The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets
- Autores
- Franchini, Gisela Raquel; Pórfido, Jorge Luis; Ibáñez, Marina; Rey, María Florencia; Bélgamo, Julián Alberto; Smith, Brian O.; Kennedy, Malcolm W.; Córsico, Betina
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In this review paper we aim at presenting the current knowledge on structural aspects of soluble lipid binding proteins (LBPs) found in parasitic helminths and to discuss their potential role as novel drug targets. Helminth parasites produce and secrete a great variety of LBPs that may participate in the acquisition of nutrients from their host, such as fatty acids and cholesterol. It is also postulated that LBPs might interfere in the regulation of the host׳s immune response by sequestering lipidic intermediates or delivering bioactive lipids. A detailed comprehension of the structure of these proteins, as well as their interactions with ligands and membranes, is important to understand host–parasite relationships that they may mediate. This information could also contribute to determining the role that these proteins may play in the biology of parasitic helminths and how they modulate the immune systems of their hosts, and also towards the development of new therapeutics and prevention of the diseases caused by these highly pathogenic parasites.
Fil: Franchini, Gisela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Pórfido, Jorge Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Ibáñez, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Rey, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Bélgamo, Julián Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Smith, Brian O.. University of Glasgow; Reino Unido
Fil: Kennedy, Malcolm W.. University of Glasgow; Reino Unido
Fil: Córsico, Betina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina - Materia
-
Lipid Binding Proteins
Parasitic Helminths
Nematodes
Fatty Acids - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/34003
Ver los metadatos del registro completo
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The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targetsFranchini, Gisela RaquelPórfido, Jorge LuisIbáñez, MarinaRey, María FlorenciaBélgamo, Julián AlbertoSmith, Brian O.Kennedy, Malcolm W.Córsico, BetinaLipid Binding ProteinsParasitic HelminthsNematodesFatty Acidshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In this review paper we aim at presenting the current knowledge on structural aspects of soluble lipid binding proteins (LBPs) found in parasitic helminths and to discuss their potential role as novel drug targets. Helminth parasites produce and secrete a great variety of LBPs that may participate in the acquisition of nutrients from their host, such as fatty acids and cholesterol. It is also postulated that LBPs might interfere in the regulation of the host׳s immune response by sequestering lipidic intermediates or delivering bioactive lipids. A detailed comprehension of the structure of these proteins, as well as their interactions with ligands and membranes, is important to understand host–parasite relationships that they may mediate. This information could also contribute to determining the role that these proteins may play in the biology of parasitic helminths and how they modulate the immune systems of their hosts, and also towards the development of new therapeutics and prevention of the diseases caused by these highly pathogenic parasites.Fil: Franchini, Gisela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaFil: Pórfido, Jorge Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaFil: Ibáñez, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaFil: Rey, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaFil: Bélgamo, Julián Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaFil: Smith, Brian O.. University of Glasgow; Reino UnidoFil: Kennedy, Malcolm W.. University of Glasgow; Reino UnidoFil: Córsico, Betina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaElsevier2014-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/34003Franchini, Gisela Raquel; Pórfido, Jorge Luis; Ibáñez, Marina; Rey, María Florencia; Bélgamo, Julián Alberto; et al.; The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets; Elsevier; Prostaglandins Leukotrienes and Essential Fatty Acids; 93; 10-2014; 31-360952-3278CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.plefa.2014.08.003info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0952327814001410info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:31Zoai:ri.conicet.gov.ar:11336/34003instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:31.868CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets |
title |
The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets |
spellingShingle |
The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets Franchini, Gisela Raquel Lipid Binding Proteins Parasitic Helminths Nematodes Fatty Acids |
title_short |
The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets |
title_full |
The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets |
title_fullStr |
The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets |
title_full_unstemmed |
The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets |
title_sort |
The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets |
dc.creator.none.fl_str_mv |
Franchini, Gisela Raquel Pórfido, Jorge Luis Ibáñez, Marina Rey, María Florencia Bélgamo, Julián Alberto Smith, Brian O. Kennedy, Malcolm W. Córsico, Betina |
author |
Franchini, Gisela Raquel |
author_facet |
Franchini, Gisela Raquel Pórfido, Jorge Luis Ibáñez, Marina Rey, María Florencia Bélgamo, Julián Alberto Smith, Brian O. Kennedy, Malcolm W. Córsico, Betina |
author_role |
author |
author2 |
Pórfido, Jorge Luis Ibáñez, Marina Rey, María Florencia Bélgamo, Julián Alberto Smith, Brian O. Kennedy, Malcolm W. Córsico, Betina |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Lipid Binding Proteins Parasitic Helminths Nematodes Fatty Acids |
topic |
Lipid Binding Proteins Parasitic Helminths Nematodes Fatty Acids |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
In this review paper we aim at presenting the current knowledge on structural aspects of soluble lipid binding proteins (LBPs) found in parasitic helminths and to discuss their potential role as novel drug targets. Helminth parasites produce and secrete a great variety of LBPs that may participate in the acquisition of nutrients from their host, such as fatty acids and cholesterol. It is also postulated that LBPs might interfere in the regulation of the host׳s immune response by sequestering lipidic intermediates or delivering bioactive lipids. A detailed comprehension of the structure of these proteins, as well as their interactions with ligands and membranes, is important to understand host–parasite relationships that they may mediate. This information could also contribute to determining the role that these proteins may play in the biology of parasitic helminths and how they modulate the immune systems of their hosts, and also towards the development of new therapeutics and prevention of the diseases caused by these highly pathogenic parasites. Fil: Franchini, Gisela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina Fil: Pórfido, Jorge Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina Fil: Ibáñez, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina Fil: Rey, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina Fil: Bélgamo, Julián Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina Fil: Smith, Brian O.. University of Glasgow; Reino Unido Fil: Kennedy, Malcolm W.. University of Glasgow; Reino Unido Fil: Córsico, Betina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina |
description |
In this review paper we aim at presenting the current knowledge on structural aspects of soluble lipid binding proteins (LBPs) found in parasitic helminths and to discuss their potential role as novel drug targets. Helminth parasites produce and secrete a great variety of LBPs that may participate in the acquisition of nutrients from their host, such as fatty acids and cholesterol. It is also postulated that LBPs might interfere in the regulation of the host׳s immune response by sequestering lipidic intermediates or delivering bioactive lipids. A detailed comprehension of the structure of these proteins, as well as their interactions with ligands and membranes, is important to understand host–parasite relationships that they may mediate. This information could also contribute to determining the role that these proteins may play in the biology of parasitic helminths and how they modulate the immune systems of their hosts, and also towards the development of new therapeutics and prevention of the diseases caused by these highly pathogenic parasites. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/34003 Franchini, Gisela Raquel; Pórfido, Jorge Luis; Ibáñez, Marina; Rey, María Florencia; Bélgamo, Julián Alberto; et al.; The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets; Elsevier; Prostaglandins Leukotrienes and Essential Fatty Acids; 93; 10-2014; 31-36 0952-3278 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/34003 |
identifier_str_mv |
Franchini, Gisela Raquel; Pórfido, Jorge Luis; Ibáñez, Marina; Rey, María Florencia; Bélgamo, Julián Alberto; et al.; The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets; Elsevier; Prostaglandins Leukotrienes and Essential Fatty Acids; 93; 10-2014; 31-36 0952-3278 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.plefa.2014.08.003 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0952327814001410 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |