Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention

Autores
Etcheverry, Susana Beatriz; Ferrer, Evelina Gloria; Naso, Luciana Gissella; Rivadeneira, Josefina; Salinas, María Victoria; Williams, Patricia Ana María
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Vanadium compounds are known for a variety of pharmacological properties. Many of them display antitumoral and osteogenic effects in several cell lines. Free radicals induce the development of tumoral processes. Natural polyphenols such as flavonoids have antioxidant properties since they scavenge different free radicals. For these reasons it is interesting to investigate the effects of a new complex generated between the vanadyl(IV) cation and the flavonoid hesperidin. The complex has been synthesized and characterized by physicochemical methods. Spectroscopic analysis revealed a 1:1 stoichiometry of ligand:VO and coordination by deprotonated cis-hydroxyl groups to the disaccharide moiety of the ligand. The complex improves the superoxide dismutase (SOD)-like activity of the ligand, but the scavenging of other radicals tested does not change upon complexation. When tested on two tumoral cell lines in culture (one of them derived from a rat osteosarcoma UMR106 and the other from human colon adenocarcinoma Caco-2), the complex enhanced the antiproliferative effects of the free ligand, and this effect correlated with the morphological alterations toward apoptosis. Also, on the osteoblastic cell line the complex stimulated cell proliferation and collagen type I production at low concentrations. At higher doses the complex behaved as a cytotoxic compound for the osteoblasts.
Facultad de Ciencias Exactas
Centro de Química Inorgánica
Materia
Ciencias Exactas
Química
Antioxidants
Antitumoral
Vanadium hesperidin complex
Cellular morphology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/142249
Acceder
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network_name_str SEDICI (UNLP)
spelling Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemopreventionEtcheverry, Susana BeatrizFerrer, Evelina GloriaNaso, Luciana GissellaRivadeneira, JosefinaSalinas, María VictoriaWilliams, Patricia Ana MaríaCiencias ExactasQuímicaAntioxidantsAntitumoralVanadium hesperidin complexCellular morphologyVanadium compounds are known for a variety of pharmacological properties. Many of them display antitumoral and osteogenic effects in several cell lines. Free radicals induce the development of tumoral processes. Natural polyphenols such as flavonoids have antioxidant properties since they scavenge different free radicals. For these reasons it is interesting to investigate the effects of a new complex generated between the vanadyl(IV) cation and the flavonoid hesperidin. The complex has been synthesized and characterized by physicochemical methods. Spectroscopic analysis revealed a 1:1 stoichiometry of ligand:VO and coordination by deprotonated cis-hydroxyl groups to the disaccharide moiety of the ligand. The complex improves the superoxide dismutase (SOD)-like activity of the ligand, but the scavenging of other radicals tested does not change upon complexation. When tested on two tumoral cell lines in culture (one of them derived from a rat osteosarcoma UMR106 and the other from human colon adenocarcinoma Caco-2), the complex enhanced the antiproliferative effects of the free ligand, and this effect correlated with the morphological alterations toward apoptosis. Also, on the osteoblastic cell line the complex stimulated cell proliferation and collagen type I production at low concentrations. At higher doses the complex behaved as a cytotoxic compound for the osteoblasts.Facultad de Ciencias ExactasCentro de Química Inorgánica2008-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf435-447http://sedici.unlp.edu.ar/handle/10915/142249enginfo:eu-repo/semantics/altIdentifier/issn/0949-8257info:eu-repo/semantics/altIdentifier/issn/1432-1327info:eu-repo/semantics/altIdentifier/doi/10.1007/s00775-007-0332-9info:eu-repo/semantics/altIdentifier/pmid/18097692info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:32Zoai:sedici.unlp.edu.ar:10915/142249Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:33.16SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
title Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
spellingShingle Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
Etcheverry, Susana Beatriz
Ciencias Exactas
Química
Antioxidants
Antitumoral
Vanadium hesperidin complex
Cellular morphology
title_short Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
title_full Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
title_fullStr Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
title_full_unstemmed Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
title_sort Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
dc.creator.none.fl_str_mv Etcheverry, Susana Beatriz
Ferrer, Evelina Gloria
Naso, Luciana Gissella
Rivadeneira, Josefina
Salinas, María Victoria
Williams, Patricia Ana María
author Etcheverry, Susana Beatriz
author_facet Etcheverry, Susana Beatriz
Ferrer, Evelina Gloria
Naso, Luciana Gissella
Rivadeneira, Josefina
Salinas, María Victoria
Williams, Patricia Ana María
author_role author
author2 Ferrer, Evelina Gloria
Naso, Luciana Gissella
Rivadeneira, Josefina
Salinas, María Victoria
Williams, Patricia Ana María
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
Antioxidants
Antitumoral
Vanadium hesperidin complex
Cellular morphology
topic Ciencias Exactas
Química
Antioxidants
Antitumoral
Vanadium hesperidin complex
Cellular morphology
dc.description.none.fl_txt_mv Vanadium compounds are known for a variety of pharmacological properties. Many of them display antitumoral and osteogenic effects in several cell lines. Free radicals induce the development of tumoral processes. Natural polyphenols such as flavonoids have antioxidant properties since they scavenge different free radicals. For these reasons it is interesting to investigate the effects of a new complex generated between the vanadyl(IV) cation and the flavonoid hesperidin. The complex has been synthesized and characterized by physicochemical methods. Spectroscopic analysis revealed a 1:1 stoichiometry of ligand:VO and coordination by deprotonated cis-hydroxyl groups to the disaccharide moiety of the ligand. The complex improves the superoxide dismutase (SOD)-like activity of the ligand, but the scavenging of other radicals tested does not change upon complexation. When tested on two tumoral cell lines in culture (one of them derived from a rat osteosarcoma UMR106 and the other from human colon adenocarcinoma Caco-2), the complex enhanced the antiproliferative effects of the free ligand, and this effect correlated with the morphological alterations toward apoptosis. Also, on the osteoblastic cell line the complex stimulated cell proliferation and collagen type I production at low concentrations. At higher doses the complex behaved as a cytotoxic compound for the osteoblasts.
Facultad de Ciencias Exactas
Centro de Química Inorgánica
description Vanadium compounds are known for a variety of pharmacological properties. Many of them display antitumoral and osteogenic effects in several cell lines. Free radicals induce the development of tumoral processes. Natural polyphenols such as flavonoids have antioxidant properties since they scavenge different free radicals. For these reasons it is interesting to investigate the effects of a new complex generated between the vanadyl(IV) cation and the flavonoid hesperidin. The complex has been synthesized and characterized by physicochemical methods. Spectroscopic analysis revealed a 1:1 stoichiometry of ligand:VO and coordination by deprotonated cis-hydroxyl groups to the disaccharide moiety of the ligand. The complex improves the superoxide dismutase (SOD)-like activity of the ligand, but the scavenging of other radicals tested does not change upon complexation. When tested on two tumoral cell lines in culture (one of them derived from a rat osteosarcoma UMR106 and the other from human colon adenocarcinoma Caco-2), the complex enhanced the antiproliferative effects of the free ligand, and this effect correlated with the morphological alterations toward apoptosis. Also, on the osteoblastic cell line the complex stimulated cell proliferation and collagen type I production at low concentrations. At higher doses the complex behaved as a cytotoxic compound for the osteoblasts.
publishDate 2008
dc.date.none.fl_str_mv 2008-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/142249
url http://sedici.unlp.edu.ar/handle/10915/142249
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0949-8257
info:eu-repo/semantics/altIdentifier/issn/1432-1327
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00775-007-0332-9
info:eu-repo/semantics/altIdentifier/pmid/18097692
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
435-447
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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