Diferente susceptibilidad de ratones endocriados libres de patógenos específicos a la inoculación experimental de Serpulina hyodysenteriae

Autores
Giacoboni, Gabriela Isabel; Risso, Miguel Atilio; Massone, Adriana Raquel; Perfumo, Carlos Juan
Año de publicación
1998
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In order to determine susceptibility to Serpulina hyodysenteriae infection four inbred strains of SPF mice(Balb/cAnN, Balb/J, C57BL/6J and C57BL/6N) were inoculated with a single intragastric dose of 107 to 108colony forming units ( CFU ) Serpulina hyodysenteriae DJ 70 strain ( S.h ). The criteria used to evaluate theinfection were shedding of bacteria, in faeces at 3, 5, and 7 days post-inoculation (d.p.i), CFU per gram ofcecum, cecal macroscopic changes and histopathological lesions at 14 d.p.i. According to the bacteriologicalcounts and the degree of macroscopic changes the C57BL/6J mice strain seemed to be the most susceptible.Globlet cell hyperplasia, mononuclear cell infiltration of lamina propria and inflammatory oedema ofsubmucosa membrane were the most remarkable changes. No correlation between the lesions and the degreeof macroscopic findings was observed. Histopathological changes found in mice were correlated with thosereported previously in this species, but they differed from those found in pigs. However, progressivebacteriological counts and gross changes of cecum appeared to be a good indicators of S.h infection inC57BL/6J mice and this strain may be a useful animal model in order to study the "in vivo" sensibility of S.h to different antibiotics and chemotherapeutic.
Facultad de Ciencias Veterinarias
Materia
Ciencias Veterinarias
Serpulina hyodysenteriae
Inoculación experimental
Cepas de ratones SPF
Bacteriología-Patología
Experimental inoculation
SPF mice strains
Bacteriology-pathology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/117579
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/117579
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Diferente susceptibilidad de ratones endocriados libres de patógenos específicos a la inoculación experimental de Serpulina hyodysenteriaeDifferent susceptibility of inbred specific pathogen free strains of mice to experimental inoculation with Serpulina hyodysenteriaeGiacoboni, Gabriela IsabelRisso, Miguel AtilioMassone, Adriana RaquelPerfumo, Carlos JuanCiencias VeterinariasSerpulina hyodysenteriaeInoculación experimentalCepas de ratones SPFBacteriología-PatologíaExperimental inoculationSPF mice strainsBacteriology-pathologyIn order to determine susceptibility to Serpulina hyodysenteriae infection four inbred strains of SPF mice(Balb/cAnN, Balb/J, C57BL/6J and C57BL/6N) were inoculated with a single intragastric dose of 107 to 108colony forming units ( CFU ) Serpulina hyodysenteriae DJ 70 strain ( S.h ). The criteria used to evaluate theinfection were shedding of bacteria, in faeces at 3, 5, and 7 days post-inoculation (d.p.i), CFU per gram ofcecum, cecal macroscopic changes and histopathological lesions at 14 d.p.i. According to the bacteriologicalcounts and the degree of macroscopic changes the C57BL/6J mice strain seemed to be the most susceptible.Globlet cell hyperplasia, mononuclear cell infiltration of lamina propria and inflammatory oedema ofsubmucosa membrane were the most remarkable changes. No correlation between the lesions and the degreeof macroscopic findings was observed. Histopathological changes found in mice were correlated with thosereported previously in this species, but they differed from those found in pigs. However, progressivebacteriological counts and gross changes of cecum appeared to be a good indicators of S.h infection inC57BL/6J mice and this strain may be a useful animal model in order to study the "in vivo" sensibility of S.h to different antibiotics and chemotherapeutic.Facultad de Ciencias Veterinarias1998info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/117579spainfo:eu-repo/semantics/altIdentifier/issn/0301-732Xinfo:eu-repo/semantics/altIdentifier/doi/10.4067/S0301-732X1998000200005info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0/Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:27:39Zoai:sedici.unlp.edu.ar:10915/117579Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:27:40.08SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Diferente susceptibilidad de ratones endocriados libres de patógenos específicos a la inoculación experimental de Serpulina hyodysenteriae
Different susceptibility of inbred specific pathogen free strains of mice to experimental inoculation with Serpulina hyodysenteriae
title Diferente susceptibilidad de ratones endocriados libres de patógenos específicos a la inoculación experimental de Serpulina hyodysenteriae
spellingShingle Diferente susceptibilidad de ratones endocriados libres de patógenos específicos a la inoculación experimental de Serpulina hyodysenteriae
Giacoboni, Gabriela Isabel
Ciencias Veterinarias
Serpulina hyodysenteriae
Inoculación experimental
Cepas de ratones SPF
Bacteriología-Patología
Experimental inoculation
SPF mice strains
Bacteriology-pathology
title_short Diferente susceptibilidad de ratones endocriados libres de patógenos específicos a la inoculación experimental de Serpulina hyodysenteriae
title_full Diferente susceptibilidad de ratones endocriados libres de patógenos específicos a la inoculación experimental de Serpulina hyodysenteriae
title_fullStr Diferente susceptibilidad de ratones endocriados libres de patógenos específicos a la inoculación experimental de Serpulina hyodysenteriae
title_full_unstemmed Diferente susceptibilidad de ratones endocriados libres de patógenos específicos a la inoculación experimental de Serpulina hyodysenteriae
title_sort Diferente susceptibilidad de ratones endocriados libres de patógenos específicos a la inoculación experimental de Serpulina hyodysenteriae
dc.creator.none.fl_str_mv Giacoboni, Gabriela Isabel
Risso, Miguel Atilio
Massone, Adriana Raquel
Perfumo, Carlos Juan
author Giacoboni, Gabriela Isabel
author_facet Giacoboni, Gabriela Isabel
Risso, Miguel Atilio
Massone, Adriana Raquel
Perfumo, Carlos Juan
author_role author
author2 Risso, Miguel Atilio
Massone, Adriana Raquel
Perfumo, Carlos Juan
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Veterinarias
Serpulina hyodysenteriae
Inoculación experimental
Cepas de ratones SPF
Bacteriología-Patología
Experimental inoculation
SPF mice strains
Bacteriology-pathology
topic Ciencias Veterinarias
Serpulina hyodysenteriae
Inoculación experimental
Cepas de ratones SPF
Bacteriología-Patología
Experimental inoculation
SPF mice strains
Bacteriology-pathology
dc.description.none.fl_txt_mv In order to determine susceptibility to Serpulina hyodysenteriae infection four inbred strains of SPF mice(Balb/cAnN, Balb/J, C57BL/6J and C57BL/6N) were inoculated with a single intragastric dose of 107 to 108colony forming units ( CFU ) Serpulina hyodysenteriae DJ 70 strain ( S.h ). The criteria used to evaluate theinfection were shedding of bacteria, in faeces at 3, 5, and 7 days post-inoculation (d.p.i), CFU per gram ofcecum, cecal macroscopic changes and histopathological lesions at 14 d.p.i. According to the bacteriologicalcounts and the degree of macroscopic changes the C57BL/6J mice strain seemed to be the most susceptible.Globlet cell hyperplasia, mononuclear cell infiltration of lamina propria and inflammatory oedema ofsubmucosa membrane were the most remarkable changes. No correlation between the lesions and the degreeof macroscopic findings was observed. Histopathological changes found in mice were correlated with thosereported previously in this species, but they differed from those found in pigs. However, progressivebacteriological counts and gross changes of cecum appeared to be a good indicators of S.h infection inC57BL/6J mice and this strain may be a useful animal model in order to study the "in vivo" sensibility of S.h to different antibiotics and chemotherapeutic.
Facultad de Ciencias Veterinarias
description In order to determine susceptibility to Serpulina hyodysenteriae infection four inbred strains of SPF mice(Balb/cAnN, Balb/J, C57BL/6J and C57BL/6N) were inoculated with a single intragastric dose of 107 to 108colony forming units ( CFU ) Serpulina hyodysenteriae DJ 70 strain ( S.h ). The criteria used to evaluate theinfection were shedding of bacteria, in faeces at 3, 5, and 7 days post-inoculation (d.p.i), CFU per gram ofcecum, cecal macroscopic changes and histopathological lesions at 14 d.p.i. According to the bacteriologicalcounts and the degree of macroscopic changes the C57BL/6J mice strain seemed to be the most susceptible.Globlet cell hyperplasia, mononuclear cell infiltration of lamina propria and inflammatory oedema ofsubmucosa membrane were the most remarkable changes. No correlation between the lesions and the degreeof macroscopic findings was observed. Histopathological changes found in mice were correlated with thosereported previously in this species, but they differed from those found in pigs. However, progressivebacteriological counts and gross changes of cecum appeared to be a good indicators of S.h infection inC57BL/6J mice and this strain may be a useful animal model in order to study the "in vivo" sensibility of S.h to different antibiotics and chemotherapeutic.
publishDate 1998
dc.date.none.fl_str_mv 1998
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/117579
url http://sedici.unlp.edu.ar/handle/10915/117579
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0301-732X
info:eu-repo/semantics/altIdentifier/doi/10.4067/S0301-732X1998000200005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.format.none.fl_str_mv application/pdf
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institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
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