Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid

Autores
Garofalo, Federico Mariano; Sbaraglini, María Laura; Barrionuevo, Emilia Mercedes; Peralta, Estefanía; Bonifazi, Evelyn L.; Talevi, Alan; Gavernet, Luciana
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This article focuses on the design of new anticonvulsant compounds that combine the chemical structure of valproic acid with other interesting scaffolds with anticonvulsant or anti-inflammatory properties. These compounds protected against in vivo acute seizure models (mice). The results revealed the capacity of combining known scaffolds into a single structure to generate new active compounds with multitarget purposes.
Facultad de Ciencias Exactas
Universidad de Buenos Aires
Laboratorio de Investigación y Desarrollo de Bioactivos
Materia
Biología
anti-inflammatory drugs
anticonvulsant drugs
codrugs
epilepsy
hybrid drugs
multitarget drugs
nipecotic acid
parabens
valproic acid
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/160072
Acceder
id SEDICI_f99f84ae136a8c76f71c8ef3180f555e
oai_identifier_str oai:sedici.unlp.edu.ar:10915/160072
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Synthesis and biological evaluation of new antiseizure compounds derived from valproic acidGarofalo, Federico MarianoSbaraglini, María LauraBarrionuevo, Emilia MercedesPeralta, EstefaníaBonifazi, Evelyn L.Talevi, AlanGavernet, LucianaBiologíaanti-inflammatory drugsanticonvulsant drugscodrugsepilepsyhybrid drugsmultitarget drugsnipecotic acidparabensvalproic acidThis article focuses on the design of new anticonvulsant compounds that combine the chemical structure of valproic acid with other interesting scaffolds with anticonvulsant or anti-inflammatory properties. These compounds protected against in vivo acute seizure models (mice). The results revealed the capacity of combining known scaffolds into a single structure to generate new active compounds with multitarget purposes.Facultad de Ciencias ExactasUniversidad de Buenos AiresLaboratorio de Investigación y Desarrollo de Bioactivos2023-05-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/160072enginfo:eu-repo/semantics/altIdentifier/issn/1756-8927info:eu-repo/semantics/altIdentifier/doi/10.4155/fmc-2022-0222info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:41:52Zoai:sedici.unlp.edu.ar:10915/160072Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:41:52.64SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
title Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
spellingShingle Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
Garofalo, Federico Mariano
Biología
anti-inflammatory drugs
anticonvulsant drugs
codrugs
epilepsy
hybrid drugs
multitarget drugs
nipecotic acid
parabens
valproic acid
title_short Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
title_full Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
title_fullStr Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
title_full_unstemmed Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
title_sort Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid
dc.creator.none.fl_str_mv Garofalo, Federico Mariano
Sbaraglini, María Laura
Barrionuevo, Emilia Mercedes
Peralta, Estefanía
Bonifazi, Evelyn L.
Talevi, Alan
Gavernet, Luciana
author Garofalo, Federico Mariano
author_facet Garofalo, Federico Mariano
Sbaraglini, María Laura
Barrionuevo, Emilia Mercedes
Peralta, Estefanía
Bonifazi, Evelyn L.
Talevi, Alan
Gavernet, Luciana
author_role author
author2 Sbaraglini, María Laura
Barrionuevo, Emilia Mercedes
Peralta, Estefanía
Bonifazi, Evelyn L.
Talevi, Alan
Gavernet, Luciana
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Biología
anti-inflammatory drugs
anticonvulsant drugs
codrugs
epilepsy
hybrid drugs
multitarget drugs
nipecotic acid
parabens
valproic acid
topic Biología
anti-inflammatory drugs
anticonvulsant drugs
codrugs
epilepsy
hybrid drugs
multitarget drugs
nipecotic acid
parabens
valproic acid
dc.description.none.fl_txt_mv This article focuses on the design of new anticonvulsant compounds that combine the chemical structure of valproic acid with other interesting scaffolds with anticonvulsant or anti-inflammatory properties. These compounds protected against in vivo acute seizure models (mice). The results revealed the capacity of combining known scaffolds into a single structure to generate new active compounds with multitarget purposes.
Facultad de Ciencias Exactas
Universidad de Buenos Aires
Laboratorio de Investigación y Desarrollo de Bioactivos
description This article focuses on the design of new anticonvulsant compounds that combine the chemical structure of valproic acid with other interesting scaffolds with anticonvulsant or anti-inflammatory properties. These compounds protected against in vivo acute seizure models (mice). The results revealed the capacity of combining known scaffolds into a single structure to generate new active compounds with multitarget purposes.
publishDate 2023
dc.date.none.fl_str_mv 2023-05-25
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/160072
url http://sedici.unlp.edu.ar/handle/10915/160072
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1756-8927
info:eu-repo/semantics/altIdentifier/doi/10.4155/fmc-2022-0222
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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