Gene transfer-based strategies for heart regeneration

Autores
Crottogini, Alberto José; Laguens, Rubén P.
Año de publicación
2009
Idioma
inglés
Tipo de recurso
reseña artículo
Estado
versión publicada
Descripción
Ischemic heart disease is the leading cause of mortality worldwide. Its most frequent and serious complication is acute myocardial infarction, after which the remaining contractile tissue undergoes a process characterized by myocyte hypertrophy and death of the remaining myocardium, and its progressive replacement by fibrosis (Sutton and Sharpe 2000). This process, termed remodeling, eventually leads to left ventricular dilation and heart failure. The extent of remodeling is largely dependent upon infarct size (Lenderink et al. 1995). Small infarcts do not induce significant remodeling. Large ones, contrarily, provoke substantial remodeling and therefore evolve towards contractile failure. This explains why regenerating the contractile tissue, a process named cardiomyogenesis, has become a major objective in biomedical research.
Sociedad Argentina de Fisiología
Materia
Ciencias Médicas
ischemic heart disease
cardiomyogenesis
heart regeneration
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/129072
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/129072
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Gene transfer-based strategies for heart regenerationCrottogini, Alberto JoséLaguens, Rubén P.Ciencias Médicasischemic heart diseasecardiomyogenesisheart regenerationIschemic heart disease is the leading cause of mortality worldwide. Its most frequent and serious complication is acute myocardial infarction, after which the remaining contractile tissue undergoes a process characterized by myocyte hypertrophy and death of the remaining myocardium, and its progressive replacement by fibrosis (Sutton and Sharpe 2000). This process, termed remodeling, eventually leads to left ventricular dilation and heart failure. The extent of remodeling is largely dependent upon infarct size (Lenderink <i>et al.</i> 1995). Small infarcts do not induce significant remodeling. Large ones, contrarily, provoke substantial remodeling and therefore evolve towards contractile failure. This explains why regenerating the contractile tissue, a process named cardiomyogenesis, has become a major objective in biomedical research.Sociedad Argentina de Fisiología2009info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf29-35http://sedici.unlp.edu.ar/handle/10915/129072enginfo:eu-repo/semantics/altIdentifier/issn/1669-5402info:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:31:27Zoai:sedici.unlp.edu.ar:10915/129072Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:31:27.728SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Gene transfer-based strategies for heart regeneration
title Gene transfer-based strategies for heart regeneration
spellingShingle Gene transfer-based strategies for heart regeneration
Crottogini, Alberto José
Ciencias Médicas
ischemic heart disease
cardiomyogenesis
heart regeneration
title_short Gene transfer-based strategies for heart regeneration
title_full Gene transfer-based strategies for heart regeneration
title_fullStr Gene transfer-based strategies for heart regeneration
title_full_unstemmed Gene transfer-based strategies for heart regeneration
title_sort Gene transfer-based strategies for heart regeneration
dc.creator.none.fl_str_mv Crottogini, Alberto José
Laguens, Rubén P.
author Crottogini, Alberto José
author_facet Crottogini, Alberto José
Laguens, Rubén P.
author_role author
author2 Laguens, Rubén P.
author2_role author
dc.subject.none.fl_str_mv Ciencias Médicas
ischemic heart disease
cardiomyogenesis
heart regeneration
topic Ciencias Médicas
ischemic heart disease
cardiomyogenesis
heart regeneration
dc.description.none.fl_txt_mv Ischemic heart disease is the leading cause of mortality worldwide. Its most frequent and serious complication is acute myocardial infarction, after which the remaining contractile tissue undergoes a process characterized by myocyte hypertrophy and death of the remaining myocardium, and its progressive replacement by fibrosis (Sutton and Sharpe 2000). This process, termed remodeling, eventually leads to left ventricular dilation and heart failure. The extent of remodeling is largely dependent upon infarct size (Lenderink <i>et al.</i> 1995). Small infarcts do not induce significant remodeling. Large ones, contrarily, provoke substantial remodeling and therefore evolve towards contractile failure. This explains why regenerating the contractile tissue, a process named cardiomyogenesis, has become a major objective in biomedical research.
Sociedad Argentina de Fisiología
description Ischemic heart disease is the leading cause of mortality worldwide. Its most frequent and serious complication is acute myocardial infarction, after which the remaining contractile tissue undergoes a process characterized by myocyte hypertrophy and death of the remaining myocardium, and its progressive replacement by fibrosis (Sutton and Sharpe 2000). This process, termed remodeling, eventually leads to left ventricular dilation and heart failure. The extent of remodeling is largely dependent upon infarct size (Lenderink <i>et al.</i> 1995). Small infarcts do not induce significant remodeling. Large ones, contrarily, provoke substantial remodeling and therefore evolve towards contractile failure. This explains why regenerating the contractile tissue, a process named cardiomyogenesis, has become a major objective in biomedical research.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/review
info:eu-repo/semantics/publishedVersion
Revision
http://purl.org/coar/resource_type/c_dcae04bc
info:ar-repo/semantics/resenaArticulo
format review
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/129072
url http://sedici.unlp.edu.ar/handle/10915/129072
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1669-5402
info:eu-repo/semantics/altIdentifier/issn/1669-5410
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
29-35
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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