White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
- Autores
- Pagano, E. S.; Spinedi, Eduardo Julio; Gagliardino, Juan José
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on the whole adipogenic process involved in white adipose tissue (WAT) mass expansion, namely due to a mechanism whereby WAT cells become hypertrophic, thus inducing a serious local (WAT) inflammatory condition that in turn, will impair not only the cross-talk between the hypothalamus and the WAT, but also favoring the development of deep and widespread neuroendocrine-metabolic dysfunction. Moreover, we also have revisited the circadian clock genes involved in dysfunctional WAT mass expansion and the mechanisms that may lead to obesity development, including early metabolic dysfunctions, enhanced oxidative stress and distorted energy homeostasis. The epigenetic changes of clock genes driving metabolic disease and obesity development have also been included in this review. Finally, we have also underlined the relevance of metabolic homeostasis regulation by central and peripheral organ clocks, sleep disturbances, nutrients, and feeding time, as key factors in obesity development as well as both, classical and chronotherapeutic approaches for its prevention and treatment.
Centro de Endocrinología Experimental y Aplicada - Materia
-
Ciencias Médicas
Adipose tissue dysfunction
Adipose tissue mass expansion
Central/peripheral clocks
Chronobiology
Chronotherapeutic approach
Clock genes
Feeding time
Glucose regulation
Nutrients
Obesity pathogenesis
prevention
Obesity treatment - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/87731
Ver los metadatos del registro completo
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White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapiesPagano, E. S.Spinedi, Eduardo JulioGagliardino, Juan JoséCiencias MédicasAdipose tissue dysfunctionAdipose tissue mass expansionCentral/peripheral clocksChronobiologyChronotherapeutic approachClock genesFeeding timeGlucose regulationNutrientsObesity pathogenesispreventionObesity treatmentA combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on the whole adipogenic process involved in white adipose tissue (WAT) mass expansion, namely due to a mechanism whereby WAT cells become hypertrophic, thus inducing a serious local (WAT) inflammatory condition that in turn, will impair not only the cross-talk between the hypothalamus and the WAT, but also favoring the development of deep and widespread neuroendocrine-metabolic dysfunction. Moreover, we also have revisited the circadian clock genes involved in dysfunctional WAT mass expansion and the mechanisms that may lead to obesity development, including early metabolic dysfunctions, enhanced oxidative stress and distorted energy homeostasis. The epigenetic changes of clock genes driving metabolic disease and obesity development have also been included in this review. Finally, we have also underlined the relevance of metabolic homeostasis regulation by central and peripheral organ clocks, sleep disturbances, nutrients, and feeding time, as key factors in obesity development as well as both, classical and chronotherapeutic approaches for its prevention and treatment.Centro de Endocrinología Experimental y Aplicada2016-11-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf347-363http://sedici.unlp.edu.ar/handle/10915/87731enginfo:eu-repo/semantics/altIdentifier/issn/0028-3835info:eu-repo/semantics/altIdentifier/doi/10.1159/000453317info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:49:31Zoai:sedici.unlp.edu.ar:10915/87731Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:49:31.459SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies |
title |
White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies |
spellingShingle |
White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies Pagano, E. S. Ciencias Médicas Adipose tissue dysfunction Adipose tissue mass expansion Central/peripheral clocks Chronobiology Chronotherapeutic approach Clock genes Feeding time Glucose regulation Nutrients Obesity pathogenesis prevention Obesity treatment |
title_short |
White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies |
title_full |
White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies |
title_fullStr |
White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies |
title_full_unstemmed |
White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies |
title_sort |
White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies |
dc.creator.none.fl_str_mv |
Pagano, E. S. Spinedi, Eduardo Julio Gagliardino, Juan José |
author |
Pagano, E. S. |
author_facet |
Pagano, E. S. Spinedi, Eduardo Julio Gagliardino, Juan José |
author_role |
author |
author2 |
Spinedi, Eduardo Julio Gagliardino, Juan José |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas Adipose tissue dysfunction Adipose tissue mass expansion Central/peripheral clocks Chronobiology Chronotherapeutic approach Clock genes Feeding time Glucose regulation Nutrients Obesity pathogenesis prevention Obesity treatment |
topic |
Ciencias Médicas Adipose tissue dysfunction Adipose tissue mass expansion Central/peripheral clocks Chronobiology Chronotherapeutic approach Clock genes Feeding time Glucose regulation Nutrients Obesity pathogenesis prevention Obesity treatment |
dc.description.none.fl_txt_mv |
A combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on the whole adipogenic process involved in white adipose tissue (WAT) mass expansion, namely due to a mechanism whereby WAT cells become hypertrophic, thus inducing a serious local (WAT) inflammatory condition that in turn, will impair not only the cross-talk between the hypothalamus and the WAT, but also favoring the development of deep and widespread neuroendocrine-metabolic dysfunction. Moreover, we also have revisited the circadian clock genes involved in dysfunctional WAT mass expansion and the mechanisms that may lead to obesity development, including early metabolic dysfunctions, enhanced oxidative stress and distorted energy homeostasis. The epigenetic changes of clock genes driving metabolic disease and obesity development have also been included in this review. Finally, we have also underlined the relevance of metabolic homeostasis regulation by central and peripheral organ clocks, sleep disturbances, nutrients, and feeding time, as key factors in obesity development as well as both, classical and chronotherapeutic approaches for its prevention and treatment. Centro de Endocrinología Experimental y Aplicada |
description |
A combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on the whole adipogenic process involved in white adipose tissue (WAT) mass expansion, namely due to a mechanism whereby WAT cells become hypertrophic, thus inducing a serious local (WAT) inflammatory condition that in turn, will impair not only the cross-talk between the hypothalamus and the WAT, but also favoring the development of deep and widespread neuroendocrine-metabolic dysfunction. Moreover, we also have revisited the circadian clock genes involved in dysfunctional WAT mass expansion and the mechanisms that may lead to obesity development, including early metabolic dysfunctions, enhanced oxidative stress and distorted energy homeostasis. The epigenetic changes of clock genes driving metabolic disease and obesity development have also been included in this review. Finally, we have also underlined the relevance of metabolic homeostasis regulation by central and peripheral organ clocks, sleep disturbances, nutrients, and feeding time, as key factors in obesity development as well as both, classical and chronotherapeutic approaches for its prevention and treatment. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-11-16 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
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publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/87731 |
url |
http://sedici.unlp.edu.ar/handle/10915/87731 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/altIdentifier/issn/0028-3835 info:eu-repo/semantics/altIdentifier/doi/10.1159/000453317 |
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info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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application/pdf 347-363 |
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