Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy

Autores
Bottasso Arias, Natalia María; García, Marina; Bondar, Constanza María; Guzman, Luciana; Redondo, Agustina; Chopita, Néstor Alfredo; Córsico, Betina; Chirdo, Fernando Gabriel
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Celiac disease (CD) is an immune-mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes at the intestinal mucosa observed in untreated CD patients are linked to changes in the level and in the pattern of expression of different genes. Fully differentiated epithelial cells express two isoforms of fatty acid binding proteins (FABPs): intestinal and liver, IFABP and LFABP, respectively. These proteins bind and transport long chain fatty acids and also have other important biological roles in signaling pathways, particularly those related to PPARγ and inflammatory processes. Herein, we analyze the serum levels of IFABP and characterize the expression of both FABPs at protein and mRNA level in small intestinal mucosa in severe enteropathy and normal tissue. As a result, we observed higher levels of circulating IFABP in untreated CD patients compared with controls and patients on gluten-free diet. In duodenal mucosa a differential FABPs expression pattern was observed with a reduction in mRNA levels compared to controls explained by the epithelium loss in severe enteropathy. In conclusion, we report changes in FABPs' expression pattern in severe enteropathy. Consequently, there might be alterations in lipid metabolism and the inflammatory process in the small intestinal mucosa.
Instituto de Investigaciones Bioquímicas de La Plata
Instituto de Estudios Inmunológicos y Fisiopatológicos
Materia
Ciencias Médicas
Fatty Acid-Binding Proteins
Carrier Proteins
Liver fatty
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/3.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/85887
Acceder
id SEDICI_e916f182550b437f985f56bacba97b59
oai_identifier_str oai:sedici.unlp.edu.ar:10915/85887
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease EnteropathyBottasso Arias, Natalia MaríaGarcía, MarinaBondar, Constanza MaríaGuzman, LucianaRedondo, AgustinaChopita, Néstor AlfredoCórsico, BetinaChirdo, Fernando GabrielCiencias MédicasFatty Acid-Binding ProteinsCarrier ProteinsLiver fattyCeliac disease (CD) is an immune-mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes at the intestinal mucosa observed in untreated CD patients are linked to changes in the level and in the pattern of expression of different genes. Fully differentiated epithelial cells express two isoforms of fatty acid binding proteins (FABPs): intestinal and liver, IFABP and LFABP, respectively. These proteins bind and transport long chain fatty acids and also have other important biological roles in signaling pathways, particularly those related to PPARγ and inflammatory processes. Herein, we analyze the serum levels of IFABP and characterize the expression of both FABPs at protein and mRNA level in small intestinal mucosa in severe enteropathy and normal tissue. As a result, we observed higher levels of circulating IFABP in untreated CD patients compared with controls and patients on gluten-free diet. In duodenal mucosa a differential FABPs expression pattern was observed with a reduction in mRNA levels compared to controls explained by the epithelium loss in severe enteropathy. In conclusion, we report changes in FABPs' expression pattern in severe enteropathy. Consequently, there might be alterations in lipid metabolism and the inflammatory process in the small intestinal mucosa.Instituto de Investigaciones Bioquímicas de La PlataInstituto de Estudios Inmunológicos y Fisiopatológicos2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/85887enginfo:eu-repo/semantics/altIdentifier/issn/0962-9351info:eu-repo/semantics/altIdentifier/doi/10.1155/2015/738563info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/Creative Commons Attribution 3.0 Unported (CC BY 3.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:08:51Zoai:sedici.unlp.edu.ar:10915/85887Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:08:51.601SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
spellingShingle Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
Bottasso Arias, Natalia María
Ciencias Médicas
Fatty Acid-Binding Proteins
Carrier Proteins
Liver fatty
title_short Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_full Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_fullStr Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_full_unstemmed Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
title_sort Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
dc.creator.none.fl_str_mv Bottasso Arias, Natalia María
García, Marina
Bondar, Constanza María
Guzman, Luciana
Redondo, Agustina
Chopita, Néstor Alfredo
Córsico, Betina
Chirdo, Fernando Gabriel
author Bottasso Arias, Natalia María
author_facet Bottasso Arias, Natalia María
García, Marina
Bondar, Constanza María
Guzman, Luciana
Redondo, Agustina
Chopita, Néstor Alfredo
Córsico, Betina
Chirdo, Fernando Gabriel
author_role author
author2 García, Marina
Bondar, Constanza María
Guzman, Luciana
Redondo, Agustina
Chopita, Néstor Alfredo
Córsico, Betina
Chirdo, Fernando Gabriel
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Fatty Acid-Binding Proteins
Carrier Proteins
Liver fatty
topic Ciencias Médicas
Fatty Acid-Binding Proteins
Carrier Proteins
Liver fatty
dc.description.none.fl_txt_mv Celiac disease (CD) is an immune-mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes at the intestinal mucosa observed in untreated CD patients are linked to changes in the level and in the pattern of expression of different genes. Fully differentiated epithelial cells express two isoforms of fatty acid binding proteins (FABPs): intestinal and liver, IFABP and LFABP, respectively. These proteins bind and transport long chain fatty acids and also have other important biological roles in signaling pathways, particularly those related to PPARγ and inflammatory processes. Herein, we analyze the serum levels of IFABP and characterize the expression of both FABPs at protein and mRNA level in small intestinal mucosa in severe enteropathy and normal tissue. As a result, we observed higher levels of circulating IFABP in untreated CD patients compared with controls and patients on gluten-free diet. In duodenal mucosa a differential FABPs expression pattern was observed with a reduction in mRNA levels compared to controls explained by the epithelium loss in severe enteropathy. In conclusion, we report changes in FABPs' expression pattern in severe enteropathy. Consequently, there might be alterations in lipid metabolism and the inflammatory process in the small intestinal mucosa.
Instituto de Investigaciones Bioquímicas de La Plata
Instituto de Estudios Inmunológicos y Fisiopatológicos
description Celiac disease (CD) is an immune-mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes at the intestinal mucosa observed in untreated CD patients are linked to changes in the level and in the pattern of expression of different genes. Fully differentiated epithelial cells express two isoforms of fatty acid binding proteins (FABPs): intestinal and liver, IFABP and LFABP, respectively. These proteins bind and transport long chain fatty acids and also have other important biological roles in signaling pathways, particularly those related to PPARγ and inflammatory processes. Herein, we analyze the serum levels of IFABP and characterize the expression of both FABPs at protein and mRNA level in small intestinal mucosa in severe enteropathy and normal tissue. As a result, we observed higher levels of circulating IFABP in untreated CD patients compared with controls and patients on gluten-free diet. In duodenal mucosa a differential FABPs expression pattern was observed with a reduction in mRNA levels compared to controls explained by the epithelium loss in severe enteropathy. In conclusion, we report changes in FABPs' expression pattern in severe enteropathy. Consequently, there might be alterations in lipid metabolism and the inflammatory process in the small intestinal mucosa.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/85887
url http://sedici.unlp.edu.ar/handle/10915/85887
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0962-9351
info:eu-repo/semantics/altIdentifier/doi/10.1155/2015/738563
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/
Creative Commons Attribution 3.0 Unported (CC BY 3.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/
Creative Commons Attribution 3.0 Unported (CC BY 3.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1846064145335582720
score 13.221938

Publicaciones similares