Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats

Autores
Escudero, Eduardo Manuel; Camilión de Hurtado, María Cristina; Pérez, Néstor Gustavo; Tufare, Ana Laura
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aims. The present study was attempted to determine whether LV midwall mechanics yielded different conclusions about LV systolic function than the assessment of endocardial LV mechanics by echocardiography in spontaneously hypertensive rats (SHR). Methods and results. Thirty-six (18 Wistar normotensive (W), 18 [SHR]) anesthetized rats were studied with two-dimensional directed M-mode echocardiogram to analyze LV structure (LV diameter, left ventricular wall thickness and LV mass [LVM]) and LV function (endocardial shortening [ES] and midwall shortening [MS]). Measurements were made from three consecutive cardiac cycles on the M-mode tracings. There was no significant difference in LV dimension. LVM was higher in SHR (SHR: 595 ± 111 mg, W: 413 ± 83 mg - p < 0.01). ES was higher in SHR (SHR: 64.1 ± 6%, w: 58.2 ± 4% - p < 0.01), whereas no significant difference was found in MS (SHR: 27 ± 4%, W: 27.6 ± 4% - ns). Twelve of 18 (66%) SHR showed endocardial shortening higher than normally predicted, compared with 3/18 (16%) with observed enhanced MS (p < 0.01). Conclusion. These results suggest that the analysis of midwall mechanics by echo allows us to better understand the LV performance in SHR and that the exaggerated endocardial motion could not represent a really supernormal systolic performance.
Facultad de Ciencias Médicas
Centro de Investigaciones Cardiovasculares
Materia
Ciencias Médicas
Echocardiography
Left ventricular function
Left ventricular hypertrophy
Midventricular mechanics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/84464
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/84464
network_acronym_str SEDICI
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network_name_str SEDICI (UNLP)
spelling Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive ratsEscudero, Eduardo ManuelCamilión de Hurtado, María CristinaPérez, Néstor GustavoTufare, Ana LauraCiencias MédicasEchocardiographyLeft ventricular functionLeft ventricular hypertrophyMidventricular mechanicsAims. The present study was attempted to determine whether LV midwall mechanics yielded different conclusions about LV systolic function than the assessment of endocardial LV mechanics by echocardiography in spontaneously hypertensive rats (SHR). Methods and results. Thirty-six (18 Wistar normotensive (W), 18 [SHR]) anesthetized rats were studied with two-dimensional directed M-mode echocardiogram to analyze LV structure (LV diameter, left ventricular wall thickness and LV mass [LVM]) and LV function (endocardial shortening [ES] and midwall shortening [MS]). Measurements were made from three consecutive cardiac cycles on the M-mode tracings. There was no significant difference in LV dimension. LVM was higher in SHR (SHR: 595 ± 111 mg, W: 413 ± 83 mg - p < 0.01). ES was higher in SHR (SHR: 64.1 ± 6%, w: 58.2 ± 4% - p < 0.01), whereas no significant difference was found in MS (SHR: 27 ± 4%, W: 27.6 ± 4% - ns). Twelve of 18 (66%) SHR showed endocardial shortening higher than normally predicted, compared with 3/18 (16%) with observed enhanced MS (p < 0.01). Conclusion. These results suggest that the analysis of midwall mechanics by echo allows us to better understand the LV performance in SHR and that the exaggerated endocardial motion could not represent a really <i>supernormal</i> systolic performance.Facultad de Ciencias MédicasCentro de Investigaciones Cardiovasculares2004info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf169-175http://sedici.unlp.edu.ar/handle/10915/84464enginfo:eu-repo/semantics/altIdentifier/issn/1525-2167info:eu-repo/semantics/altIdentifier/doi/10.1016/j.euje.2003.11.004info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:48:32Zoai:sedici.unlp.edu.ar:10915/84464Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:48:32.397SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
title Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
spellingShingle Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
Escudero, Eduardo Manuel
Ciencias Médicas
Echocardiography
Left ventricular function
Left ventricular hypertrophy
Midventricular mechanics
title_short Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
title_full Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
title_fullStr Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
title_full_unstemmed Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
title_sort Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
dc.creator.none.fl_str_mv Escudero, Eduardo Manuel
Camilión de Hurtado, María Cristina
Pérez, Néstor Gustavo
Tufare, Ana Laura
author Escudero, Eduardo Manuel
author_facet Escudero, Eduardo Manuel
Camilión de Hurtado, María Cristina
Pérez, Néstor Gustavo
Tufare, Ana Laura
author_role author
author2 Camilión de Hurtado, María Cristina
Pérez, Néstor Gustavo
Tufare, Ana Laura
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Echocardiography
Left ventricular function
Left ventricular hypertrophy
Midventricular mechanics
topic Ciencias Médicas
Echocardiography
Left ventricular function
Left ventricular hypertrophy
Midventricular mechanics
dc.description.none.fl_txt_mv Aims. The present study was attempted to determine whether LV midwall mechanics yielded different conclusions about LV systolic function than the assessment of endocardial LV mechanics by echocardiography in spontaneously hypertensive rats (SHR). Methods and results. Thirty-six (18 Wistar normotensive (W), 18 [SHR]) anesthetized rats were studied with two-dimensional directed M-mode echocardiogram to analyze LV structure (LV diameter, left ventricular wall thickness and LV mass [LVM]) and LV function (endocardial shortening [ES] and midwall shortening [MS]). Measurements were made from three consecutive cardiac cycles on the M-mode tracings. There was no significant difference in LV dimension. LVM was higher in SHR (SHR: 595 ± 111 mg, W: 413 ± 83 mg - p < 0.01). ES was higher in SHR (SHR: 64.1 ± 6%, w: 58.2 ± 4% - p < 0.01), whereas no significant difference was found in MS (SHR: 27 ± 4%, W: 27.6 ± 4% - ns). Twelve of 18 (66%) SHR showed endocardial shortening higher than normally predicted, compared with 3/18 (16%) with observed enhanced MS (p < 0.01). Conclusion. These results suggest that the analysis of midwall mechanics by echo allows us to better understand the LV performance in SHR and that the exaggerated endocardial motion could not represent a really <i>supernormal</i> systolic performance.
Facultad de Ciencias Médicas
Centro de Investigaciones Cardiovasculares
description Aims. The present study was attempted to determine whether LV midwall mechanics yielded different conclusions about LV systolic function than the assessment of endocardial LV mechanics by echocardiography in spontaneously hypertensive rats (SHR). Methods and results. Thirty-six (18 Wistar normotensive (W), 18 [SHR]) anesthetized rats were studied with two-dimensional directed M-mode echocardiogram to analyze LV structure (LV diameter, left ventricular wall thickness and LV mass [LVM]) and LV function (endocardial shortening [ES] and midwall shortening [MS]). Measurements were made from three consecutive cardiac cycles on the M-mode tracings. There was no significant difference in LV dimension. LVM was higher in SHR (SHR: 595 ± 111 mg, W: 413 ± 83 mg - p < 0.01). ES was higher in SHR (SHR: 64.1 ± 6%, w: 58.2 ± 4% - p < 0.01), whereas no significant difference was found in MS (SHR: 27 ± 4%, W: 27.6 ± 4% - ns). Twelve of 18 (66%) SHR showed endocardial shortening higher than normally predicted, compared with 3/18 (16%) with observed enhanced MS (p < 0.01). Conclusion. These results suggest that the analysis of midwall mechanics by echo allows us to better understand the LV performance in SHR and that the exaggerated endocardial motion could not represent a really <i>supernormal</i> systolic performance.
publishDate 2004
dc.date.none.fl_str_mv 2004
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/84464
url http://sedici.unlp.edu.ar/handle/10915/84464
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1525-2167
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.euje.2003.11.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
169-175
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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