ACE2 a double-edged sword?
- Autores
- Campagnole Santos, Maria Jose; Santos, Robson A. S.; Magalhaes, Gisele S.; Motta Santos, Daisy; Rodrigues Machado, Maria da Glória
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Angiotensin-converting enzyme 2 (ACE2) is the binding protein/receptor used by the new SARS-CoV-2, which causes 2019 coronavirus disease (COVID-19), to enter host cells [1,2]. In 2003, Li and colleagues [3] at the Harvard Medical School, USA had previously described that a protein (spike proteins - S1 domain) da família do coronavirus binds efficiently to ACE2 [3,4]. From binding to ACE2, the virus envelope fuses into the host cell membrane allowing its genetic material entering the cell and replicate, triggering severe respiratory disease, including acute respiratory distress syndrome (ARDS), a devastating lung disease with high mortality rates (3060%).
Sociedad Argentina de Fisiología - Materia
-
Ciencias Médicas
Coronavirus
ACE2
Proteínas - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/148827
Ver los metadatos del registro completo
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ACE2 a double-edged sword?Campagnole Santos, Maria JoseSantos, Robson A. S.Magalhaes, Gisele S.Motta Santos, DaisyRodrigues Machado, Maria da GlóriaCiencias MédicasCoronavirusACE2ProteínasAngiotensin-converting enzyme 2 (ACE2) is the binding protein/receptor used by the new SARS-CoV-2, which causes 2019 coronavirus disease (COVID-19), to enter host cells [1,2]. In 2003, Li and colleagues [3] at the Harvard Medical School, USA had previously described that a protein (spike proteins - S1 domain) da família do coronavirus binds efficiently to ACE2 [3,4]. From binding to ACE2, the virus envelope fuses into the host cell membrane allowing its genetic material entering the cell and replicate, triggering severe respiratory disease, including acute respiratory distress syndrome (ARDS), a devastating lung disease with high mortality rates (3060%).Sociedad Argentina de Fisiología2020-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/148827enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/wp-content/uploads/2022/12/special_issue_coronavirus_2020.pdfinfo:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:19:02Zoai:sedici.unlp.edu.ar:10915/148827Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:19:02.47SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
ACE2 a double-edged sword? |
| title |
ACE2 a double-edged sword? |
| spellingShingle |
ACE2 a double-edged sword? Campagnole Santos, Maria Jose Ciencias Médicas Coronavirus ACE2 Proteínas |
| title_short |
ACE2 a double-edged sword? |
| title_full |
ACE2 a double-edged sword? |
| title_fullStr |
ACE2 a double-edged sword? |
| title_full_unstemmed |
ACE2 a double-edged sword? |
| title_sort |
ACE2 a double-edged sword? |
| dc.creator.none.fl_str_mv |
Campagnole Santos, Maria Jose Santos, Robson A. S. Magalhaes, Gisele S. Motta Santos, Daisy Rodrigues Machado, Maria da Glória |
| author |
Campagnole Santos, Maria Jose |
| author_facet |
Campagnole Santos, Maria Jose Santos, Robson A. S. Magalhaes, Gisele S. Motta Santos, Daisy Rodrigues Machado, Maria da Glória |
| author_role |
author |
| author2 |
Santos, Robson A. S. Magalhaes, Gisele S. Motta Santos, Daisy Rodrigues Machado, Maria da Glória |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
Ciencias Médicas Coronavirus ACE2 Proteínas |
| topic |
Ciencias Médicas Coronavirus ACE2 Proteínas |
| dc.description.none.fl_txt_mv |
Angiotensin-converting enzyme 2 (ACE2) is the binding protein/receptor used by the new SARS-CoV-2, which causes 2019 coronavirus disease (COVID-19), to enter host cells [1,2]. In 2003, Li and colleagues [3] at the Harvard Medical School, USA had previously described that a protein (spike proteins - S1 domain) da família do coronavirus binds efficiently to ACE2 [3,4]. From binding to ACE2, the virus envelope fuses into the host cell membrane allowing its genetic material entering the cell and replicate, triggering severe respiratory disease, including acute respiratory distress syndrome (ARDS), a devastating lung disease with high mortality rates (3060%). Sociedad Argentina de Fisiología |
| description |
Angiotensin-converting enzyme 2 (ACE2) is the binding protein/receptor used by the new SARS-CoV-2, which causes 2019 coronavirus disease (COVID-19), to enter host cells [1,2]. In 2003, Li and colleagues [3] at the Harvard Medical School, USA had previously described that a protein (spike proteins - S1 domain) da família do coronavirus binds efficiently to ACE2 [3,4]. From binding to ACE2, the virus envelope fuses into the host cell membrane allowing its genetic material entering the cell and replicate, triggering severe respiratory disease, including acute respiratory distress syndrome (ARDS), a devastating lung disease with high mortality rates (3060%). |
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2020 |
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2020-03 |
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