Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardize...

Autores
Locatelli, Paola; Olea, Fernanda Daniela; De Lorenzi, Andrea; Salmo, Fabián; Vera Janavel, Gustavo; Hnatiuk, Anna; Guevara, Eduardo; Crottogini, Alberto Jose
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ovine models of ischemic heart disease and cardiac failure are increasingly used in translational research. However, reliable extrapolation of the results to the clinical setting requires knowing if ovine normal left ventricular (LV) function is comparable to that of humans. We thus assessed for echocardiographic LV dimensions and indexes in a large normal adult sheep population and compared them with standardized values in normal human adults. Bidimensional and tissue Doppler echocardiograms were performed in 69 young adult Corriedale sheep under light sedation. LV dimensions and indexes of systolic and diastolic function were measured. Absolute and body surface areanormalized values were compared to those for normal adult humans and their statistical distribution was assessed. Normalized dimensions (except for end diastolic diameter) as well as ejection fraction and fractional shortening fell within the ranges established by the American Society of Echocardiography and European Association of Echocardiography for normal adult humans. Normalized end diastolic diameter exceeded the upper normal limit but got close to it when correcting for the higher heart mass/body surface area ratio of sheep with respect to humans. Diastolic parameters also fell within normal human ranges except for a slightly lower mitral deceleration time. All values exhibited a Gaussian distribution. We conclude that echocardiographic parameters of systolic and diastolic LV performance in young adult sheep can be reliably extrapolated to the adult human, thus supporting the use of ovine models of human heart disease in translational research.
Fil: Locatelli, Paola. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Olea, Fernanda Daniela. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: De Lorenzi, Andrea. Fundación Favaloro; Argentina
Fil: Salmo, Fabián. Fundación Favaloro; Argentina
Fil: Vera Janavel, Gustavo. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; Argentina
Fil: Hnatiuk, Anna. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; Argentina
Fil: Guevara, Eduardo. Fundación Favaloro; Argentina
Fil: Crottogini, Alberto Jose. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ECHOCARDIOGRAPHY
SHEEP
LEFT VENTRICULAR FUNCTION
OVINE MODELS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/194126
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/194126
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humansLocatelli, PaolaOlea, Fernanda DanielaDe Lorenzi, AndreaSalmo, FabiánVera Janavel, GustavoHnatiuk, AnnaGuevara, EduardoCrottogini, Alberto JoseECHOCARDIOGRAPHYSHEEPLEFT VENTRICULAR FUNCTIONOVINE MODELShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Ovine models of ischemic heart disease and cardiac failure are increasingly used in translational research. However, reliable extrapolation of the results to the clinical setting requires knowing if ovine normal left ventricular (LV) function is comparable to that of humans. We thus assessed for echocardiographic LV dimensions and indexes in a large normal adult sheep population and compared them with standardized values in normal human adults. Bidimensional and tissue Doppler echocardiograms were performed in 69 young adult Corriedale sheep under light sedation. LV dimensions and indexes of systolic and diastolic function were measured. Absolute and body surface areanormalized values were compared to those for normal adult humans and their statistical distribution was assessed. Normalized dimensions (except for end diastolic diameter) as well as ejection fraction and fractional shortening fell within the ranges established by the American Society of Echocardiography and European Association of Echocardiography for normal adult humans. Normalized end diastolic diameter exceeded the upper normal limit but got close to it when correcting for the higher heart mass/body surface area ratio of sheep with respect to humans. Diastolic parameters also fell within normal human ranges except for a slightly lower mitral deceleration time. All values exhibited a Gaussian distribution. We conclude that echocardiographic parameters of systolic and diastolic LV performance in young adult sheep can be reliably extrapolated to the adult human, thus supporting the use of ovine models of human heart disease in translational research.Fil: Locatelli, Paola. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Olea, Fernanda Daniela. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: De Lorenzi, Andrea. Fundación Favaloro; ArgentinaFil: Salmo, Fabián. Fundación Favaloro; ArgentinaFil: Vera Janavel, Gustavo. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; ArgentinaFil: Hnatiuk, Anna. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; ArgentinaFil: Guevara, Eduardo. Fundación Favaloro; ArgentinaFil: Crottogini, Alberto Jose. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinae-Century Publishing Corporation2011-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/194126Locatelli, Paola; Olea, Fernanda Daniela; De Lorenzi, Andrea; Salmo, Fabián; Vera Janavel, Gustavo; et al.; Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans; e-Century Publishing Corporation; International Journal of Clinical and Experimental Medicine; 4; 4; 11-2011; 258-2641940-59011940-5901CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://e-century.us/web/journal_toc.php?journal=ijcem&volume=4&number=4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:03Zoai:ri.conicet.gov.ar:11336/194126instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:03.578CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans
title Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans
spellingShingle Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans
Locatelli, Paola
ECHOCARDIOGRAPHY
SHEEP
LEFT VENTRICULAR FUNCTION
OVINE MODELS
title_short Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans
title_full Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans
title_fullStr Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans
title_full_unstemmed Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans
title_sort Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans
dc.creator.none.fl_str_mv Locatelli, Paola
Olea, Fernanda Daniela
De Lorenzi, Andrea
Salmo, Fabián
Vera Janavel, Gustavo
Hnatiuk, Anna
Guevara, Eduardo
Crottogini, Alberto Jose
author Locatelli, Paola
author_facet Locatelli, Paola
Olea, Fernanda Daniela
De Lorenzi, Andrea
Salmo, Fabián
Vera Janavel, Gustavo
Hnatiuk, Anna
Guevara, Eduardo
Crottogini, Alberto Jose
author_role author
author2 Olea, Fernanda Daniela
De Lorenzi, Andrea
Salmo, Fabián
Vera Janavel, Gustavo
Hnatiuk, Anna
Guevara, Eduardo
Crottogini, Alberto Jose
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ECHOCARDIOGRAPHY
SHEEP
LEFT VENTRICULAR FUNCTION
OVINE MODELS
topic ECHOCARDIOGRAPHY
SHEEP
LEFT VENTRICULAR FUNCTION
OVINE MODELS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Ovine models of ischemic heart disease and cardiac failure are increasingly used in translational research. However, reliable extrapolation of the results to the clinical setting requires knowing if ovine normal left ventricular (LV) function is comparable to that of humans. We thus assessed for echocardiographic LV dimensions and indexes in a large normal adult sheep population and compared them with standardized values in normal human adults. Bidimensional and tissue Doppler echocardiograms were performed in 69 young adult Corriedale sheep under light sedation. LV dimensions and indexes of systolic and diastolic function were measured. Absolute and body surface areanormalized values were compared to those for normal adult humans and their statistical distribution was assessed. Normalized dimensions (except for end diastolic diameter) as well as ejection fraction and fractional shortening fell within the ranges established by the American Society of Echocardiography and European Association of Echocardiography for normal adult humans. Normalized end diastolic diameter exceeded the upper normal limit but got close to it when correcting for the higher heart mass/body surface area ratio of sheep with respect to humans. Diastolic parameters also fell within normal human ranges except for a slightly lower mitral deceleration time. All values exhibited a Gaussian distribution. We conclude that echocardiographic parameters of systolic and diastolic LV performance in young adult sheep can be reliably extrapolated to the adult human, thus supporting the use of ovine models of human heart disease in translational research.
Fil: Locatelli, Paola. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Olea, Fernanda Daniela. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: De Lorenzi, Andrea. Fundación Favaloro; Argentina
Fil: Salmo, Fabián. Fundación Favaloro; Argentina
Fil: Vera Janavel, Gustavo. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; Argentina
Fil: Hnatiuk, Anna. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; Argentina
Fil: Guevara, Eduardo. Fundación Favaloro; Argentina
Fil: Crottogini, Alberto Jose. Universidad Favaloro. Instituto de Invest.en Cs.basicas. Departamento D/cs.fisiológicas,farmacológicas y Bioquímicas. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Ovine models of ischemic heart disease and cardiac failure are increasingly used in translational research. However, reliable extrapolation of the results to the clinical setting requires knowing if ovine normal left ventricular (LV) function is comparable to that of humans. We thus assessed for echocardiographic LV dimensions and indexes in a large normal adult sheep population and compared them with standardized values in normal human adults. Bidimensional and tissue Doppler echocardiograms were performed in 69 young adult Corriedale sheep under light sedation. LV dimensions and indexes of systolic and diastolic function were measured. Absolute and body surface areanormalized values were compared to those for normal adult humans and their statistical distribution was assessed. Normalized dimensions (except for end diastolic diameter) as well as ejection fraction and fractional shortening fell within the ranges established by the American Society of Echocardiography and European Association of Echocardiography for normal adult humans. Normalized end diastolic diameter exceeded the upper normal limit but got close to it when correcting for the higher heart mass/body surface area ratio of sheep with respect to humans. Diastolic parameters also fell within normal human ranges except for a slightly lower mitral deceleration time. All values exhibited a Gaussian distribution. We conclude that echocardiographic parameters of systolic and diastolic LV performance in young adult sheep can be reliably extrapolated to the adult human, thus supporting the use of ovine models of human heart disease in translational research.
publishDate 2011
dc.date.none.fl_str_mv 2011-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/194126
Locatelli, Paola; Olea, Fernanda Daniela; De Lorenzi, Andrea; Salmo, Fabián; Vera Janavel, Gustavo; et al.; Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans; e-Century Publishing Corporation; International Journal of Clinical and Experimental Medicine; 4; 4; 11-2011; 258-264
1940-5901
1940-5901
CONICET Digital
CONICET
url http://hdl.handle.net/11336/194126
identifier_str_mv Locatelli, Paola; Olea, Fernanda Daniela; De Lorenzi, Andrea; Salmo, Fabián; Vera Janavel, Gustavo; et al.; Reference values for echocardiographic parameters and indexes of left ventricular function in healthy, young adult sheep used in translational research: comparison with standardized values in humans; e-Century Publishing Corporation; International Journal of Clinical and Experimental Medicine; 4; 4; 11-2011; 258-264
1940-5901
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://e-century.us/web/journal_toc.php?journal=ijcem&volume=4&number=4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv e-Century Publishing Corporation
publisher.none.fl_str_mv e-Century Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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