeticiaDRUG REPURPOSINGDRUG REPOSITIONINGINTELLECTUAL PROPERTYBIG DATAhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Drug repurposing(or repositioning) implies finding new therapeutic indications for existingdrugs (including approved, failed, discontinued and experimental drugs), andrepresents a substantial percentage of recent drug approvals, generating anestimated revenue of USD 250 billion per annum (25% of the total revenue).Accordingly, the drug discovery community is now actively engaged in organized,systematic drug repositioning.Here, we present a brief overview of the mainchallenges faced by repurposing projects, including legal and commercialbarriers, the need of tools to assimilate heterogeneous large-scale data, andthe fact that the universe of repurposing candidates is finite and expandsslowly, possibly requiring to progressively move repurposing efforts tounexplored areas of therapeutics.Opportunities within the field are alsobriefly presented, including newcollaborative models and the impact ofprecision medicine, ar also discussed.Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bellera, Carolina Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; ArgentinaInforma Healthcare2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/127305Talevi, Alan; Bellera, Carolina Leticia; Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics; Informa Healthcare; Expert Opinion On Drug Discovery; 15; 4; 12-2019; 397-4011746-0441CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/17460441.2020.1704729info:eu-repo/semantics/altIdentifier/doi/10.1080/17460441.2020.1704729info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:40Zoai:ri.conicet.gov.ar:11336/127305instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:40.668CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics
title Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics
spellingShingle Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics
Talevi, Alan
DRUG REPURPOSING
DRUG REPOSITIONING
INTELLECTUAL PROPERTY
BIG DATA
title_short Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics
title_full Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics
title_fullStr Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics
title_full_unstemmed Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics
title_sort Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics
dc.creator.none.fl_str_mv Talevi, Alan
Bellera, Carolina Leticia
author Talevi, Alan
author_facet Talevi, Alan
Bellera, Carolina Leticia
author_role author
author2 Bellera, Carolina Leticia
author2_role author
dc.subject.none.fl_str_mv DRUG REPURPOSING
DRUG REPOSITIONING
INTELLECTUAL PROPERTY
BIG DATA
topic DRUG REPURPOSING
DRUG REPOSITIONING
INTELLECTUAL PROPERTY
BIG DATA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Drug repurposing(or repositioning) implies finding new therapeutic indications for existingdrugs (including approved, failed, discontinued and experimental drugs), andrepresents a substantial percentage of recent drug approvals, generating anestimated revenue of USD 250 billion per annum (25% of the total revenue).Accordingly, the drug discovery community is now actively engaged in organized,systematic drug repositioning.Here, we present a brief overview of the mainchallenges faced by repurposing projects, including legal and commercialbarriers, the need of tools to assimilate heterogeneous large-scale data, andthe fact that the universe of repurposing candidates is finite and expandsslowly, possibly requiring to progressively move repurposing efforts tounexplored areas of therapeutics.Opportunities within the field are alsobriefly presented, including newcollaborative models and the impact ofprecision medicine, ar also discussed.
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bellera, Carolina Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina
description Drug repurposing(or repositioning) implies finding new therapeutic indications for existingdrugs (including approved, failed, discontinued and experimental drugs), andrepresents a substantial percentage of recent drug approvals, generating anestimated revenue of USD 250 billion per annum (25% of the total revenue).Accordingly, the drug discovery community is now actively engaged in organized,systematic drug repositioning.Here, we present a brief overview of the mainchallenges faced by repurposing projects, including legal and commercialbarriers, the need of tools to assimilate heterogeneous large-scale data, andthe fact that the universe of repurposing candidates is finite and expandsslowly, possibly requiring to progressively move repurposing efforts tounexplored areas of therapeutics.Opportunities within the field are alsobriefly presented, including newcollaborative models and the impact ofprecision medicine, ar also discussed.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/127305
Talevi, Alan; Bellera, Carolina Leticia; Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics; Informa Healthcare; Expert Opinion On Drug Discovery; 15; 4; 12-2019; 397-401
1746-0441
CONICET Digital
CONICET
url http://hdl.handle.net/11336/127305
identifier_str_mv Talevi, Alan; Bellera, Carolina Leticia; Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics; Informa Healthcare; Expert Opinion On Drug Discovery; 15; 4; 12-2019; 397-401
1746-0441
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/17460441.2020.1704729
info:eu-repo/semantics/altIdentifier/doi/10.1080/17460441.2020.1704729
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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