Antifungal Activity of Essential Oils Against <i>Candida</i> Species Isolated from Clinical Samples

Autores
Córdoba, Susana Beatriz; Vivot, Walter; Szusz, Wanda; Albo, Graciela Noemí
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We evaluated the in vitro antifungal activity of essential oils obtained from the aromatic plants Laurus nobilis, Thymus vulgaris, Mentha piperita, Cymbopogon citratus and Lippia junelliana against the following Candida species isolated from clinical samples: C. krusei (n = 10); C. albicans (n = 50); C. glabrata (n = 70) and C. parapsilosis (n = 80). The minimal inhibitory concentration (MIC) was determined according to EDef 7.3.1 document from EUCAST. Amphotericin B and fluconazole were the antifungal drugs used as inhibition control. The concentration ranges evaluated were 0.4–800 and 0.03–128 mg l⁻¹ for essential oils and antifungal drugs, respectively. MIC₅₀ and MIC₉₀, mode and ranges were calculated. All the Candida spp. evaluated were susceptible to amphotericin B (MIC ≤ 1 mg l⁻¹), while fluconazole was inactive for C. krusei (MIC ≥ 32 mg l⁻¹) and intermediate for C. glabrata (MIC ≤ 32 mg l⁻¹). The essential oils showed antifungal activity on Candida spp. tested with MIC₉₀ values ranging from 0.8 to 800 mg l⁻¹. In general, the most active essential oils were L. nobilis and T. vulgaris (MIC₉₀ 0.8–0.16 mg l⁻¹), and the least active was C. officinalis (MIC₉₀ 400–800 mg l⁻¹). C. krusei was inhibited by 5/6 of the essential oils evaluated, and C. glabrata was the least susceptible one. This in vitro study confirms the antifungal activity of these six essential oils assayed which could be a potential source of new molecules useful to control fungal infections caused by some Candida species, including those resistant to antifungal drugs.
Facultad de Ciencias Veterinarias
Facultad de Ciencias Agrarias y Forestales
Materia
Ciencias Veterinarias
Essential oils
Candida spp.
Laurus nobilis
Thymus vulgaris
Mentha piperita
Cymbopogon citratus
Lippia junelliana
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/138564
Acceder
id SEDICI_f8f6b729fd51a1a293eb933158e34342
oai_identifier_str oai:sedici.unlp.edu.ar:10915/138564
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Antifungal Activity of Essential Oils Against <i>Candida</i> Species Isolated from Clinical SamplesCórdoba, Susana BeatrizVivot, WalterSzusz, WandaAlbo, Graciela NoemíCiencias VeterinariasEssential oilsCandida spp.Laurus nobilisThymus vulgarisMentha piperitaCymbopogon citratusLippia junellianaWe evaluated the in vitro antifungal activity of essential oils obtained from the aromatic plants <i>Laurus nobilis</i>, <i>Thymus vulgaris</i>, <i>Mentha piperita</i>, <i>Cymbopogon citratus</i> and <i>Lippia junelliana</i> against the following <i>Candida</i> species isolated from clinical samples: <i>C. krusei</i> (n = 10); <i>C. albicans</i> (n = 50); <i>C. glabrata</i> (n = 70) and <i>C. parapsilosis</i> (n = 80). The minimal inhibitory concentration (MIC) was determined according to EDef 7.3.1 document from EUCAST. Amphotericin B and fluconazole were the antifungal drugs used as inhibition control. The concentration ranges evaluated were 0.4–800 and 0.03–128 mg l⁻¹ for essential oils and antifungal drugs, respectively. MIC₅₀ and MIC₉₀, mode and ranges were calculated. All the <i>Candida</i> spp. evaluated were susceptible to amphotericin B (MIC ≤ 1 mg l⁻¹), while fluconazole was inactive for <i>C. krusei</i> (MIC ≥ 32 mg l⁻¹) and intermediate for <i>C. glabrata</i> (MIC ≤ 32 mg l⁻¹). The essential oils showed antifungal activity on <i>Candida</i> spp. tested with MIC₉₀ values ranging from 0.8 to 800 mg l⁻¹. In general, the most active essential oils were <i>L. nobilis</i> and <i>T. vulgaris</i> (MIC₉₀ 0.8–0.16 mg l⁻¹), and the least active was <i>C. officinalis</i> (MIC₉₀ 400–800 mg l⁻¹). <i>C. krusei</i> was inhibited by 5/6 of the essential oils evaluated, and <i>C. glabrata</i> was the least susceptible one. This in vitro study confirms the antifungal activity of these six essential oils assayed which could be a potential source of new molecules useful to control fungal infections caused by some <i>Candida</i> species, including those resistant to antifungal drugs.Facultad de Ciencias VeterinariasFacultad de Ciencias Agrarias y Forestales2019-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf615-623http://sedici.unlp.edu.ar/handle/10915/138564enginfo:eu-repo/semantics/altIdentifier/issn/1573-0832info:eu-repo/semantics/altIdentifier/issn/0301-486Xinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s11046-019-00364-5info:eu-repo/semantics/altIdentifier/pmid/31359292info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:04:09Zoai:sedici.unlp.edu.ar:10915/138564Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:04:09.463SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Antifungal Activity of Essential Oils Against <i>Candida</i> Species Isolated from Clinical Samples
title Antifungal Activity of Essential Oils Against <i>Candida</i> Species Isolated from Clinical Samples
spellingShingle Antifungal Activity of Essential Oils Against <i>Candida</i> Species Isolated from Clinical Samples
Córdoba, Susana Beatriz
Ciencias Veterinarias
Essential oils
Candida spp.
Laurus nobilis
Thymus vulgaris
Mentha piperita
Cymbopogon citratus
Lippia junelliana
title_short Antifungal Activity of Essential Oils Against <i>Candida</i> Species Isolated from Clinical Samples
title_full Antifungal Activity of Essential Oils Against <i>Candida</i> Species Isolated from Clinical Samples
title_fullStr Antifungal Activity of Essential Oils Against <i>Candida</i> Species Isolated from Clinical Samples
title_full_unstemmed Antifungal Activity of Essential Oils Against <i>Candida</i> Species Isolated from Clinical Samples
title_sort Antifungal Activity of Essential Oils Against <i>Candida</i> Species Isolated from Clinical Samples
dc.creator.none.fl_str_mv Córdoba, Susana Beatriz
Vivot, Walter
Szusz, Wanda
Albo, Graciela Noemí
author Córdoba, Susana Beatriz
author_facet Córdoba, Susana Beatriz
Vivot, Walter
Szusz, Wanda
Albo, Graciela Noemí
author_role author
author2 Vivot, Walter
Szusz, Wanda
Albo, Graciela Noemí
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Veterinarias
Essential oils
Candida spp.
Laurus nobilis
Thymus vulgaris
Mentha piperita
Cymbopogon citratus
Lippia junelliana
topic Ciencias Veterinarias
Essential oils
Candida spp.
Laurus nobilis
Thymus vulgaris
Mentha piperita
Cymbopogon citratus
Lippia junelliana
dc.description.none.fl_txt_mv We evaluated the in vitro antifungal activity of essential oils obtained from the aromatic plants <i>Laurus nobilis</i>, <i>Thymus vulgaris</i>, <i>Mentha piperita</i>, <i>Cymbopogon citratus</i> and <i>Lippia junelliana</i> against the following <i>Candida</i> species isolated from clinical samples: <i>C. krusei</i> (n = 10); <i>C. albicans</i> (n = 50); <i>C. glabrata</i> (n = 70) and <i>C. parapsilosis</i> (n = 80). The minimal inhibitory concentration (MIC) was determined according to EDef 7.3.1 document from EUCAST. Amphotericin B and fluconazole were the antifungal drugs used as inhibition control. The concentration ranges evaluated were 0.4–800 and 0.03–128 mg l⁻¹ for essential oils and antifungal drugs, respectively. MIC₅₀ and MIC₉₀, mode and ranges were calculated. All the <i>Candida</i> spp. evaluated were susceptible to amphotericin B (MIC ≤ 1 mg l⁻¹), while fluconazole was inactive for <i>C. krusei</i> (MIC ≥ 32 mg l⁻¹) and intermediate for <i>C. glabrata</i> (MIC ≤ 32 mg l⁻¹). The essential oils showed antifungal activity on <i>Candida</i> spp. tested with MIC₉₀ values ranging from 0.8 to 800 mg l⁻¹. In general, the most active essential oils were <i>L. nobilis</i> and <i>T. vulgaris</i> (MIC₉₀ 0.8–0.16 mg l⁻¹), and the least active was <i>C. officinalis</i> (MIC₉₀ 400–800 mg l⁻¹). <i>C. krusei</i> was inhibited by 5/6 of the essential oils evaluated, and <i>C. glabrata</i> was the least susceptible one. This in vitro study confirms the antifungal activity of these six essential oils assayed which could be a potential source of new molecules useful to control fungal infections caused by some <i>Candida</i> species, including those resistant to antifungal drugs.
Facultad de Ciencias Veterinarias
Facultad de Ciencias Agrarias y Forestales
description We evaluated the in vitro antifungal activity of essential oils obtained from the aromatic plants <i>Laurus nobilis</i>, <i>Thymus vulgaris</i>, <i>Mentha piperita</i>, <i>Cymbopogon citratus</i> and <i>Lippia junelliana</i> against the following <i>Candida</i> species isolated from clinical samples: <i>C. krusei</i> (n = 10); <i>C. albicans</i> (n = 50); <i>C. glabrata</i> (n = 70) and <i>C. parapsilosis</i> (n = 80). The minimal inhibitory concentration (MIC) was determined according to EDef 7.3.1 document from EUCAST. Amphotericin B and fluconazole were the antifungal drugs used as inhibition control. The concentration ranges evaluated were 0.4–800 and 0.03–128 mg l⁻¹ for essential oils and antifungal drugs, respectively. MIC₅₀ and MIC₉₀, mode and ranges were calculated. All the <i>Candida</i> spp. evaluated were susceptible to amphotericin B (MIC ≤ 1 mg l⁻¹), while fluconazole was inactive for <i>C. krusei</i> (MIC ≥ 32 mg l⁻¹) and intermediate for <i>C. glabrata</i> (MIC ≤ 32 mg l⁻¹). The essential oils showed antifungal activity on <i>Candida</i> spp. tested with MIC₉₀ values ranging from 0.8 to 800 mg l⁻¹. In general, the most active essential oils were <i>L. nobilis</i> and <i>T. vulgaris</i> (MIC₉₀ 0.8–0.16 mg l⁻¹), and the least active was <i>C. officinalis</i> (MIC₉₀ 400–800 mg l⁻¹). <i>C. krusei</i> was inhibited by 5/6 of the essential oils evaluated, and <i>C. glabrata</i> was the least susceptible one. This in vitro study confirms the antifungal activity of these six essential oils assayed which could be a potential source of new molecules useful to control fungal infections caused by some <i>Candida</i> species, including those resistant to antifungal drugs.
publishDate 2019
dc.date.none.fl_str_mv 2019-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/138564
url http://sedici.unlp.edu.ar/handle/10915/138564
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1573-0832
info:eu-repo/semantics/altIdentifier/issn/0301-486X
info:eu-repo/semantics/altIdentifier/doi/10.1007/s11046-019-00364-5
info:eu-repo/semantics/altIdentifier/pmid/31359292
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
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instname_str Universidad Nacional de La Plata
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repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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