White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies

Autores
Pagano, E. S.; Spinedi, Eduardo Julio; Gagliardino, Juan José
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on the whole adipogenic process involved in white adipose tissue (WAT) mass expansion, namely due to a mechanism whereby WAT cells become hypertrophic, thus inducing a serious local (WAT) inflammatory condition that in turn, will impair not only the cross-talk between the hypothalamus and the WAT, but also favoring the development of deep and widespread neuroendocrine-metabolic dysfunction. Moreover, we also have revisited the circadian clock genes involved in dysfunctional WAT mass expansion and the mechanisms that may lead to obesity development, including early metabolic dysfunctions, enhanced oxidative stress and distorted energy homeostasis. The epigenetic changes of clock genes driving metabolic disease and obesity development have also been included in this review. Finally, we have also underlined the relevance of metabolic homeostasis regulation by central and peripheral organ clocks, sleep disturbances, nutrients, and feeding time, as key factors in obesity development as well as both, classical and chronotherapeutic approaches for its prevention and treatment.
Centro de Endocrinología Experimental y Aplicada
Materia
Ciencias Médicas
Adipose tissue dysfunction
Adipose tissue mass expansion
Central/peripheral clocks
Chronobiology
Chronotherapeutic approach
Clock genes
Feeding time
Glucose regulation
Nutrients
Obesity pathogenesis
prevention
Obesity treatment
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/87731

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oai_identifier_str oai:sedici.unlp.edu.ar:10915/87731
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repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapiesPagano, E. S.Spinedi, Eduardo JulioGagliardino, Juan JoséCiencias MédicasAdipose tissue dysfunctionAdipose tissue mass expansionCentral/peripheral clocksChronobiologyChronotherapeutic approachClock genesFeeding timeGlucose regulationNutrientsObesity pathogenesispreventionObesity treatmentA combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on the whole adipogenic process involved in white adipose tissue (WAT) mass expansion, namely due to a mechanism whereby WAT cells become hypertrophic, thus inducing a serious local (WAT) inflammatory condition that in turn, will impair not only the cross-talk between the hypothalamus and the WAT, but also favoring the development of deep and widespread neuroendocrine-metabolic dysfunction. Moreover, we also have revisited the circadian clock genes involved in dysfunctional WAT mass expansion and the mechanisms that may lead to obesity development, including early metabolic dysfunctions, enhanced oxidative stress and distorted energy homeostasis. The epigenetic changes of clock genes driving metabolic disease and obesity development have also been included in this review. Finally, we have also underlined the relevance of metabolic homeostasis regulation by central and peripheral organ clocks, sleep disturbances, nutrients, and feeding time, as key factors in obesity development as well as both, classical and chronotherapeutic approaches for its prevention and treatment.Centro de Endocrinología Experimental y Aplicada2016-11-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf347-363http://sedici.unlp.edu.ar/handle/10915/87731enginfo:eu-repo/semantics/altIdentifier/issn/0028-3835info:eu-repo/semantics/altIdentifier/doi/10.1159/000453317info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:49:31Zoai:sedici.unlp.edu.ar:10915/87731Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:49:31.459SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
title White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
spellingShingle White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
Pagano, E. S.
Ciencias Médicas
Adipose tissue dysfunction
Adipose tissue mass expansion
Central/peripheral clocks
Chronobiology
Chronotherapeutic approach
Clock genes
Feeding time
Glucose regulation
Nutrients
Obesity pathogenesis
prevention
Obesity treatment
title_short White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
title_full White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
title_fullStr White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
title_full_unstemmed White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
title_sort White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
dc.creator.none.fl_str_mv Pagano, E. S.
Spinedi, Eduardo Julio
Gagliardino, Juan José
author Pagano, E. S.
author_facet Pagano, E. S.
Spinedi, Eduardo Julio
Gagliardino, Juan José
author_role author
author2 Spinedi, Eduardo Julio
Gagliardino, Juan José
author2_role author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Adipose tissue dysfunction
Adipose tissue mass expansion
Central/peripheral clocks
Chronobiology
Chronotherapeutic approach
Clock genes
Feeding time
Glucose regulation
Nutrients
Obesity pathogenesis
prevention
Obesity treatment
topic Ciencias Médicas
Adipose tissue dysfunction
Adipose tissue mass expansion
Central/peripheral clocks
Chronobiology
Chronotherapeutic approach
Clock genes
Feeding time
Glucose regulation
Nutrients
Obesity pathogenesis
prevention
Obesity treatment
dc.description.none.fl_txt_mv A combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on the whole adipogenic process involved in white adipose tissue (WAT) mass expansion, namely due to a mechanism whereby WAT cells become hypertrophic, thus inducing a serious local (WAT) inflammatory condition that in turn, will impair not only the cross-talk between the hypothalamus and the WAT, but also favoring the development of deep and widespread neuroendocrine-metabolic dysfunction. Moreover, we also have revisited the circadian clock genes involved in dysfunctional WAT mass expansion and the mechanisms that may lead to obesity development, including early metabolic dysfunctions, enhanced oxidative stress and distorted energy homeostasis. The epigenetic changes of clock genes driving metabolic disease and obesity development have also been included in this review. Finally, we have also underlined the relevance of metabolic homeostasis regulation by central and peripheral organ clocks, sleep disturbances, nutrients, and feeding time, as key factors in obesity development as well as both, classical and chronotherapeutic approaches for its prevention and treatment.
Centro de Endocrinología Experimental y Aplicada
description A combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on the whole adipogenic process involved in white adipose tissue (WAT) mass expansion, namely due to a mechanism whereby WAT cells become hypertrophic, thus inducing a serious local (WAT) inflammatory condition that in turn, will impair not only the cross-talk between the hypothalamus and the WAT, but also favoring the development of deep and widespread neuroendocrine-metabolic dysfunction. Moreover, we also have revisited the circadian clock genes involved in dysfunctional WAT mass expansion and the mechanisms that may lead to obesity development, including early metabolic dysfunctions, enhanced oxidative stress and distorted energy homeostasis. The epigenetic changes of clock genes driving metabolic disease and obesity development have also been included in this review. Finally, we have also underlined the relevance of metabolic homeostasis regulation by central and peripheral organ clocks, sleep disturbances, nutrients, and feeding time, as key factors in obesity development as well as both, classical and chronotherapeutic approaches for its prevention and treatment.
publishDate 2016
dc.date.none.fl_str_mv 2016-11-16
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/87731
url http://sedici.unlp.edu.ar/handle/10915/87731
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0028-3835
info:eu-repo/semantics/altIdentifier/doi/10.1159/000453317
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
347-363
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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