Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger

Autores
Cingolani, Horacio Eugenio; Pérez, Néstor Gustavo; Caldiz, Claudia Irma; Garciarena, Carolina Denis; De Giusti, Verónica Celeste; Correa, María Verónica; Villa Abrille, María Celeste; Yeves, Alejandra del Milagro; Ennis, Irene Lucía; Chiappe de Cingolani, Gladys Ethel; Aiello, Ernesto Alejandro; Kamkin, Andre; Kiseleva, Irina
Año de publicación
2010
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
In this chapter the enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy.We propose that the chain of events triggered by stretch begins with the release of small amounts of angiotensin II which in turn induce the release/formation of endothelin. The actions of these hormones trigger the production of mitochondrial reactive oxygen species that enhances NHE-1 activity, causing an increment in the intracellular Na+ concentration which promotes the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger. This [Ca2+]i increase would trigger cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways.
Centro de Investigaciones Cardiovasculares
Materia
Ciencias Médicas
Myocardium
Stretch
Sodium/hydrogen exchanger
Reactive oxygen species
Hypertrophy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/138476
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/138476
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen ExchangerCingolani, Horacio EugenioPérez, Néstor GustavoCaldiz, Claudia IrmaGarciarena, Carolina DenisDe Giusti, Verónica CelesteCorrea, María VerónicaVilla Abrille, María CelesteYeves, Alejandra del MilagroEnnis, Irene LucíaChiappe de Cingolani, Gladys EthelAiello, Ernesto AlejandroKamkin, AndreKiseleva, IrinaCiencias MédicasMyocardiumStretchSodium/hydrogen exchangerReactive oxygen speciesHypertrophyIn this chapter the enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy.We propose that the chain of events triggered by stretch begins with the release of small amounts of angiotensin II which in turn induce the release/formation of endothelin. The actions of these hormones trigger the production of mitochondrial reactive oxygen species that enhances NHE-1 activity, causing an increment in the intracellular Na+ concentration which promotes the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger. This [Ca2+]i increase would trigger cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways.Centro de Investigaciones CardiovascularesSpringer2010info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionCapitulo de librohttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/138476enginfo:eu-repo/semantics/altIdentifier/isbn/978-90-481-2850-1info:eu-repo/semantics/altIdentifier/doi/10.1007/978-90-481-2850-1_13info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-17T10:17:54Zoai:sedici.unlp.edu.ar:10915/138476Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-17 10:17:54.599SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
title Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
spellingShingle Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
Cingolani, Horacio Eugenio
Ciencias Médicas
Myocardium
Stretch
Sodium/hydrogen exchanger
Reactive oxygen species
Hypertrophy
title_short Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
title_full Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
title_fullStr Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
title_full_unstemmed Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
title_sort Early Hypertrophic Signals After Myocardial Stretch : Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger
dc.creator.none.fl_str_mv Cingolani, Horacio Eugenio
Pérez, Néstor Gustavo
Caldiz, Claudia Irma
Garciarena, Carolina Denis
De Giusti, Verónica Celeste
Correa, María Verónica
Villa Abrille, María Celeste
Yeves, Alejandra del Milagro
Ennis, Irene Lucía
Chiappe de Cingolani, Gladys Ethel
Aiello, Ernesto Alejandro
Kamkin, Andre
Kiseleva, Irina
author Cingolani, Horacio Eugenio
author_facet Cingolani, Horacio Eugenio
Pérez, Néstor Gustavo
Caldiz, Claudia Irma
Garciarena, Carolina Denis
De Giusti, Verónica Celeste
Correa, María Verónica
Villa Abrille, María Celeste
Yeves, Alejandra del Milagro
Ennis, Irene Lucía
Chiappe de Cingolani, Gladys Ethel
Aiello, Ernesto Alejandro
Kamkin, Andre
Kiseleva, Irina
author_role author
author2 Pérez, Néstor Gustavo
Caldiz, Claudia Irma
Garciarena, Carolina Denis
De Giusti, Verónica Celeste
Correa, María Verónica
Villa Abrille, María Celeste
Yeves, Alejandra del Milagro
Ennis, Irene Lucía
Chiappe de Cingolani, Gladys Ethel
Aiello, Ernesto Alejandro
Kamkin, Andre
Kiseleva, Irina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Myocardium
Stretch
Sodium/hydrogen exchanger
Reactive oxygen species
Hypertrophy
topic Ciencias Médicas
Myocardium
Stretch
Sodium/hydrogen exchanger
Reactive oxygen species
Hypertrophy
dc.description.none.fl_txt_mv In this chapter the enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy.We propose that the chain of events triggered by stretch begins with the release of small amounts of angiotensin II which in turn induce the release/formation of endothelin. The actions of these hormones trigger the production of mitochondrial reactive oxygen species that enhances NHE-1 activity, causing an increment in the intracellular Na+ concentration which promotes the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger. This [Ca2+]i increase would trigger cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways.
Centro de Investigaciones Cardiovasculares
description In this chapter the enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy.We propose that the chain of events triggered by stretch begins with the release of small amounts of angiotensin II which in turn induce the release/formation of endothelin. The actions of these hormones trigger the production of mitochondrial reactive oxygen species that enhances NHE-1 activity, causing an increment in the intracellular Na+ concentration which promotes the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger. This [Ca2+]i increase would trigger cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/bookPart
info:eu-repo/semantics/publishedVersion
Capitulo de libro
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
format bookPart
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/138476
url http://sedici.unlp.edu.ar/handle/10915/138476
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/isbn/978-90-481-2850-1
info:eu-repo/semantics/altIdentifier/doi/10.1007/978-90-481-2850-1_13
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.001348

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