Effects of remote ischemic preconditioning on early myocardial post-infarction remodeling

Autores
Bin, E. P.; Penas, Federico Nicolás; Goren, Nora Beatriz; Gelpi, Ricardo J.; Donato, Martin Alejandro
Año de publicación
2020
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Introduction: It is known that remote ischemic preconditioning(rIPC) reduces infarct size in experimental models of myocardialinfarction (MI); while its effect is controversial in the clinical setting.Particularly, the effect of rIPC on post-infarction ventricular remod eling is unknown. The aim of this work is to evaluate the effect ofrIPC on early ventricular remodeling, considering the myocardialinfarction expansion.Methods: Male FVB mice, 2-6 months old, underwent MI by permanentligation (for 7 days) of the left anterior coronary artery; In a secondgroup, a rIPC protocol (3 cycles of 5 min ischemia/reperfusionin the left lower limb) was performed prior to MI. Finally, a third groupwas undergoing to left thoracotomy, but without myocardial ischemia(Sham). Infarct size was measured with triphenyltetrazolium, ventricularfunction by hemodynamic and echocardiography, and MMPs2 and 9 activity was evaluated by zymography.Results: There were no significant differences in the risk area andinfarct size between groups. IM decreased ejection fraction andarea shortening fraction to a value of 55,06±2,6% and 26,76±1,21%;respectively (p≤0,05 vs sham). rIPC improved systolic function increasingejection fraction and the area shortening fraction to a valueof 67,64%±1,42 and 37,41±2,37%, respectively (p≤0,05 vs IM).We did not observe significant differences between groups in theend-systolic stress values (afterload index). The relationship betweenend-systolic stress and ejection fraction was plotted, observinga significant improvement in the rIPC group, compared to the MIgroup. Finally, rIPC reduced significantly MMP-9 activity in the leftventricle (infarct area), but not MMP-2.Conclusion: We have showed that rIPC has a beneficial effect onearly remodeling, reducing myocardial post-infarction expansionand improving ventricular function. This beneficial effect could berelated to a lower MMP-9 activity.
Fil: Bin, E. P.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; Argentina
Fil: Penas, Federico Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Goren, Nora Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Gelpi, Ricardo J.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; Argentina
Fil: Donato, Martin Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; Argentina
LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Sociedad Argentina de Fisiología
Materia
ISCHEMIC PRECONDITIONING
HEART
POST-INFARCTION
REMODELING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/260667
Acceder
id CONICETDig_80a9e62f4c971d7c5e5fd8cb85c22274
oai_identifier_str oai:ri.conicet.gov.ar:11336/260667
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of remote ischemic preconditioning on early myocardial post-infarction remodelingBin, E. P.Penas, Federico NicolásGoren, Nora BeatrizGelpi, Ricardo J.Donato, Martin AlejandroISCHEMIC PRECONDITIONINGHEARTPOST-INFARCTIONREMODELINGhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Introduction: It is known that remote ischemic preconditioning(rIPC) reduces infarct size in experimental models of myocardialinfarction (MI); while its effect is controversial in the clinical setting.Particularly, the effect of rIPC on post-infarction ventricular remod eling is unknown. The aim of this work is to evaluate the effect ofrIPC on early ventricular remodeling, considering the myocardialinfarction expansion.Methods: Male FVB mice, 2-6 months old, underwent MI by permanentligation (for 7 days) of the left anterior coronary artery; In a secondgroup, a rIPC protocol (3 cycles of 5 min ischemia/reperfusionin the left lower limb) was performed prior to MI. Finally, a third groupwas undergoing to left thoracotomy, but without myocardial ischemia(Sham). Infarct size was measured with triphenyltetrazolium, ventricularfunction by hemodynamic and echocardiography, and MMPs2 and 9 activity was evaluated by zymography.Results: There were no significant differences in the risk area andinfarct size between groups. IM decreased ejection fraction andarea shortening fraction to a value of 55,06±2,6% and 26,76±1,21%;respectively (p≤0,05 vs sham). rIPC improved systolic function increasingejection fraction and the area shortening fraction to a valueof 67,64%±1,42 and 37,41±2,37%, respectively (p≤0,05 vs IM).We did not observe significant differences between groups in theend-systolic stress values (afterload index). The relationship betweenend-systolic stress and ejection fraction was plotted, observinga significant improvement in the rIPC group, compared to the MIgroup. Finally, rIPC reduced significantly MMP-9 activity in the leftventricle (infarct area), but not MMP-2.Conclusion: We have showed that rIPC has a beneficial effect onearly remodeling, reducing myocardial post-infarction expansionand improving ventricular function. This beneficial effect could berelated to a lower MMP-9 activity.Fil: Bin, E. P.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; ArgentinaFil: Penas, Federico Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Goren, Nora Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Gelpi, Ricardo J.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; ArgentinaFil: Donato, Martin Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; ArgentinaLXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de FisiologíaArgentinaSociedad Argentina de Investigación ClínicaSociedad Argentina de InmunologíaSociedad Argentina de FisiologíaFundación Revista Medicina2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/260667Effects of remote ischemic preconditioning on early myocardial post-infarction remodeling; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Argentina; 2020; 54-551669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://medicinabuenosaires.com/revistas/vol80-20/s5/Mv80s5.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:32Zoai:ri.conicet.gov.ar:11336/260667instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:32.92CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of remote ischemic preconditioning on early myocardial post-infarction remodeling
title Effects of remote ischemic preconditioning on early myocardial post-infarction remodeling
spellingShingle Effects of remote ischemic preconditioning on early myocardial post-infarction remodeling
Bin, E. P.
ISCHEMIC PRECONDITIONING
HEART
POST-INFARCTION
REMODELING
title_short Effects of remote ischemic preconditioning on early myocardial post-infarction remodeling
title_full Effects of remote ischemic preconditioning on early myocardial post-infarction remodeling
title_fullStr Effects of remote ischemic preconditioning on early myocardial post-infarction remodeling
title_full_unstemmed Effects of remote ischemic preconditioning on early myocardial post-infarction remodeling
title_sort Effects of remote ischemic preconditioning on early myocardial post-infarction remodeling
dc.creator.none.fl_str_mv Bin, E. P.
Penas, Federico Nicolás
Goren, Nora Beatriz
Gelpi, Ricardo J.
Donato, Martin Alejandro
author Bin, E. P.
author_facet Bin, E. P.
Penas, Federico Nicolás
Goren, Nora Beatriz
Gelpi, Ricardo J.
Donato, Martin Alejandro
author_role author
author2 Penas, Federico Nicolás
Goren, Nora Beatriz
Gelpi, Ricardo J.
Donato, Martin Alejandro
author2_role author
author
author
author
dc.subject.none.fl_str_mv ISCHEMIC PRECONDITIONING
HEART
POST-INFARCTION
REMODELING
topic ISCHEMIC PRECONDITIONING
HEART
POST-INFARCTION
REMODELING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: It is known that remote ischemic preconditioning(rIPC) reduces infarct size in experimental models of myocardialinfarction (MI); while its effect is controversial in the clinical setting.Particularly, the effect of rIPC on post-infarction ventricular remod eling is unknown. The aim of this work is to evaluate the effect ofrIPC on early ventricular remodeling, considering the myocardialinfarction expansion.Methods: Male FVB mice, 2-6 months old, underwent MI by permanentligation (for 7 days) of the left anterior coronary artery; In a secondgroup, a rIPC protocol (3 cycles of 5 min ischemia/reperfusionin the left lower limb) was performed prior to MI. Finally, a third groupwas undergoing to left thoracotomy, but without myocardial ischemia(Sham). Infarct size was measured with triphenyltetrazolium, ventricularfunction by hemodynamic and echocardiography, and MMPs2 and 9 activity was evaluated by zymography.Results: There were no significant differences in the risk area andinfarct size between groups. IM decreased ejection fraction andarea shortening fraction to a value of 55,06±2,6% and 26,76±1,21%;respectively (p≤0,05 vs sham). rIPC improved systolic function increasingejection fraction and the area shortening fraction to a valueof 67,64%±1,42 and 37,41±2,37%, respectively (p≤0,05 vs IM).We did not observe significant differences between groups in theend-systolic stress values (afterload index). The relationship betweenend-systolic stress and ejection fraction was plotted, observinga significant improvement in the rIPC group, compared to the MIgroup. Finally, rIPC reduced significantly MMP-9 activity in the leftventricle (infarct area), but not MMP-2.Conclusion: We have showed that rIPC has a beneficial effect onearly remodeling, reducing myocardial post-infarction expansionand improving ventricular function. This beneficial effect could berelated to a lower MMP-9 activity.
Fil: Bin, E. P.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; Argentina
Fil: Penas, Federico Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Goren, Nora Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Gelpi, Ricardo J.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; Argentina
Fil: Donato, Martin Alejandro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; Argentina
LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Sociedad Argentina de Fisiología
description Introduction: It is known that remote ischemic preconditioning(rIPC) reduces infarct size in experimental models of myocardialinfarction (MI); while its effect is controversial in the clinical setting.Particularly, the effect of rIPC on post-infarction ventricular remod eling is unknown. The aim of this work is to evaluate the effect ofrIPC on early ventricular remodeling, considering the myocardialinfarction expansion.Methods: Male FVB mice, 2-6 months old, underwent MI by permanentligation (for 7 days) of the left anterior coronary artery; In a secondgroup, a rIPC protocol (3 cycles of 5 min ischemia/reperfusionin the left lower limb) was performed prior to MI. Finally, a third groupwas undergoing to left thoracotomy, but without myocardial ischemia(Sham). Infarct size was measured with triphenyltetrazolium, ventricularfunction by hemodynamic and echocardiography, and MMPs2 and 9 activity was evaluated by zymography.Results: There were no significant differences in the risk area andinfarct size between groups. IM decreased ejection fraction andarea shortening fraction to a value of 55,06±2,6% and 26,76±1,21%;respectively (p≤0,05 vs sham). rIPC improved systolic function increasingejection fraction and the area shortening fraction to a valueof 67,64%±1,42 and 37,41±2,37%, respectively (p≤0,05 vs IM).We did not observe significant differences between groups in theend-systolic stress values (afterload index). The relationship betweenend-systolic stress and ejection fraction was plotted, observinga significant improvement in the rIPC group, compared to the MIgroup. Finally, rIPC reduced significantly MMP-9 activity in the leftventricle (infarct area), but not MMP-2.Conclusion: We have showed that rIPC has a beneficial effect onearly remodeling, reducing myocardial post-infarction expansionand improving ventricular function. This beneficial effect could berelated to a lower MMP-9 activity.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/260667
Effects of remote ischemic preconditioning on early myocardial post-infarction remodeling; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Argentina; 2020; 54-55
1669-9106
CONICET Digital
CONICET
url http://hdl.handle.net/11336/260667
identifier_str_mv Effects of remote ischemic preconditioning on early myocardial post-infarction remodeling; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXVIII Reunión Anual de la Sociedad Argentina de Inmunología y Reunión Anual de la Sociedad Argentina de Fisiología; Argentina; 2020; 54-55
1669-9106
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://medicinabuenosaires.com/revistas/vol80-20/s5/Mv80s5.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Fundación Revista Medicina
publisher.none.fl_str_mv Fundación Revista Medicina
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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