Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice

Autores
Minvielle, Marta Cecilia; Basualdo Farjat, Juan Ángel; Ciarmela, María Laura; Niedfeld, Germán
Año de publicación
1999
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The anthelmintic effect of tinidazole (100 mg/kg per day for 3 successive days) was tested in male Swiss CF-1 mice infected with second-stage Toxocara canis larvae at challenge doses of 250, 500, 1000, and 1500 embryonated eggs per mouse. The drug was given orally on days 3–5 postinfection (p.i.) to one-half of the animals, and all mice were killed on day 40 p.i. The number of larvae recovered from each mouse's brain and skeletal muscle was then scored in both groups. Tinidazole yielded a highly significant reduction in the total recovery of larvae from the test animals' brains at the second and third inoculum levels but no statistically significant reduction at the highest larval dose as compared with the values obtained in the untreated control animals.
Facultad de Ciencias Médicas
Materia
Medicina
Toxocara canis
tinidazole
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/141455

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network_name_str SEDICI (UNLP)
spelling Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in miceMinvielle, Marta CeciliaBasualdo Farjat, Juan ÁngelCiarmela, María LauraNiedfeld, GermánMedicinaToxocara canistinidazoleThe anthelmintic effect of tinidazole (100 mg/kg per day for 3 successive days) was tested in male Swiss CF-1 mice infected with second-stage Toxocara canis larvae at challenge doses of 250, 500, 1000, and 1500 embryonated eggs per mouse. The drug was given orally on days 3–5 postinfection (p.i.) to one-half of the animals, and all mice were killed on day 40 p.i. The number of larvae recovered from each mouse's brain and skeletal muscle was then scored in both groups. Tinidazole yielded a highly significant reduction in the total recovery of larvae from the test animals' brains at the second and third inoculum levels but no statistically significant reduction at the highest larval dose as compared with the values obtained in the untreated control animals.Facultad de Ciencias Médicas1999-08-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf830-832http://sedici.unlp.edu.ar/handle/10915/141455enginfo:eu-repo/semantics/altIdentifier/issn/0932-0113info:eu-repo/semantics/altIdentifier/issn/1432-1955info:eu-repo/semantics/altIdentifier/doi/10.1007/s004360050640info:eu-repo/semantics/altIdentifier/pmid/10494809info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:24:03Zoai:sedici.unlp.edu.ar:10915/141455Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:24:03.417SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
title Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
spellingShingle Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
Minvielle, Marta Cecilia
Medicina
Toxocara canis
tinidazole
title_short Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
title_full Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
title_fullStr Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
title_full_unstemmed Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
title_sort Anthelmintic efficacy of tinidazole against the progression of Toxocara canis larvae to the brain in mice
dc.creator.none.fl_str_mv Minvielle, Marta Cecilia
Basualdo Farjat, Juan Ángel
Ciarmela, María Laura
Niedfeld, Germán
author Minvielle, Marta Cecilia
author_facet Minvielle, Marta Cecilia
Basualdo Farjat, Juan Ángel
Ciarmela, María Laura
Niedfeld, Germán
author_role author
author2 Basualdo Farjat, Juan Ángel
Ciarmela, María Laura
Niedfeld, Germán
author2_role author
author
author
dc.subject.none.fl_str_mv Medicina
Toxocara canis
tinidazole
topic Medicina
Toxocara canis
tinidazole
dc.description.none.fl_txt_mv The anthelmintic effect of tinidazole (100 mg/kg per day for 3 successive days) was tested in male Swiss CF-1 mice infected with second-stage Toxocara canis larvae at challenge doses of 250, 500, 1000, and 1500 embryonated eggs per mouse. The drug was given orally on days 3–5 postinfection (p.i.) to one-half of the animals, and all mice were killed on day 40 p.i. The number of larvae recovered from each mouse's brain and skeletal muscle was then scored in both groups. Tinidazole yielded a highly significant reduction in the total recovery of larvae from the test animals' brains at the second and third inoculum levels but no statistically significant reduction at the highest larval dose as compared with the values obtained in the untreated control animals.
Facultad de Ciencias Médicas
description The anthelmintic effect of tinidazole (100 mg/kg per day for 3 successive days) was tested in male Swiss CF-1 mice infected with second-stage Toxocara canis larvae at challenge doses of 250, 500, 1000, and 1500 embryonated eggs per mouse. The drug was given orally on days 3–5 postinfection (p.i.) to one-half of the animals, and all mice were killed on day 40 p.i. The number of larvae recovered from each mouse's brain and skeletal muscle was then scored in both groups. Tinidazole yielded a highly significant reduction in the total recovery of larvae from the test animals' brains at the second and third inoculum levels but no statistically significant reduction at the highest larval dose as compared with the values obtained in the untreated control animals.
publishDate 1999
dc.date.none.fl_str_mv 1999-08-24
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/141455
url http://sedici.unlp.edu.ar/handle/10915/141455
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0932-0113
info:eu-repo/semantics/altIdentifier/issn/1432-1955
info:eu-repo/semantics/altIdentifier/doi/10.1007/s004360050640
info:eu-repo/semantics/altIdentifier/pmid/10494809
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
830-832
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
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instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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