The role of cytokines in the fibrotic responses in Crohn's disease

Autores
Curciarello, Renata; Docena, Guillermo Horacio; MacDonald, Thomas T.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Crohn's disease is an idiopathic disorder of the gut thought to be caused by a combination of environmental and genetic factors in susceptible individuals. It is characterized by chronic transmural inflammation of the terminal ileum and colon, with typical transmural lesions. Complications, including fibrosis, mean that between 40 and 70% of patients require surgery in the first 10 years after diagnosis. Presently, there is no evidence that the current therapies which dampen inflammation modulate or reverse intestinal fibrosis. In this review, we focus on cytokines that may lead to fibrosis and stenosis and the contribution of experimental models for understanding and treatment of gut fibrosis.
Instituto de Estudios Inmunológicos y Fisiopatológicos
Materia
Ciencias Exactas
Chronic inflammation
Crohn's disease
Cytokines
Extracellular matrix
Fibrosis
Fibrostenosis
Strictures
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/87426
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/87426
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling The role of cytokines in the fibrotic responses in Crohn's diseaseCurciarello, RenataDocena, Guillermo HoracioMacDonald, Thomas T.Ciencias ExactasChronic inflammationCrohn's diseaseCytokinesExtracellular matrixFibrosisFibrostenosisStricturesCrohn's disease is an idiopathic disorder of the gut thought to be caused by a combination of environmental and genetic factors in susceptible individuals. It is characterized by chronic transmural inflammation of the terminal ileum and colon, with typical transmural lesions. Complications, including fibrosis, mean that between 40 and 70% of patients require surgery in the first 10 years after diagnosis. Presently, there is no evidence that the current therapies which dampen inflammation modulate or reverse intestinal fibrosis. In this review, we focus on cytokines that may lead to fibrosis and stenosis and the contribution of experimental models for understanding and treatment of gut fibrosis.Instituto de Estudios Inmunológicos y Fisiopatológicos2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/87426enginfo:eu-repo/semantics/altIdentifier/issn/2296-858Xinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fmed.2017.00126info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:17:18Zoai:sedici.unlp.edu.ar:10915/87426Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:17:19.141SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The role of cytokines in the fibrotic responses in Crohn's disease
title The role of cytokines in the fibrotic responses in Crohn's disease
spellingShingle The role of cytokines in the fibrotic responses in Crohn's disease
Curciarello, Renata
Ciencias Exactas
Chronic inflammation
Crohn's disease
Cytokines
Extracellular matrix
Fibrosis
Fibrostenosis
Strictures
title_short The role of cytokines in the fibrotic responses in Crohn's disease
title_full The role of cytokines in the fibrotic responses in Crohn's disease
title_fullStr The role of cytokines in the fibrotic responses in Crohn's disease
title_full_unstemmed The role of cytokines in the fibrotic responses in Crohn's disease
title_sort The role of cytokines in the fibrotic responses in Crohn's disease
dc.creator.none.fl_str_mv Curciarello, Renata
Docena, Guillermo Horacio
MacDonald, Thomas T.
author Curciarello, Renata
author_facet Curciarello, Renata
Docena, Guillermo Horacio
MacDonald, Thomas T.
author_role author
author2 Docena, Guillermo Horacio
MacDonald, Thomas T.
author2_role author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Chronic inflammation
Crohn's disease
Cytokines
Extracellular matrix
Fibrosis
Fibrostenosis
Strictures
topic Ciencias Exactas
Chronic inflammation
Crohn's disease
Cytokines
Extracellular matrix
Fibrosis
Fibrostenosis
Strictures
dc.description.none.fl_txt_mv Crohn's disease is an idiopathic disorder of the gut thought to be caused by a combination of environmental and genetic factors in susceptible individuals. It is characterized by chronic transmural inflammation of the terminal ileum and colon, with typical transmural lesions. Complications, including fibrosis, mean that between 40 and 70% of patients require surgery in the first 10 years after diagnosis. Presently, there is no evidence that the current therapies which dampen inflammation modulate or reverse intestinal fibrosis. In this review, we focus on cytokines that may lead to fibrosis and stenosis and the contribution of experimental models for understanding and treatment of gut fibrosis.
Instituto de Estudios Inmunológicos y Fisiopatológicos
description Crohn's disease is an idiopathic disorder of the gut thought to be caused by a combination of environmental and genetic factors in susceptible individuals. It is characterized by chronic transmural inflammation of the terminal ileum and colon, with typical transmural lesions. Complications, including fibrosis, mean that between 40 and 70% of patients require surgery in the first 10 years after diagnosis. Presently, there is no evidence that the current therapies which dampen inflammation modulate or reverse intestinal fibrosis. In this review, we focus on cytokines that may lead to fibrosis and stenosis and the contribution of experimental models for understanding and treatment of gut fibrosis.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/87426
url http://sedici.unlp.edu.ar/handle/10915/87426
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2296-858X
info:eu-repo/semantics/altIdentifier/doi/10.3389/fmed.2017.00126
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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