The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets

Autores
Franchini, Gisela Raquel; Pórfido, Jorge Luis; Ibáñez, Marina; Rey, María Florencia; Bélgamo, Julián Alberto; Smith, Brian O.; Kennedy, Malcolm W.; Córsico, Betina
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this review paper we aim at presenting the current knowledge on structural aspects of soluble lipid binding proteins (LBPs) found in parasitic helminths and to discuss their potential role as novel drug targets. Helminth parasites produce and secrete a great variety of LBPs that may participate in the acquisition of nutrients from their host, such as fatty acids and cholesterol. It is also postulated that LBPs might interfere in the regulation of the host׳s immune response by sequestering lipidic intermediates or delivering bioactive lipids. A detailed comprehension of the structure of these proteins, as well as their interactions with ligands and membranes, is important to understand host–parasite relationships that they may mediate. This information could also contribute to determining the role that these proteins may play in the biology of parasitic helminths and how they modulate the immune systems of their hosts, and also towards the development of new therapeutics and prevention of the diseases caused by these highly pathogenic parasites.
Fil: Franchini, Gisela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Pórfido, Jorge Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Ibáñez, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Rey, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Bélgamo, Julián Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Smith, Brian O.. University of Glasgow; Reino Unido
Fil: Kennedy, Malcolm W.. University of Glasgow; Reino Unido
Fil: Córsico, Betina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Materia
Lipid Binding Proteins
Parasitic Helminths
Nematodes
Fatty Acids
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/34003
Acceder
id CONICETDig_69b9551656440d0133d51b7a4ef63963
oai_identifier_str oai:ri.conicet.gov.ar:11336/34003
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targetsFranchini, Gisela RaquelPórfido, Jorge LuisIbáñez, MarinaRey, María FlorenciaBélgamo, Julián AlbertoSmith, Brian O.Kennedy, Malcolm W.Córsico, BetinaLipid Binding ProteinsParasitic HelminthsNematodesFatty Acidshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In this review paper we aim at presenting the current knowledge on structural aspects of soluble lipid binding proteins (LBPs) found in parasitic helminths and to discuss their potential role as novel drug targets. Helminth parasites produce and secrete a great variety of LBPs that may participate in the acquisition of nutrients from their host, such as fatty acids and cholesterol. It is also postulated that LBPs might interfere in the regulation of the host׳s immune response by sequestering lipidic intermediates or delivering bioactive lipids. A detailed comprehension of the structure of these proteins, as well as their interactions with ligands and membranes, is important to understand host–parasite relationships that they may mediate. This information could also contribute to determining the role that these proteins may play in the biology of parasitic helminths and how they modulate the immune systems of their hosts, and also towards the development of new therapeutics and prevention of the diseases caused by these highly pathogenic parasites.Fil: Franchini, Gisela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaFil: Pórfido, Jorge Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaFil: Ibáñez, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaFil: Rey, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaFil: Bélgamo, Julián Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaFil: Smith, Brian O.. University of Glasgow; Reino UnidoFil: Kennedy, Malcolm W.. University of Glasgow; Reino UnidoFil: Córsico, Betina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaElsevier2014-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/34003Franchini, Gisela Raquel; Pórfido, Jorge Luis; Ibáñez, Marina; Rey, María Florencia; Bélgamo, Julián Alberto; et al.; The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets; Elsevier; Prostaglandins Leukotrienes and Essential Fatty Acids; 93; 10-2014; 31-360952-3278CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.plefa.2014.08.003info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0952327814001410info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:58:11Zoai:ri.conicet.gov.ar:11336/34003instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:58:12.036CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets
title The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets
spellingShingle The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets
Franchini, Gisela Raquel
Lipid Binding Proteins
Parasitic Helminths
Nematodes
Fatty Acids
title_short The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets
title_full The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets
title_fullStr The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets
title_full_unstemmed The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets
title_sort The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets
dc.creator.none.fl_str_mv Franchini, Gisela Raquel
Pórfido, Jorge Luis
Ibáñez, Marina
Rey, María Florencia
Bélgamo, Julián Alberto
Smith, Brian O.
Kennedy, Malcolm W.
Córsico, Betina
author Franchini, Gisela Raquel
author_facet Franchini, Gisela Raquel
Pórfido, Jorge Luis
Ibáñez, Marina
Rey, María Florencia
Bélgamo, Julián Alberto
Smith, Brian O.
Kennedy, Malcolm W.
Córsico, Betina
author_role author
author2 Pórfido, Jorge Luis
Ibáñez, Marina
Rey, María Florencia
Bélgamo, Julián Alberto
Smith, Brian O.
Kennedy, Malcolm W.
Córsico, Betina
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Lipid Binding Proteins
Parasitic Helminths
Nematodes
Fatty Acids
topic Lipid Binding Proteins
Parasitic Helminths
Nematodes
Fatty Acids
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this review paper we aim at presenting the current knowledge on structural aspects of soluble lipid binding proteins (LBPs) found in parasitic helminths and to discuss their potential role as novel drug targets. Helminth parasites produce and secrete a great variety of LBPs that may participate in the acquisition of nutrients from their host, such as fatty acids and cholesterol. It is also postulated that LBPs might interfere in the regulation of the host׳s immune response by sequestering lipidic intermediates or delivering bioactive lipids. A detailed comprehension of the structure of these proteins, as well as their interactions with ligands and membranes, is important to understand host–parasite relationships that they may mediate. This information could also contribute to determining the role that these proteins may play in the biology of parasitic helminths and how they modulate the immune systems of their hosts, and also towards the development of new therapeutics and prevention of the diseases caused by these highly pathogenic parasites.
Fil: Franchini, Gisela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Pórfido, Jorge Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Ibáñez, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Rey, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Bélgamo, Julián Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Smith, Brian O.. University of Glasgow; Reino Unido
Fil: Kennedy, Malcolm W.. University of Glasgow; Reino Unido
Fil: Córsico, Betina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
description In this review paper we aim at presenting the current knowledge on structural aspects of soluble lipid binding proteins (LBPs) found in parasitic helminths and to discuss their potential role as novel drug targets. Helminth parasites produce and secrete a great variety of LBPs that may participate in the acquisition of nutrients from their host, such as fatty acids and cholesterol. It is also postulated that LBPs might interfere in the regulation of the host׳s immune response by sequestering lipidic intermediates or delivering bioactive lipids. A detailed comprehension of the structure of these proteins, as well as their interactions with ligands and membranes, is important to understand host–parasite relationships that they may mediate. This information could also contribute to determining the role that these proteins may play in the biology of parasitic helminths and how they modulate the immune systems of their hosts, and also towards the development of new therapeutics and prevention of the diseases caused by these highly pathogenic parasites.
publishDate 2014
dc.date.none.fl_str_mv 2014-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/34003
Franchini, Gisela Raquel; Pórfido, Jorge Luis; Ibáñez, Marina; Rey, María Florencia; Bélgamo, Julián Alberto; et al.; The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets; Elsevier; Prostaglandins Leukotrienes and Essential Fatty Acids; 93; 10-2014; 31-36
0952-3278
CONICET Digital
CONICET
url http://hdl.handle.net/11336/34003
identifier_str_mv Franchini, Gisela Raquel; Pórfido, Jorge Luis; Ibáñez, Marina; Rey, María Florencia; Bélgamo, Julián Alberto; et al.; The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets; Elsevier; Prostaglandins Leukotrienes and Essential Fatty Acids; 93; 10-2014; 31-36
0952-3278
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.plefa.2014.08.003
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0952327814001410
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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