Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart
- Autores
- Cingolani, Horacio Eugenio; Pérez, Néstor Gustavo; Camilión de Hurtado, María Cristina
- Año de publicación
- 2003
- Idioma
- español castellano
- Tipo de recurso
- parte de libro
- Estado
- versión publicada
- Descripción
- An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves the release of angiotensin II (Ang II), the release/increased formation of endothelin (ET), the activation of the Na+/H+ exchanger (NHE), the increase in intracellular Na+ concentration ([Na+]i), and the increase in the Ca2+ transient that underlies the so called slow force response (SFR) to stretch. This autocrine/paracrine mechanism could explain how a change in afterload alters cardiac contractility as was reported by Anrep in 1912.
Facultad de Ciencias Médicas - Materia
-
Medicina
myocardial stretch
Na+/Ca2+ exchange
angiotensin II
endothelin hypertrophy - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/133387
Ver los metadatos del registro completo
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Stretch-Elicited Autocrine/Paracrine Mechanism in the HeartCingolani, Horacio EugenioPérez, Néstor GustavoCamilión de Hurtado, María CristinaMedicinamyocardial stretchNa+/Ca2+ exchangeangiotensin IIendothelin hypertrophyAn autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves the release of angiotensin II (Ang II), the release/increased formation of endothelin (ET), the activation of the Na<sup>+</sup>/H<sup>+</sup> exchanger (NHE), the increase in intracellular Na<sup>+</sup> concentration ([Na<sup>+</sup>]<sub>i</sub>), and the increase in the Ca<sup>2+</sup> transient that underlies the so called slow force response (SFR) to stretch. This autocrine/paracrine mechanism could explain how a change in afterload alters cardiac contractility as was reported by Anrep in 1912.Facultad de Ciencias MédicasSpringer2003info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionCapitulo de librohttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdf37-48http://sedici.unlp.edu.ar/handle/10915/133387spainfo:eu-repo/semantics/altIdentifier/isbn/978-1-4615-0347-7info:eu-repo/semantics/altIdentifier/issn/1389-1774info:eu-repo/semantics/altIdentifier/doi/10.1007/978-1-4615-0347-7_3info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:23:37Zoai:sedici.unlp.edu.ar:10915/133387Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:23:38.083SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart |
| title |
Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart |
| spellingShingle |
Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart Cingolani, Horacio Eugenio Medicina myocardial stretch Na+/Ca2+ exchange angiotensin II endothelin hypertrophy |
| title_short |
Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart |
| title_full |
Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart |
| title_fullStr |
Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart |
| title_full_unstemmed |
Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart |
| title_sort |
Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart |
| dc.creator.none.fl_str_mv |
Cingolani, Horacio Eugenio Pérez, Néstor Gustavo Camilión de Hurtado, María Cristina |
| author |
Cingolani, Horacio Eugenio |
| author_facet |
Cingolani, Horacio Eugenio Pérez, Néstor Gustavo Camilión de Hurtado, María Cristina |
| author_role |
author |
| author2 |
Pérez, Néstor Gustavo Camilión de Hurtado, María Cristina |
| author2_role |
author author |
| dc.subject.none.fl_str_mv |
Medicina myocardial stretch Na+/Ca2+ exchange angiotensin II endothelin hypertrophy |
| topic |
Medicina myocardial stretch Na+/Ca2+ exchange angiotensin II endothelin hypertrophy |
| dc.description.none.fl_txt_mv |
An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves the release of angiotensin II (Ang II), the release/increased formation of endothelin (ET), the activation of the Na<sup>+</sup>/H<sup>+</sup> exchanger (NHE), the increase in intracellular Na<sup>+</sup> concentration ([Na<sup>+</sup>]<sub>i</sub>), and the increase in the Ca<sup>2+</sup> transient that underlies the so called slow force response (SFR) to stretch. This autocrine/paracrine mechanism could explain how a change in afterload alters cardiac contractility as was reported by Anrep in 1912. Facultad de Ciencias Médicas |
| description |
An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves the release of angiotensin II (Ang II), the release/increased formation of endothelin (ET), the activation of the Na<sup>+</sup>/H<sup>+</sup> exchanger (NHE), the increase in intracellular Na<sup>+</sup> concentration ([Na<sup>+</sup>]<sub>i</sub>), and the increase in the Ca<sup>2+</sup> transient that underlies the so called slow force response (SFR) to stretch. This autocrine/paracrine mechanism could explain how a change in afterload alters cardiac contractility as was reported by Anrep in 1912. |
| publishDate |
2003 |
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2003 |
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info:eu-repo/semantics/bookPart info:eu-repo/semantics/publishedVersion Capitulo de libro http://purl.org/coar/resource_type/c_3248 info:ar-repo/semantics/parteDeLibro |
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http://sedici.unlp.edu.ar/handle/10915/133387 |
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Springer |
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