Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
- Autores
- Minvielle, Marta Cecilia; Basualdo Farjat, Juan Ángel; Ciarmela, María Laura; Niedfeld, Germán
- Año de publicación
- 1999
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The anthelmintic effect of tinidazole (100 mg/kg per day for 3 successive days) was tested in male Swiss CF-1 mice infected with second-stage Toxocara canis larvae at challenge doses of 250, 500, 1000, and 1500 embryonated eggs per mouse. The drug was given orally on days 3–5 postinfection (p.i.) to one-half of the animals, and all mice were killed on day 40 p.i. The number of larvae recovered from each mouse's brain and skeletal muscle was then scored in both groups. Tinidazole yielded a highly significant reduction in the total recovery of larvae from the test animals' brains at the second and third inoculum levels but no statistically significant reduction at the highest larval dose as compared with the values obtained in the untreated control animals.
Facultad de Ciencias Médicas - Materia
-
Medicina
Toxocara canis
tinidazole - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/141455
Ver los metadatos del registro completo
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Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in miceMinvielle, Marta CeciliaBasualdo Farjat, Juan ÁngelCiarmela, María LauraNiedfeld, GermánMedicinaToxocara canistinidazoleThe anthelmintic effect of tinidazole (100 mg/kg per day for 3 successive days) was tested in male Swiss CF-1 mice infected with second-stage Toxocara canis larvae at challenge doses of 250, 500, 1000, and 1500 embryonated eggs per mouse. The drug was given orally on days 3–5 postinfection (p.i.) to one-half of the animals, and all mice were killed on day 40 p.i. The number of larvae recovered from each mouse's brain and skeletal muscle was then scored in both groups. Tinidazole yielded a highly significant reduction in the total recovery of larvae from the test animals' brains at the second and third inoculum levels but no statistically significant reduction at the highest larval dose as compared with the values obtained in the untreated control animals.Facultad de Ciencias Médicas1999-08-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf830-832http://sedici.unlp.edu.ar/handle/10915/141455enginfo:eu-repo/semantics/altIdentifier/issn/0932-0113info:eu-repo/semantics/altIdentifier/issn/1432-1955info:eu-repo/semantics/altIdentifier/doi/10.1007/s004360050640info:eu-repo/semantics/altIdentifier/pmid/10494809info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:24:03Zoai:sedici.unlp.edu.ar:10915/141455Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:24:03.417SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice |
title |
Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice |
spellingShingle |
Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice Minvielle, Marta Cecilia Medicina Toxocara canis tinidazole |
title_short |
Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice |
title_full |
Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice |
title_fullStr |
Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice |
title_full_unstemmed |
Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice |
title_sort |
Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice |
dc.creator.none.fl_str_mv |
Minvielle, Marta Cecilia Basualdo Farjat, Juan Ángel Ciarmela, María Laura Niedfeld, Germán |
author |
Minvielle, Marta Cecilia |
author_facet |
Minvielle, Marta Cecilia Basualdo Farjat, Juan Ángel Ciarmela, María Laura Niedfeld, Germán |
author_role |
author |
author2 |
Basualdo Farjat, Juan Ángel Ciarmela, María Laura Niedfeld, Germán |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Medicina Toxocara canis tinidazole |
topic |
Medicina Toxocara canis tinidazole |
dc.description.none.fl_txt_mv |
The anthelmintic effect of tinidazole (100 mg/kg per day for 3 successive days) was tested in male Swiss CF-1 mice infected with second-stage Toxocara canis larvae at challenge doses of 250, 500, 1000, and 1500 embryonated eggs per mouse. The drug was given orally on days 3–5 postinfection (p.i.) to one-half of the animals, and all mice were killed on day 40 p.i. The number of larvae recovered from each mouse's brain and skeletal muscle was then scored in both groups. Tinidazole yielded a highly significant reduction in the total recovery of larvae from the test animals' brains at the second and third inoculum levels but no statistically significant reduction at the highest larval dose as compared with the values obtained in the untreated control animals. Facultad de Ciencias Médicas |
description |
The anthelmintic effect of tinidazole (100 mg/kg per day for 3 successive days) was tested in male Swiss CF-1 mice infected with second-stage Toxocara canis larvae at challenge doses of 250, 500, 1000, and 1500 embryonated eggs per mouse. The drug was given orally on days 3–5 postinfection (p.i.) to one-half of the animals, and all mice were killed on day 40 p.i. The number of larvae recovered from each mouse's brain and skeletal muscle was then scored in both groups. Tinidazole yielded a highly significant reduction in the total recovery of larvae from the test animals' brains at the second and third inoculum levels but no statistically significant reduction at the highest larval dose as compared with the values obtained in the untreated control animals. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-08-24 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/141455 |
url |
http://sedici.unlp.edu.ar/handle/10915/141455 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/0932-0113 info:eu-repo/semantics/altIdentifier/issn/1432-1955 info:eu-repo/semantics/altIdentifier/doi/10.1007/s004360050640 info:eu-repo/semantics/altIdentifier/pmid/10494809 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
dc.format.none.fl_str_mv |
application/pdf 830-832 |
dc.source.none.fl_str_mv |
reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
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SEDICI (UNLP) |
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SEDICI (UNLP) |
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Universidad Nacional de La Plata |
instacron_str |
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UNLP |
repository.name.fl_str_mv |
SEDICI (UNLP) - Universidad Nacional de La Plata |
repository.mail.fl_str_mv |
alira@sedici.unlp.edu.ar |
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1846064294806945792 |
score |
13.22299 |