The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector Rhodnius prolixus

Autores
Capriotti, Natalia; Ianowski, Juan Pablo; Gioino, Paula; Ons, Sheila
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Given that hematophagous insects ingest large quantities of blood in a single meal, they must undergo a rapid post-prandial diuresis in order to maintain homeostasis. In the kissing bug Rhodnius prolixus (Hemiptera: Reduviidae), the coordinated activity of the Malpighian tubules and anterior midgut maintains water and ion balance during the post-prandial diuresis. Three to four hours after the meal, the diuretic process finishes, and the animal enters an antidiuretic state to ensure water conservation until the next blood intake. The diuretic and antidiuretic processes are tightly regulated by serotonin and neuropeptides in this insect. In the present work, we report that the neuropeptide precursor CCHamide2 is involved in the regulation of the post-prandial diuresis in R. prolixus. Our results suggest a dual effect of RhoprCCHamide2 peptide, enhancing the serotonin-induced secretion by Malpighian tubules, and inhibiting serotonin-induced absorption across the anterior midgut. To our knowledge, this is the first report of a hormone presenting opposite effects in the two osmoregulatory organs (i.e. midgut and Malpighian tubules) in insects, probably reflecting the importance of a well-tuned diuretic process in hematophagous insects during different moments after the blood meal.
Fil: Capriotti, Natalia. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Ianowski, Juan Pablo. University of Saskatchewan; Canadá
Fil: Gioino, Paula. University of Saskatchewan; Canadá
Fil: Ons, Sheila. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
ANTERIOR MIDGUT
HEMATOPHAGY
INSECT
KISSING BUG
MALPIGHIAN TUBULES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/119440
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector Rhodnius prolixusCapriotti, NataliaIanowski, Juan PabloGioino, PaulaOns, SheilaANTERIOR MIDGUTHEMATOPHAGYINSECTKISSING BUGMALPIGHIAN TUBULEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Given that hematophagous insects ingest large quantities of blood in a single meal, they must undergo a rapid post-prandial diuresis in order to maintain homeostasis. In the kissing bug Rhodnius prolixus (Hemiptera: Reduviidae), the coordinated activity of the Malpighian tubules and anterior midgut maintains water and ion balance during the post-prandial diuresis. Three to four hours after the meal, the diuretic process finishes, and the animal enters an antidiuretic state to ensure water conservation until the next blood intake. The diuretic and antidiuretic processes are tightly regulated by serotonin and neuropeptides in this insect. In the present work, we report that the neuropeptide precursor CCHamide2 is involved in the regulation of the post-prandial diuresis in R. prolixus. Our results suggest a dual effect of RhoprCCHamide2 peptide, enhancing the serotonin-induced secretion by Malpighian tubules, and inhibiting serotonin-induced absorption across the anterior midgut. To our knowledge, this is the first report of a hormone presenting opposite effects in the two osmoregulatory organs (i.e. midgut and Malpighian tubules) in insects, probably reflecting the importance of a well-tuned diuretic process in hematophagous insects during different moments after the blood meal.Fil: Capriotti, Natalia. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Ianowski, Juan Pablo. University of Saskatchewan; CanadáFil: Gioino, Paula. University of Saskatchewan; CanadáFil: Ons, Sheila. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaCompany of Biologists2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/119440Capriotti, Natalia; Ianowski, Juan Pablo; Gioino, Paula; Ons, Sheila; The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector Rhodnius prolixus; Company of Biologists; Journal of Experimental Biology; 222; 10; 5-2019; 1-80022-0949CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jeb.biologists.org/lookup/doi/10.1242/jeb.203000info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.203000info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/31053646/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:28Zoai:ri.conicet.gov.ar:11336/119440instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:28.819CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector Rhodnius prolixus
title The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector Rhodnius prolixus
spellingShingle The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector Rhodnius prolixus
Capriotti, Natalia
ANTERIOR MIDGUT
HEMATOPHAGY
INSECT
KISSING BUG
MALPIGHIAN TUBULES
title_short The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector Rhodnius prolixus
title_full The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector Rhodnius prolixus
title_fullStr The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector Rhodnius prolixus
title_full_unstemmed The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector Rhodnius prolixus
title_sort The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector Rhodnius prolixus
dc.creator.none.fl_str_mv Capriotti, Natalia
Ianowski, Juan Pablo
Gioino, Paula
Ons, Sheila
author Capriotti, Natalia
author_facet Capriotti, Natalia
Ianowski, Juan Pablo
Gioino, Paula
Ons, Sheila
author_role author
author2 Ianowski, Juan Pablo
Gioino, Paula
Ons, Sheila
author2_role author
author
author
dc.subject.none.fl_str_mv ANTERIOR MIDGUT
HEMATOPHAGY
INSECT
KISSING BUG
MALPIGHIAN TUBULES
topic ANTERIOR MIDGUT
HEMATOPHAGY
INSECT
KISSING BUG
MALPIGHIAN TUBULES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Given that hematophagous insects ingest large quantities of blood in a single meal, they must undergo a rapid post-prandial diuresis in order to maintain homeostasis. In the kissing bug Rhodnius prolixus (Hemiptera: Reduviidae), the coordinated activity of the Malpighian tubules and anterior midgut maintains water and ion balance during the post-prandial diuresis. Three to four hours after the meal, the diuretic process finishes, and the animal enters an antidiuretic state to ensure water conservation until the next blood intake. The diuretic and antidiuretic processes are tightly regulated by serotonin and neuropeptides in this insect. In the present work, we report that the neuropeptide precursor CCHamide2 is involved in the regulation of the post-prandial diuresis in R. prolixus. Our results suggest a dual effect of RhoprCCHamide2 peptide, enhancing the serotonin-induced secretion by Malpighian tubules, and inhibiting serotonin-induced absorption across the anterior midgut. To our knowledge, this is the first report of a hormone presenting opposite effects in the two osmoregulatory organs (i.e. midgut and Malpighian tubules) in insects, probably reflecting the importance of a well-tuned diuretic process in hematophagous insects during different moments after the blood meal.
Fil: Capriotti, Natalia. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Ianowski, Juan Pablo. University of Saskatchewan; Canadá
Fil: Gioino, Paula. University of Saskatchewan; Canadá
Fil: Ons, Sheila. Universidad Nacional de La Plata. Centro Regional de Estudios Genómicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description Given that hematophagous insects ingest large quantities of blood in a single meal, they must undergo a rapid post-prandial diuresis in order to maintain homeostasis. In the kissing bug Rhodnius prolixus (Hemiptera: Reduviidae), the coordinated activity of the Malpighian tubules and anterior midgut maintains water and ion balance during the post-prandial diuresis. Three to four hours after the meal, the diuretic process finishes, and the animal enters an antidiuretic state to ensure water conservation until the next blood intake. The diuretic and antidiuretic processes are tightly regulated by serotonin and neuropeptides in this insect. In the present work, we report that the neuropeptide precursor CCHamide2 is involved in the regulation of the post-prandial diuresis in R. prolixus. Our results suggest a dual effect of RhoprCCHamide2 peptide, enhancing the serotonin-induced secretion by Malpighian tubules, and inhibiting serotonin-induced absorption across the anterior midgut. To our knowledge, this is the first report of a hormone presenting opposite effects in the two osmoregulatory organs (i.e. midgut and Malpighian tubules) in insects, probably reflecting the importance of a well-tuned diuretic process in hematophagous insects during different moments after the blood meal.
publishDate 2019
dc.date.none.fl_str_mv 2019-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/119440
Capriotti, Natalia; Ianowski, Juan Pablo; Gioino, Paula; Ons, Sheila; The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector Rhodnius prolixus; Company of Biologists; Journal of Experimental Biology; 222; 10; 5-2019; 1-8
0022-0949
CONICET Digital
CONICET
url http://hdl.handle.net/11336/119440
identifier_str_mv Capriotti, Natalia; Ianowski, Juan Pablo; Gioino, Paula; Ons, Sheila; The neuropeptide CCHamide2 regulates diuresis in the Chagas disease vector Rhodnius prolixus; Company of Biologists; Journal of Experimental Biology; 222; 10; 5-2019; 1-8
0022-0949
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://jeb.biologists.org/lookup/doi/10.1242/jeb.203000
info:eu-repo/semantics/altIdentifier/doi/10.1242/jeb.203000
info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/31053646/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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