The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector <i>Rhodnius prolixus</i>

Autores
Capriotti, Natalia; Ianowski, Juan P.; Gioino, Paula; Ons, Sheila
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Given that hematophagous insects ingest large quantities of blood in a single meal, they must undergo a rapid post-prandial diuresis in order to maintain homeostasis. In the kissing bug Rhodnius prolixus (Hemiptera: Reduviidae), the coordinated activity of the Malpighian tubules and anterior midgut maintains water and ion balance during the post-prandial diuresis. Three to four hours after the meal the diuretic process finishes, and the animal enters an antidiuretic state to ensure water conservation until the next blood intake. The diuretic and antidiuretic processes are tightly regulated by serotonin and neuropeptides in this insect. In the present work, we report that the neuropeptide precursor CCHamide 2 is involved in the regulation of the post-prandial diuresis in the kissing bug R. prolixus. Our results suggest a dual effect of RhoprCCHamide2 peptide, enhancing the serotonin-induced secretion by Malpighian tubules, and inhibiting serotonin-induced absorption across the anterior midgut. To our knowledge, this is the first report of a hormone presenting opposite effects in the two osmoregulatory organs (i.e. midgut and Malpighian tubules) in insects, probably reflecting the importance of a well-tuned diuretic process in hematophagous insects during different moments after the blood meal.
Facultad de Ciencias Exactas
Centro Regional de Estudios Genómicos
Materia
Ciencias Exactas
Insect
Anterior midgut
Malpighian tubules
Kissing bug
Hematophagy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/124684
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/124684
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repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector <i>Rhodnius prolixus</i>Capriotti, NataliaIanowski, Juan P.Gioino, PaulaOns, SheilaCiencias ExactasInsectAnterior midgutMalpighian tubulesKissing bugHematophagyGiven that hematophagous insects ingest large quantities of blood in a single meal, they must undergo a rapid post-prandial diuresis in order to maintain homeostasis. In the kissing bug <i>Rhodnius prolixus</i> (Hemiptera: Reduviidae), the coordinated activity of the Malpighian tubules and anterior midgut maintains water and ion balance during the post-prandial diuresis. Three to four hours after the meal the diuretic process finishes, and the animal enters an antidiuretic state to ensure water conservation until the next blood intake. The diuretic and antidiuretic processes are tightly regulated by serotonin and neuropeptides in this insect. In the present work, we report that the neuropeptide precursor CCHamide 2 is involved in the regulation of the post-prandial diuresis in the kissing bug <i>R. prolixus</i>. Our results suggest a dual effect of RhoprCCHamide2 peptide, enhancing the serotonin-induced secretion by Malpighian tubules, and inhibiting serotonin-induced absorption across the anterior midgut. To our knowledge, this is the first report of a hormone presenting opposite effects in the two osmoregulatory organs (i.e. midgut and Malpighian tubules) in insects, probably reflecting the importance of a well-tuned diuretic process in hematophagous insects during different moments after the blood meal.Facultad de Ciencias ExactasCentro Regional de Estudios Genómicos2019-05-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/124684enginfo:eu-repo/semantics/altIdentifier/issn/1477-9145info:eu-repo/semantics/altIdentifier/issn/0022-0949info:eu-repo/semantics/altIdentifier/pmid/31053646info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.203000info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:29:49Zoai:sedici.unlp.edu.ar:10915/124684Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:29:49.36SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector <i>Rhodnius prolixus</i>
title The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector <i>Rhodnius prolixus</i>
spellingShingle The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector <i>Rhodnius prolixus</i>
Capriotti, Natalia
Ciencias Exactas
Insect
Anterior midgut
Malpighian tubules
Kissing bug
Hematophagy
title_short The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector <i>Rhodnius prolixus</i>
title_full The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector <i>Rhodnius prolixus</i>
title_fullStr The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector <i>Rhodnius prolixus</i>
title_full_unstemmed The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector <i>Rhodnius prolixus</i>
title_sort The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector <i>Rhodnius prolixus</i>
dc.creator.none.fl_str_mv Capriotti, Natalia
Ianowski, Juan P.
Gioino, Paula
Ons, Sheila
author Capriotti, Natalia
author_facet Capriotti, Natalia
Ianowski, Juan P.
Gioino, Paula
Ons, Sheila
author_role author
author2 Ianowski, Juan P.
Gioino, Paula
Ons, Sheila
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Insect
Anterior midgut
Malpighian tubules
Kissing bug
Hematophagy
topic Ciencias Exactas
Insect
Anterior midgut
Malpighian tubules
Kissing bug
Hematophagy
dc.description.none.fl_txt_mv Given that hematophagous insects ingest large quantities of blood in a single meal, they must undergo a rapid post-prandial diuresis in order to maintain homeostasis. In the kissing bug <i>Rhodnius prolixus</i> (Hemiptera: Reduviidae), the coordinated activity of the Malpighian tubules and anterior midgut maintains water and ion balance during the post-prandial diuresis. Three to four hours after the meal the diuretic process finishes, and the animal enters an antidiuretic state to ensure water conservation until the next blood intake. The diuretic and antidiuretic processes are tightly regulated by serotonin and neuropeptides in this insect. In the present work, we report that the neuropeptide precursor CCHamide 2 is involved in the regulation of the post-prandial diuresis in the kissing bug <i>R. prolixus</i>. Our results suggest a dual effect of RhoprCCHamide2 peptide, enhancing the serotonin-induced secretion by Malpighian tubules, and inhibiting serotonin-induced absorption across the anterior midgut. To our knowledge, this is the first report of a hormone presenting opposite effects in the two osmoregulatory organs (i.e. midgut and Malpighian tubules) in insects, probably reflecting the importance of a well-tuned diuretic process in hematophagous insects during different moments after the blood meal.
Facultad de Ciencias Exactas
Centro Regional de Estudios Genómicos
description Given that hematophagous insects ingest large quantities of blood in a single meal, they must undergo a rapid post-prandial diuresis in order to maintain homeostasis. In the kissing bug <i>Rhodnius prolixus</i> (Hemiptera: Reduviidae), the coordinated activity of the Malpighian tubules and anterior midgut maintains water and ion balance during the post-prandial diuresis. Three to four hours after the meal the diuretic process finishes, and the animal enters an antidiuretic state to ensure water conservation until the next blood intake. The diuretic and antidiuretic processes are tightly regulated by serotonin and neuropeptides in this insect. In the present work, we report that the neuropeptide precursor CCHamide 2 is involved in the regulation of the post-prandial diuresis in the kissing bug <i>R. prolixus</i>. Our results suggest a dual effect of RhoprCCHamide2 peptide, enhancing the serotonin-induced secretion by Malpighian tubules, and inhibiting serotonin-induced absorption across the anterior midgut. To our knowledge, this is the first report of a hormone presenting opposite effects in the two osmoregulatory organs (i.e. midgut and Malpighian tubules) in insects, probably reflecting the importance of a well-tuned diuretic process in hematophagous insects during different moments after the blood meal.
publishDate 2019
dc.date.none.fl_str_mv 2019-05-22
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/124684
url http://sedici.unlp.edu.ar/handle/10915/124684
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1477-9145
info:eu-repo/semantics/altIdentifier/issn/0022-0949
info:eu-repo/semantics/altIdentifier/pmid/31053646
info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.203000
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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